Ro10-5824

Ro10-5824
IUPAC ime
	2-metil-5-[(4-fenil-3,6-dihidro-2H-piridin-1-il)metil]pirimidin-4-amin
Identifikatori
CAS broj	189744-46-5
ATC kod	none
PubChem	CID 16759175
Hemijski podaci
Formula	C17H20N4
Molarna masa	280,367 g/mol
	SMILES c3ccccc3C(=CC2)CCN2Cc1cnc(C)nc1N; ;

Ro10-5824 je lek koji deluje kao dopaminski agonist. On je selektivni parcijalni agonist D₄ podtipa. Ro10-5824 deluje kao kognitivni pojačivač u životinjskim studijama.^[1]^[2]

Reference

^ Powell SB, Paulus MP, Hartman DS, Godel T, Geyer MA (2003). „RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice”. Neuropharmacology. 44 (4): 473—81. PMID 12646284. doi:10.1016/S0028-3908(02)00412-4.
^ Newman-Tancredi A, Heusler P, Martel JC, Ormière AM, Leduc N, Cussac D (2008). „Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells”. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). 11 (3): 293—307. PMID 17897483. doi:10.1017/S1461145707008061.

Spoljašnje veze

[pmid12646284-1] Powell SB, Paulus MP, Hartman DS, Godel T, Geyer MA (2003). „RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice”. Neuropharmacology. 44 (4): 473—81. PMID 12646284. doi:10.1016/S0028-3908(02)00412-4.

[pmid17897483-2] Newman-Tancredi A, Heusler P, Martel JC, Ormière AM, Leduc N, Cussac D (2008). „Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells”. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). 11 (3): 293—307. PMID 17897483. doi:10.1017/S1461145707008061.

[1]

[2]

Reference

Spoljašnje veze

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