On 10 February, St Helens began their Super League campaign against Catalans Dragons. In a rematch of the 2021 Grand Final they repeated their success, this time with a 28–8 win.[1] This was followed with a 38–6 win Hull F.C. that saw St Helens move to top of the table on points difference.[2] Their good form continued as they won their opening five games[3] before suffering an unexpected 22–20 away loss to Toulouse Olympique.[4] In April, St Helens faced Catalans Dragons in the quarter-finals of the Challenge Cup and progressed with a 36–20 win.[5] They then reinforced their position at the top of the league with wins over Wigan Warriors and Huddersfield Giants.[6] In the semi-finals of the Challenge Cup, St Helens lost to Wigan.[7] Meanwhile they continued to perform well in the league and a 13–12 win over Wakefield Trinity in July moved them six points clear at the top of the table.[8]
At the end of August, St Helens suffered their only home loss of the season, 34–18 to Wakefield, but despite this were confirmed as league leaders' as Wigan also lost.[9] The final round of the regular season was a top against bottom clash in which St Helens won 36–16 over an already relegated Toulouse.[10] As league leaders', St Helens began their play-off campaign at the semi-finals stage with a 19–12 home win over Salford Red Devils.[11] At the 2022 Super League Awards on 20 September, Jack Welsby was named the Young Player of the Year.[12] On 24 September, St Helens won 24–12 against Leeds Rhinos to become the first club to win four consecutive Super League Grand Finals. Jonny Lomax was named as the man of the match.[13]