1.

Causes spurious decrease in MCV

A. Cryofibrinogen

B. hyperglycemia

C. autoaggutination

D. high WBC ct

E. reduced red cell deformability

Ans: A

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2. When the entire CBC is

suppressed due to either anemia,

infection, or hemorrhage is called?

A. Erythroplasia
B. Thrombocytopenia

C. Pancytopenia

D. Leukopenia

Ans: C

3. Total RBC count for Women is?

A. 4.4-6

B. 4.2-5

C. 4.0-5.0

D. 4.2-5.2

Ans: C

4. Total RBC for men?

A. 4.0-5.0

B. 4.6-6.0

C. 4.2-6.5

D. 4.0-6.0

Ans: B

5. What is the major metabolically

available storage form of iron in the

body?

A. Hemosiderin

B. Ferritin
C. Transferrin

D. Hemoglobin

Ans: B

6. The best source of active bone

marrow from a 20-year old would be:

A. Iliac Crest (hip)

B. Femur (thigh)

C. Distal radius (forearm)

D. Tibia (shin)

Ans: A

7. Laboratory Studies: Red Cell Indices:

Determination of relative size of RBC.

82-98 f1
A. MCH

B. MCV

C. MCHC

D. PCV

Ans: B

8. Laboratory Studies: Red Cell Indices:

Measurement of average weight of

Hb/RBC. 27-33 pg

A. MCH

B. MCV

C. MCHC

D. PCV

Ans: B
9. Laboratory Studies: Red Cell Indices

Evaluation of RBC saturation with Hb.

32-36%

A. MCV

B. MCH

C. MCHC

D. PCV

Ans: C

10. There are 3 classifications of

Anemia. What are they?

A. In adequate production of Hb
B. Decreased RBC production

C. Increased Erythrocyte destruction

D. Blood loss

Ans: A

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11. What is the major metabolically

available storage form of iron in the

body?

A. Hemosiderin

B. Ferritin

C. Transferrin

D. Hemoglobin

Ans: B

12. Folic acid therapy can cause sickle

cell anemia

A. True

B. False

C. Both

D. none

Ans: B

14. Hydroxyurea increases hemoglobin

production and decreases reticulocyte

cells.

A. True
B. False

C. Both

D. none

Ans: A

15. Hydroxyurea:

A. decreases nitric oxide

B. increases neutrophil and monocytes

C. inhibits DNA synthesis by acting as a

ribonucleotide reductase inhibitor

D. none

Ans: C

16. Hydroxyurea icreases thhe serum

uric acid levels.

A. True

B. False

C. Both

D. none

Ans: A

17. Decitabine increases the fetal

hemoglobin production by inducing

methylation of DNA and thus prevents

the switch from gamma to beta-globin

production.

A. True
B. False

C. Both

D. none

Ans: B

18. Hypocupremia is seen in

A. osetoporosis, nephrotic disease

B. sprue, cliac disease

C. cardiovascular disease, colon cancer

D. A andB

E. B and C

F. All of the above

Ans: F
19. Wilsons disease can cause liver

problems

A. True

B. False

C. Both

D. none

Ans: A

20. What are the treatment options forr

wilson's disease?
A. Pencillamine

B. Riboflavin

C. Trientine

D. Potassium disulfide

E. Zinc

F. A, B and C

G. A, C, and D

H. A, C, D, and E

Ans: H

21. Aplasia can occur because of

riboflavin deficiency?

A. True

B. False
C. Both

D. none

Ans: A

22. Angular stomatitis.cheilosis is a

symptom of vitamin B12 deficiency?

A. True

B. False

C. Both

D. none

Ans: B

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23. What is the major metabolically

available storage form of iron in the

body?

A. Hemosiderin

B. Ferritin

C. Transferrin

D. Hemoglobin

Ans: B

24. Which test can be used to detect

hemolytic anemia?

A. Coombs test

B. Genetic testing
C. Peripheral blood smear (PBS)

D. Schilling test

Ans: A

25. Which anemia is classified as not

being able to use iron properly to

synthesize hemoglobin because of a

inherited cause.

A. Iron deficiency anemia

B. hypochromic anemia

C. aplastic anemia

Ans: B

26. what is normal fasting Blood sugar,

A. 100-200
B. 70-110

C. 90_120

D None

Ans.. B

27. This fatal disorder results from

clot/thrombus formation in the blood

ciruclation

A. thromboembolism

B. DVT

C. PAD

D. Pulmonary embolism

E. All of the above

Ans: E

28. Homan's sign is classified as pain

behind the knee

A. True

B. False

C. None

Ans: A

29. Patients that are sensitive to aspirin

can take

A. Sulfinpyrazone
B. Clopidogrel

C. Ticlopidine

D. 1 and 2

E. 2 and 3

Ans: E

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30. What is the life span of RBC

A. 120

B. 100

C. 200

D. 80

Ans: A

31. What is the major metabolically

available storage form of iron in the

body?

