Zinc finger protein 334

Zinc finger protein 334 is a protein that in humans is encoded by the ZNF334 gene.

ZNF334
Identifiers
Aliases	ZNF334, zinc finger protein 334
External IDs	MGI: 2388656; HomoloGene: 23076; GeneCards: ZNF334; OMA:ZNF334 - orthologs
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H3 Start 165,216,184 bp End 165,230,179 bp
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding metal ion binding nucleic acid binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55713 228876 Ensembl ENSG00000198185 ENSMUSG00000017667 UniProt Q9HCZ1 A2A4U6 RefSeq (mRNA) NM_001270497 NM_018102 NM_199441 NM_178411 RefSeq (protein) NP_001257426 NP_060572 NP_001340742 NP_001340743 NP_001340744 NP_001340745 NP_001340746 NP_001340747 NP_001340748 NP_001340749 NP_001340750 NP_001340751 NP_001340752 NP_001340753 NP_001340754 NP_001340755 NP_955473 NP_848498 Location (UCSC) n/a Chr 2: 165.22 – 165.23 Mb PubMed search
Wikidata
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Function

This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Further reading

• Henc I, Soroczyńska-Cybula M, Bryl E, Witkowski JM (2015). "The in vitro modulatory effect of TNFα on the mRNA expression and protein levels of zinc finger protein ZNF334 in CD4(+) lymphocytes of healthy people". Acta Biochim. Pol. 62 (1): 113–7. doi:10.18388/abp.2014_857. PMID 25738173.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.