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  1. Pheochromocytoma (Pheo) represents a potential metastatic neuroendocrine tumor. As a tumor suppressor gene, LRP1B is involved in the regulation of tumor progression. However, the precise regulatory mechanism of L...

    Authors: Min Sun, Yanrong Ma, Jing Wan, Bingli Zheng, Zhenfeng Shi and Jiuzhi Li
    Citation: Epigenetics & Chromatin 2025 18:29
    Content type: Research Published on:

  2. Thyroid-associated ophthalmopathy (TAO) is an autoimmune orbital disease influenced by multiple factors, including genetic and immune factors. The enlargement of orbital fat tissues are mainly due to abnormal ...

    Authors: Yuyan Xu, Jing Hu, Yuhang Fan, Licheng Sun, Ning Shen, Qihuang Jin, Ling Zhang, Jin Zhang, Fang Zhang and Hui Chen
    Citation: Epigenetics & Chromatin 2025 18:28
    Content type: Research Published on:

  3. The development of breast cancer is known to be greatly influenced by epigenetic changes. The impact of histone acetyltransferase KAT2B on AIM2 and AKT/Wnt/β-catenin signaling have not been studied yet.

    Authors: Yaqiong Li, Lingcheng Wang, Wei Wei Wangb, Wei Huang and Shengchun Liu
    Citation: Epigenetics & Chromatin 2025 18:27
    Content type: Research Published on:

  4. Heterochromatin is a fundamental component of eukaryotic chromosome architecture, crucial for genome stability and cell type-specific gene regulation. In mammalian nuclei, heterochromatin forms condensed B com...

    Authors: Kei Fukuda, Chikako Shimura and Yoichi Shinkai
    Citation: Epigenetics & Chromatin 2025 18:26
    Content type: Research Published on:

  5. Respiratory syncytial virus (RSV) poses significant morbidity and mortality risks in childhood, particularly for previously healthy infants admitted to hospitals lacking predisposing risk factors for severe di...

    Authors: Sara Pischedda, Alberto Gómez-Carballa, Jacobo Pardo-Seco, Sandra Viz-Lasheras, Alba Camino-Mera, Xabier Bello, María José Curras-Tuala, Irene Rivero-Calle, Ana I. Dacosta-Urbieta, Federico Martinón-Torres and Antonio Salas
    Citation: Epigenetics & Chromatin 2025 18:25
    Content type: Research Published on:

  6. Repeat-induced epigenetic changes are observed in many repeat expansion disorders (REDs). These changes result in transcriptional deficits and/or silencing of the associated gene. MSH2, a mismatch repair prote...

    Authors: Jessalyn Grant-Bier, Kathryn Ruppert, Bruce Hayward, Karen Usdin and Daman Kumari
    Citation: Epigenetics & Chromatin 2025 18:24
    Content type: Research Published on:

  7. Heterozygous histone H3.3K27M mutation is a primary oncogenic driver of Diffuse Midline Glioma (DMG). H3.3K27M inhibits the Polycomb Repressive Complex 2 (PRC2) methyltransferase activity, leading to global re...

    Authors: Suraj Bhattarai, Faruck L. Hakkim, Charles A. Day, Florina Grigore, Alyssa Langfald, Igor Entin, Edward H. Hinchcliffe and James P. Robinson
    Citation: Epigenetics & Chromatin 2025 18:23
    Content type: Research Published on:

  10. In Drosophila, architectural proteins are frequently found in promoters, including those of genes with extremely high expression levels, such as ribosomal protein genes (RPGs). The involvement of several of th...

    Authors: Igor Osadchiy, Anastasia Umnova, Galina V. Pokholkova, Anton Golovnin, Vladimir A. Gvozdev, Igor F. Zhimulev, Pavel Georgiev and Oksana Maksimenko
    Citation: Epigenetics & Chromatin 2025 18:20
    Content type: Research Published on:

  11. Epigenetic modifications provide mechanisms for influencing gene expression, regulating cell differentiation and maintaining long-term memory of cellular identity and function. As oocytes transmit epigenetic i...

