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GPAT Physical Pharmacy Syllabus

The GPAT Physical Pharmacy Syllabus covers 8 topics related to physical pharmacy: 1) properties of matter, 2) micromeritics and powder rheology, 3) surface and interfacial phenomenon, 4) viscosity and rheology, 5) dispersion systems, 6) complexation, 7) buffers, and 8) solubility. The syllabus outlines key concepts to be learned within each topic area, such as states of matter, particle size determination methods, surface tension measurement, non-Newtonian fluid behavior, colloidal dispersion properties, buffer equations and capacity, and factors influencing drug solubility.

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703 views2 pages

GPAT Physical Pharmacy Syllabus

The GPAT Physical Pharmacy Syllabus covers 8 topics related to physical pharmacy: 1) properties of matter, 2) micromeritics and powder rheology, 3) surface and interfacial phenomenon, 4) viscosity and rheology, 5) dispersion systems, 6) complexation, 7) buffers, and 8) solubility. The syllabus outlines key concepts to be learned within each topic area, such as states of matter, particle size determination methods, surface tension measurement, non-Newtonian fluid behavior, colloidal dispersion properties, buffer equations and capacity, and factors influencing drug solubility.

Uploaded by

kumar Harsh
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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GPAT Physical Pharmacy Syllabus

1. Matter, properties of matter

States of matter, change in the state of matter, latent heat and vapor pressure,
sublimation-critical point, eutectic mixtures, gases, aerosols- inhalers, relative
humidity, liquid complexes, liquid crystals, glasses state, solid crystalline and
amorphous polymorphism.

2. Micromeritics and powder rheology

Particle size and distribution, average particle size number and weight distribution,
particle number, methods of determining particle size and volume, optical
microscopy, sieving, sedimentation, determining surface areas, permeability,
adsorption, derived properties of powders, porosity, packing arrangement densities,
bulkiness and flow properties.

3. Surface and interfacial phenomenon

Liquid interface, surface and interfacial tensions, surface free energy,


measurement of surface and interfacial tension, spreading coefficient, adsorption
and liquid interfaces, surface active agents, HLB classification, solubilization,
detergency, absorption at solid interfaces, solid gas and solid-liquid interfaces,
complex films, electrical properties of interfaces.

4. Viscosity and rheology

Newtonian systems, law of flow, kinematics viscosity, effect of temperature, non-


Newtoniansystems, pseudoplastics, dilatant, plastic, thixotropy in formulations,
determination of viscosity and thixotropy by capillary, falling ball, rotational
viscometer, application of theology in pharmacy

5. Dispersion systems

 Colloidal dispersions: Definition, types, properties of colloids, protective


colloids, application of colloids in pharmacy.
 Suspensions and emulsions: Interfacial properties of suspended particles
settling in suspension, theory of sedimentation, effect of Brownian movement,
sedimentation of flocculated particles, sedimentation parameters, wetting of
particles, significance of electrical properties in dispersions, controlled
flocculation, flocculation in structured vehicles, rheological considerations,
emulsions: types, theories, physical stability.

6. Complexation

Classification of complexes, methods of preparations and analysis, applications.

7. Buffer

Buffer equations and buffer capacity in general. Buffers in pharmaceutical systems,


preparations and stability, buffered isotonic solutions. Measurements of tonicity
calculations and methods of adjusting isotonicity.

8. Solubility

 Miscibility-influence of foreign substances three component systems;


 dielectric constant and solubility,
 solubility of solids in liquids
 ideal and non-ideal solutions
 solvation and association in solutions
 solubility of salts in water
 solubility of slightly soluble and weak electrolyte
 calculating solubility of weak electrolytes as influenced by pH,
influence of solvents on the solubility of drugs
 combined effect of pH and solvents, distribution of solutes between
immiscible solvents, effect of ionic dissociation and molecular
association on partition, extraction, preservatives action of weak acids in
emulsions, drug action and distribution coefficient.
 Concepts of dissolution and diffusion.

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