A. Hemosiderin

B. Ferritin

C. Transferrin

D. Hemoglobin

Ans: B

32. The most common type of protein

found in the cell membrane is:

A. Lipoprotein

B. Mucoprotein

C. Glycoprotein

D. Nucleoprotein

Ans: C

33. A multilineage cytokine among the

ILs is

A. IL-1

B. IL-2

C. IL-3

D. IL-4

Ans: A
34. Warfarin should be used with

caution in the following:

A. Alcoholic liver disease

B. Gastrointestinal bleeding

C. recent neurosugery

D. Liver impairment

Ans: D

35. Isozymes of 2C can greatly effect

warfarin

A. True

B. False
C. none

Ans: A

36. absolute lymphocytosis

5000/mm^3) without adenopathy,

hepatosplenomegaly, anemia,

thrombocytopenia is what stage in CLL

prognosis Scoring-Rai Staging System?

A. Stage 0

B. Stage I

C. Stage II

D. Stage III

E. Stage IV

Ans: A
37. Conventional treatment is

Rai stage II for

A. Antibiotics

B. chemotherapy

C. Antivirals

D. rest

Ans: B

38. In patients with low numbers of

neoplastic cells, sometimes due to

treatment, PCR to amplify DNA can

improve sensitivity, and detect signs of

relapse.

A. True
B. False

C. none

Ans: A

39. Chronic lymphocytic leukemia is

most common leukemia in what kind of

people? Slide 4

A. young adults

B. older adults

C. None

Ans: B
40. absolute lymphocytosis and

thrombocytopenia( < 100,000/mm^3)

with or without lymphadenopathy,

hepatomegaly, splenomegaly, or

anemia is what stage in CLL prognosis

Scoring-Rai Staging System?

A. Stage 0

B. Stage I

C. Stage II

D. Stage III

E. Stage IVN

Ans: E

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Objective type Questions

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41. Chronic Lymphocytic Leukemia is

characterized by peripheral blood and

bone marrow

A. lymphocytopenia

B. lymphocytosis

Ans: B

44. absolute lymphocytosis with either hepatomegaly or splenomegaly with or without

lymphadenopathy is what

stage in CLL prognosis Scoring-Rai

Staging System?

A. Stage 0

B. Stage II

C. Stage II

D. Stage II
E. Stage Iv

Ans: C

45. absolute lymphocytosis without lymphadenopathy without hepatosplenomegaly, anemia, or

thrombocytopenia is what stage in CLL

prognosis Scoring Rai Staging System?

A. Stage 0

B. Stage I

C. Stage II

D. Stage II

E. Stage IV

Ans: B

46. IN Chronic Lymphocytic Leukemia the Lymphocyte appearance: small or slightly larger than normal,
hyper-condensed(almost.nuclear chromatin patter, bare nuclei

called "smudge cells" are common.

A. soccer-ball

B. basketball

C. football

D. tennis-ball

Ans: A

47. Which of the following forms of Hh molecule has the lowest affinity for oxygen?

A. Tense

B. Relaxed

C. Arterial

D. Venous

Ans: A

48. What is the recommended cleaner for removing all oil from objective lens?
A. 70 % alcohol or lens cleaner

B. Xylene

C. Water

D. Benzene

Ans: A

49. Intravascular hemolysis is the result of trauma to RBCs while in the

circulation

A. True

B. False

Ans: A

50. Blood Hb level changes in mornging and evening Time.

A 1gm%

B. 2gm%

C. 1.5Gm%

D. 2.5gm%

answer -C

51. The shape of a cell is maintained by which of the following?

A. Microtubules

B. Spindle Fibers

C. Ribosomes

D. Centrioles

Ans: A

52. At which month of fetal development does the bone marrow become the primary site of

hematopoiesis?

A. 2nd
B.5th

C. End of 6th month

D. End of 7th month

Ans: C

53. Which types of cells develop from yolk sacs (Mesoblastic phase)?

A. Hb F, Hg A2, and Hg A

B. Gower 1 and Gower 2 Hgb

C. Portland Hgb

D. Only Erythrobla

Ans: D

54. Normal Adult Hb A contains the following polypeptide chains:

A. alpha and beta

B. alpha and epsilon

C. alpha and delta

D. alpha and brotherton

Ans: A

55. Allergic reactions are frequently associated with an increase in the prescence of:

A. Lymphocytes

B. Neutrophils

C. Monocytes

D. Eosinophils

Ans: D

56. Lipid exchange between the RBC membrane and the plasma occurs:

A. To replace lost lipids in the membrane

B. To provide a mechanism for excretion

of lipid-soluble RBC waste products

C. To ensure symmetry between the

composition of the interior and exterior

lipid layers

D. To provide lipid-soluble nutrients to the

RBC

Ans: A

57. After the microscope has been adjusted for Kohler illumination, light

intensity should never be regulated by using the...

A. Rheostat

B. Neutral density filter

C. Kohler magnifier

D. Condenser

Ans: D

58. Which of the followong types of microscopy is valuable in the

identification of crystals that are able

to rotate ight?

