Scribd
Upload
12 views9 pages

Presentation of WAQAR ALI

Aging is a complex process influenced by various mechanisms such as cellular senescence, telomere shortening, oxidative stress, inflammation, mitochondrial dysfunction, and epigenetic changes. These factors contribute to the decline in cellular function and the development of age-related diseases. Understanding these mechanisms is essential for developing interventions to promote healthy aging and prevent related diseases.

Uploaded by

waqaralikhoso7867
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
12 views9 pages

Presentation of WAQAR ALI

Aging is a complex process influenced by various mechanisms such as cellular senescence, telomere shortening, oxidative stress, inflammation, mitochondrial dysfunction, and epigenetic changes. These factors contribute to the decline in cellular function and the development of age-related diseases. Understanding these mechanisms is essential for developing interventions to promote healthy aging and prevent related diseases.

Uploaded by

waqaralikhoso7867
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
You are on page 1/ 9

Introduction

to Aging
Mechanisms in
Humans
Aging is a complex and multifaceted process that involves a variety
of interconnected mechanisms within the human body. This
presentation will explore the key factors that contribute to the
aging process, providing a comprehensive understanding of how
our cells and systems change over time.

WA by Waqar Ali
As cells age, they
become unable to Senescent cells The accumulation of
divide and replicate, release senescent cells
leading to a buildup inflammatory impairs the body's
of senescent cells factors, which can ability to regenerate
that no longer contribute to tissue and repair damaged
function properly. dysfunction and the tissues, further
development of age- exacerbating the
related diseases. aging process.
Telomere
Shortening
1 Chromosome Ends
Telomeres are the protective caps at the ends of chromosomes, which
shorten with each cell division.

2 Replicative Lifespan
As telomeres become shorter, cells lose their ability to divide,
contributing to cellular senescence and aging.

3 Genomic Instability
Shortened telomeres can also lead to chromosomal abnormalities,
further exacerbating the aging process.
Oxidative
Stress
Free Antioxidant Cellular
Radicals Defenses Dysfunction
Reactive oxygen species The body has natural Uncontrolled oxidative
and other free radicals can antioxidant systems to stress leads to cellular
damage cellular neutralize free radicals, dysfunction, contributing
components, including DNA, but these systems can to the development of
proteins, and lipids. become overwhelmed age-related diseases.
with age.
Inflammation and Immune
Dysfunction
Chronic Inflammation Immune Senescence
Aging is associated with a state of low- The immune system becomes less
grade, chronic inflammation, which can effective with age, leading to a reduced
exacerbate tissue damage and age- ability to fight off infections and cancer.
related diseases.

Autoimmunity Inflammaging
Older adults are more prone to The interplay between inflammation
developing autoimmune disorders, and immune dysfunction is a key
where the immune system mistakenly driver of the aging process, known as
attacks the body's own tissues. "inflammaging".
Mitochondrial
Dysfunction
1 3
2
Mitochondrial Energy Cellular
Damage Production Dysfunction
Oxidative stress and Impaired mitochondrial Mitochondrial dysfunction
other factors can function leads to is linked to a wide range of
damage mitochondria, reduced energy age- related diseases,
the powerhouses of production, including
our cells. contributing to cellular neurodegenerative
senescence and tissue disorders and metabolic
deterioration. disorders.
Epigenetic
Changes
DNA Methylation Histone Non-Coding RNA
Modifications
Alterations in DNA Dysregulation of non-coding
methylation patterns can Changes in histone RNAs, including microRNAs,
lead to changes in gene modifications, such as can disrupt gene regulatory
expression, contributing to acetylation and networks and promote
the aging process. methylation, can also affect aging.
gene expression and
cellular function.
Lifestyle Factors
Influencing Aging
Die A balanced, nutrient-rich diet can
t support cellular health and reduce
the impact of oxidative stress and
inflammation.
Exercise Regular physical activity can improve
mitochondrial function, reduce
inflammation, and promote healthy
aging.
Stress Management Chronic stress can accelerate cellular
aging, making stress reduction and
relaxation techniques important.

Sleep Adequate, high-quality sleep is


essential for cellular repair and
regeneration, as well as immune
function.
Conclusion and
Future
Directions
Understanding the complex mechanisms of aging is crucial for
developing effective interventions to promote healthy aging and
prevent age-related diseases. Ongoing research in areas such as
senolytic therapies, telomere maintenance, and personalized
medicine hold promise for the future.

You might also like

pFad - Phonifier reborn

Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy