Alyn Tapleras, RPh.

MSPh
Intended Learning Outcomes:
 At the end of the lesson, the students are
expected to:
 1. List examples of cosmetics.
 2. Enumerate scientific areas in the study of
cosmetic science and identify their
importance.
 3. Demonstrate knowledge on the application
of cosmetic product notification to
government agencies.
BOSS LEADER

➢ POWER ➢ LEAD
➢ POINT FINGERS ➢ Extend hand
➢ Demand ➢ Coach
➢ command ➢ Watch over
➢ Criticism ➢ Encourage
➢ Authority ➢ Motivate
➢ Know ➢ Show
➢ Rules ➢ Leading
➢ What to do? ➢ Guide what to do
➢ Blaming ➢ Responsible
➢ Self-centered ➢ Open –minded
➢ Decision making ➢ Right –hand
➢ User ➢ Develop
➢ Hear ➢ Listen
➢ Settle ➢ Role model
➢ manipulate ➢ inspiration
 Cosmetic
➢ is a Greek word which means to 'adorn'
(addition of something decorative to a person
or a thing).
➢ It may be defined as a substance which comes in
contact with various parts of the human body
like
a. skin,
b. hair,
c. nail,
d. lips,
e. teeth, and mucous membranes etc.,
Cosmetic
➢ substances help in improving or changing the
outward show of the body and also masks
the odour of the body.
➢ It protects the skin and keeps it in good
condition.
In general, cosmetics are external
preparations which are applied on the
external parts the body.
➢ Now days, cosmetics are considered as essential
components in life.
➢ They not only, attract the people towards it but
also impart psychological effects. It has gained
popularity in the last 3-4 decades and its use
has been increased exponentially both-in
males and females.
➢ The most popular cosmetics are hair dyes,
powders and creams (Sharma, Ghadiya and
Dhanawat, 2018).
➢ comes from the Greek word kosmeticos which
means adorn
➢ Under the law, some of the products commonly
referred to as "personal care products" are
cosmetics.
These include, for example:
a. skin moisturizers,
b. perfumes,
c. lipsticks,
d. fingernail polishes,
e. eye and facial makeup preparations,
f. shampoos,
g. permanent waves,
h. hair colors,
i. toothpastes, and
j. deodorants
1. They are used as a cleansing, moisturizing and
beautifying agent.
2. They help in enhancing attractiveness of the
body.
3. They help in altering the appearance of the body
without affecting its functions.
4. Sunscreen products help in protecting the body
from UV rays and treating sunburns.
5. Acne, wrinkles, dark circles under eyes and
other skin imperfections are treated or repaired
by treatment products.
6. Cosmetics help in treating skin infection.
 the study of the effects that raw materials
and mixtures can have on parts of the human
body like hair, skin, lips and nails
It is identified as follows:

a. commercial science – that tries to find

reasons for selling a product

b. comparative science – based on the fact that

many manufacturers compare their own
products to other manufacturers’ products
and try to convince consumers why to buy
their products instead of other companies’
products
c. traditional science – such as chemistry or
physics, where there are hypotheses and
scientists try to justify or deny them by
performing a number of tests and reactions

d. borderline science – as it is a transition

among a different scientific fields among
pharmacy, chemistry, dermatology, and
marketing, among others
1. Anatomy and Physiology
- to understand the structure and function of
the skin, hair, lips, teeth, and so on, to where
the products are usually applied
2. Chemistry
- may include organic, inorganic, colloid, and
polymer chemistry
- to be able to formulate effective, stable, and
safe products that have appealing aesthetics,
appropriate performance, and compatibility
with application surfaces
- to understand the basic physical, chemical,
and physicochemical properties of the raw
ingredients that are usually used
3. Pharmacology
- the basic properties and therapeutic effects
on the raw materials on the target surfaces to
be able to choose appropriate ingredients
4. Pharmaceutics
- to be aware of and understand the different
dosage forms which they can choose to
incorporate the ingredients
- to know the various manufacturing techniques
that are used to produce the dosage forms
5. Current rules and regulations
- to be aware of and understand the rules
that regulate labeling and packaging of a final
cosmetic product