A. Compound brightfield

B. Darkfield

C. Polarizing

D. Phase-contrast

Ans: C

59. During the Medullary Phase of hematopoietic development, which

bone is the first to show hematopoietic

activity?
A. Femur

B. Iliac Crest

C. Skull

D. Clavicle

Ans: D

60. Given the following values,

calculate the RPI Observed reticulocyte

count - 6% Hct-30°%

A. 2

B. 3

C.4

D. 5

Ans: A

61. The lipids of the RBC membrane are arranged:

A. In chains beneath a protein exoskeleton

B.So that the hydrophobic portions are

facing the plasma

C. In a hexagonal lattice

D. In two layers that are not symmetric in

composition

Ans: D

62. The hexose monophosphate pathway activity increases the RBC

source of

A. Glucose and lactic acid

B. 2,3-BPG and methemoglobin

C. NADPH and reduced glutathione

D. ATP and other purine metabolites

Ans: C

63. Which single feature of normal RBC's is most responsible for limiting

their life span?

A. Loss of mitochondria

B. Increased flexibility of the cell

membrane

C. Reduction of Hb iron

D. Loss of nucleus

Ans: D

64. In the Iron cycle, the transferrin receptor carries:

A. Iron out of duodenal cells from the intestinal lumen

B. Iron out of duodenal cells into the

plasma

C. transferrin-bound iron in the plasma

D. transferrin-bound iron into

erythrocytes

Ans: D

65. A multilineage cytokine among the ILs is

A. IL-1

B. IL-2

C. IL-3

D. IL-4

Ans: A
66. Which of the following cells may develop in sites other than the bone marrow?

A. Monocyte

B. Lymphocyte

C. Megakaryocyte

D. Neutrophil

Ans: B

67. The acceptable range for

hemoglobin values on a control sample

is 13+or-0.4 g/dL. A hemoglobin

determination is performed five times

in succession on the same control

sample. The results are (in g/dL. 12 12.3,

12, 12.2, and 12.1) These results are:

A. Precise, but not accurate

B. Both accurate and precise

C. Accurate, but not precise

D. Neither accurate nor precise

Ans: A

68. The layer of the erythrocyte

membrane that is largely responsible

for the shape, structure, and

deformability of the cell is the

A. Integral protein

B. Exterior lipid

C. Peripheral protein
D. Interior lipid

Ans: C

69. During midfetal life, the primary

source of blood cells is the:

A. Bone marrow

B. Spleen

C. Lymph Nodes

D. Liver

Ans: D

70. In the bone marrow, RBC precursors

are located:

A. In the center of the hematopoietic cords

B. Adjacent to megakaryocytes along the

adventitial cell lining

C. Surrounding fat cells in apoptotic

islands

D. Surrounding macrophages near the

sinus membrane

Ans: D

71. Which of the following gathers,

organizes, and directs light through the

specimen?

A. Ocular

B. Objective lens

C. Condenser
D. Optical Tube

Ans: C

72. How are the globin chains genes

arranged? Note: a means alpha, B

means beta

A. With a genes and B genes on the same

chromosome including two a genes and

two B genes

B. With a genes and B genes on seperate

chromosomes, two a genes on one

chromosome and one B gene on a

different chromosome

C. With a genes and B genes on the same

chromosome - including four a genes and

four B genes

D. With a genes and B genes orn separate

chromosomes - four a genes on one

chromosome and two B genes on a

different chromosome

Ans: B

73. The maximum number of

erythrocytes generated by one

Multipotential Stem Cell is:

A. 8
B. 1

C. 12

D. 16

Ans: D

74. What is the distribution of normal

Hh in adults?

A. 80-90% Hb A, 5-10% Hb A2, 1-5% Hb F

B.>95% Hb A, <3.5 % Hb A2, <1-2% Hb F

Ans: B

75. The most frequent cause of needle

punctures is:

A. Patient movement during venipuncture

B. Improper disposal of phlebotomy

equipment

C. Inattention during removal of needle

after venipuncture

D. Faiure to attach needle firmly to tube

holder

Ans: B

76. Iron is incorporated into the heme

molecule in which of the following8

forms:

A. Ferrop

B. Ferrous

C. Ferric
D. Apoferritin

Ans: B

77. The most important practice in

preventing the spread of disease is:

A. Wearing masks during patient contact

B. Proper handwashing

C. Wearing disposable lab coats

D. Identifying specimens from known or

suspected HIV and HBV patients with a

red label

Ans: B

78. Which of the following would

correlate with an elevated ESR value?

A. Osteoarthritis

B. Polycythemia

C. Decreased globulins

D. Inflanmmation

Ans: D

79. The enzyme deficiency in the

Embden-Meyerhof pathway that is

responsible for most cases of

nonspherocytic hemolytic anemia is:

A. Hexokinase

B. Phosphotriptokinase

C. Pyruvate Kinase
D. Glyceraldehyde 3-Phosphate

Ans: C

80. The most common type of protein

found in the cell membrane is:

A. Lipoprotein

B. Mucoprotein

C. Glycoprotein

D. Nucleoprotein

Ans: C