    Authors: Chloe A. Edwards-Lee, Ellen G. Jarred and Patrick S. Western
    Citation: Epigenetics & Chromatin 2025 18:19
    Content type: Research Published on:

  13. DNA methylation plays a crucial role in gene regulation and epigenetic inheritance across diverse organisms. Daphnia magna, a model organism in ecological and evolutionary research, has been widely used to study ...

    Authors: Ruoshui Liu, Marco Morselli, Lev Y. Yampolsky, Leonid Peshkin and Matteo Pellegrini
    Citation: Epigenetics & Chromatin 2025 18:17
    Content type: Research Published on:

  15. De novo DNA methylation by DNMT3A is a fundamental epigenetic modification for transcriptional regulation. Histone tails and regulatory proteins regulate DNMT3A, and the crosstalk between these epigenetic mech...

    Authors: Jonathan E. Sandoval, Nancy V. N. Carullo, Aaron J. Salisbury, Jeremy J. Day and Norbert O. Reich
    Citation: Epigenetics & Chromatin 2025 18:15
    Content type: Research Published on:

  16. Linker histones constitute a class of proteins that are responsible for the formation of higher-order chromatin structures. Core histones are integral components of nucleosome core particles (NCPs), whereas li...

    Authors: Miharu Hisaoka, Tetsuro Komatsu, Takuma Hashimoto, Jianhuang Lin, Yasuyuki Ohkawa and Mitsuru Okuwaki
    Citation: Epigenetics & Chromatin 2025 18:14
    Content type: Research Published on:

  17. Lysine crotonylation (Kcr), a previously unknown post-translational modification (PTM), plays crucial roles in regulating cellular processes, including gene expression, chromatin remodeling, and cellular metab...

    Authors: Yu Ji, Shanshan Liu, Yiqiao Zhang, Yiyang Min, Luyang Wei, Chengjian Guan, Huajing Yu and Zhongtao Zhang
    Citation: Epigenetics & Chromatin 2025 18:13
    Content type: Review Published on:

  18. The origins of many diseases can be traced to the dynamic interplay of genetic predispositions and environmental exposures post-birth. Epigenetic modifications have recently gained prominence as a significant ...

    Authors: Xi Zheng, Xueli Liu, Yuqian Guo, Yi Lv, Chensheng Lin, Dan Wang, Shaobing Wang, Yiping Liu and Xuefeng Hu
    Citation: Epigenetics & Chromatin 2025 18:12
    Content type: Review Published on:

  19. Pulmonary fibrosis is a relentless and ultimately fatal lung disorder. Despite a wealth of research, the intricate molecular pathways that contribute to the onset of PF, especially the aspects related to epige...

    Authors: Zhongzheng Li, Mengke Zhang, Yujie Zhang, Yulong Gan, Zhao Zhu, Jiawei Wang, Yanlin Zhou, Guoying Yu and Lan Wang
    Citation: Epigenetics & Chromatin 2025 18:11
    Content type: Research Published on:

  21. Human immunodeficiency virus type 1 (HIV-1) is a retrovirus that infects multiple immune cell types and integrates into host cell DNA termed provirus. Under antiretroviral control, provirus in cells is able to...

    Authors: Joanna E. Jones, Chelsea E. Gunderson, Brian Wigdahl and Michael R. Nonnemacher
    Citation: Epigenetics & Chromatin 2025 18:9
    Content type: Review Published on:

  22. Epigenes are defined as proteins that perform post-translational modification of histones or DNA, reading of post-translational modifications, form complexes with epigenetic factors or changing the general str...

    Authors: Leroy Bondhus, Aileen A. Nava, Isabelle S. Liu and Valerie A. Arboleda
    Citation: Epigenetics & Chromatin 2025 18:8
    Content type: Research Published on:

  23. The DNA methylation-based epigenetic clocks are increasingly recognized for their precision in predicting aging and its health implications. Although prior research has identified connections between accelerat...