6. Analytical Science
- to understand the different types of tests
and testing methods that are performed for
cosmetics
7. Microbiology
8. Consumer needs
- to understand what consumer expect from
products and what their needs are
9. Marketing and business
- to understand how a business , such as the
cosmetic industry, works
→cosmetics + pharmaceutics
→are cosmetic products with biologically
active ingredients purporting to have
medical or drug-like benefits

The difference between cosmetic and

cosmeceutical.
 What is cosmetic product notification?
In the Philippines, the Food and Drug
Administration (FDA) (formerly the Bureau of
Food and Drugs) created under the
Department of Health, is responsible for
regulating cosmetic products and ensuring
the safety, purity, and quality of cosmetics in
Philippines market.
 The main competent department for the
regulation of cosmetic products is the Center
for Cosmetics Regulation and Research
(CCRR), which belongs to the Philippines FDA
and has 2 sub-branches, the Licensing and
Registration Division and the Product
Research and Standard Development Division.
a) Secure a CCRR User Account by sending a
request to info@fda.gov.ph following with the
following information:
Email address (preferably company email
address)
Name
Position
Contact No.
Company name
Company address
Product classification: cosmetics
 b) After securing the CCRR user account, log in
at the FDA e-Portal (https://ww2.fda.gov.ph)
c) Select “New Case” and accomplish the ASEAN
Notification Form.
d) Download the Order of Payment and assign
the task to FDA Cashier.
e) Pay the fee at any Landbank Branch or thru
online Bancnet payment and wait for the Result
of Application.
h) If approved, download and print the notice of
acknowledgement.
Cosmetic labeling in the Philippines should
contain the following information:
-Product content in weight/volume
-Brand, product name and function
-Batch number
-Manufacturing/expiration date of the product
in clear terms (month/year)
-Country of Manufacture
-Instructions/Directions for use
-List of all ingredients
-Special precautions
-Name and address of company or person
who placed the product on the market.
Cosmetic Product and Devices
Intended Learning Outcomes:
At the end of the lesson, the students are
expected to:
1. Enumerate the properties of shampoos.
2. List the raw materials needed in the
formulation of shampoo.
3. Demonstrate knowledge on the evaluation of
the safety and antimicrobial property of
shampoo.
 Hair is a complex structure composed by
many components that act as a unit, with the
biological purpose of protecting the scalp, as
well as physical attractiveness to the self-
perception of beauty.
Nowadays, hair care and style play a very
important role in people’s lives, both for men
and women, so knowledge of hair products,
mode of action, efficacy, ingredients and hair
procedures has become more relevant in
dermatologists’ medical practice.
 The amount of money spent to enhance
the hair beauty is an indication of how much
attention is given today to the hair
appearance. On the other hand, these data
are emphasized in patients suffering from
hair disease.
 Hair cosmetics are also an important tool
for increasing patient’s adhesion to scalp
treatments, according to the diversity of hair
types and ethnicity
True described them as “preparations
intended for placing in contact with the hair
and scalp, with the purpose of cleansing,
promoting attractiveness, altering
appearance, and/or protecting them in order
to maintain them in good condition”.
Hair cosmetics can be distinguished into two
main categories:
(1) Cosmetics with temporary effect on the
hair, for example shampoos, conditioners,
sprays, and temporary colors; and
(2) Cosmetics that produce permanent effect
on the hair shaft, such as permanent waves,
relaxers, bleaches and permanent colors
(Alessandrini and Piraccini, 2016).
Definition:
→A viscous cosmetic preparation with
synthetic detergent used for washing hair. Its
principle function is to clean the scalp
such that it should become free from
sebum and foreign substances. Shampoo
also makes the hair lustrous and good
looking.
1. It should have optimum viscosity such that
it facilitates ease during application.
2. It should have good spreading
properties.
3. It should produce sufficient lather after
application.
4. It should be able to remove waste
material such as debris, soil, sebum, dead
cells, salts (due to sweat) etc., from the scalp.
5. It should not form any kind of film on scalp.
6. It should rinse out completely after washing.
7. It should produce lather with both hot and cold
water.
8. It should facilitate ease of combing after
shampooing.
9. After drying, the hair should not give rough
appearance.
10. It should provide lustre to the hair.
11. It should produce good odour both before
and after shampooing.
12. It should not produce any kind of irritation
or itching to the scalp.
13. It should not support any microbial growth.
14. It should be stable and have a half life of
about 2 to 3 years.
15. It should be economical.
1. Clear liquid shampoos
2. Liquid cream shampoos
3. Cream shampoos
4. Gel shampoos
5. Powder shampoos
6. Aerosol shampoos (Foam type)
7. Special shampoos
a. Medicated shampoo
b. Conditioner
FORMULATION
1. Surfactants
→tocleanse and to produce foam.
Four types:
(a) Anionic Surfactants - used as principle
surfactant
- have good foaming property
- considered as main ingredient of shampoo
formulation
i. Alkyl Sulphates - Lauryl sulphate,
Myristylsulphate (most widely used because
they give foam)
ii. Alkyl polyethylene Glycol Sulphates
iii. Alkyl Benzene Sulphonates
iv. α- olefin Sulphate
 (b) Non-ionic Surfactants - considered as secondary surfactants
- used as foam boosters, viscosity inducers, emulsion
stabilizers and opacifiers

