Fourphit
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| Other names | 4-Isothiocyanato-PCP |
| Drug class | Irreversible dopamine transporter blocker; Reversible NMDA receptor antagonist; Psychostimulant antagonist |
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| Formula | C18H24N2S |
| Molar mass | 300.46 g·mol−1 |
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Fourphit, also known as 4-isothiocyanato-PCP, is an irreversible dopamine transporter (DAT) blocker and a reversible NMDA receptor antagonist.[1][2] It blocks the binding of methylphenidate to the DAT in vitro,[1] though apparently not in vivo.[2] In any case, the drug reduces the stimulant-like effects of cocaine in animals,[2] whilst producing mostly negligible behavioral effects itself.[2] Fourphit is an acylating derivative of phencyclidine (PCP) and a positional isomer of metaphit (3-isothiocyanato-PCP).[1]
See also
[edit]References
[edit]- ^ a b c Schweri MM, Thurkauf A, Mattson MV, Rice KC (June 1992). "Fourphit: a selective probe for the methylphenidate binding site on the dopamine transporter". J Pharmacol Exp Ther. 261 (3): 936–942. PMID 1602399.
- ^ a b c d Schweri MM, de Costa BR, Rice KC (July 1998). "Fourphit, an acylating phencyclidine derivative, attenuates cocaine-induced hyperactivity in rats". Pharmacol Biochem Behav. 60 (3): 615–623. doi:10.1016/s0091-3057(98)00040-9. PMID 9678644.
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