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In enzymology, 6,7-dihydropteridine reductase (EC 1.5.1.34, also Dihydrobiopterin reductase) is an enzyme that catalyzes the chemical reaction 5,6,7,8-tetrahydropteridine + NAD(P)+ 6,7-dihydropteridine + NAD(P)H + H+ The four substrates for this enzyme are a 6,7-dihydropteridine (dihydrobiopterin), NADH, NADPH, and H+ and its three products are 5,6,7,8-tetrahydropteridine (tetrahydrobiopterin), NAD+, and NADP+ This enzyme participates in folate biosynthesis. In the human genome, the enzyme is encoded by the QDPR gene.

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dbo:abstract
  • In enzymology, 6,7-dihydropteridine reductase (EC 1.5.1.34, also Dihydrobiopterin reductase) is an enzyme that catalyzes the chemical reaction 5,6,7,8-tetrahydropteridine + NAD(P)+ 6,7-dihydropteridine + NAD(P)H + H+ The four substrates for this enzyme are a 6,7-dihydropteridine (dihydrobiopterin), NADH, NADPH, and H+ and its three products are 5,6,7,8-tetrahydropteridine (tetrahydrobiopterin), NAD+, and NADP+ This enzyme participates in folate biosynthesis. In the human genome, the enzyme is encoded by the QDPR gene. (en)
  • 6,7-ジヒドロプテリジンレダクターゼ(6,7-dihydropteridine reductase、DHPR)は、葉酸生合成酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 5,6,7,8-テトラヒドロプテリジン + NAD(P)+ 6,7-ジヒドロプテリジン + NAD(P)H + H+ 反応式の通り、この酵素の基質は5,6,7,8-テトラヒドロプテリジンとNAD+(またはNADP+)、生成物は6,7-ジヒドロプテリジンとNADH(NADPH)とH+である。 組織名は5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductaseで、別名に6,7-dihydropteridine:NAD(P)H oxidoreductase、NAD(P)H:6,7-dihydropteridine oxidoreductase、NADH-dihydropteridine reductase、NADPH-dihydropteridine reductase、NADPH-specific dihydropteridine reductase、dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase、dihydropteridine reductase、dihydropteridine reductase (NADH)、5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductaseがある。 (ja)
  • La 6,7-diidropteridina reduttasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: a 5,6,7,8-tetraidropteridina + NAD(P)+ ⇄ una 6,7-diidropteridina + NAD(P)H + H+ Il substrato è la forma della diidropteridina. Non è uguale alla diidrofolato reduttasi (numero EC 1.5.1.3). (it)
  • Reduktaza dihydropterydyny (EC 1.5.1.34) jest enzymem z klasy oksydoreduktaz. Współpracuje z dinukleotydem nikotynamidoadeninowym. Przeprowadza odwracalną reakcję redukcji dihydropterydyny do tetrahydropterydyny, utleniając tym samym NAD(P)H do NAD(P)+. (pl)
  • 6,7-Дигидроптеридинредуктаза — фермент, катализирующий следующую реакцию: 5,6,7,8-тетрагидроптеридин + NAD+ = 6,7-дигидроптеридин + H+ + NADH Дигидроптеридинредуктаза играет важную роль в регенерации тетрагидробиоптерина — кофактора, участвующего в ряде реакций гидроксилирования, в результате которых происходит образование тирозина, дофамина, норадреналина и серотонина. В организме человека данный фермент кодируется геном . (ru)
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  • 1.5.1.34
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  • Dihydropteridine reductase dimer, Human (en)
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  • 9074-11-07 (xsd:date)
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  • 1.500000 (xsd:double)
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  • 4155 (xsd:integer)
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  • 1 (xsd:integer)
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rdfs:comment
  • In enzymology, 6,7-dihydropteridine reductase (EC 1.5.1.34, also Dihydrobiopterin reductase) is an enzyme that catalyzes the chemical reaction 5,6,7,8-tetrahydropteridine + NAD(P)+ 6,7-dihydropteridine + NAD(P)H + H+ The four substrates for this enzyme are a 6,7-dihydropteridine (dihydrobiopterin), NADH, NADPH, and H+ and its three products are 5,6,7,8-tetrahydropteridine (tetrahydrobiopterin), NAD+, and NADP+ This enzyme participates in folate biosynthesis. In the human genome, the enzyme is encoded by the QDPR gene. (en)
  • La 6,7-diidropteridina reduttasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: a 5,6,7,8-tetraidropteridina + NAD(P)+ ⇄ una 6,7-diidropteridina + NAD(P)H + H+ Il substrato è la forma della diidropteridina. Non è uguale alla diidrofolato reduttasi (numero EC 1.5.1.3). (it)
  • Reduktaza dihydropterydyny (EC 1.5.1.34) jest enzymem z klasy oksydoreduktaz. Współpracuje z dinukleotydem nikotynamidoadeninowym. Przeprowadza odwracalną reakcję redukcji dihydropterydyny do tetrahydropterydyny, utleniając tym samym NAD(P)H do NAD(P)+. (pl)
  • 6,7-Дигидроптеридинредуктаза — фермент, катализирующий следующую реакцию: 5,6,7,8-тетрагидроптеридин + NAD+ = 6,7-дигидроптеридин + H+ + NADH Дигидроптеридинредуктаза играет важную роль в регенерации тетрагидробиоптерина — кофактора, участвующего в ряде реакций гидроксилирования, в результате которых происходит образование тирозина, дофамина, норадреналина и серотонина. В организме человека данный фермент кодируется геном . (ru)
  • 6,7-ジヒドロプテリジンレダクターゼ(6,7-dihydropteridine reductase、DHPR)は、葉酸生合成酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 5,6,7,8-テトラヒドロプテリジン + NAD(P)+ 6,7-ジヒドロプテリジン + NAD(P)H + H+ 反応式の通り、この酵素の基質は5,6,7,8-テトラヒドロプテリジンとNAD+(またはNADP+)、生成物は6,7-ジヒドロプテリジンとNADH(NADPH)とH+である。 (ja)
rdfs:label
  • 6,7-dihydropteridine reductase (en)
  • 6,7-diidropteridina reduttasi (it)
  • 6,7-ジヒドロプテリジンレダクターゼ (ja)
  • Reduktaza dihydrobiopterydyny (pl)
  • 6,7-Дигидроптеридинредуктаза (ru)
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  • 6,7-dihydropteridine reductase (en)
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