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Highlights

  • Enhancing the Cre-loxP system

    Two new genetic tools – roxCre and loxCre – can improve the performance of the Cre-loxP system for making genetic modifications in vivo.

    Mengyang Shi, Jie Li ... Bin Zhou
    Reviewed Preprint Updated

  • Cell mechanics and metastasis

    The discovery of a pro-invasive mechanotransduction pathway driven by cell crowding suggests that an ion channel called TRPV4 may be a promising therapeutic target for inhibiting metastasis.

    Xiangning Bu, Nathanael Ashby ... Inhee Chung
    Reviewed Preprint Updated

  • Science Under Threat in the US

    The new administration in the US is conducting an assault on science and scientists – how should the scientific community respond?

    Collection

Latest research

    1. Cell Biology

    Clearance of protein aggregates during cell division

    Shoukang Du, Yuhan Wang ... Ting Gang Chew
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Medicine

    Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa

    Hyun Beom Song, Laura Campello ... Anand Swaroop
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Developmental Biology

    Oviductin sets the species-specificity of the mammalian zona pellucida

    Daniel de la Fuente, Maria Maroto ... Alfonso Gutiérrez-Adán
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Cell Biology

    C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin

    Jessica Mella, Regan Volk ... Abigail Buchwalter
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Structural Biology and Molecular Biophysics

    Structural and Dynamic Impacts of Single-atom Disruptions to Guide RNA Interactions within the Recognition Lobe of Geobacillus stearothermophilus Cas9

    Helen B Belato, Alexa L Knight ... George P Lisi
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity

    Jordan M Mancl, Wenguang G Liang ... Wei-Jen Tang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Sense of control buffers against stress

    Jennifer C Fielder, Jinyu Shi ... Nikolaus Steinbeis
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Developmental Biology

    Transcriptome profiling of tendon fibroblasts at the onset of embryonic muscle contraction reveals novel force-responsive genes

    Pavan K Nayak, Arul Subramanian, Thomas F Schilling
    1. Cell Biology

    CDK-mediated phosphorylation of PNKP is required for end-processing of single-strand DNA gaps on Okazaki fragments and genome stability

    Kaima Tsukada, Rikiya Imamura ... Mikio Shimada
    It was revealed that phosphorylation of the DNA repair enzyme PNKP at threonine 118 by CDK is required for DNA replication through the gap filling of Okazaki fragments.
    1. Developmental Biology
    2. Genetics and Genomics

    Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice

    Menglei Yang, Hafiz Muhammad Jafar Hussain ... Baolu Shi
    DNAH12 is essential for sperm flagellar development and male fertility in both humans and mice by interacting with dynein proteins DNAH1 and DNALI1.
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Magazine

  1. Science Under Threat in the United States: Campaigning for science and scientists

    Adriana Bankston
    1. Neuroscience

    Memory: Integrating past experiences

    Thomas MW Leir, Matthew PH Gardner

  3. Science Under Threat in the United States: How to make science more efficient

    Stuart Buck
  4. Scientists at a Stand Up For Science rally

    Science Under Threat in the US

    Edited by Peter A Rodgers

  5. Science Under Threat in the United States: The impact on undergraduate students

    Reenie Tian, Kamna Kalkunte ... Mayank Chugh

  6. Science Under Threat in the United States: Research turns hope into reality

    Anna C Greene, Casey S Greene

  7. Science Under Threat in the United States: Feeling abandoned but energized

    Vaughn S Cooper
  8. See more Magazine articles

Research categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Plant Biology
  17. Stem Cells and Regenerative Medicine
  18. Structural Biology and Molecular Biophysics
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