ITEM 29 CFR 1910.1450 REQUIREMENT REF NO.

YFS NO COMMENTS

RECORDKEEPING

36 A recordkeeping system is established to maintain,

for each employee, accurate records of measurements
taken to monitor employee exposures and any medical
consultations and examinations (j)(l)

37 Records are kept, transferred, and made available in

accordance with 29 CFR 1910.20 (j)(2)

Notes: (Use additional sheets as necessary)

Conducted By: Title(s) Date:

Reveiwed By: Title(s) Date:

FOR ASSISTANCE CONTACT: ELB & Associates, Inc., Chapel Hill, NC (800) 334-5478
 OSHA
LABORATORY
STANDARD
29 CFR 19910.1450

IMPLEMENTATION GUIDE

Leo C. Hearn, Jr. CIH

Steven L. Goode, CSP, CIH
David F. Coble, CSP

CR
C
~y~~f~~~~~"P
Boca Raton London New York

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 Implementation Manual

for
OCCUPATIONAL EXPOSURE TO HAZARDOUS
CHEMICALS IN LABORATORIES

29 CFR 1910.1450

On January 31, 1990, the Occupational Safety and Health Administration (OSHA) published in
the Federal Register the Occupational Exposure to Hazardous Chemicals in Laboratories
standard (Laboratory Standard), 29 CFR 1910.1450. The basis for this standard is a
determination by the Assistant Secretary that laboratories typically differ from industrial
operations in their use and handling of hazardous chemicals and that a different approach than
that found in OSHA's substance specific health standards is warranted to protect laboratory
workers.

The effective dates of the standard are:

This standard becomes effective 05/01/90

Implementation of a Chemical Hygiene Plan 01/31/91

The purpose of the standard is to ensure the hazards of all chemicals handled and used in
laboratories are evaluated, and the information concerning the hazards is transmitted to affected
employers and employees by means of a comprehensive Chemical Hygiene Plan.

Implementation of the OSHA Laboratory Standard requires extensive planning by companies

with laboratories affected by the standard. Responsibilities must be assigned and tasks defined
to assure effective implementation.

OSHA's Laboratory Standard is only one of many occupational safety and health items needing
managements' attention. This standard, like all OSHA standards and numerous safety and
health requirements, must be effectively managed by all levels of management. The
commitment and involvement of laboratory supervisors is very important for assuring proper
compliance with this standard.

This implementation manual contains an implementation plan, implementation schedule, the

complete OSHA Laboratory Standard, and a written Chemical Hygiene Plan for adaptation to
your facility. The Chemical Hygiene Plan is contained on an ASCI file diskette in the pocket
on the front cover for use in adapting the Chemical Hygiene Plan to the specifics at your
facility.
HOW TO USE THIS MANUAL

This manual is divided into four sections: the Implementation Plan, Part 1; the Implementation
Schedule, Part 2; the OSHA Laboratory Standard, Part 3; and, a Chemical Hygiene Plan, Part
4.

Part 1, the Implementation Plan, has eight sections each describing pertinent steps to take for
compliance with the OSHA standard. In addition, information is presented and explained in
detail to assist you with implementation. A message, printed in italics, is found at the end of
each section describing the applicable items of Part 2, the Implementation Schedule.

Part 2, the Implementation Schedule, should be completed by assigning responsible persons

and target completion dates. This schedule should be referred to on a continuing basis until all
items have been successfully implemented.

Part 3 contains a copy of the OSHA Laboratory Standard, 29 CFR 1910.1450. This section is
presented for your information and future reference.

Part 4 contains a Chemical Hygiene Plan which can be edited to your specific laboratory needs.
This section provides a good base for writing your Chemical Hygiene Plan.
 Implementation Manual

for

OCCUPATIONAL EXPOSURE TO HAZARDOUS

CHEMICALS IN LABORATORIES

29 CFR 1910.1450

TABLE OF CONTENTS

TAB SECTION

1 Implementation Plan

2 Implementation Schedule

3 OSHA Laboratory Standard

4 Chemical Hygiene Plan

 Part I
Implementation Plan
TABLE OF CONTENTS

SECTION TITLE PAGE

1.0 APPLICABILITY ............................................................. 1

2.0 ASSIGNMENTS .............................................................. 2

2.1 Chemical Hygiene Officer. ........................................ 2

2.2 Chemical Hygiene Committee .................................... 3

3.0 CHEMICAL HYGIENE PLAN ............................................. 3

4.0 EXPOSURE MONITORING ............................................... 4

4.1 Permissible Exposure Limits ..................................... 4

4.2 Employee Exposure Determination,

Initial Monitoring ................................................... 4

4.3 Periodic Monitoring ................................................ 5

4.4 Termination ofMonitoring ........................................ 5

4.5 Employee Notification of

Monitoring Results ................................................. 5

5.0 EMPLOYEE EDUCATION AND TRAINING ........................... 5

5. 1 Information ......................................................... 6

5. 2 Training ............................................................. 7

6.0 MEDICAL CONSULTATION .............................................. 7

7.0 HAZARD IDENTIFICATION .............................................. 8

8.0 RECORD KEEPING SYSTEMS ............................................ 8

Part I
Implementation Plan
Table of Contents
 Implementation Plan

for
OCCUPATIONAL EXPOSURE TO HAZARDOUS
CHEMICALS IN LABORATORIES

29 CFR 1910.1450

1. 0 APPLICABILITY

The Laboratory Standard applies to all employers engaged in the laboratory use of hazardous
chemicals. Laboratory use of hazardous chemicals is defined as the use or handling of
chemicals in which all of the following conditions are met:

