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Botulism

Botulism is caused by the bacterium Clostridium botulinum which produces a toxin that causes paralysis. It can be transmitted through foodborne, infant, wound, and inhalation routes. Foodborne botulism occurs when the toxin is produced in contaminated food. Infant botulism mainly affects children under 6 months when toxin is produced after spore ingestion. Wound botulism develops when spores enter the body through wounds. Inhalation botulism is rare and associated with accidents. The toxin works by blocking nerve impulses causing symptoms like blurred vision and paralysis. Treatment requires antitoxin administration and respiratory support. Botox uses botulinum toxin for both clinical and cos

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70 views16 pages

Botulism

Botulism is caused by the bacterium Clostridium botulinum which produces a toxin that causes paralysis. It can be transmitted through foodborne, infant, wound, and inhalation routes. Foodborne botulism occurs when the toxin is produced in contaminated food. Infant botulism mainly affects children under 6 months when toxin is produced after spore ingestion. Wound botulism develops when spores enter the body through wounds. Inhalation botulism is rare and associated with accidents. The toxin works by blocking nerve impulses causing symptoms like blurred vision and paralysis. Treatment requires antitoxin administration and respiratory support. Botox uses botulinum toxin for both clinical and cos

Uploaded by

Elena ro al
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PPTX, PDF, TXT or read online on Scribd
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BOTULISM

Elena Rodríguez Álvarez


E.U.E Meixoeiro
Index
1. Botulism.
2. Clostridium botulinum.
3. Transmission.
3.1. Foodborn botulism.
3.2. Infant botulism.
3.3. Wound botulism.
3.4. Inhalation botulism.
4. Pathogeny.
5. Symptomatology.
6. Treatment.
7. Botox applications.
8. Bibliography.
Botulism
❖ Botulism is a serious but unusual ❖ The bacterium produces dangerous
disease caused by a bacterium toxins (botulinum toxins) under low-
called Clostridium botulinum. oxygen conditions.
Clostridium botulinum

Gram-positive Rod-shaped

Anaerobic Spore-forming

Movility Toxin botulinum


Transmission

Botulism

Foodborne Infant Wound Inhalation


Foodborne botulism

❖ It happens when C. botulinum grows


and produces toxins in food.

❖ The bacterium will not grow in acidic


conditions.

❖ The spores are heat-resistant but the


toxin is destroyed by boiling.

❖ The toxin has been found in canned


foods.
Infant botulism
❖ It happens mostly in infants under 6
months of age.

❖ It occurs when infants ingest the


spores, which germinate into bacteria
that colonize in the gut and release
toxins.

❖ Is produced by spore-contaminated
honey.
Wound botulism
❖ Unusual.

❖ It occurs when the spores get into


an open wound in an anaerobic
conditions.

❖ Symptoms may take up to 2 weeks


to appear.

❖ It is related to drug use, specifically


the black tar heroin.
Inhalation botulism

❖ Unusual.

❖ Associated with accidents and


bioterrorism.

❖ The letal dose is 3 times greater


than in foodborne cases.

❖ The symptoms become visible


between 1–3 days.
Pathogeny

❖ The toxin works by blocking the


release of acetylcholine, preventing
the transmission of the nerve
impulse.

❖ The toxin reaches the cholinergic


nerve endings lymphatically or by
blood.

❖ Peripheral nervous system.


NORMAL BOTULISM
Symptomatology

Abdominal colic Dyspnoea Double vision


Symptomatology

Dysphagia Vomiting Paralysis


Treatment

Botulinum antitoxin Respirators Feeding probe Intravenous fluids


‘Botox’ applications

Clinical Cosmetic
applications applications

Tourette
Squint Dystonia Paraplejia Wrinkles
syndrome
Bibliography
1. Iowa State University. Botulismo. Iowa. 2010 [Consulted on April 3th of 2020]. Available
on: http://www.cfsph.iastate.edu/Factsheets/es/botulism-es.pdf
2. Medline Plus. Botulismo. 2019 [Consulted on April 5th of 2020]. Available on:
https://medlineplus.gov/spanish/ency/article/000598.htm
3. Agencia Española de Seguridad Alimentaria y Nutrición. Botulismo. España. 2019
[Consulted on April 1st of 2020]. Available on:
http://www.aecosan.msssi.gob.es/AECOSAN/web/seguridad_alimentaria/subdetalle/Bot
ulismo.htm
4. Sanitas. Aplicaciones médicas del bótox. [Consulted on April 3th of 2020]. Available on:
https://www.sanitas.es/sanitas/seguros/es/particulares/biblioteca-de-salud/prevencion-s
alud/aplicaciones-medicas-botox.html
5. World Health Organization. Botulism. [Consulted on April 3th of 2020]. Available on:
https://www.who.int/en/news-room/fact-sheets/detail/botulism
END

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