Ramón López de Osornio (1685 – 1757) was a Spanish landowner and military man who served as commander of provincial militias during the colonial period of Argentina. He owned farms in the towns of La Matanza and Magdalena, where he dedicated himself to raising cattle. He was the uncle of Clemente López de Osornio, a known military man and landowner killed during an indigenous raid on his ranch, and relative to Casimiro Alegre. a distinguished commander of militias in the towns of Magdalena and San Vicente.