Erapol EME140F Isocyanate Prepolymer

Version 2.0 No data available

ChemwatchSafety Data Sheet (Conforms to Regulations (EC) No 1907 / 2006, (EC) No 1272 / 2008 (CLP)) Print Date: 18-May-2011
CHEMWATCH SDS Revision Date: 9-Mar-2011
Issue Date: 9-Mar-2011

SAFETY DATA SHEET

SECTION 1: Identification of the substance / mixture and of the company / undertaking
1.1. Product Identifier
Product name: Erapol EME140F Isocyanate Prepolymer
Chemical product name: No data available
Synonyms: No data available
Proper shipping name: No data available
Chemical formula: No data available
Other means of No data available
identification:
Index number: No data available
ID number: No data available
CAS number: No data available
REACH registration number: No data available
EC number: Not Available

1.2. Relevant identified uses of the substance or mixture and uses advised against
Relevant identified uses: Used according to manufacturer's directions. Polyurethane prepolymer.
Uses advised against: No data available

1.3. Details of the supplier of the safety data sheet

Registered company name: Era Polymers Pty Ltd
Address: 25-27 Green Street,Banksmeadow,NSW, 2019,AUS
Telephone: +61 2 9666 3788
Fax: +61 2 9666 4805
Email:
Website: www.erapol.com.au

1.4. Emergency telephone number

Association / Organisation:
Other emergency telephone 1800 039 008 (AUS)
numbers:
Other emergency telephone +61 3 9573 3112; +800 243 62255
numbers:

SECTION 2: Hazards identification

2.1. Classification of the substance or mixture
DSD classification: In case of mixtures, classification has been prepared by following DPD (Directive 1999/45/EC) or CLP (Regulation (EC) No 1272/2008) regulations
DSD classification No data available
(additional):
DPD classification: R20 Harmful by inhalation.
R36/37/38 Irritating to eyes, respiratory system and skin.
R40(3) Limited evidence of a carcinogenic effect.
R42/43 May cause SENSITISATION by inhalation and skin contact.
R48/20 Harmful: danger of serious damage to health by prolonged exposure through inhalation.

CLP classification: Acute Toxicity (Inhalation) Category 4

Skin Corrosion/Irritation Category 2
Eye Irritation Category 2A
Respiratory Sensitizer Category 1
Skin Sensitizer Category 1
Carcinogen Category 2
STOT - SE (Resp. Irr.) Category 3
STOT - RE Category 2

CLP classification No data available

(additional):

2.2. Label elements

CLP label elements
Signal word: DANGER
Hazard statement(s): H332 Harmful if inhaled
H315 Causes skin irritation
H319 Causes serious eye irritation
H334 May cause allergic or asthmatic symptoms or breathing difficulties if inhaled
H317 May cause allergic skin reaction
H351 Suspected of causing cancer
H335 May cause respiratory irritation
H373 May cause damage to organs through prolonged or repeated exposure by inhalation.
Determined by Chemwatch using CLP criteria
Additional Statement(s): No data available
Supplementary Code Phrase
statement(s):
Precautionary statement(s): Prevention
Code Phrase
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P285 In case of inadequate ventilation wear respiratory protection.
Response
Code Phrase
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P304+P340 IF INHALED: Remove to fresh air and keep at rest in a position comfortable for
breathing.
IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a
P304+P341
position comfortable for breathing.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
P305+P351+P338
lenses, if present and easy to do. Continue rinsing.
P308+P313 IF exposed or concerned: Get medical advice/ attention.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P314 Get medical advice/attention if you feel unwell.
P333+P313 If skin irritation or rash occurs: Get medical advice/attention.
P337+P313 If eye irritation persists: Get medical advice/attention.
If experiencing respiratory symptoms: Call a POISON CENTER or
P342+P311
doctor/physician.
P363 Wash contaminated clothing before reuse.
Storage
Code Phrase
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.

DSD / DPD label elements

Relevant risk statements are found in section 2.1

Indication(s) of danger: CONSIDERED A DANGEROUS MIXTURE ACCORDING TO DIRECTIVE 1999/45/EC AND ITS AMENDMENTS.
Safety advice: S23 Do not breathe gas/fumes/vapour/spray.
S25 Avoid contact with eyes.
S36 Wear suitable protective clothing.
S51 Use only in well ventilated areas.
S09 Keep container in a well ventilated place.
S401 To clean the floor and all objects contaminated by this material, use water and detergent.
S07 Keep container tightly closed.
 S13 Keep away from food, drink and animal feeding stuffs.
S26 In case of contact with eyes, rinse with plenty of water and contact Doctor or Poisons Information Centre.
S46 If swallowed, IMMEDIATELY contact Doctor or Poisons Information Centre. (show this container or label).

2.3. Other hazards

•No relevant data
No data available

PBT/vPvB criteria No data available

SECTION 3: Composition / information on ingredients

3.1. Substances
See 'Composition on ingredients' in section 3.2
3.2. Mixtures
1. CAS No
2. EC No Classification according to Directive Classification according to (EC) No 1272/2008
3. Index No %[weight] Name 1999/45/EC [DPD] [CLP]
4. REACH No
1.
2. >60 polyurethane prepolymer
3.
4.
Carc. 2
Acute Tox. 4 *
Xn R20 R48/20 STOT RE 2 *
R36/37/38 Eye Irrit. 2
1. 101-68-8
2. 202-966-0, 247-714-0 4,4'-diphenylmethane diisocyanate R40 STOT SE 3
30-60
3. 615-005-00-9 (MDI) Skin Irrit. 2
4. No data available R42/
43 Resp. Sens. 1
Skin Sens. 1
CLP classification according to Annex VI of CLP
(Regulation (EC) No 1272/2008)

Identification of PBT / vPvB

substances / mixtures: No data available

SECTION 4: First aid measures

4.1. Description of first aid measures
General: No data available
Ingestion:
For advice, contact a Poisons Information Centre or a doctor.
If swallowed do NOT induce vomiting.
If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain open airway and prevent aspiration.
Observe the patient carefully.
Never give liquid to a person showing signs of being sleepy or with reduced awareness; i.e. becoming unconscious.
Give water to rinse out mouth, then provide liquid slowly and as much as casualty can comfortably drink.
Seek medical advice.

Eye Contact: If this product comes in contact with the eyes:

Wash out immediately with fresh running water.
Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting the upper and lower
lids.
Seek medical attention without delay; if pain persists or recurs seek medical attention.
Removal of contact lenses after an eye injury should only be undertaken by skilled personnel.

