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BD-1047

С Википедије, слободне енциклопедије
BD-1047
IUPAC ime
N'-[2-(3,4-dichlorophenyl)ethyl]-N,N,N'-trimethylethane-1,2-diamine
Identifikatori
CAS broj138356-20-4 ДаY
ATC kodnone
PubChemCID 188914
Hemijski podaci
FormulaC13H20Cl2N2
Molarna masa275.217 g/mol
  • Clc1ccc(CCN(C)CCN(C)C)cc1Cl

BD-1047 je antagonist sigma receptora koji je selektivan za σ1 tip. Istraživanja na životinjama su pokazala da ovaj ligand potencijalno može da nađe primernu kao antipsihotik i u lečenju neuropatskog bola.[1][2]

  1. ^ Skuza G, Rogóz Z (2006). „Effect of BD 1047, a sigma1 receptor antagonist, in the animal models predictive of antipsychotic activity”. Pharmacological Reports : PR. 58 (5): 626—35. PMID 17085854. 
  2. ^ Roh DH, Kim HW, Yoon SY, Seo HS, Kwon YB, Kim KW, Han HJ, Beitz AJ, Na HS, Lee JH (2008). „Intrathecal injection of the sigma(1) receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain”. Anesthesiology. 109 (5): 879—89. PMID 18946301. doi:10.1097/ALN.0b013e3181895a83. 


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