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Cell Kinetics and Fermenter Design Solution Manual

This document provides information from two studies on cell kinetics and fermenter design: 1) Aiba et al. reported results from a chemostat study on yeast growth including a table of data. The study looked at determining rate equations for cell growth and product (ethanol) formation. 2) Andrews proposed a model for microorganism growth with inhibitory substrates. The document provides instructions to determine kinetic parameters from a table of experimental data and calculate steady-state cell concentration given other parameters. It also asks to explain what might happen if substrate concentration is suddenly increased and why this could cause process instability.

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Marthy Dayag
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1K views5 pages

Cell Kinetics and Fermenter Design Solution Manual

This document provides information from two studies on cell kinetics and fermenter design: 1) Aiba et al. reported results from a chemostat study on yeast growth including a table of data. The study looked at determining rate equations for cell growth and product (ethanol) formation. 2) Andrews proposed a model for microorganism growth with inhibitory substrates. The document provides instructions to determine kinetic parameters from a table of experimental data and calculate steady-state cell concentration given other parameters. It also asks to explain what might happen if substrate concentration is suddenly increased and why this could cause process instability.

Uploaded by

Marthy Dayag
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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Cell Kinetics and Fermenter Design Solution Manual

6.2 Aiba et al. (1968) reported the results of a chemostat study on the growth of a specific strain of baker's yeast as
shown in the following table. The inlet stream of the chemostat did not contain any cells or products.

a. Find the rate equation for cell growth.


b. Find the rate equation for product (ethanol) formation.
6.3. Andrews (1968) proposed the following model for the growth of microorganisms utilizing inhibitory substrates.

Assume that a chemostat study was performed with a microorganism. The volume of the fermenter content was 1 L.
The inlet stream was sterile. The flow rate and inlet substrate concentration were varied and the steady-state
concentration of glucose in the fermenter was measured and recorded as shown in the table (the data are arbitrary).
a. Determine the kinetic parameters (µmax, KS, and KI) of this microorganism.
b. If the cell yield, YX/S, is 0.46 g/g, what is the steady-state cell concentration when the flow rate is 0.20 L/h?
Andrews concluded in his paper that the primary result of substrate inhibition in a continuous culture may be
process instability. Explain what might happen if you suddenly increase the substrate concentration from 30 to 60
g/L and why.
c. Andrews concluded in his paper that the primary result of substrate inhibition in a continuous culture may be
process instability. Explain what might happen if you suddenly increase the substrate concentration from 30 to 60
g/L and why.

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