Skin Contact: If skin contact occurs:

Immediately remove all contaminated clothing, including footwear.
Flush skin and hair with running water (and soap if available).
Seek medical attention in event of irritation.

Inhalation:
If fumes or combustion products are inhaled remove from contaminated area.
Lay patient down. Keep warm and rested.
Prostheses such as false teeth, which may block airway, should be removed, where possible, prior to initiating first aid procedures.
Apply artificial respiration if not breathing, preferably with a demand valve resuscitator, bag-valve mask device, or pocket mask as trained. Perform
CPR if necessary.
Transport to hospital, or doctor.

4.2. Most important symptoms and effects, both acute and delayed
Inhaled: • Evidence shows, or practical experience predicts, that the material produces irritation of the respiratory system, in a substantial number of individuals,
following inhalation. In contrast to most organs, the lung is able to respond to a chemical insult by first removing or neutralising the irritant and then repairing
the damage. The repair process, which initially evolved to protect mammalian lungs from foreign matter and antigens, may however, produce further lung
damage resulting in the impairment of gas exchange, the primary function of the lungs. Respiratory tract irritation often results in an inflammatory response
involving the recruitment and activation of many cell types, mainly derived from the vascular system. • Inhalation of aerosols (mists, fumes), generated by the
material during the course of normal handling, may be harmful. • The vapour/mist may be highly irritating to the upper respiratory tract and lungs; the response
may be severe enough to produce bronchitis and pulmonary oedema. Possible neurological symptoms arising from isocyanate exposure include headache,
insomnia, euphoria, ataxia, anxiety neurosis, depression and paranoia. Gastrointestinal disturbances are characterised by nausea and vomiting. Pulmonary
sensitisation may produce asthmatic reactions ranging from minor breathing difficulties to severe allergic attacks; this may occur following a single acute
exposure or may develop without warning for several hours after exposure. Sensitized people can react to very low doses, and should not be allowed to
 work in situations allowing exposure to this material. Continued exposure of sensitised persons may lead to possible long term respiratory impairment.
Inhalation hazard is increased at higher temperatures.
Ingestion: The material is not thought to produce adverse health effects following ingestion (as classified by EC Directives using animal models). Nevertheless, adverse
systemic effects have been produced following exposure of animals by at least one other route and good hygiene practice requires that exposure be kept to
a minimum.
Skin Contact: • Evidence exists, or practical experience predicts, that the material either produces inflammation of the skin in a substantial number of individuals following
direct contact, and/or produces significant inflammation when applied to the healthy intact skin of animals, for up to four hours, such inflammation being
present twenty-four hours or more after the end of the exposure period. Skin irritation may also be present after prolonged or repeated exposure; this may
result in a form of contact dermatitis (nonallergic). The dermatitis is often characterised by skin redness (erythema) and swelling (oedema) which may
progress to blistering (vesiculation), scaling and thickening of the epidermis. At the microscopic level there may be intercellular oedema of the spongy layer of
the skin (spongiosis) and intracellular oedema of the epidermis. • The material may accentuate any pre-existing dermatitis condition. • Open cuts, abraded or
irritated skin should not be exposed to this material.
Eye: Evidence exists, or practical experience predicts, that the material may cause eye irritation in a substantial number of individuals and/or may produce
significant ocular lesions which are present twenty-four hours or more after instillation into the eye(s) of experimental animals. Repeated or prolonged eye
contact may cause inflammation characterised by a temporary redness (similar to windburn) of the conjunctiva (conjunctivitis); temporary impairment of
vision and/or other transient eye damage/ulceration may occur.
Chronic: On the basis, primarily, of animal experiments, concern has been expressed that the material may produce carcinogenic or mutagenic effects; in respect of
the available information, however, there presently exists inadequate data for making a satisfactory assessment.
Practical evidence shows that inhalation of the material is capable of inducing a sensitisation reaction in a substantial number of individuals at a greater
frequency than would be expected from the response of a normal population.
Pulmonary sensitisation, resulting in hyperactive airway dysfunction and pulmonary allergy may be accompanied by fatigue, malaise and aching. Significant
symptoms of exposure may persist for extended periods, even after exposure ceases. Symptoms can be activated by a variety of nonspecific
environmental stimuli such as automobile exhaust, perfumes and passive smoking.
Practical experience shows that skin contact with the material is capable either of inducing a sensitisation reaction in a substantial number of individuals,
and/or of producing a positive response in experimental animals.
Harmful: danger of serious damage to health by prolonged exposure through inhalation.
Serious damage (clear functional disturbance or morphological change which may have toxicological significance) is likely to be caused by repeated or
prolonged exposure. As a rule the material produces, or contains a substance which produces severe lesions. Such damage may become apparent
following direct application in subchronic (90 day) toxicity studies or following sub-acute (28 day) or chronic (two-year) toxicity tests.
Persons with a history of asthma or other respiratory problems or are known to be sensitised, should not be engaged in any work involving the handling of
isocyanates. [CCTRADE-Bayer, APMF]
Isocyanate vapours/mists are irritating to the upper respiratory tract and lungs; the response may be severe enough to produce bronchitis with wheezing,
gasping and severe distress, even sudden loss of consciousness, and pulmonary oedema. Possible neurological symptoms arising from isocyanate
exposure include headache, insomnia, euphoria, ataxia, anxiety neurosis, depression and paranoia. Gastrointestinal disturbances are characterised by
nausea and vomiting. Pulmonary sensitisation may produce asthmatic reactions ranging from minor breathing difficulties to severe allergic attacks; this may
occur following a single acute exposure or may develop without warning after a period of tolerance. A respiratory response may occur following minor skin
contact. Skin sensitisation is possible and may result in allergic dermatitis responses including rash, itching, hives and swelling of extremities.
Isocyanate-containing vapours/ mists may cause inflammation of eyes and nasal passages.
Onset of symptoms may be immediate or delayed for several hours after exposure. Sensitised people can react to very low levels of airborne isocyanates.
Unprotected or sensitised persons should not be allowed to work in situations allowing exposure to this material.
Respiratory sensitisation may result in allergic/asthma like responses; from coughing and minor breathing difficulties to bronchitis with wheezing, gasping.