i. Poly Alkoxylated Derivatives

- ethoxylated alcohols and phenols, block polymers,
sorbitol ester (polyethoxylated) and polyglyceryl
ethers
ii Fatty Acid alkanolamides (mono alkanolamides and
diethanolamides)
• Solubilising Agent:
Example: Lauric Monoethanolamide
• Viscosity Inducing Agent:
Example: Lauric Monoethanolamide
• Pearlescent and Thickening Agent:
Example: Stearic Ethanolamide
* Softening and Hair Conditioning Agent:
Example: Oleic Ethanolamide
• Foam Boosters
iii Amine Oxides (Coconut and dodecyl dimethylamine oxides)
(c) Cationic Surfactants - contains positive charge
- used as both principle and secondary surfactants
- used in low concentrations because they are toxic to
eye
- used as principle surfactants in conditioner
shampoo

i. Alkylamines
ii. Ethoxylatedamines
iii. Alkyl-Betains

(d) Amphoteric Surfactants - possess both cationic and

anionic charges with respect to acidic and basic media
- form zwitterions when the pH of media is
neutral
- possess excellent hair conditioning property
and hence used as secondary surfactants

i. Dialkyl Ethylene Diamines

ii. N-alkyl Amino Acids
2. Foam Boosters
→stabilize or strengthen foam produced by
surfactants
→make the foam dense and it to remain for
long duration
→addedin quantity of about 2 to 5%
Ex: fatty acid alkanolamides, amine oxides

3. Germicide and Anti-dandruff Agents

→Germicides are the agents which prevent the
growth of microorganism on the scalp whereas
anti-dandruff agents are used to eliminate
dandruff from the scalp.
Examples of Germicides are:
• Quaternary ammonium compounds (Benzalkonium
Chloride, Cetrimide)
Examples of Anti-dandruff Agents are:
• Selenium Sulphide
• Cadmium Sulphide
4. Conditioning Agents
→improve the condition of hair
→ have the property of reducing, electric
charges the hair, as a result, hair become
lustrous and hence easily manageable
→exhibit a bactericidal effect
→make the hair silky and shiny
Ex: lanolin, oils, herbal extracts, egg, amino acids
5. Pearlescent Agent
→usually added as adjuvants to the
conditioning agents
→improve the conditioning property
→also imparts brightness to hair
→ make the preparation transparent or
opaque; hence they are also called as
opacifying agents
Ex: alkanolamides and coumarins like 4-methyl-
7-diethyl aminocoumarin, 4-methyl-5, 7-
dihydrocoumarin
6. Sequestrants
→are complex forming agents
→form complex with metal ions like calcium
and magnesium
→preventscomplex formation between metal
and surfactant
Ex: EDTA, citric acid

