ଓକ୍ଟ୍ରିଓଏଟାଇଡ

ଓକ୍ଟ୍ରିଓଏଟାଇଡ
Clinical data
Trade names	Sandostatin, Bynfezia Pen, Mycapssa, others
AHFS/Drugs.com	monograph
MedlinePlus	a693049
data	US DailyMed: Octreotide;
Pregnancy; category	AU: C ; US: B (No risk in non-human studies) ; ;
Routes of; administration	Subcutaneous, intramuscular, intravenous, by mouth
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	60% (IM), 100% (SC)
Protein binding	40–65%
Metabolism	Liver
Elimination half-life	1.7–1.9 hours
Excretion	Urine (32%)
Identifiers
	IUPAC name (4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-; [[(2R)-2-amino-3-phenyl-propanoyl]amino]-16-; benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-; (1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,; 15,18-pentaoxo-1,2-dithia-5,8,11,14,17-; pentazacycloicosane-4-carboxamide;
Chemical and physical data
Formula	C49H66N10O10S2
Molar mass	୧,୦୧୯.୨୫ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@H]([C@H]1C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N1)CCCCN)Cc2c[nH]c3c2cccc3)Cc4ccccc4)NC(=O)[C@@H](Cc5ccccc5)N)C(=O)N[C@H](CO)[C@@H](C)O)O;
	InChI InChI=1S/C49H66N10O10S2/c1-28(61)39(25-60)56-48(68)41-27-71-70-26-40(57-43(63)34(51)21-30-13-5-3-6-14-30)47(67)54-37(22-31-15-7-4-8-16-31)45(65)55-38(23-32-24-52-35-18-10-9-17-33(32)35)46(66)53-36(19-11-12-20-50)44(64)59-42(29(2)62)49(69)58-41/h3-10,13-18,24,28-29,34,36-42,52,60-62H,11-12,19-23,25-27,50-51H2,1-2H3,(H,53,66)(H,54,67)(H,55,65)(H,56,68)(H,57,63)(H,58,69)(H,59,64)/t28-,29-,34-,36+,37+,38-,39-,40+,41+,42+/m1/s1 ; Key:DEQANNDTNATYII-OULOTJBUSA-N ;
(verify)

ଓକ୍ଟ୍ରିଓଏଟାଇଡ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ବିକ୍ରି ହେଉଥିବା ନାମ ସାଣ୍ଡୋସ୍ଟାଇନ, ଏକ ଓଷଧ ଯାହା କାର୍ସିନଏଡ୍ ସିଣ୍ଡ୍ରୋମ, ଆକ୍ରୋମେଗାଲି, ଜନ୍ମଗତ ହାଇପରିନସୁଲିନାଇଜିମ, ସ୍ଫିତ ଗ୍ରାସନଳୀ ଶିରା ଏବଂ ଖାଦ୍ୟନଳୀ ରକ୍ତସ୍ରାବର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | ^[୧] ^[୨] ଏହା ଶିରା କିମ୍ବା ମାଂସପେଶୀରେ ଇଞ୍ଜେକ୍ସନ ଆକାରରେ ଦିଆଯାଇପାରେ | ^[୩] ତୁରନ୍ତ କାର୍ଯ୍ୟକ୍ଷମ ଔଷଧ ୧୨ ଘଣ୍ଟା ପର୍ଯ୍ୟନ୍ତ ପ୍ରଭାବଶାଳୀ ହୋଇପାରେ | ^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାନ୍ତି, ଧୀର ହୃତ୍‌ପିଣ୍ଡ ଗତି ଏବଂ ପେଟ ବେଆରାମ ଲାଗିପାରେ | ^[୧] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କମ୍ କିମ୍ବା ଉଚ୍ଚ ରକ୍ତ ଶର୍କରା ସ୍ତର, ପିତ୍ତକୋଷ ସମସ୍ୟା ଏବଂ ଆନାଫାଇଲକ୍‌ସ ହୋଇପାରେ | ^[୩] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ସୁରକ୍ଷିତ କି ନାହିଁ ତାହା ଅସ୍ପଷ୍ଟ ରହିଛି। ^[୪] ସ୍ତନ୍ୟପାନ କରାଇବା ସମୟରେ ବ୍ୟବହାର ସୁପାରିଶ କରାଯାଏ ନାହିଁ | ^[୫] ଏହା ପ୍ରାକୃତିକ ସୋମାଟୋଷ୍ଟାଟିନର ପ୍ରଭାବକୁ ଅନୁକରଣ କରିଥାଏ ଏବଂ ଗ୍ରୋଥ ହରମୋନ, ସେରୋଟୋନିନ, ଇନସୁଲିନ ଓ ଗ୍ଲୁକାଗନ ମୁକ୍ତିକୁ ପ୍ରତିରୋଧ କରିଥାଏ | ^[୩]

