Jordan University of Science and Technology

Faculty of Engineering
Biomedical Engineering Department

BME 531A: Physiological Modeling

Course Catalog
Design of system elements, case studies of medical system examples, computer-aided design methods, design of
subsystems, product reliability. Dynamic modeling and control of selected biological and physiological processes.

Text Book(s)

Title Mathematical and Computer Modeling of physiological systems.

Author(s) Vincent C.Rideout
Publisher Prentice Hall
Year 1996
Title Physiological Control Systems - Analysis, Simulation, and Estimation
Author(s) Michael C.K Khoo
Publisher IEEE Press/John Wiley
Year 2000

References
Books • Mathematical Modelling of Dynamic Biological Systems
Ludwik Finkelstein & Ewart R. Carson (1986)
• Modelling Dynamic Biological Systems
Bruce Hannon & Matthias Ruth (1997)
• Introduction To Matlab For Engineers
William J. Palm III (2005)
• Mathematical Models in Biology
Leah Edelstein-Keshet (1988)
• A First Course in Mathematical Modeling
Franck R. Giordano, William P. Fox, Steven B. Horton & Maurice D.
Weir(2009)
• Mathematical Modeling in The Life Sciences
Paul Doucet & Peter B. Sloep (1992)
• Modeling Differential Equation in Biology
Clifford Henry Taubes (2008)
• Modeling and Simulating in Medicine and the life sciences (2nd edition)
Franck C.Hoppensteadt and charles S.Peskin Springer,New York,2002
• Introduction to Biomedical Engineering
John ENderle, Elsevier, 1999, Second

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 Journals • Annals of Biomedical Engineering
• Journal of Medical Engineering and Technology
• Computer Programs and Methods in Medicine
• Medical Engineering and Physics
• IEEE EMBS Book Series
• IEEE Transactions on Biomedical Engineering
• IEEE Transactions on Information Technology in Biomedicine
• Physiological Measurement
Internet links • http://www.bmes.org/
• http://arjournals.annualreviews.org/loi/bioeng?cookieSet=1
• http://www.aami.org/publications/BIT/index.html
• http://www.biophysj.org/
• http://emb-magazine.bme.uconn.edu/
• http://emb-magazine.bme.uconn.edu/
• http://www.iee.org/Publish/Journals/ProfJourn/MBEC/
• http://spie.org/app/Publications/index.cfm?fuseaction=journals&type=jbo
• http://www.biomedical-engineering-online.com/start.asp

Prerequisites
Prerequisites by topic Biomedical Transport Phenomena
Prerequisites by course BME 452
Co-requisites by course NA
Prerequisite for Artificial Organs, Bioinformatics

Objectives and Outcomes

Objectives Outcomes
To provide the students with a • Learn how to describe systems using Laplace transform and
guide to mathematical modeling differential equations
techniques (a,b,c,d,e,g,k) • Solving the mathematical models using different numerical and
analytical method.
To provide the students with a
• Learn how to use Matlab/Simulink as simulation software.
tool for simulation physiological
systems (a,b,c,d,e,g,k,l) • Use Simulink to simulate physiological systems
Understand how to build,
analyze and develop models for • Develop and build engineering models that describe pressure flow
physiological systems such as cardiovascular and respiratory function
systems(a,b,c,d,e,g,k,l)
Understand the simulation and
• Simulate cardiovascular systems and Mass-Transport compartment
control of selected physiological
modeling
processes and biological systems
(a,b,c,d,e,g,k,l) • Analyze Pharmacokinetic System

Topics Covered
Week Topics Chapters in Text
1 Introduction to mathematical modeling Chapter 1 (Text 2) and notes

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 using Matlab/Simulink/Berkeley

2-3 Mathematical Modeling Chapter 2 (Text 2) and notes

4 Static analysis of physiological systems Chapter 3 (Text 2) and notes
5-6 Analysis of linear systems Chapter 4 (Text 2) and notes
7-8 Pressure flow modeling. Chapter 4 (Text 1) and notes
Cardiovascular modeling.

9-10 Respiratory system modeling Chapter 5 (Text 1) and notes

11-12 Mass Transport :Compartment Modeling Chapter 2-3 (Text 1) and notes
13-14 Multiple Modeling Chapter 6 (Text 1) and notes
15-16 Heart flow and Thermoregulation Chapter 7 (Text 2) and notes
Modeling

Policy
Attendance Class attendance is required and applied according to the university regulations (student’s
guide page 43). Data support the idea that class attendance improves learning. It is very
difficult as well as uninspiring for me to help a student who does not attend lectures. What
is created in the classroom cannot be reenacted.
Make-up tests will be done according to the university regulations. Please see student’s
guide pages 44-45.
Homework Working homework problems is an essential part of this course and they represent a key
opportunity to learn the subjects discussed. All homework problems assigned during a
given week are due at the beginning of class on the second meeting of the following week
unless otherwise stated. Late homework will not be accepted. Failure to turn in this
particular homework on time will result in a grade of 0 (zero) for the homework
contribution to your final grade. Team work is encouraged; however, the work one hands
in must represent his/her own effort. Homework solutions will be discussed in class.
There will be no handouts of homework solutions.

Student Conduct All University regulations apply to this course. In particular, the policies concerning
academic dishonesty and withdrawal from a course apply.

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 Teaching & Learning Methods
- Active learning, where students should be active and involved in the learning process inside the classroom,
will be emphasized in the delivery of this course.
- Different active learning methods/approaches such as: Engaged Learning, Project-Based Learning,
Cooperative Learning, Problem-based Learning, Structured Problem-solving, will be used.
- The teaching method that will be used in this course will be composed of a series of mini lectures
interrupted with frequent discussions and brainstorming exercises. PowerPoint presentations will be
prepared for the course materials.
- A typical lecture would start with a short review (~ 5 minutes) using both PowerPoint presentations and
the blackboard. This review will also depend on discussions which will gauge the students’ digestion of the
previous material. Then, the students would have a lecture on new materials using PowerPoint
presentations and blackboard. The lecture presentation will be paused every 15 – 20 minutes with
brainstorming questions and discussions that will allow the students to reflect and think in more depth
about what they learned in that presentation. Then, some example problems will be presented and
discussed with the students to illustrate the appropriate problem solving skills that the students should
learn. The lecture will be continued for another 15 – 20 minutes, followed by examples and/or a quiz
covering the materials taught in the previous two weeks.

Evaluation
Assessment
Expected Due Date Weight
Tool
Homework, One week after homework problems are assigned 10%
Project and
quizzes
First Exam According to the University examination schedule 25 %
Second Exam According to the University examination schedule 25 %
Final Exam According to the University final examination schedule 40 %

Contribution of Course to Meeting the Professional Component

The course contributes to building the fundamental basic concepts in Biomedical Engineering and Modeling.

ABET Category Content

Engineering Science 3.0 Credit

Engineering Design