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Piperacillin Tazobactam (Zosynpiperacillin)

This clinical medications worksheet provides information on piperacillin-tazobactam including its classification as an anti-infective, dosing of 3-4g IV every 4-6 hours up to 24g per day, and mechanism of action in treating serious infections caused by susceptible organisms. Nursing implications include monitoring for hypersensitivity reactions, renal impairment, drug interactions, and teaching the patient to report signs of superinfection or allergy like diarrhea or fever. The nursing process involves assessing the patient for infection with vital signs and appearance of secretions, evaluating for resolution of symptoms, and holding the medication in cases of anaphylaxis or aller

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4K views1 page

Piperacillin Tazobactam (Zosynpiperacillin)

This clinical medications worksheet provides information on piperacillin-tazobactam including its classification as an anti-infective, dosing of 3-4g IV every 4-6 hours up to 24g per day, and mechanism of action in treating serious infections caused by susceptible organisms. Nursing implications include monitoring for hypersensitivity reactions, renal impairment, drug interactions, and teaching the patient to report signs of superinfection or allergy like diarrhea or fever. The nursing process involves assessing the patient for infection with vital signs and appearance of secretions, evaluating for resolution of symptoms, and holding the medication in cases of anaphylaxis or aller

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Copyright
© Attribution Non-Commercial (BY-NC)
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INDEX NURS 2236 Clinical Form 3: Clinical Medications Worksheet

(You will need to made additional copies of these forms)


Generic Trade Classification Dose Route Time/Frequency
Name Name anti-infectives
piperacillin Zosynpiperacillin 3-4g IV every 4-6 hr (up to 24g/day)
tazobactam

Peak Onset Duration For IV meds, compatability with IV drips and/or solutions
end of infusion rapid 4-6 hr
Why is your patient taking this medication?

Mechanism of action and indications Nursing Implications (what to focus on)


Treatment of serious infections due to susceptible organisms Contraindications/warnings/interactions hypersensitivity to penicillins,
including: skin and skin structure infections; bone and betalactams, cephalosporins, or tazobactam (cross sensitivity may occur); Renal
joint infections; septicemia; respiratory tract infections; impairment; sodium restriction; pregnancy and lactation.
intra-abdominal infections; gynecologic and urinary
tract infections; has been combined with other antibiotic
in the treatment of infections in immunosuppressed Common side effects Seizures (higher doses); confusion; lethargy;
patients. Prophylactic anti-infective in abdominal, arrhythmias; CHF; pseudomembranous colitis; diarrhea; superinfection;
genitourinary, and head and neck surgery. Appendicitis nausea; interstital nephritis; rashes; urticaria; hypokalemia; hypernatremia;
Death of susceptible bacteria. bleeding leukopenia; neutropenia; phelbitis at IV site; metabolic alkalosis;
Hypersensitivity reactions including anaphylaxis and serum sickness; fever
Interactions with other patient drugs, OTC, or herbal Lab value alterations caused by medicine
medicines (ask patient specifically)
Probenecid; lithium; potassium-losing diuretics;
corticosteroids; amphotericin B; hepatotoxic agents;
aminoglycosides; methotrexate. Be sure to teach the patient the following about this medication
Report and sign of superinfection (black furry overgrowth on tongue, vaginal
itching or discharge, loose or foul-smelling stools) and allergy. Contact doctor
if fever and diarrhea occur.

Nursing Process - Assessment Assessment Evaluation


(Pre-administration assessment Why would you hold or not give Check after giving
Assess patient for infection this med? Resolution of the signs and symptoms of
Vital signs; appearance of wound, sputum,urine, anaphylaxis infection. Length of time for complete
and stool; WBC and beginning of and throughout allergy resolution depends on the organism and site
therapy. Allergy to medication. Observe for signs of infection.
of anaphylaxis (rash, pruritus, laryngeal edema,
wheezing.

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