ଏହା ପ୍ରଥମେ ୧୯୭୯ରେ ରସାୟନ ବିଜ୍ଞାନୀ ୱିଲଫ୍ରିଡ୍ ବାଉରଦ୍ୱାରା ନିର୍ମିତ ହୋଇଥିଲା | ^[୬] ୧୯୮୮ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ପାଇଁ ଏହାକୁ ଅନୁମୋଦନ କରାଯାଇଥିଲା | ^[୭] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ^[୫] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୦ ସୁଦ୍ଧା ଏହାର ୫୦ ug ଡୋଜରେ ପ୍ରାୟ ୩ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହୁଏ। ^[୮] ^[୯] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣ ୨୦୨୦ ସୁଦ୍ଧା ପ୍ରାୟ ୫.୩୦ ଡଲାର ଅଟେ।

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Octreotide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 25 December 2020.
↑ Cat, TB; Liu-DeRyke, X (September 2010). "Medical management of variceal hemorrhage". Critical care nursing clinics of North America. 22 (3): 381–93. doi:10.1016/j.ccell.2010.02.004. PMID 20691388.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ "Octreotide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 25 December 2020.
↑ "Octreotide Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 20 January 2021. Retrieved 25 December 2020.
↑ ^୫.୦ ^୫.୧ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1002. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ MD, Laura Lamps; MD, Andrew Bellizzi; MD, Wendy L. Frankel; MD, Rhonda Yantiss; MD, Scott R. Owens (2015). Neoplastic Gastrointestinal Pathology: An Illustrated Guide (in ଇଂରାଜୀ). Springer Publishing Company. p. 40. ISBN 978-1-936287-72-7. Archived from the original on 28 August 2021. Retrieved 25 December 2020.
↑ "Octreotide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 25 December 2020.
↑ "Octreotide Prices and Octreotide Coupons". GoodRx (in ଆମେରିକୀୟ ଇଂରାଜୀ). Retrieved 25 December 2020.
↑ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1002. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[AHSF2020-1] ୧.୦ ^୧.୧ "Octreotide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 25 December 2020.

[Cat2010-2] Cat, TB; Liu-DeRyke, X (September 2010). "Medical management of variceal hemorrhage". Critical care nursing clinics of North America. 22 (3): 381–93. doi:10.1016/j.ccell.2010.02.004. PMID 20691388.

[autogen4-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ "Octreotide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 25 December 2020.

[Preg2020-4] "Octreotide Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 20 January 2021. Retrieved 25 December 2020.

[BNF80-5] ୫.୦ ^୫.୧ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1002. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[6] MD, Laura Lamps; MD, Andrew Bellizzi; MD, Wendy L. Frankel; MD, Rhonda Yantiss; MD, Scott R. Owens (2015). Neoplastic Gastrointestinal Pathology: An Illustrated Guide (in ଇଂରାଜୀ). Springer Publishing Company. p. 40. ISBN 978-1-936287-72-7. Archived from the original on 28 August 2021. Retrieved 25 December 2020.

[AHFS2020-7] "Octreotide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 25 December 2020.

[GX2020-8] "Octreotide Prices and Octreotide Coupons". GoodRx (in ଆମେରିକୀୟ ଇଂରାଜୀ). Retrieved 25 December 2020.

[autogen2-9] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1002. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

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ଆଧାର

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