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Beta Nanoparticles

This document discusses the use of nanoparticles in nanomedicine. It outlines how nanoparticles can be used for drug delivery by encapsulating drugs in smart nanoparticles, hydrogel systems, or magnetic nanoparticles that target specific sites. Nanoparticles like carbon nanotubes, gold nanoparticles, and silicon nanowires can also be used for disease detection by attaching antibodies to identify cancer cells or viruses. Molecular imaging is another application where quantum dots or gold nanoparticles are used to track movement of molecules or angiogenesis. While nanoparticles show promise for medical applications, further research is still needed to fully understand their biological effects and safety.

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Joel Mathew
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37 views15 pages

Beta Nanoparticles

This document discusses the use of nanoparticles in nanomedicine. It outlines how nanoparticles can be used for drug delivery by encapsulating drugs in smart nanoparticles, hydrogel systems, or magnetic nanoparticles that target specific sites. Nanoparticles like carbon nanotubes, gold nanoparticles, and silicon nanowires can also be used for disease detection by attaching antibodies to identify cancer cells or viruses. Molecular imaging is another application where quantum dots or gold nanoparticles are used to track movement of molecules or angiogenesis. While nanoparticles show promise for medical applications, further research is still needed to fully understand their biological effects and safety.

Uploaded by

Joel Mathew
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPT, PDF, TXT or read online on Scribd
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Nanoparticles and their medical

applications

By:
Maryam Liaqat
Jason Feng
Eric Ma
Outline

 Nanomedicine – what is it?

 Nanoparticle Applications:
– Drug Delivery - Maryam
– Detection - Eric
– Imaging - Jason

 Nanotechnology Concerns
Nanomedicine

 Nanotechnology applied medically


 New breakthroughs in medicine
– Advanced biomedical research tools
– Labels to experiments
– Study of DNA and its component genes
– Diagnostic tests
– In bone implants etc…
Drug Delivery Methods

 Systems that deliver drugs to specific sites

 Sample Methods:
– Smart Drugs

– Nanocomposite hydrogel systems

– Magnetic Nanoparticles
Drug Delivery

 Smart drugs
– Attack specific antigens
– Immunotoxins that are protein in nature
– Consist of an antibody part and toxic part
Drug Delivery

 Nanocomposite hydrogel systems


– Thermo therapeutic process
– Releases drugs that are encapsulated on heating
– Gold nanoshells/nanoparticles can be used
– Ideal wavelengths of light are infra red i.e 800-1200nm
Drug Delivery

 Magnetic Nanoparticles
– Drugs are bound to magnetic nanoparticles
– Carry drugs to malignant sites with magnetic fields
– Release the drugs by enzymatic activity
Disease Detection

 Cancer/Virus Detection
– Carbon Nanotubes
– Gold nanoparticles & Nanodots
– Nanowires
 Gene Detection
– Silicon nanowires

Picture taken from


http://mednews.wustl.edu/tips/page/normal/5036.html
Cancer/Virus Detection
 Carbon Nanotubes:
– Covered with monoclonal antibodies
– Antibodies for growth factor receptor commonly found in
cancer cells
– Current increases measured
 Silicon Nanowires
– Similar in use to nanotubes
– Antibodies attached to wire Taken from http://www.news.harvard.edu/gazette/
– Current changes measured 2004/10.07/01-nanovirus.html

– Can be applied to cancer cells and viruses


Cancer/Virus Detection

 Gold Nanoparticles & Nanodots


– Similar application
– Antibodies attached to nanoparticles
– Nanoparticle antibodies bind to cancer cells
– Colors reflected when light hits particles
– Shapes and sizes affect color

Taken from http://www.gatech.edu/news-room


/release.php?id=561
Gene Detection

 Silicon nanowire:
– Can detect specific genes
– Nucleic acids attached to nanowires
– Specific sequences can be created
– Sensor capable of differentiating mutated and
nonmutated genes
– PCR not needed -> detection time lowered
Imaging Techniques

 Conventional Techniques:
– X-ray, MRI, Fluoroscopy
– CAT scan
 Limitations
– Limited detail
– Difficult to track movement
Taken from: http://www.besttreatments.co.uk/btuk
/images/lung_cancer_xray.jpg
Imaging Applications

 Molecular Tracking:
– Use Quantum Dots as labels
 Dots attached to molecules before injection
– Fluoroscopy used to track movement
 Colors from dots seen and imaged
Imaging Applications

 Tracking blood flow:


– Tag proteins of cells with gold nanoparticles
– View process of angiogenesis
 Important for cancer detection and imaging
 Cancer Imaging:
– Injection of gold nanoparticles
– Localization around tumors
– CT scan shows cancerous regions Taken from http://www.rsna.org/
Publications/rsnanews/oct05/nanoparticles.cfm
Possible Concerns

 Negative biological side-effects:


– Toxicity of quantum nanodots
– Effects on living organisms not well known
 Gold nanoparticles safer:
– Biologically inert
– Won’t interact with other chemicals

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