4.3. Indication of any immediate medical attention and special treatment needed
For sub-chronic and chronic exposures to isocyanates:
This material may be a potent pulmonary sensitiser which causes bronchospasm even in patients without prior airway hyperreactivity.
Clinical symptoms of exposure involve mucosal irritation of respiratory and gastrointestinal tracts.
Conjunctival irritation, skin inflammation (erythema, pain vesiculation) and gastrointestinal disturbances occur soon after exposure.
Pulmonary symptoms include cough, burning, substernal pain and dyspnoea.
Some cross-sensitivity occurs between different isocyanates.
Noncardiogenic pulmonary edema and bronchospasm are the most serious consequences of exposure. Markedly symptomatic patients should receive oxygen, ventilatory support and
an intravenous line.
Treatment for asthma includes inhaled sympathomimetics (epinephrine [adrenalin], terbutaline) and steroids.
Activated charcoal (1 g/kg) and a cathartic (sorbitol, magnesium citrate) may be useful for ingestion.
Mydriatics, systemic analgesics and topical antibiotics (Sulamyd) may be used for corneal abrasions.
There is no effective therapy for sensitised workers.
[Ellenhorn and Barceloux; Medical Toxicology]
NOTE: Isocyanates cause airway restriction in naive individuals with the degree of response dependant on the concentration and duration of exposure. They induce smooth muscle contraction
which leads to bronchoconstrictive episodes. Acute changes in lung function, such as decreased FEV1, may not represent sensitivity.
[Karol & Jin, Frontiers in Molecular Toxicology, pp 56-61, 1992]
SECTION 5: Firefighting measures
5.1. Extinguishing media
Flooding quantities of water only.
Foam.
Dry chemical powder.
BCF (where regulations permit).
Carbon dioxide.
Water spray or fog - Large fires only.

5.2. Special hazards arising from the substrate or mixture

Fire Incompatibility:
Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine bleaches, pool chlorine etc. as ignition may result

5.3. Advice for firefighters

Fire Fighting:
Alert Fire Brigade and tell them location and nature of hazard.
Wear full body protective clothing with breathing apparatus.
Prevent, by any means available, spillage from entering drains or water course.
Use water delivered as a fine spray to control fire and cool adjacent area.
Avoid spraying water onto liquid pools.
DO NOT approach containers suspected to be hot.
Cool fire exposed containers with water spray from a protected location.
If safe to do so, remove containers from path of fire.

Fire/Explosion Hazard:
Combustible.
Moderate fire hazard when exposed to heat or flame.
 When heated to high temperatures decomposes rapidly generating vapour which pressures and may then rupture containers with release of
flammable and highly toxic isocyanate vapour.
Burns with acrid black smoke and poisonous fumes.
Combustion yields traces of highly toxic hydrogen cyanide HCN, plus toxic nitrogen oxides NOx and carbon monoxide.
Combustion products include:
carbon dioxide (CO2)
isocyanates
and minor amounts of
hydrogen cyanide
nitrogen oxides (NOx)
other pyrolysis products typical of burning organic material
When heated at high temperatures many isocyanates decompose rapidly generating a vapour which pressurises containers, possibly to the point of rupture.
Release of toxic and/or flammable isocyanate vapours may then occur
May emit poisonous fumes.

SECTION 6: Accidental release measures

6.1. Personal precautions, protective equipment and emergency procedures
Personal Protective
Breathing apparatus.Gas tight chemical resistant suit.Limit exposure duration to 1 BA set 30 mins.
Equipment:
Minor Spills:
Remove all ignition sources.
Clean up all spills immediately.
Avoid breathing vapours and contact with skin and eyes.
Control personal contact by using protective equipment.
Contain and absorb spill with sand, earth, inert material or vermiculite.
Wipe up.
Place in a suitable, labelled container for waste disposal.

Major Spills:
Liquid Isocyanates and high isocyanate vapour concentrations will penetrate seals on self contained breathing apparatus - SCBA should be used
inside encapsulating suit where this exposure may occur.
Treat isocyanate spills with sufficient amounts of isocyanate decontaminant preparation.
Typically, such a preparation may consist of: sawdust: 20 parts by weight Kieselguhr 40 parts by weight plus a mixture of {ammonia (s.g. 0.880) 8%
v/v non-ionic surfactant 2% v/v water 90% v/v}.
Let stand for 24 hours.
Avoid contamination with water, alkalies and detergent solutions.
Material reacts with water and generates gas, pressurises containers with even drum rupture resulting.
DO NOT reseal container if contamination is suspected.
Open all containers with care.

Moderate hazard.
Clear area of personnel and move upwind.
Alert Fire Brigade and tell them location and nature of hazard.
Wear breathing apparatus plus protective gloves.
Prevent, by any means available, spillage from entering drains or water course.
No smoking, naked lights or ignition sources.
Increase ventilation.
Stop leak if safe to do so.
Contain spill with sand, earth or vermiculite.
Collect recoverable product into labelled containers for recycling.
Absorb remaining product with sand, earth or vermiculite.
Collect solid residues and seal in labelled drums for disposal.
Wash area and prevent runoff into drains.
If contamination of drains or waterways occurs, advise emergency services.

6.2. Environmental precautions

The maximum airborne concentration below which it is believed that nearly all individuals could be exposed for up to one hour WITHOUT experiencing or developing
life-threatening health effects is:

4,4'-diphenylmethane diisocyanate (MDI) 25mg/m³

irreversible or other serious effects or symptoms which could impair an individual's ability to take protective action is:

4,4'-diphenylmethane diisocyanate (MDI) 2mg/m³

other than mild, transient adverse effects without perceiving a clearly defined odour is:

4,4'-diphenylmethane diisocyanate (MDI) 0.2mg/m³

American Industrial Hygiene Association (AIHA)

Ingredients considered according to the following cutoffs
Very Toxic (T+) >= 0.1% Toxic (T) >= 3.0%
R50 >= 0.25% Corrosive (C) >= 5.0%
R51 >= 2.5%
else >= 10%
where percentage is percentage of ingredient found in the mixture

6.3. Methods and material for containment and cleaning up

6.4. Reference to other sections
Personal Protective Equipment advice is contained in Section 8 of the MSDS
 Personal Protective Equipment advice is contained in Section 8 of the MSDS

SECTION 7: Handling and storage

7.1. Precautions for safe handling
Safe handling
DO NOT allow clothing wet with material to stay in contact with skin
Avoid all personal contact, including inhalation.
Wear protective clothing when risk of exposure occurs.
Use in a well-ventilated area.
Prevent concentration in hollows and sumps.
DO NOT enter confined spaces until atmosphere has been checked.
Avoid smoking, naked lights or ignition sources.
Avoid contact with incompatible materials.
When handling, DO NOT eat, drink or smoke.
Keep containers securely sealed when not in use.
Avoid physical damage to containers.
Always wash hands with soap and water after handling.
Work clothes should be laundered separately.
Use good occupational work practice.
Observe manufacturer's storing and handling recommendations.
Atmosphere should be regularly checked against established exposure standards to ensure safe working conditions.

Fire and explosion See section 5

protection
Other information for commercial quantities of isocyanates:
Isocyanates should be stored in adequately bunded areas. Nothing else should be kept within the same bunding. Pre-polymers need not be
segregated. Drums of isocyanates should be stored under cover, out of direct sunlight, protected from rain, protected from physical damage and well
away from moisture, acids and alkalis.
Where isocyanates are stored at elevated temperatures to prevent solidifying, adequate controls should be installed to prevent the high temperatures
and precautions against fire should be taken.
Where stored in tanks, the more reactive isocyanates should be blanketed with a non-reactive gas such as nitrogen and equipped with absorptive
type breather valve (to prevent vapour emissions)..
Transfer systems for isocyanates in bulk storage should be fully enclosed and use pump or vacuum systems. Warning signs, in appropriate
languages, should be posted where necessary.
Areas in which polyurethane foam products are stored should be supplied with good general ventilation. Residual amounts of unreacted isocyanate
may be present in the finished foam, resulting in hazardous atmospheric concentrations.

Store in original containers.

Keep containers securely sealed.
No smoking, naked lights or ignition sources.
Store in a cool, dry, well-ventilated area.
Store away from incompatible materials and foodstuff containers.
Protect containers against physical damage and check regularly for leaks.
Observe manufacturer's storing and handling recommendations.

SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS

+ X + X X +
+: May be stored together.
O: May be stored together with specific preventions.
X: Must not be stored together.

7.2. Conditions for safe storage, including any incompatibilities

Suitable container:
Metal can or drum
Packaging as recommended by manufacturer.
Check all containers are clearly labelled and free from leaks.

Storage incompatibility:
Avoid reaction with water, alcohols and detergent solutions.
Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with
amines, strong bases, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidisers, hydrides, phenols, and peroxides can cause
vigorous releases of heat. Acids and bases initiate polymerisation reactions in these materials.
Isocyanates easily form adducts with carbodiimides, isothiocyanates, ketenes, or with substrates containing activated CC or CN bonds.
Some isocyanates react with water to form amines and liberate carbon dioxide. This reaction may also generate large volumes of foam and heat.
Foaming in confined spaces may produce pressure in confined spaces or containers. Gas generation may pressurise drums to the point of rupture.
Do NOT reseal container if contamination is expected
Open all containers with care
Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur
with explosive violence,
Isocyanates will attack and embrittle some plastics and rubbers.
A range of exothermic decomposition energies for isocyanates is given as 20-30 kJ/mol.
The relationship between energy of decomposition and processing hazards has been the subject of discussion; it is suggested that values of energy
released per unit of mass, rather than on a molar basis (J/g) be used in the assessment.
For example, in "open vessel processes" (with man-hole size openings, in an industrial setting), substances with exothermic decomposition energies
below 500 J/g are unlikely to present a danger, whilst those in "closed vessel processes" (opening is a safety valve or bursting disk) present some
danger where the decomposition energy exceeds 150 J/g.
BRETHERICK: Handbook of Reactive Chemical Hazards, 4th Edition
Package Material
Incompatibilities: No data available
7.3. Specific end use(s)
See section 1.2

SECTION 8: Exposure controls / personal protection

8.1. Control parameters
Derived No Effect Level (DNEL)
Exposure Pattern Workers General Population
Long term - dermal, systemic effects No data available No data available
Long term - inhalation, systemic effects No data available No data available
Long term - oral, systemic effects No data available No data available
Long term - dermal, local effects No data available No data available
Long term - inhalation, local effects No data available No data available

Occupational Exposure Limits (OEL)

TWA TWA STEL STEL Peak Peak TWA
Source Material ppm mg/m³ ppm mg/m³ ppm mg/m³ F/CC Notes
UK Workplace Exposure 4,4'-diphenylmethane diisocyanate (MDI) 0.02 0.07 Sen, HSC/E plans to review the limit values for
Limits (WELs) (Isocyanates, all (as -NCO)) this substance
EMERGENCY EXPOSURE LIMITS
Material Revised IDLH Value (mg/m³) Revised IDLH Value (ppm)
4,4'-diphenylmethane diisocyanate (MDI)|2489 75

ERAPOL EME140F ISOCYANATE PREPOLYMER:

Not available
4,4'-DIPHENYLMETHANE DIISOCYANATE (MDI):
for diphenylmethane diisocyanate (methylene bisphenyl isocyanate; MDI)
Odour Threshold Value: 0.39 ppm
IDLH Level: 10 mg/m3
Mean MDI exposures of less than 0.003 ppm appear to have no acute or chronic effect on pulmonary function.
MDI produces identical toxicological responses to those produced by TDI and the recommended TLV-TWA is identical for the two isocyanates. Exposure at or below the recommended value is
thought to protect the worker against pulmonary function decrements as well as to minimise the potential for respiratory tract sensitisation. Individuals who may be hypersusceptible or
otherwise unusually responsive to exposure to certain industrial chemicals may not adequately protected from adverse health effects caused by MDI at the recommended TLV-TWA. Ceiling
values recommended by NIOSH and OSHA are synonymous with normal excursions allowable for exposures to the TLV-TWA (in excess of 3 x TLV-TWA for no more than a total of 30
minutes during a work day but in any case not exceeding 5 x TLV-TWA).

8.2. Exposure controls

8.2.1. Appropriate engineering controls

Spraying of material or material in admixture with other components must be carried out in conditions conforming to local state regulations.
Local exhaust ventilation with full face positive-pressure air supplied breathing apparatus (hood or helmet type) is normally required.
Spraying should be performed in a spray booth fitted with an effective exhaust system which complies with local environmental legislation.
The spray booth area must be isolated from unprotected personnel whilst spraying is in progress and until all spraying mist has cleared.
NOTE: Isocyanate vapours will not be adequately absorbed by organic vapour respirators. Air contaminants generated in the workplace possess varying "escape" velocities which, in turn,
determine the "capture velocities" of fresh circulating air required to effectively remove the contaminant.
Type of Contaminant: Air Speed:
direct spray, spray painting in shallow booths, drum filling, conveyer loading, crusher dusts, 1-2.5 m/s (200-500 f/min.)
gas discharge (active generation into zone of rapid air motion)
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range
1: Room air currents minimal or favourable to capture 1: Disturbing room air currents
2: Contaminants of low toxicity or of nuisance value only 2: Contaminants of high toxicity
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in motion 4: Small hood-local control only
Simple theory shows that air velocity falls rapidly with distance away from the opening of a simple extraction pipe. Velocity generally decreases with the square of distance from the extraction
point should be adjusted, accordingly, after reference to distance from the contaminating source. The air velocity at the extraction fan, for example, should be a minimum of 4-10 m/s (800-2000
f/min.) for extraction of solvents generated by spraying at a point 2 meters distant from the extraction point. Other mechanical considerations, producing performance deficits within the
extraction apparatus, make it essential that theoretical air velocities are multiplied by factors of 10 or more when extraction systems are installed or used.
8.2.2. Personal protection

Eye and face protection:

Safety glasses with side shields.
Chemical goggles.
Contact lenses may pose a special hazard; soft contact lenses may absorb and concentrate irritants. A written policy document, describing the
wearing of lens or restrictions on use, should be created for each workplace or task. This should include a review of lens absorption and
adsorption for the class of chemicals in use and an account of injury experience. Medical and first-aid personnel should be trained in their removal
and suitable equipment should be readily available. In the event of chemical exposure, begin eye irrigation immediately and remove contact lens as
soon as practicable. Lens should be removed at the first signs of eye redness or irritation - lens should be removed in a clean environment only after
workers have washed hands thoroughly. [CDC NIOSH Current Intelligence Bulletin 59]

Skin protection: See Hand protection: below

Hand protection: NOTE:
The material may produce skin sensitisation in predisposed individuals. Care must be taken, when removing gloves and other protective equipment,
to avoid all possible skin contact.
Contaminated leather items, such as shoes, belts and watch-bands should be removed and destroyed.
Suitability and durability of glove type is dependent on usage. Important factors in the selection of gloves include: such as:
frequency and duration of contact,
chemical resistance of glove material,
glove thickness and
dexterity
Select gloves tested to a relevant standard (e.g. Europe EN 374, US F739).
When prolonged or frequently repeated contact may occur, a glove with a protection class of 5 or higher (breakthrough time greater than 240
minutes according to EN 374) is recommended.
When only brief contact is expected, a glove with a protection class of 3 or higher (breakthrough time greater than 60 minutes according to EN 374)
is recommended.
Contaminated gloves should be replaced.

Gloves must only be worn on clean hands. After using gloves, hands should be washed and dried thoroughly. Application of a non-perfumed moisturiser is
recommended.
Isocyanate resistant materials include Teflon, Viton, nitrile rubber and some PVA gloves.
Protective gloves and overalls should be worn as specified in the appropriate national standard.
Contaminated garments should be removed promptly and should not be re-used until they have been decontaminated.
NOTE: Natural rubber, neoprene, PVC can be affected by isocyanates

Body protection: See Other protection: below

Other protection:
Overalls.
P.V.C. apron.
Barrier cream.
Skin cleansing cream.
Eye wash unit.

Respiratory protection: No data available

Thermal hazards: No data available
Recommended material(s): Glove selection is based on a modified presentation of the:
"Forsberg Clothing Performance Index".
The effect(s) of the following substance(s) are taken into account in the computer-generated selection:
4,4'-diphenylmethane diisocyanate (MDI)
Material CPI
PE/EVAL/PE A
* CPI - Chemwatch Performance Index
A: Best Selection
B: Satisfactory; may degrade after 4 hours continuous immersion
C: Poor to Dangerous Choice for other than short term immersion
NOTE: As a series of factors will influence the actual performance of the glove, a final selection must be based on detailed observation. -
* Where the glove is to be used on a short term, casual or infrequent basis, factors such as "feel" or convenience (e.g. disposability), may dictate a choice
of gloves which might otherwise be unsuitable following long-term or frequent use. A qualified practitioner should be consulted.

8.2.3. Environmental exposure controls

See section 12
SECTION 9: Physical and chemical properties
9.1. Information on basic physical and chemical properties
Appearance Milky liquid; reacts with water.
Odour No data available
Odour threshold No data available
Taste No data available
pH (1% solution) No data available
pH (as supplied) No data available
Melting point / freezing point No data available
Initial boiling point and boiling range No data available
Flash point No data available
Evaporation rate No data available
Flammability No data available
Upper / lower flammability or exposure limits No data available
Vapour pressure No data available
Vapour density No data available
Relative density 1.16
Solubility(ies) Reacts
Partition coefficient: n-octanol / water No data available
Auto-ignition temperature No data available
Critical temperature No data available
Viscosity No data available
Explosive properties No data available
Oxidising properties No data available
Physical state Liquid
Upper Explosive Limit No data available
Lower Explosive Limit No data available
 Surface Tension No data available
Volatile Component (%vol) No data available
Gas group No data available
Molecular weight No data available
Viscosity No data available
Evaporation Rate No data available
IUCLID Remarks No data available

9.2. Other information

No data available
SECTION 10: Stability and reactivity
10.1. Reactivity See section 7.2
10.2. Chemical stability ¦

Presence of incompatible materials.

Product is considered stable.
Hazardous polymerisation will not occur.
.

Presence of elevated temperatures.

.
10.3. Possibility of
hazardous See section 7.2
reactions
10.4. Conditions to avoid See section 7.2
10.5. Incompatible
materials See section 7.2
10.6. Hazardous
decomposition See section 5.3
products

SECTION 11: Toxicological information

11.1. Information on toxicological effects
Mutagenicity: No data available
Reproductive Toxicity: No data available
Carcinogenicity: No data available
STOT - single exposure: No data available

ERAPOL EME140F ISOCYANATE PREPOLYMER:¦ Not available. Refer to individual constituents. 4,4'-DIPHENYLMETHANE DIISOCYANATE (MDI):¦ unless otherwise specified
data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Oral (rat) LDLo: 9200 mg/kg Skin (rabbit): 500 mg /24 hours
Inhalation (rat) LC50: 178 mg/m³/4h Dermal Sensitiser *
Oral (mouse) LD50: 2200 mg/kg Respiratory Sensitiser (g.pig) *
Dermal (rabbit) LD50: >6200 mg/kg * [* = Bayer CCINFO 2133615]
Oral (Rat) LD50: 9200 mg/kg
¦ for diisocyanates:In general, there appears to be little or no difference between aromatic and aliphatic diisocyanates as toxicants. In addition, there are
insufficient data available to make any major distinctions between polymeric (<1000 MW) and monomeric diisocyanates. Based on repeated dose studies in
animals by the inhalation route, both aromatic and aliphatic diisocyanates appear to be of high concern for pulmonary toxicity at low exposure levels. Based
upon a very limited data set, it appears that diisocyanate prepolymers exhibit the same respiratory tract effects as the monomers in repeated dose studies.
There is also evidence that both aromatic and aliphatic diisocyanates are acutely toxic via the inhalation route. Most members of the diisocyanate category
have not been tested for carcinogenic potential. Though the aromatic diisocyanates tested positive and the one aliphatic diisocyanate tested negative in one
species, it is premature to make any generalizations about the carcinogenic potential of aromatic versus aliphatic diisocyanates. In the absence of more
human data, it would be prudent at this time to assume that both aromatic and aliphatic diisocyanates are respiratory sensitisers. Diisocyanates are
moderate to strong dermal sensitisers in animal studies. Skin irritation studies performed on rabbits and guinea pigs indicate no difference in the effects of
aromatic versus aliphatic diisocyanates.For monomers, effects on the respiratory tract (lungs and nasal cavities) were observed in animal studies at exposure
concentrations of less than 0.005 mg/L. The experimental animal data available on prepolymeric diisocyanates show similar adverse effects at levels that
range from 0.002 mg/L to 0.026 mg/L.There is also evidence that both aromatic and aliphatic diisocyanates are acutely toxic via the inhalation
routeOncogenicity: Most members of the diisocyanate category have not been tested for carcinogenic potential. Commercially available Poly-MDI was tested
in a 2-year inhalation study in rats. The tested material contained 47% aromatic 4,4'-methylenediphenyl diisocyanate (MDI) and 53% higher molecular weight
oligomers. Interim sacrifices at one year showed that males and females in the highest dose group (6 mg/m3) had treatment related histological changes in
the nasal cavity, lungs and mediastinal lymph nodes. The incidence and severity of degeneration and basal cell hyperplasia of the olfactory epithelium and
Bowman's gland hyperplasia were increased in males at the mid and high doses and in females at the high dose following the two year exposure period.
Pulmonary adenomas were found in 6 males and 2 females, and pulmonary adenocarcinoma in one male in the high dose group. However, aliphatic
hexamethylene diisocyanate (HDI) was found not to be carcinogenic in a two year repeated dose study in rats by the inhalation route. HDI has not been
tested in mice by the inhalation route.Though the oral route is not an expected route of exposure to humans, it should be noted that in two year repeated dose
studies by the oral route, aromatic toluene diisocyanate (TDI) and 3,3'-dimethoxy-benzidine-4,4'-diisocyanate (dianisidine diisocyanate, DADI) were found to
be carcinogenic in rodents. TDI induced a statistically significant increase in the incidence of liver tumors in rats and mice as well as dose-related
hemangiosarcomas of the circulatory system and has been classified by the Agency as a B2 carcinogen. DADI was found to be carcinogenic in rats, but not
in mice, with a statistically increase in the incidence of pancreatic tumors observed.Respiratory and Dermal Sensitization: Based on the available toxicity
data in animals and epidemiologic studies of humans, aromatic diisocyanates such as TDI and MDI are strong respiratory sensitisers. Aliphatic diisocyanates
are generally not active in animal models for respiratory sensitization. However, HDI and possibly isophorone diisocyanate (IPDI), are reported to be
associated with respiratory sensitization in humans. Symptoms resulting from occupational exposure to HDI include shortness of breath, increased
bronchoconstriction reaction to histamine challenges, asthmatic reactions, wheezing and coughing. Two case reports of human exposure to IPDI by inhalation
suggest IPDI is a respiratory sensitiser in humans. In view of the information from case reports in humans, it would be prudent at this time to assume that
both aromatic and aliphatic diisocyanates are respiratory sensitisers. Studies in both human and mice using TDI, HDI, MDI and dicyclohexylmethane-4,4'-
diisocyanate (HMDI) suggest cross-reactivity with the other diisocyanates, irrespective of whether the challenge compound was an aliphatic or aromatic
diisocyanate. Diisocyanates are moderate to strong dermal sensitisers in animal studies. There seems to be little or no difference in the level of reactivity
between aromatic and aliphatic diisocyanates.Dermal Irritation: Skin irritation studies performed on rabbits and guinea pigs indicate no difference in the effects
of aromatic versus aliphatic diisocyanates. The level of irritation ranged from slightly to severely irritating to the skin. One chemical, hydrogenated MDI (1,1-
methylenebis-4-isocyanatocyclohexane), was found to be corrosive to the skin in guinea pigs.Contact allergies quickly manifest themselves as contact
eczema, more rarely as urticaria or Quincke's oedema. The pathogenesis of contact eczema involves a cell-mediated (T lymphocytes) immune reaction of the
delayed type. Other allergic skin reactions, e.g. contact urticaria, involve antibody-mediated immune reactions. The significance of the contact allergen is not
simply determined by its sensitisation potential: the distribution of the substance and the opportunities for contact with it are equally important. A weakly
sensitising substance which is widely distributed can be a more important allergen than one with stronger sensitising potential with which few individuals
come into contact. From a clinical point of view, substances are noteworthy if they produce an allergic test reaction in more than 1% of the persons
tested.Asthma-like symptoms may continue for months or even years after exposure to the material ceases. This may be due to a non-allergenic condition
known as reactive airways dysfunction syndrome (RADS) which can occur following exposure to high levels of highly irritating compound. Key criteria for the
diagnosis of RADS include the absence of preceding respiratory disease, in a non-atopic individual, with abrupt onset of persistent asthma-like symptoms
within minutes to hours of a documented exposure to the irritant. A reversible airflow pattern, on spirometry, with the presence of moderate to severe bronchial
hyperreactivity on methacholine challenge testing and the lack of minimal lymphocytic inflammation, without eosinophilia, have also been included in the
criteria for diagnosis of RADS. RADS (or asthma) following an irritating inhalation is an infrequent disorder with rates related to the concentration of and
duration of exposure to the irritating substance. Industrial bronchitis, on the other hand, is a disorder that occurs as result of exposure due to high
concentrations of irritating substance (often particulate in nature) and is completely reversible after exposure ceases. The disorder is characterised by
dyspnea, cough and mucus production.Allergic reactions which develop in the respiratory passages as bronchial asthma or rhinoconjunctivitis, are mostly the
result of reactions of the allergen with specific antibodies of the IgE class and belong in their reaction rates to the manifestation of the immediate type. In
addition to the allergen-specific potential for causing respiratory sensitisation, the amount of the allergen, the exposure period and the genetically determined
disposition of the exposed person are likely to be decisive. Factors which increase the sensitivity of the mucosa may play a role in predisposing a person to
allergy. They may be genetically determined or acquired, for example, during infections or exposure to irritant substances. Immunologically the low molecular
weight substances become complete allergens in the organism either by binding to peptides or proteins (haptens) or after metabolism (prohaptens).Particular
attention is drawn to so-called atopic diathesis which is characterised by an increased susceptibility to allergic rhinitis, allergic bronchial asthma and atopic
eczema (neurodermatitis) which is associated with increased IgE synthesis.Exogenous allergic alveolitis is induced essentially by allergen specific immune-
complexes of the IgG type; cell-mediated reactions (T lymphocytes) may be involved. Such allergy is of the delayed type with onset up to four hours following
exposure.Isocyanate vapours/mists are irritating to the upper respiratory tract and lungs; the response may be severe enough to produce bronchitis with
wheezing, gasping and severe distress, even sudden loss of consciousness, and pulmonary oedema. Possible neurological symptoms arising from
isocyanate exposure include headache, insomnia, euphoria, ataxia, anxiety neurosis, depression and paranoia. Gastrointestinal disturbances are
characterised by nausea and vomiting. Pulmonary sensitisation may produce asthmatic reactions ranging from minor breathing difficulties to severe allergic
attacks; this may occur following a single acute exposure or may develop without warning after a period of tolerance. A respiratory response may occur
following minor skin contact. Skin sensitisation is possible and may result in allergic dermatitis responses including rash, itching, hives and swelling of
extremities. Isocyanate-containing vapours/ mists may cause inflammation of eyes and nasal passages.Onset of symptoms may be immediate or delayed for
several hours after exposure. Sensitised people can react to very low levels of airborne isocyanates. Unprotected or sensitised persons should not be allowed
to work in situations allowing exposure to this material.The material may produce moderate eye irritation leading to inflammation. Repeated or prolonged
exposure to irritants may produce conjunctivitis.The substance is classified by IARC as Group 3: NOT classifiable as to its carcinogenicity to
humans.Evidence of carcinogenicity may be inadequate or limited in animal testing.Inhalation (human) TCLo: 0.13 ppm/30 mins Eye (rabbit): 0.10 mg
moderate
SECTION 12: Ecological information
12.1. Toxicity
Fish: No data available
Daphnia Magna: No data available
Algae: No data available
Toxic to aquatic micro- No data available
organisms:
4,4'-DIPHENYLMETHANE DIISOCYANATE (MDI):
Half-life Soil - High (hours): 24
Half-life Soil - Low (hours): 6
Half-life Air - High (hours): 5.8
Half-life Air - Low (hours): 0.58
Half-life Surface water - 24
High (hours):
Half-life Surface water - 6
Low (hours):
Half-life Ground water - 24
High (hours):
Half-life Ground water - 6
Low (hours):
Aqueous biodegradation - 672
Aerobic - High (hours):
Aqueous biodegradation - 168
Aerobic - Low (hours):
Aqueous biodegradation -
Anaerobic - High (hours): 2688
Aqueous biodegradation -
Anaerobic - Low (hours): 672
Photooxidation half-life air -
High (hours): 5.8
Photooxidation half-life air -
Low (hours): 0.58
First order hydrolysis half- 12
life (hours):
Hydrolysis would represents the primary fate mechanism for the majority of the commercial isocyanate monomers, but, is tempered somewhat by the lack of water solubility. In the absence
of hydrolysis, sorption to solids (e.g., sludge and sediments) will be the primary mechanism of removal. Biodegradation is minimal for most compounds and volatilisation is negligible.
Atmospheric degradation is not expected with removal from air occurring by washout or dry deposition. Volatilisation from surface waters (e.g., lakes and rivers) is expected to take
years. In wastewater treatment this process is not expected to be significant.
Review of the estimated properties of the isocyanates suggest that sorption is the primary removal mechanism in the ambient environment and in wastewater treatment in the absence of
significant hydrolysis. Sorption to solids in wastewater treatment is considered strong to very strong for most compounds. Sorption to sediments and soils in the ambient environment is
very strong in most instances. Migration to groundwater and surface waters is not expected due to sorption or hydrolysis.
Hydrolysis of the N=C=O will occur in less than hours in most instances and within minutes for more than 90% of the commercial isocyanates. However, the low to very low solubility of
 these substances will generally lessen the effectiveness of hydrolysis as a fate pathway. But hydrolysis should be considered one of the two major fate processes for the isocyanates.
Aerobic and/or anaerobic biodegradation of the isocyanates is not expected to occur at significant levels. Most of the substances take several months to degrade.
Degradation of the hydrolysis products will occur at varying rates depending on the moiety formed.
DO NOT discharge into sewer or waterways.
Toxicity Fish: LC50(96)95.24-134.37mg/L

12.2. Persistence and degradability

Ingredient Persistence: Water/Soil Persistence: Air
Erapol EME140F Isocyanate Prepolymer No Data Available No Data Available
4,4'-diphenylmethane diisocyanate (MDI) LOW LOW
12.3. Bioaccumulative potential
Ingredient Bioaccumulation
4,4'-diphenylmethane diisocyanate (MDI) LOW
12.4. Mobility in soil
Ingredient Mobility
4,4'-diphenylmethane diisocyanate (MDI) LOW (ESTIMATED)
12.5. Results of PBT and vPvB assessment
P B T
Relevant available data No data available No data available No data available
PBT and vPvB Criteria
fulfilled? No data available No data available No data available

12.6. Other adverse effects

No data available
SECTION 13: Disposal considerations
13.1. Waste treatment methods
Product / Packaging Legislation addressing waste disposal requirements may differ by country, state and/ or territory. Each user must refer to laws operating in their area. In
disposal: some areas, certain wastes must be tracked.
A Hierarchy of Controls seems to be common - the user should investigate:
Reduction
Reuse
Recycling
Disposal (if all else fails)
This material may be recycled if unused, or if it has not been contaminated so as to make it unsuitable for its intended use. If it has been contaminated, it may
be possible to reclaim the product by filtration, distillation or some other means. Shelf life considerations should also be applied in making decisions of this
type. Note that properties of a material may change in use, and recycling or reuse may not always be appropriate.
DO NOT allow wash water from cleaning or process equipment to enter drains.
It may be necessary to collect all wash water for treatment before disposal.
In all cases disposal to sewer may be subject to local laws and regulations and these should be considered first.
Where in doubt contact the responsible authority.
DO NOT recycle spilled material.
Consult State Land Waste Management Authority for disposal.
Neutralise spill material carefully and decontaminate empty containers and spill residues with 10% ammonia solution plus detergent or a proprietary
decontaminant prior to disposal.
DO NOT seal or stopper drums being decontaminated as CO2 gas is generated and may pressurise containers.
Puncture containers to prevent re-use.
Bury or incinerate residues at an approved site.