    Authors: Hongwei Liu, Hanqing Zhang, Zhaoxu Yin and Miaomiao Hou
    Citation: Epigenetics & Chromatin 2025 18:7
    Content type: Research Published on:

  24. Histone modification H3K27me3 plays a critical role in normal development and is associated with various diseases, including cancer. This modification forms large chromatin domains, known as Large Organized Ch...

    Authors: Yuan Liang, Mengni Liu, Bingyuan Liu, Benjamin Ziman, Guanjie Peng, Qiong Mao, Xingzhe Wang, Lizhen Jiang, De-Chen Lin and Yueyuan Zheng
    Citation: Epigenetics & Chromatin 2025 18:6
    Content type: Research Published on:

  25. DNA methylation, catalyzed by DNA methyltransferases (DNMT), plays pivotal role in regulating embryonic development, gene expression, adaption to environmental stress, and maintaining genome integrity. DNMT fa...

    Authors: Dániel Márton Tóth, Flóra Szeri, Mária Ashaber, Muhyiddeen Muazu, Lóránt Székvölgyi and Tamás Arányi
    Citation: Epigenetics & Chromatin 2025 18:5
    Content type: Review Published on:

  26. DNA methylation plays a crucial role in mammalian development. While methylome changes acquired in the parental genomes are believed to be erased by epigenetic reprogramming, accumulating evidence suggests tha...

    Authors: Keiko Nohara, Takehiro Suzuki, Kazuyuki Okamura, Tomoko Kawai and Kazuhiko Nakabayashi
    Citation: Epigenetics & Chromatin 2025 18:4
    Content type: Research Published on:

  27. Colorectal cancer (CRC) remains one of the most common causes of cancer-related mortality worldwide. Its progression is influenced by complex interactions involving genetic, epigenetic, and environmental facto...

    Authors: Seyed Reza Taha, Mehdi Karimi, Bahar Mahdavi, Milad Yousefi Tehrani, Ali Bemani, Shahriar Kabirian, Javad Mohammadi, Sina Jabbari, Meysam Hushmand, Alireza Mokhtar and Mohammad Hossein Pourhanifeh
    Citation: Epigenetics & Chromatin 2025 18:3
    Content type: Review Published on:

  28. Post-translational modifications of histone H3 on lysine 9, specifically acetylation (H3K9ac) and tri-methylation (H3K9me3), play a critical role in regulating chromatin accessibility. However, the role of the...

    Authors: Wilhelm Bouchereau, Hong-Thu Pham, Worawalan Samruan, Van-Hong Vu, Thierry Joly, Marielle Afanassieff, Pierre Savatier, Rangsun Parnpai and Nathalie Beaujean
    Citation: Epigenetics & Chromatin 2025 18:2
    Content type: Research Published on:

  29. Despite significant advances in HIV treatment, a definitive cure remains elusive. The first-in-human clinical trial of Excision BioTherapeutics’ CRISPR-based HIV cure, EBT-101, demonstrated safety but failed t...

    Authors: Punitha Letchumanan and Kumitaa Theva Das
    Citation: Epigenetics & Chromatin 2025 18:1
    Content type: Review Published on:

  30. DNA methylation is an essential epigenetic mechanism for regulation of gene expression, through which many physiological (X-chromosome inactivation, genetic imprinting, chromatin structure and miRNA regulation...

    Authors: Alexandra Chera, Mircea Stancu-Cretu, Nicolae Radu Zabet and Octavian Bucur
    Citation: Epigenetics & Chromatin 2024 17:39
    Content type: Review Published on:

  31. There has been a notable increase in interest in the transcriptional regulator Kaiso, which has been linked to the regulation of clonal hematopoiesis, myelodysplastic syndrome, and tumorigenesis. Nevertheless,...

