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Trimetoprim/sulfametoksazol

Izvor: Wikipedija

Trimetoprim/sulfametoksazol

Klinički podaci

AHFS/Drugs.com

Identifikatori

PubChem^[1]^[2]

Hemijski podaci

C₂₄H₂₉N₇O₆S

543,595

eMolekuli & PubHem

InChI
InChI=1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13) Key: WZRJTRPJURQBRM-UHFFFAOYSA-N^Y

Farmakoinformacioni podaci

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Trimetoprim/sulfametoksazol je organsko jedinjenje, koje sadrži 24 atoma ugljenika i ima molekulsku masu od 543,595 Da.

Osobine

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Osobina	Vrednost
Broj akceptora vodonika	11
Broj donora vodonika	4
Broj rotacionih veza	8
Particioni koeficijent^[4] (ALogP)	2,3
Rastvorljivost^[5] (logS, log(mol/L))	-6,9
Polarna površina^[6] (PSA, Å²)	212,1

Reference

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↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A 102: 3762-3772. DOI:10.1021/jp980230o.
↑ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488-1493. DOI:10.1021/ci000392t. PMID 11749573.
↑ Ertl P., Rohde B., Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714-3717. DOI:10.1021/jm000942e. PMID 11020286.

Literatura

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Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9.

Vanjske veze

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	Portal Medicina
	Portal Hemija

Trimetoprim/sulfametoksazol na Wikimedijinoj ostavi

Trimethoprim/sulfamethoxazole

Šablon:Antibiotici inhibitori nukleinskih kiselina

Izvor: https://sh.wikipedia.org/w/index.php?title=Trimetoprim/sulfametoksazol&oldid=42290453

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