Waste treatment options:

Sewage disposal No relevant data
options:
Other disposal
recommendations:

SECTION 14: Transport information

Labels Required: No data available
Land transport (ADR / RID / GGVSE)
No data available
14.1. UN number None 14.4. Packing group No data available
14.2. UN proper shipping No data available 14.5. Environmental No relevant data
name hazard
14.3. Transport hazard 14.6. Special precautions
class(es) for user Hazard identification No data available
(Kemler)
Classification Code No data available
No data available Hazard Label No data available
Special provisions No data available
Add limited quantity No data available

Air transport (ICAO-IATA / DGR)

No data available
14.1. UN number 14.4. Packing group
14.1. UN number None 14.4. Packing group No data available
14.2. UN proper shipping No data available 14.5. Environmental No relevant data
name hazard
14.3. Transport hazard 14.6. Special precautions
class(es) for user Special provisions No data available
Cargo Only Packing No data available
Instructions
Cargo Only Maximum No data available
Qty / Pack
ICAO/IATA Class Passenger and Cargo No data available
(Subrisk): No data available Packing Instructions
ERG Code No data available Passenger and Cargo No data available
Maximum Qty / Pack
Passenger and Cargo
Limited Quantity No data available
Packing Instructions
Passenger and Cargo No data available
Maximum Qty / Pack

Sea transport (IMDG-Code / GGVSee)

No data available
14.1. UN number None 14.4. Packing group No data available
14.2. UN proper shipping No data available 14.5. Environmental No relevant data
name hazard
14.3. Transport hazard 14.6. Special precautions EMS Number No data available
class(es) for user
No data available IMDG
Subrisk No data available Special provisions No data available
Limited Quantities No data available

Inland waterways transport (ADNR / River Rhine)

No data available
14.1. UN number None 14.4. Packing group No data available
14.2. UN proper shipping No data available 14.5. Environmental No relevant data
name hazard
14.3. Transport hazard 14.6. Special precautions Classification code No data available
class(es) for user
ADNR Limited quantity No data available
No data available Label No data available
Equipment required No data available
Fire cones number No data available

14.7. Transport in bulk according to Annex II of MARPOL 73 / 78 and the IBC code
No data available
SECTION 15: Regulatory information
15.1. Safety, health and environmental regulations / legislation specific for the substance or mixture
Regulations for ingredients
4,4'-diphenylmethane diisocyanate (MDI) (CAS: 101-68-8,26447-40-5) is found on the following regulatory lists;
"EU Directive 2002/72/EC Plastic materials and articles intended to come into contact with foodstuffs - Annex II Section A: List of authorised monomers and other starting
substances","European Chemicals Agency (ECHA) List of substances identified for registration in 2010","European Customs Inventory of Chemical Substances (English)","European Union
- European Inventory of Existing Commercial Chemical Substances (EINECS) (English)","European Union (EU) Annex I to Directive 67/548/EEC on Classification and Labelling of Dangerous
Substances - updated by ATP: 31","European Union (EU) Control of Major Accident Hazards Involving Dangerous Substances - Seveso Category","European Union (EU) Regulation (EC) No
1272/2008 on Classification, Labelling and Packaging of Substances and Mixtures - Annex VI","GESAMP/EHS Composite List - GESAMP Hazard Profiles","IMO IBC Code Chapter 17:
Summary of minimum requirements","IMO MARPOL 73/78 (Annex II) - List of Noxious Liquid Substances Carried in Bulk","International Agency for Research on Cancer (IARC) - Agents
Reviewed by the IARC Monographs","International Air Transport Association (IATA) Dangerous Goods Regulations","OECD Representative List of High Production Volume (HPV)
Chemicals","Scotland Pollution Inventory"
No data for Erapol EME140F Isocyanate Prepolymer (CW: 24-3812)
This safety data sheet is in compliance with the following EU legislation and its adaptations – as far as applicable - : 67/548/EEC, 1999/45/EC, 76/769/EEC, 98/24/EC, 92/85/EEC, 94/33/EC,
91/689/EEC, 1999/13/EC, as well as the following British legislation:
- The Control of Substances Hazardous to Health Regulations (COSHH) 2002
- COSHH Essentials
- The Management of Health and Safety at Work Regulations 1999

15.2. Chemical safety assessment

ANNEX 1
Ingredient Annex 1 67/548/EEC
4,4'-diphenylmethane diisocyanate (MDI) 615-005-00-9
4,4'-diphenylmethane diisocyanate (MDI) 615-005-00-9

Annex VI
Acute Toxicity (Inhalation) Category 4
Skin Corrosion/Irritation Category 2
Eye Irritation Category 2A
Respiratory Sensitizer Category 1
Skin Sensitizer Category 1
 Carcinogen Category 2
STOT - SE (Resp. Irr.) Category 3
STOT - RE Category 2

RISK
Risk Codes Risk Phrases
R20 Harmful by inhalation.
R36/37/38 Irritating to eyes, respiratory system and skin.
R40(3) Limited evidence of a carcinogenic effect.
R42/43 May cause SENSITISATION by inhalation and skin contact.
R48/20 Harmful: danger of serious damage to health by prolonged exposure through inhalation.

SECTION 16: Other information

ANNEX 2: Indications of Danger
Xn Harmful

Substance CAS Suggested codes

4, 4' - diphenylmethane diisocyanate 26447- 40- 5 R43

(MDI)
ND
INGREDIENTS WITH MULTIPLE CAS NUMBERS

Ingredient Name CAS

4,4'-diphenylmethane diisocyanate (MDI) 101-68-8, 26447-40-5

OTHER
Classification of the preparation and its individual components has drawn on official and authoritative sources as well as independent review by the Chemwatch Classification committee
using available literature references.
A list of reference resources used to assist the committee may be found at:
www.chemwatch.net/references

The (M)SDS is a Hazard Communication tool and should be used to assist in the Risk Assessment. Many factors determine whether the reported Hazards are Risks in the workplace or
other settings. Risks may be determined by reference to Exposures Scenarios. Scale of use, frequency of use and current or available engineering controls must be considered.

For detailed advice on Personal Protective Equipment, refer to the following EU CEN Standards:
EN 16 Personal eye-protection
EN 340 Protective clothing
EN 374 Protective gloves against chemicals and micro-organisms
EN 13832 Footwear protecting against chemicals
EN 133 Respiratory protective devices

This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or criticism, as permitted under the Copyright Act, no part may be reproduced by
any process without written permission from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 9-Mar-2011
Print Date: 18-May-2011

No data available
Annex to extended safety data sheet (eSDS) (REACH)
Exposure scenario
Use of the preparation / substance in the following processes is inadvisable in the
Industrial / Professional Worker and Consumer use scenarios unless the following exposure controls are modified:
Respiratory Protection
A lower duration of use
Increased Ventilation

NO RESTRICTIONS