Hydrocortisone buteprate

Hydrocortisone buteprate
Clinical data
Trade names	Pandel
Other names	Hydrocortisone probutate; Hydrocortisone 17α-butyrate 21-propionate; Hydrocortisone butyrate propionate, hydrocortisone probutate (USAN US)
AHFS/Drugs.com	Monograph
Pregnancy; category	AU: A; ;
Routes of; administration	Topical
ATC code	D07AB11 (WHO) ;
Legal status
Legal status	US: OTC;
Identifiers
	IUPAC name (11β)-11-hydroxy-3,20-dioxo-21-(propionyloxy)pregn-4-en-17-yl butyrate;
CAS Number	72590-77-3 ;
PubChem CID	636398;
DrugBank	DB14543 ;
ChemSpider	552186 ;
UNII	O6550D6K3A;
KEGG	D01886; C13358;
ChEBI	CHEBI:31675;
ChEMBL	ChEMBL200953;
CompTox Dashboard (EPA)	DTXSID3048603 ;
ECHA InfoCard	100.069.730
Chemical and physical data
Formula	C28H40O7
Molar mass	488.621 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)C(=O)COC(=O)CC;
	InChI InChI=1S/C28H40O7/c1-5-7-24(33)35-28(22(31)16-34-23(32)6-2)13-11-20-19-9-8-17-14-18(29)10-12-26(17,3)25(19)21(30)15-27(20,28)4/h14,19-21,25,30H,5-13,15-16H2,1-4H3/t19-,20-,21-,25+,26-,27-,28-/m0/s1 ; Key:FOGXJPFPZOHSQS-AYVLZSQQSA-N ;
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Hydrocortisone buteprate, also known as hydrocortisone probutate and as hydrocortisone butyrate propionate, is a topical corticosteroid.^[2]^[3] It is an ester of hydrocortisone (cortisol) with butyric acid and propionic acid.

References

^ ^a ^b "Hydrocortisone topical Use During Pregnancy". Drugs.com. 5 December 2019. Retrieved 13 September 2020.
^ Drugs.com: Hydrocortisone Buteprate topical
^ Sears HW, Bailer JW, Yeadon A (1997). "Efficacy and safety of hydrocortisone buteprate 0.1% cream in patients with atopic dermatitis". Clinical Therapeutics. 19 (4): 710–9. doi:10.1016/s0149-2918(97)80095-1. PMID 9377615.

"Hydrocortisone probutate". Drug Information Portal. U.S. National Library of Medicine.

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