    Authors: Alexey Starshin, Pavel Abramov, Yaroslava Lobanova, Fedor Sharko, Galina Filonova, Dmitry Kaluzhny, Daria Kaplun, Igor Deyev, Alexander Mazur, Egor Prokhortchou and Svetlana Zhenilo
    Citation: Epigenetics & Chromatin 2024 17:38
    Content type: Research Published on:

    The Correction to this article has been published in Epigenetics & Chromatin 2025 18:10

  32. Dental stem cells, with their exceptional proliferative capacity and multidirectional differentiation potential, hold significant promise for dental and oral tissue regeneration. Epigenetic inheritance, which ...

    Authors: Yan Li, Xinwei Guo, Hua Yao, Zhimin Zhang and Hongyan Zhao
    Citation: Epigenetics & Chromatin 2024 17:37
    Content type: Review Published on:

  33. To avoid exaggerated inflammation, innate immune cells adapt to become hypo-responsive or “tolerance” in response to successive exposure to stimuli, which is a part of innate immune memory. Polycomb repressive...

    Authors: Atsadang Boonmee, Salisa Benjaskulluecha, Patipark Kueanjinda, Benjawan Wongprom, Thitiporn Pattarakankul, Kittitach Sri-Ngern-Ngam, Supawadee Umthong, Junichiro Takano, Haruhiko Koseki and Tanapat Palaga
    Citation: Epigenetics & Chromatin 2024 17:36
    Content type: Research Published on:

  34. Bone remodeling is a continuous and balanced process which relies on the dynamic equilibrium between osteoclastic bone resorption and osteoblastic bone formation. During osteoclast differentiation, pro-osteocl...

    Authors: Yonghwan Shin, Sungmin Kim, Tae-Ik Choi, Cheol-Hee Kim and Woojin An
    Citation: Epigenetics & Chromatin 2024 17:35
    Content type: Research Published on:

  35. Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with an unmet clinical need, but its epigenetic regulation remains largely undefined. By performing multiomic profiling, we recent...

    Authors: Qingling He, Jianyang Hu, Hao Huang, Tan Wu, Wenxiu Li, Saravanan Ramakrishnan, Yilin Pan, Kui Ming Chan, Liang Zhang, Mengsu Yang, Xin Wang and Y. Rebecca Chin
    Citation: Epigenetics & Chromatin 2024 17:34
    Content type: Research Published on:

  36. The precise spatiotemporal expression of the hematopoietic ETS transcription factor PU.1, a key determinant of hematopoietic cell fates, is tightly regulated at the chromatin level. However, how chromatin sign...

    Authors: Kevin Qiu, Duc C. Vu, Leran Wang, Nicholas N. Nguyen, Anna K. Bookstaver, Katia Sol-Church, Hui Li, Thang N. Dinh, Adam N. Goldfarb, Daniel G. Tenen and Bon Q. Trinh
    Citation: Epigenetics & Chromatin 2024 17:33
    Content type: Research Published on:

  37. Canonical histone H3 and histone variant H3.3 are posttranslationally modified with the genomic distribution of these marks denoting different features and these modifications may influence transcription. Whil...

    Authors: Benjamin J. Patty, Cailin Jordan, Santana M. Lardo, Kris Troy and Sarah J. Hainer
    Citation: Epigenetics & Chromatin 2024 17:32
    Content type: Research Published on:

  38. Cancer has arisen from both genetic mutations and epigenetic changes, making epigenetics a crucial area of research for innovative cancer prevention and treatment strategies. This dual perspective has propelle...

    Authors: Rajkumar Prabhakaran, Rajkumar Thamarai, Sivabalan Sivasamy, Sivanesan Dhandayuthapani, Jyoti Batra, Chinnaperumal Kamaraj, Krishnasamy Karthik, Mohd Asif Shah and Saurav Mallik
    Citation: Epigenetics & Chromatin 2024 17:31
    Content type: Review Published on:

  39. It is generally accepted that methylation status of CpG sites spaced up to 50 bp apart is correlated, and accumulation of locally disordered methylation at adjacent CpG sites is involved in neoplastic transfor...

