Stratum corneum himotriptinski enzim
(преусмерено са KLK7)
| Stratum corneum himotriptinski enzim | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.117 | ||||||||
| CAS broj | 155215-90-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Stratum corneum himotriptinski enzim (EC 3.4.21.117, kalikrein 7, SCCE, KLK7, PRSS6, hK7) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje proteina sa aromatičnim bočnim lacima u P1 poziciji
Ova enzim ima široku supstratnu specifičnost, te može da degradira toplotom-denaturisani goveđi kazein i alfa-lanace prirodnog ljudskog fibrinogena.
Reference
[уреди | уреди извор]- ^ Skytt, A., Strömqvist, M. and Egelrud, T. (1995). „Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme”. Biochem. Biophys. Res. Commun. 211: 586—589. PMID 7794273.
- ^ Egelrud, T. (1993). „Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation”. J. Invest. Dermatol. 101: 200—204. PMID 8393902.
- ^ Hansson, L., Strömqvist, M., Bäckman, A., Wallbrandt, P., Carlstein, A. and Egelrud, T. (1994). „Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase”. J. Biol. Chem. 269: 19420—19426. PMID 8034709.
- ^ Yousef, G.M., Scorilas, A., Magklara, A., Soosaipillai, A. and Diamandis, E.P. (2000). „The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation”. Gene. 254: 119—128. PMID 10974542.
- ^ Vasilopoulos, Y., Cork, M.J., Murphy, R., Williams, H.C., Robinson, D.A., Duff, G.W., Ward, S.J. and Tazi-Ahnini, R. (2004). „Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis”. J. Invest. Dermatol. 123: 62—66. PMID 15191543.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Stratum+corneum+chymotryptic+enzyme на US National Library of Medicine Medical Subject Headings (MeSH)
