KAT2A Dynodwyr Cyfenwau KAT2A Dynodwyr allanol OMIM: 602301 HomoloGene: 41343 GeneCards: KAT2A Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • GO:0001105 transcription coactivator activity • N-acetyltransferase activity • transcription factor binding • histone deacetylase binding • chromatin binding • H3 histone acetyltransferase activity • GO:0001948, GO:0016582 protein binding • acetyltransferase activity • histone acetyltransferase activity (H4-K12 specific) • protein phosphatase binding • acyltransferase activity • histone acetyltransferase activity • thiol-dependent deubiquitinase • peptide-lysine-N-acetyltransferase activity • histone succinyltransferase activity Cydrannau o'r gell • transcription factor TFTC complex • nucleoplasm • histone acetyltransferase complex • mitotic spindle • extracellular space • cnewyllyn cell • Cromosom • cytoplasm • centrosome • microtubule organizing center • Cytosgerbwd • oxoglutarate dehydrogenase complex Prosesau biolegol • positive regulation of transcription regulatory region DNA binding • somitogenesis • epigenetic maintenance of chromatin in transcription-competent conformation • chromatin remodeling • metencephalon development • cellular response to nerve growth factor stimulus • GO:0009373 regulation of transcription, DNA-templated • regulation of protein stability • GO:1904578 response to organic cyclic compound • multicellular organism growth • positive regulation of protein targeting to mitochondrion • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • cardiac muscle cell differentiation • cellular response to tumor necrosis factor • histone H3-K14 acetylation • positive regulation of cell projection organization • in utero embryonic development • transcription by RNA polymerase II • transcription, DNA-templated • nervous system development • positive regulation of histone acetylation • histone deubiquitination • telencephalon development • neural tube closure • response to nutrient levels • regulation of autophagy of mitochondrion • histone acetylation • histone H3 acetylation • cell population proliferation • GO:0022415 viral process • intracellular distribution of mitochondria • histone H4-K12 acetylation • alpha-tubulin acetylation • midbrain development • protein deubiquitination • GO:0032617 cytokine production • heart development • long-term memory • internal peptidyl-lysine acetylation • regulation of regulatory T cell differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of centriole replication • regulation of synaptic plasticity • regulation of T cell activation • limb development • histone succinylation • positive regulation of cardiac muscle cell differentiation Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[ 1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn KAT2A yw KAT2A a elwir hefyd yn Lysine acetyltransferase 2A (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q21.2.[ 2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KAT2A.
"Structural basis for acyl-group discrimination by human Gcn5L2. ". Acta Crystallogr D Struct Biol . 2016. PMID 27377381 . "Lysine acetyltransfer supports platelet function. ". J Thromb Haemost . 2015. PMID 26256950 . "Quantitating the specificity and selectivity of Gcn5-mediated acetylation of histone H3. ". PLoS One . 2013. PMID 23437046 . "Investigation of the acetylation mechanism by GCN5 histone acetyltransferase. ". PLoS One . 2012. PMID 22574209 . "Knock down of GCN5 histone acetyltransferase by siRNA decreases ethanol-induced histone acetylation and affects differential expression of genes in human hepatoma cells. ". Alcohol . 2011. PMID 21367571 . 
