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In Vitro in Vivo Correlations

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Hemant Barai
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596 views4 pages

In Vitro in Vivo Correlations

Uploaded by

Hemant Barai
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Biophommauwhes and Phomocokinahs BP6097

n-Viro- In-Vivo (orralahon (IVIVC


w
Dr. Parjanya Shuhla
&
inihon- T-vtro In- vivo cOYTAahion is daind pr. M.P. Sungh Closes
-

K predchivu mahmabical modd Kas das cibes Ka


ulaionshib 6/w on mvitro propeyhs and an in-vivo
Ksponss a dos a9t omm.
Tn-Vitro broptrhs Auch as xaBi and Axtant o dimoluhon
Tn-ivo espomse 6uch as plasmo drug conunhabion and
amount odrug absorbid.
[ food and Drug Admi'nistrakon (YDa) dafiniion)
*The estabbishmnt da ahiona ulaionship btkuwn

biolegical ropaty and o physicochumical noperky


o6om dokagt om.
Unitad 8tals Phomocopoao (usP) Deinikon)

icakonA IVIVC 8y-Or. Mahendra Aralas Singa

)To asua babeh to bakh comaisBeny in


þhystalogical purfomonu
drug dr produeh
)To &tnva as o too in K davnlopmnf oa nuo dosaga fom
wih desirad in vivo bArformonu.

)T6 amisk tn validaking o AuHing diuouhion spuftaton.

T k main objechva davuloping and evaluaking on IVIVC ls

to onabl disoluhion tet to ve ar, a Sunvogala (alkarnaiva)


or in-vivo bioovailabiliby sBudius in Kuman bungs
it wduu Ho numbur of, bo-oguivalana sugnirad Po1 apoval as
wll o O-opprova change.
Som Common.ly sad quonitahiva b'nuor în-viho
in - vivo torTilakons ars - Dr. Parjanya Shukla
&
Dr. M. P. 5tngh Clawes

) (orvalaion bassd on Plasma Lvad Dalu :

HAY uinuar ulaimahip /w dinoluhon þaromatars and


plasma vas da

asom eta»
Thmor duoluhon d spucfic AUG, Cmax.
omount o
drug (g So
Amound duolvad in aprufie ku rachon abh0r.bud,
abaorpbon xab contant Ka.

Meon dioluion Hm Maan esidenu fimu, Maan


dinolukon hma, muan abaorpiontm .

) (orTaaion bosud on tK Uhinory Cxcrekon Dala-

HorA
HT dio.luhien þaram.etavs ara eorrelated to Ki amount

diug Lxcrakad unchangad n urinu

CumulaHvs amount o dru ex eratad


a unchion tm

(3) (oTalabion basad on o Phomacalogical Rusponx -

An oCuhe phamacologieal ect Auch as LDso in animals


uated to any dimoluhion param.ebr
lotiskical Momanh haoy can b ubad to date mint +R
ulahonship uch à peon disaolukion hmu (in-viho)
VATDUS mon Eidunu t'm (in-vivo)
nVifro- Th-viro (oulahion lavals:-
Dr. Pardanya Shula
Thru JVIVC Javels kovs hurn &
defind and Dr. M.P.3lngh Clases
Categovinsd in dasun ding ordXr o wsu na.
Ivs) A- Highest caBagory o coaJahon
suprsants o oint-to-point ulaionahib biho aen in viho
dinolwion and in-vivo xaks q abrorpHon
h in- viho disoluion and
in-vivo xata cunvasab»orpHon
aTA
boh
Superimposablu and mahemaheal
duvphon for
Cnvs is Ki sam.

Advantagas
) This K highest cakagory d lakion which ack as a
is
muoningu qualiky rotdursprudbch of in-vivo
PArorionu omulahon.
)Th in -viho unUA a shmulatad dimoluhon cmdikions can
Auv AUrrogak
as
or in-vivo prformanu oormulahons
Lval B- Uhias k rinuples od slahakcal moment analysis
Maon
MAon in-viro dimowion Hmu (MDT yiho) o produch is Comporad
o muon in- vivo idinu Hm
(mRTyivo
Such o COTT lakion nof o poin! to poinl conulaion
Ao
Ao OT Kis uwion Kas on (on nof uy on lavul Bcomlakion

Levsd C- i o
Aing poin (oTlaion.
w

4 sulabu on« diualuion Hmu poin(tg tsoy) to on


homorokinhic poromata buth as AUC, tmax 0 Cmax.
his luv is gannally uul only a) o uid
in ovmuakion davnlopmadl cohrod Dr. Parlanya Shukla
o quality &
to
Umitahons
Som Dr. M. P. 3tngh Caes

Mulh pluul c 4 is CoYaJabion involving ons oT AVLTOJ


PhamoCokintic poromebTAto K
amount drug dinoiad a vorious him poins.
dinoluhon profila
Tn-Vitro In-Vivo
A DimoluHon Cunva Abxorphon Gunva

b Maon Dimolukon Timu MAon Reuidunu Tim


(mDT) MRT)
C DisintaqraHon Hma, d'usluton Cmax, max, Ka,
ak y dioluton fliu'ny AUc

6-07. Mohn dro hraob Singh

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