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Bone and Lung Scan: Nuclear Medicine Safuan

1) A bone scan uses small amounts of radioactive tracer injected into the bloodstream to identify abnormalities in bone tissue through imaging. 2) It can detect cancers that have spread to bones, bone infections, bone damage from injury or disease, and other bone problems. 3) The scan involves imaging the bones at different time intervals after injection to assess blood flow, soft tissue involvement, and osteoblastic response showing areas of abnormal bone formation or activity.

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65 views10 pages

Bone and Lung Scan: Nuclear Medicine Safuan

1) A bone scan uses small amounts of radioactive tracer injected into the bloodstream to identify abnormalities in bone tissue through imaging. 2) It can detect cancers that have spread to bones, bone infections, bone damage from injury or disease, and other bone problems. 3) The scan involves imaging the bones at different time intervals after injection to assess blood flow, soft tissue involvement, and osteoblastic response showing areas of abnormal bone formation or activity.

Uploaded by

Veraaa
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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Bone and Lung Scan

Nuclear Medicine
Safuan
BONE SCAN

•Indications
• Screening of high risk patients with tumors (breast, lung, prostate or kidney) known to
metastases frequently to bone.
• Detection of early osteomyelitis.
• Detection of early avascular necrosis.
• Detection and evaluation of Paget's disease, metabolic bone disease, and other
osteopathy disease.
• Detection and evaluation of arthritis and internal joint derangements.
INDICATIONS FOR RADIONUCLIDE
BONE SCAN

• Evaluation of bone and joint pain of obscure origin.


• Evaluation following questionable abnormal skeletal radiographs.
• Serially following the course of bony response to therapeutic regimens
(radiation therapy, chemotherapy, antibiotic therapy).
• Diagnosis of reflex sympathetic dystrophy.
RADIOPHARMACEUTICAL USED Tc-99m methylene-diphosphonate (MDP)

PATIENT PREPARATION • Well hydrated.


• Empty bladder prior to imaging.
• Inform if you're pregnant.

RADIOACTIVITY ADMINISTERED • Intravenous (IV)


• 600 MBq (15 mCi)
• 800 MBq (20 mCi) for SPECT
• Scaled dose based on weight for paediatric
patients

TYPE OF Low-energy, high-resolution


COLLIMATOR USED
IMAGE ACQUISITION • When infection/tumor/mets is to be
assessed, a bolus injection is given. 3-phase
study is performed.
• Dual-head camera—scan speed 8–10
cm/min
• Spot views—minimum 500 kcounts per
view
3-PHASE BONE SCAN
Images are obtained at specific time periods after isotope injection to demonstrate
different physiologic information. Three phases are usually described:

Phase one: A dynamic flow study (radionuclide angiogram) consists of images


obtained at 1-second intervals for 60 seconds after the intravenous injection of
the radiopharmaceutical. The region of interest should be within the camera's
field of view.
Phase two: Immediately following the angiogram, static (“blood pool”) images are
obtained of the specific area or, when the localization of a lesion is not clear, a
whole body image can be acquired.
Phase three: Delayed images are acquired 2 to 4 hours after injection of
radiopharmaceutical.

Phase Name Time after Injection Purpose


One Radionuclide angiogram (Blood flow) Immediate Reflects vascularity

Two Blood pool Few minutes Reflects soft tissue involvement

Three Delayed 2 to 4 hours Reflects osteoblastic response


Normal
appearance:
Adult
There is symmetric distribution of activity
throughout the skeletal system in healthy
adults.

Urinary activity Faint renal activity

Minimal soft tissue activity

Figure 1.
Anterior (left) and posterior (right) whole
body bone scintigrams obtained in an adult
demonstrate normal anatomy.
Normal
appearance:
Children
•In children, intense symmetric uptake in
the epiphysis of long bones, which
represent centers of normal growth and
hematopoietic production, is usually
present.

•The marrow-containing flat facial bones


also demonstrate accumulation of
radiotracer in children.

Figure 2.
Anterior (left) and posterior (right) whole body
bone scintigrams obtained in a child demonstrate
normal anatomy.
Abnormal
image
Figure 4.
Extensive osseous metastases from lung
carcinoma. Anterior (left) and posterior (right)
wholebody bone scintigrams show multiple,
randomly distributed foci of abnormal
radiotracer uptake. The foci vary in size and
intensity.
Abnormal
image
Figure 5.
Paget disease.
Whole-body scintigram demonstrates increased radiotracer
accumulation in the proximal right femur and in the deformed
and enlarged tibias.

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