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Mathematical Calculations Involving Blood Components Usage in Transfusion Medicine

The document contains 5 concepts that provide tables to calculate blood component requirements for various patients and transfusion scenarios. The concepts cover calculating red blood cell and platelet transfusion needs based on initial and expected hemoglobin/hematocrit levels. They also include calculations for RhIg doses based on fetomaternal hemorrhage volume and determining platelet yields from whole blood and platelet concentrates. Additional concepts address calculating cryoprecipitate needs based on initial and desired fibrinogen/FVIII levels. The document concludes with 5 post-laboratory questions addressing efficacy of transfusion, considerations for administration, significance of preparation techniques, and research trends in blood components and best components for specific conditions.

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Natalie Cu
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660 views8 pages

Mathematical Calculations Involving Blood Components Usage in Transfusion Medicine

The document contains 5 concepts that provide tables to calculate blood component requirements for various patients and transfusion scenarios. The concepts cover calculating red blood cell and platelet transfusion needs based on initial and expected hemoglobin/hematocrit levels. They also include calculations for RhIg doses based on fetomaternal hemorrhage volume and determining platelet yields from whole blood and platelet concentrates. Additional concepts address calculating cryoprecipitate needs based on initial and desired fibrinogen/FVIII levels. The document concludes with 5 post-laboratory questions addressing efficacy of transfusion, considerations for administration, significance of preparation techniques, and research trends in blood components and best components for specific conditions.

Uploaded by

Natalie Cu
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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EXERCISE 20

MATHEMATICAL CALCULATIONS INVOLVING


BLOOD COMPONENTS USAGE IN TRANSFUSION
MEDICINE

CONCEPT 1

Application: Fill out the table completely.

PATIENT HEMOGLOBIN
Initial Expected Required units of red cell
Hemoglobin Hemoglobin product to achieve the
(pretransfusio (post transfusion expected hemoglobin level
n state) state)
7.5 g/dL 12.5 g/dL
8.2 g/dL 11.7 g/dL
9.6 g/dL 13.2 g/dL
10.3 g/dL 15.2 g/dL
11.3 g/dL 14.5 g/dL

CONCEPT 2

Application: Fill out the table completely.


PATIENT HEMATOCRIT
Initial Hematocrit Expected Required units of red cell
(pretransfusion Hematocrit product to achieve the
state) (post transfusion expected hematocrit level
state)
13% 29%
15% 28%
17% 23%
29% 35%
21% 24%
CONCEPT 3
Application: Fill out the table completely.

% fetal cells Volume Feto- Required vials of


(Based on the results Maternal RhIg (full dose)
of Kleihauer-Betke Hemorrhage
Acid Elution)
(FMH)
2.0%
3.0%
4.5%
5.0%
6.5%

CONCEPT 4

Application: Fill out the table completely.


PATIENT’S PROFILE
Type of Initial Final
# of units Platelet
Platelet Platelet
Concentrat
transfuse BSA Count/µL CCI INTERPRETATION
d Count/µL
e (m2) (Pre (1-hr post
Transfusion) transfusion
)
RDP 4 1.4 7,500 75,000
RDP 5 0.95 9,800 68,500
RDP 6 1.6 8,650 98,700
SDP 5 2.1 9,000 55,000
SDP 7 0.85 10,100 124,300
CONCEPT 5
FILL OUT THE TABLE AND ANSWER THE POST LAB QUESTIONS BELOW:

SET-UP
REFER TO THE ILLUSTRATION ON PAGE 122

SOURCE Whole Platelet Rich Platelet


Blood Plasma Concentrate
GIVEN VOLUME 450 mL 250 mL 50 mL
Platelet Count 200,000 /µL 300,000 /µL 900,000 /µL
Total Count / mL

a. Calculate the % yield from whole blood.

b. Calculate the % yield from PRP.

c. Does the product meet the required number of platelets for quality control?
CONCEPT 6a
Cryoprecipitate Transfusion for correcting fibrinogen
level
Fill out the table completely

Required Units of
PATIENT PROFILE amount of CRYO
fibrinogen needed
Initial Desired Final
Estimate Estimated Fibrinogen Fibrinogen
Weight
Hematocrit d Blood Plasma Level Level
(kg)
Volume Volume (pretransfusion (posttransfusion
) )
60 0.30 30 mg/dL 100 mg/dL
65 0.45 25 mg/dL 95 mg/dL
70 0.32 40 mg/dL 106 mg/dL
72 0.28 32 mg/dL 110 mg/dL
80 0.36 52 mg/dL 125 mg/dL

Note: Estimated Blood Volume = (given weight in kilogram) x (70 mL/kg body weight)
Estimated Plasma Volume = Estimated Blood Volume x (1-hematocrit)
Required amount of fibrinogen =

[Desired Final fibrinogen (mg/mL) – Initial Fibrinogen (mg/mL)] x plasma volume


(If concentration is expressed in mg/dL, simply divide by 100 to convert to mg/L.)

I U cryoprecipitate = 150 mg fibrinogen or I U cryoprecipitate = 250 mg fibrinogen


CONCEPT 6b
Cryoprecipitate Transfusion for correcting FVIII level (Anti-
Hemophilic Factor A)

Fill out the table completely.


Required
Units of
amount of
PATIENT PROFILE CRYO
FVIII
needed
(Units / mL)
Initial Desired Final
Estimated Estimated
Weight FVIII Level FVIII
Hematocrit Blood Plasma
(kg) (pretransfusion) Level
Volume Volume
(posttransfusion)
60 0.30 5% 60%
65 0.45 3% 70%
70 0.32 4% 50%
72 0.28 6% 65%
80 0.36 10% 55%
Note: Estimated Blood Volume = (given weight in kilogram) x (70 mL/kg body weight)
Estimated Plasma Volume = Estimated Blood Volume x (1-hematocrit)
Required amount of FVIII =

[Desired Final FVIII (Units /mL) – Initial FVIII (Units/mL)] x plasma volume

(If concentration is expressed in %, simply drop off % sign and write Units/dL. To convert it to
Units/mL, move 2 decimal places to the left.)

I U cryoprecipitate = 80 U FVIII
POST LABORATORY QUESTIONS:

1. Why is it necessary to assess the efficacy of transfusing blood


components?

2. Discuss briefly the general considerations in the administration of blood


and its components:

a. Compatible fluid

b. Leukocyte reducing filter

c. Time limit

d. Blood warmer

e. Gamma irradiation

3. Discuss the significance of the following in blood component preparation:

a. rejuvenation
b. freezing

c. filtration

d. irradiation

4. Discuss briefly the following research trends in blood components:

a. Enzyme Converted O-cells

b. Red Blood Cell Substitutes

1. Hemoglobin-Based Oxygen Carriers

2. Perfluorochemicals

c. DDAVP
d. Erythropoietin

5. Identify the BEST blood component to transfuse for patients with the
following conditions:

__________a. Hemophilia A

__________b. Repeated Febrile Transfusion Reaction due to HLA antibodies

__________c. Hemolytic Uremic Syndrome

__________d. Vitamin K deficiency

__________e. Granulocytopenia due to bone marrow aplasia

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