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Hypergonadotropic hypogonadism (HH), also known as primary or peripheral/gonadal hypogonadism or primary gonadal failure, is a condition which is characterized by hypogonadism which is due to an impaired response of the gonads to the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and in turn a lack of sex steroid production. As compensation and the lack of negative feedback, gonadotropin levels are elevated. Individuals with HH have an intact and functioning hypothalamus and pituitary glands (of the hypothalamic-pituitary-gonadal (HPA) axis) so they are still able to produce FSH and LH. HH may present as either congenital or acquired, but the majority of cases are of the former nature. HH can be treated with hormone replacement therapy.

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dbo:abstract
  • Der hypergonadotrope Hypogonadismus ist eine seltene angeborene Erkrankung mit einer Unterfunktion der Keimdrüsen (Gonaden) und mit gleichzeitig erhöhter Konzentration der Gonadotropine aufgrund verminderten oder fehlenden Ansprechens der Gonaden auf Gonadotropine. Weitere Bezeichnungen sind: Gonadotropinresistenz; primärer Hypogonadismus (de)
  • Hypergonadotropic hypogonadism (HH), also known as primary or peripheral/gonadal hypogonadism or primary gonadal failure, is a condition which is characterized by hypogonadism which is due to an impaired response of the gonads to the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and in turn a lack of sex steroid production. As compensation and the lack of negative feedback, gonadotropin levels are elevated. Individuals with HH have an intact and functioning hypothalamus and pituitary glands (of the hypothalamic-pituitary-gonadal (HPA) axis) so they are still able to produce FSH and LH. HH may present as either congenital or acquired, but the majority of cases are of the former nature. HH can be treated with hormone replacement therapy. (en)
dbo:synonym
  • Peripheral/gonadal hypogonadism
dbo:wikiPageID
  • 35933848 (xsd:integer)
dbo:wikiPageLength
  • 15710 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1104816474 (xsd:integer)
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dbp:specialty
  • endocrinology (en)
dbp:synonym
  • Peripheral/gonadal hypogonadism (en)
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gold:hypernym
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rdfs:comment
  • Der hypergonadotrope Hypogonadismus ist eine seltene angeborene Erkrankung mit einer Unterfunktion der Keimdrüsen (Gonaden) und mit gleichzeitig erhöhter Konzentration der Gonadotropine aufgrund verminderten oder fehlenden Ansprechens der Gonaden auf Gonadotropine. Weitere Bezeichnungen sind: Gonadotropinresistenz; primärer Hypogonadismus (de)
  • Hypergonadotropic hypogonadism (HH), also known as primary or peripheral/gonadal hypogonadism or primary gonadal failure, is a condition which is characterized by hypogonadism which is due to an impaired response of the gonads to the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and in turn a lack of sex steroid production. As compensation and the lack of negative feedback, gonadotropin levels are elevated. Individuals with HH have an intact and functioning hypothalamus and pituitary glands (of the hypothalamic-pituitary-gonadal (HPA) axis) so they are still able to produce FSH and LH. HH may present as either congenital or acquired, but the majority of cases are of the former nature. HH can be treated with hormone replacement therapy. (en)
rdfs:label
  • Hypergonadotroper Hypogonadismus (de)
  • Hypergonadotropic hypogonadism (en)
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