Scribd
Upload
2K views1 page

Exp 2

1. The document discusses moisture determination experiments and defines constant weight as two consecutive weighings that differ by less than 0.5 mg after additional drying. 2. It differentiates moisture content, which is water absorbed due to humidity, from water content, which is water present as a volatile component. 3. The importance of determining drug moisture content is discussed, including how moisture can deteriorate drugs, affect manufacturing processes, and require moisture corrections for active constituent calculations.

Uploaded by

Janice Malafu De Guia
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
2K views1 page

Exp 2

1. The document discusses moisture determination experiments and defines constant weight as two consecutive weighings that differ by less than 0.5 mg after additional drying. 2. It differentiates moisture content, which is water absorbed due to humidity, from water content, which is water present as a volatile component. 3. The importance of determining drug moisture content is discussed, including how moisture can deteriorate drugs, affect manufacturing processes, and require moisture corrections for active constituent calculations.

Uploaded by

Janice Malafu De Guia
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
You are on page 1/ 1

Group 2 September 12, 2017

Rating:

Experiment No. 2
MOISTURE DETERMINATION

Questions for Research:


1. Define constant weight.
The term 'constant weight', used in relation to the process of drying or the process of ignition, means that two
consecutive weighing do not differ by more than 0.5 mg, the second weighing being made after an
additional period of drying or ignition under the specified conditions appropriate to the nature and quantity of
the residue (1 hour is usually suitable).

2. Differentiate moisture content from water content.


Moisture content is the amount of water absorbed by the substance due to surrounding humidity while, Water
content is the amount of water present as a volatile component of a substance.

3. What is the importance of determining the moisture content of drugs?


Presence of moisture in a crude drug can lead to its deterioration due to either activation of certain enzymes
or growth of microbes.
Pharmaceutical procedure of granulation, tablet formation, and coating operations are affected by
moisture content.
When crude drugs (for example) are being sold with a guaranteed assay for active constituent, the percent
of the active constituent must be calculated on the basis of a moisture free drug.

4. What is the official monograph limit for moisture content of drugs?


DRUGS MOISTURE CONTENT W/W
Aloes Not more than 10
Digitalis Not more than 5
Starch Not more than 15

5. Enumerate and describe/define the other USP/NF official methods of moisture determination.
USP offers two method of determining moisture content:
a. The Karl Fischer titration is a moisture determination method specific for water and is suitable for samples
with high moisture content (titrimetry) and also for those with water contents in the ppm range
(coulometry). It was originally developed for nonaqueous liquids, but is also suitable for solids if these are
soluble or if the water they contain can be removed by heating in a stream of gas or by extraction.
b. Gravimetric method the process by which the drug is dried at 105 C untill a constant weight, so it is
considered a destructive method for plant material.

Reference:
http://www.uspbpep.com/bp2008/data/7647.asp
www.pharmaguideline.com
https://www.slideshare.net/obydullah/aquametry
https://www.slideshare.net/SudheerKandibanda/evaluation-of-crude-drugs
https://www.mt.com/de/en/home/library/know-how/lab-analytical-
instruments/moisture_determination_by_karl_fischer.html

You might also like

pFad - Phonifier reborn

Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy