Metabolic modelling as a powerful tool to identify critical components of Pneumocystis growth medium
Fig 7
In silico gene knockout experiment: serine and glycine interconversion.
(A) The biomass flux predicted by the model in the medium designed by Merali et al [16] and in equivalent medium lacking serine, glycine, or both, or where the SHMT enzyme is "switched off". Biomass flux is expressed relative to that observed for Merali’s medium. (B) Schematic representation of the above in silico experiment.