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Dengue

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osmotrial001
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7 views10 pages

Dengue

Uploaded by

osmotrial001
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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DENGUE

INTRODUCITON AND EPIDEMIOLOGY


• Dengue fever is an acute febrile illness characterized
by fever, myalgia, arthralgi and rash.
• Severe dengue infection is characterized by
abnormalities in hemostasis and by leakage of plasma
from the capillaries which may lead to shock and
death.
EPIDEMIOLOGY:
• The globlal prevalance is increased
• Endemic in more than 100 countries in Africa, America
and the Eastern Mediterranean, Southeast Asia and
Western Pacific.
• Studies estimated more than 90 million annual
symptomatic cases of dengue across the world.
• Attack rates approx. 40 -50%
• An estimated 5,00,000 cases with severe
dengue fever need hospitalization
• 2.5% dies due to dengue fever.
• Without proper diagnosis and treatment the
mortality rate can increase upto 20% due
to dengue hemorrhagic fever.
• Pre-dominant vector is the urban species
Ades aegypti
• A rapid rise in urban population increases
number of people into contact especially
due to breeding sites.
VIRUS:
• Arbovirus
• Family – Flaviviridae
• RNA type of virus
• Dengue fever is caused by
four serotypes of Arbovirus.
• Approximately 50nm in
diameter with approximately
1100 nucleotides.
• The envelop protein bears
the epitopes that are
unique to each serotypes.
• Antibodies to these
epitopes neutralizes the
virus by interfering with
entry of virus into the
cells.
• Four well defined
serotypes are: DENV-1,
DENV-2, DENV-3, DENV-
4
TRANSMISSION:
• Transmitted through bites
of infected female Ades
mosquitoes.
• They acquire virus from
the infected person
through feeding.
• Incubation period is 3-7
days in mosquitoes and
they are suceptible to
infect healthy individuals
• Infected females also transmitt the virus
through transovarial into their offsprings.
• Humans are the main amplifying hosts.
• The virus circulates in the blood for 2-7
days as approximately as same time as
fever.

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