7. Thickening Agents
→usually added to make the preparation
thick -facilitates ease of handling
Ex: methyl cellulose, alginates polyvinyl alcohol,
polyethylene glycol
8. Perfumes
→imparts good fragrance to the shampoo
→ neutralizes the undesirable odour of other
ingredients of formulation especially
surfactants
9. Preservatives
→have the ability to prevent the growth of
microorganisms
→usually added to maintain the stability of
the preparation for a desired period of time
Ex: Para-hydroxy benzoic acid and phenyl
mercuric nitrate
10. Colour
→gives pleasant appearance to the preparation
→must be water soluble and it should not
impart any colour to hair or scalp
PREPARATION
1. Initially the detergent is converted into a
solution form or a detergent solution ma ho
directly obtained from the manufacturer.
2. Take about half of the detergent solution
into a separate container. To it, add the total
amount of secondary surfactant i.e.,
alkanolamide.
3. Dissolve the alkanolamide along with
stirring. Sometimes, gentle heat is also
applied.
4. To the remaining half of the detergent
solution add suitable amount of
perfuming agent and dissolve it.
5. The perfume solution is then added to the
alkanolamide solution.
6. Colour and preservatives are dissolved
separately in sufficient volume of water
and then added to the main solution.
chloride.
7. The whole, solution is mixed well by gentle
stirring. Excessive stirring may lead to bubble
formation.
8. Final volume of the preparation is
usually adjusted by the addition of clear
sterile waste. This gives clear liquid shampoo.
9. However, when the preparation contains
lauryl alcohol ether sulphate. It is required to
adjust the viscosity of the shampoo.
10. Viscosity adjustment is done by using an
electrolyte solution. Usually, a solution of
sodium chloride is added subsequently with
constant stirring. Care must be taken to it
event the excess addition of sodium chloride
EVALUATION
* According to the regulatory authorities each
and every batch of shampoos must be evaluated
prior to marketing.
* Evaluation is a measure of activity and safety.
It also notifies the toxicity, if nowadays most of
the shampoos are prepared, from synthetic
detergents, hence evaluation becomes an
essential factor.
* However, there is also a need to evaluate
herbal shampoo, since it may contain natural
ingredient which are liable to contamination.
I. Evaluation of Safety
1. Skin Toxicity Test – using six albino rabbits
(shampoo is applied topically)
After efficient washing, the skin is examined for
any adverse reactions such as erythema, edema
etc. Based on the results obtained the shampoo is
considered as either safe or toxic.

2. Eye Toxicity Test – using six adult albino rabbits

(shampoo is administered to the eye)
The test eyes are observed at 1, 24, 48 and 72
hours respectively. They are also examined on 7th
and 14th day. The product is said to be toxic, if
there is a development of iris and corneal
lesions which remains for more than 7 days.
II. Evaluation of Antimicrobial Activity
Challenge Study:

→to evaluate the effectivity of preservatives

added to the formulation
1. Initially an appropriate strain of
microorganism is selected and is considered
as test organism. Usually the species of
Pseudomonas are selected i.e., P.aeruginosa, P.
Putida, etc.
2. A culture of any one of the above test organisms
is prepared.
3. The product (shampoo) is then inoculated
repeatedly in the culture medium and the
studies are carried out for a period of 10 to 12
weeks.
4. The inoculums usually contain 5 lakhs to1 crore
microorganisms/ gm of product.
5. Along with the test, control samples are also
prepared and reserved for reference.
6. Usually two types of control samples are
prepared i.e., one sample with preservative and
another without preservative.
7. The test comes to a conclusion only when it has
been proven that the product has not supported
the microbial growth.
 Answer the following questions in your own
words and based on what you have
understand after reading the lecture notes.
1. In your own words, how shampoo works?

2. What are the raw materials needed in the

formulation of shampoo? Give examples.

3. How to evaluate the quality of shampoos?