    Authors: Olga Taryma-Leśniak, Jan Bińkowski, Patrycja Kamila Przybylowicz, Katarzyna Ewa Sokolowska, Konrad Borowski and Tomasz Kazimierz Wojdacz
    Citation: Epigenetics & Chromatin 2024 17:30
    Content type: Research Published on:

  40. Genomic imprinting results in parent-of-origin-specific gene expression and, among vertebrates, is found only in therian mammals: marsupials and eutherians. A differentially methylated region (DMR), in which t...

    Authors: Trent Newman, Donna M. Bond, Teruhito Ishihara, Phoebe Rizzoli, Quentin Gouil, Timothy A. Hore, Geoff Shaw and Marilyn B. Renfree
    Citation: Epigenetics & Chromatin 2024 17:29
    Content type: Research Published on:

  42. Human hexokinase 2 (HK2) plays an important role in regulating Warburg effect, which metabolizes glucose to lactate acid even in the presence of ample oxygen and provides intermediate metabolites to support ca...

    Authors: Srinivasu Karri, Quinn Dickinson, Jing Jia, Yi Yang, Haiyun Gan, Zhiquan Wang, Yibin Deng and Chuanhe Yu
    Citation: Epigenetics & Chromatin 2024 17:27
    Content type: Research Published on:

  44. While the association of chronological age with DNA methylation (DNAm) in whole blood has been extensively studied, the tissue-specificity of age-related DNAm changes remains an active area of research. Studie...

    Authors: Niyati Jain, James L. Li, Lin Tong, Farzana Jasmine, Muhammad G. Kibriya, Kathryn Demanelis, Meritxell Oliva, Lin S. Chen and Brandon L. Pierce
    Citation: Epigenetics & Chromatin 2024 17:25
    Content type: Research Published on:

  45. Diesel exhaust particles (DEP), which contain hazardous compounds, are emitted during the combustion of diesel. As approximately one-third of the vehicles worldwide use diesel, there are growing concerns about...

    Authors: Alexandra Lukyanchuk, Naomi Muraki, Tomoko Kawai, Takehiro Sato, Kenichiro Hata, Tsuyoshi Ito and Atsushi Tajima
    Citation: Epigenetics & Chromatin 2024 17:24
    Content type: Research Published on:

  47. Regenerative potential is governed by a complex process of transcriptional reprogramming, involving chromatin reorganization and dynamics in transcription factor binding patterns throughout the genome. The deg...

    Authors: Phu Duong, Anjelica Rodriguez-Parks, Junsu Kang and Patrick J. Murphy
    Citation: Epigenetics & Chromatin 2024 17:22
    Content type: Methodology Published on:

  48. Cis-regulatory elements (CREs) play a pivotal role in gene expression regulation, allowing cells to serve diverse functions and respond to external stimuli. Understanding CREs is essential for personalized med...

    Authors: Chris Hartl, Jiali Zhuang, Aaron Tyler, Bing Zhou, Emily Wong, David Merberg, Brad Farrell, Chris DeBoever, Julie Bryant and Dorothée Diogo
    Citation: Epigenetics & Chromatin 2024 17:21
    Content type: Methodology Published on:

  49. Paternal allele-specific DNA methylation of the imprinting control region (H19 ICR) controls genomic imprinting at the Igf2/H19 locus. We previously demonstrated that the mouse H19 ICR transgene acquires imprinte...

    Authors: Hitomi Matsuzaki, Minami Kimura, Mizuki Morihashi and Keiji Tanimoto
    Citation: Epigenetics & Chromatin 2024 17:20
    Content type: Research Published on:

  50. Over the past several decades, the use of biochemical and fluorescent tags has elucidated mechanistic and cytological processes that would otherwise be impossible. The challenging nature of certain nuclear pro...

    Authors: Minh Bui, Songjoon Baek, Reda S. Bentahar, Daniël P. Melters and Yamini Dalal
    Citation: Epigenetics & Chromatin 2024 17:19
    Content type: Research Published on:
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Epigenetics & Chromatin

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