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Concept of CRDDS

This document discusses controlled release drug delivery systems (CRDDS) and their advantages over immediate release formulations. It introduces key concepts in CRDDS including approaches to design controlled release formulations based on diffusion, dissolution and ion exchange principles. Polymers are classified and their properties and application in CRDDS are described. The document is presented by Ms. Kaushika Patel and discusses overcoming limitations of immediate release dosage forms by developing controlled release formulations to achieve temporal delivery of drugs at a desired rate over a specified treatment period.

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2K views13 pages

Concept of CRDDS

This document discusses controlled release drug delivery systems (CRDDS) and their advantages over immediate release formulations. It introduces key concepts in CRDDS including approaches to design controlled release formulations based on diffusion, dissolution and ion exchange principles. Polymers are classified and their properties and application in CRDDS are described. The document is presented by Ms. Kaushika Patel and discusses overcoming limitations of immediate release dosage forms by developing controlled release formulations to achieve temporal delivery of drugs at a desired rate over a specified treatment period.

Uploaded by

Nirali Donga
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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B.

Pharm
Semester 7

Novel Drug Delivery Systems


(NDDS)
(BP704TP)
UNIT I
Controlled Release drug delivery systems (CRDDS)
• Introduction, terminology/definitions and rationale
• Advantages, disadvantages
• selection of drug candidates
• Approaches to design controlled release formulations based
on diffusion, dissolution and ion exchange principles.
• Physicochemical and biological properties of drugs relevant to
controlled release formulations
• Polymers: Introduction, classification, properties, advantages
and application of polymers in formulation of controlled
release drug delivery systems
BPHARM SEM 7
NDDS (BP704TP)

Presented by:
Ms. Kaushika Patel
Asst Professor,
Dept of Pharmaceutical Technology
L. J. Institute of Pharmacy, Ahmedabad
Presented by:
Ms. Kaushika Patel
Asst Professor, Dept of Pharmaceutical Technology
L. J. Institute of Pharmacy, Ahmedabad
What is Ideal Dosage Regimen?
• An ideal dosage regimen in the drug therapy of any
disease is the one which immediately attains the
desired therapeutic concentration in plasma and
maintains it constant for the entire duration of
treatment.
• It is achieved through administering a drug in a
particular dose at a particular frequency.
• The dosing interval of any drug depends upon

1. Half life or
2. Therapeutic
MRT
Index
(Mean Residence Time)
• A conventional formulation/ Immediate release (IR) dosage
form is one which is designed to release the drug contained
in it rapidly and completely after the administration.
Here the dosing interval is much shorter than the half life
of the drug resulting in several limitations
Limitations of Conventional dosage forms
 Poor patient compliance, which increased
chances of missing the dose of a drug with short half
life for which frequent administration is necessary.
 The unavoidable fluctuations of drug
concentration may lead to under medication or
over medication.
 A typical peak-valley plasma concentration time
profile is obtained which makes attainment of steady
state condition difficult.
 The fluctuations in drug levels may lead to
precipitation of adverse effects especially of a
drug with small Therapeutic Index (TI)
whenever over medication occur.
How to overcome limitations of IR dosage
forms ?

Option 1 Option 2

Development of Effective and safer use


new, better and of existing drugs
safer drugs with through concepts and
long half lives and techniques of
large therapeutic controlled and
indices targeted delivery
system
An ideal drug delivery system should deliver the drug at
desired rate over a specified period of treatment. The two
important aspects of drug delivery are

Aspect 1 Aspect 2

TEMPORAL
SPATIAL delivery delivery of drug
of drug which refers which refers to
to targeting a drug controlling the rate
to a specific organ or specific time of
or tissue drug delivery to a
specific organ or
tissue
What is controlled drug release?

Modified
Release

Delayed Targeted
Extended
release Release /
Release
Site-specific
Release

Sustained Controlled
Release Release
Modified Release: Any modification in conventional formulation with
respect to release rate, release time or site of release

Extended Release [ER, XR, XL] : Reduction in dosing frequency


through prolonging the drug release profile

Delayed Release [DR]: Release the drug at a time other than


promptly after administration

Targeted Release : Release the drug at a specific target/site in the


body
Sustained Release [SR] : Provide an immediate dose for
normal therapeutic response, followed by maintenance dose
to sustain the therapeutic response for specific extended
period of time usually 8-12 hrs

Controlled Release [SR] : Release the drug at a


predetermined constant rate, for a specific period of time,
locally or systematically

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