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Interleukin 32

Izvor: Wikipedija
Interleukin 32
Identifikatori
Simbol IL32
Alt. simboli NK4, TAIF, TAIFb, TAIFd
Entrez 9235
Hugo 16830
OMIM 606001
RefSek NM_004221
UniProt P24001
Drugi podaci
Lokus Hrom. 16 p13.3

Interleukin 32 (IL-32) je citokin koji stimuliše ćelije imunskog sistema[1] (kao što su monociti i makrofage) da izlučuju TNF-α u dodatak hemokinima kao što su IL-8 i MIP-2/CXCL2.[2][3]

IL-32 može takođe da podržava osteoklast diferencijaciju ali ne osteoklast aktivaciju putem regulisanja MAPK/ERK puta i aktin citoskeletona.[4]

Reference

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  1. Thomas J. Kindt, Richard A. Goldsby, Barbara Anne Osborne, Janis Kuby (2006). Kuby Immunology (6 izd.). New York: W H Freeman and company. ISBN 1-4292-0211-4. 
  2. Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA. (2005). „Interleukin-32: a cytokine and inducer of TNFalpha”. Immunity 22 (1): 131-42. 
  3. Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 
  4. Mabilleau G and Sabokbar A (2009). „Interleukin-32 promotes osteoclast differentiation but not osteoclast activation”. PLoS ONE 4 (1): e4173. 

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