(a) Chemical manipulations are carried out on a "laboratory scale". Laboratory

scale is defined as work with substances in which the containers used for
reactions, transfers, and other handling of substances are designed to be easily
and safety manipulated by one person. This definition excludes those
workplaces whose function is to produce commercial quantities of materials;

(b) Multiple chemical procedures or chemicals are used;

(c) The procedures involved are not part of a production process, nor in any way
simulate a production process; and

(d) "Protective laboratory practices and equipment" are available and in common
use to minimize the potential for employee exposure to hazardous chemicals.

This standard does not apply to:

(a) Uses of hazardous chemicals which do not meet the definition of laboratory
use, and in such cases, the employer shall comply with the relevant standard in
29 CPR part 1910, subpart Z, even if such use occurs in a laboratory.

(b) Laboratory uses of hazardous chemicals which provide no potential for

employee exposure.

Part I
Implementation Plan
Page 1 of 8
Where the standard does apply, it shall supersede, for laboratories, the requirements of all
other OSHA health standards in 20 CFR part 1910, subpart Z, except as follows:

(a) For any OSHA health standard, only the requirement to limit employee
exposure to the specific permissible exposure limit shall apply for laboratories,
unless that particular standard states otherwise or unless the action level (or in
the absence of an action level, the PEL) is routinely exceeded.

(b) Prohibition of eye and skin contact where specified by any OSHA health
standard shall be observed.

(c) Where the action level (or in the absence of an action level, the PEL) is routinely
exceeded for an OSHA regulated substance with exposure monitoring and
medical surveillance requirements, the employee exposure monitoring and
medical monitoring requirements of this standard shall apply.

Any substance specific standard can require coverage to remain under that standard rather than
under the laboratory standard. In the absence of a statement of preemption in a substance
specific standard, the determination of whether the laboratory standard applies must be
dependent on both "laboratory use" and "laboratory scale" criteria. Where these criteria are
met, the laboratory standard applies.

Upon completing the applicability criteria for the standard, complete Item Number 1 on the
Implementation Schedule contained in Part II of this manual.

2.0 ASSIGNMENTS

The Chief Executive Officer (CEO) has the ultimate responsibility for chemical hygiene
throughout the laboratory, and with assistance of other program administrators, must provide
continued support for chemical hygiene.

The CEO should assign a Chemical Hygiene Officer (GIO) to provide technical guidance in
the development and implementation of appropriate chemical hygiene policies and practices

2. 1 Chemical Hygiene Officer

The Chemical Hygiene Officer (CHO) is an employee who is qualified by training or

experience, to provide technical guidance for the continuing implementation of the
Chemical Hygiene Plan. The CHO should be designated by the employer.

Part I
Implementation Plan
Page 2 of 8
 The duties of the CHO are outlined in Section 7.2 of the Chemical Hygiene Plan
contained in Part IV of this manual. The designation of the CHO should not be limited
by position description or job title within the organizational structure. The designation
should be based upon the individuals ability to fulfill the responsibilities of chemical
hygiene in the facility. The CHO reports directly to management in this capacity.

2. 2 Chemical Hygiene Committee

In large facilities, or facilities with multiple laboratories, the implementation of

compliance with this standard may best be accomplished by establishing a Chemical
Hygiene Committee.

If a Chemical Hygiene Committee is selected, it should be arranged so that all

laboratory workers have maximum access to the committee members.

The Chemical Hygiene Committee should meet on a regular basis. Minutes of these
meetings should be presented to management.

Upon completing the assignments of personnel discussed in this section, complete Item
Number 2 on the Implementation Schedule contained in Part II of this manual.

3.0 CHEMICAL HYGIENE PLAN

Paragraph (e) of the standard requires employers covered by the standard to develop and carry
out the provisions of a written Chemical Hygiene Plan (CHP).

The CHP is a written program outlining procedures, equipment, personal protective

equipment, and work practices capable of:

(a) protecting employees from the health hazards presented by exposure to

hazardous chemicals in the laboratory; and

(b) maintaining employee exposures below the OSHA Permissible Exposure

Limits.

The CHO should be responsible for the development and implementation of the CHP. The
CHP should be readily available to employees, employee representatives, and upon request to
the Assistant Secretary of Labor.

Part I
Implementation Plan
Page 3 of8
Information on the mandatory contents of the CHP is found in paragraph (e) of the standard
contained in Part III of this manual. A written CHP is contained in Part N of this manual, the
text of which is contained on the diskette found on the inside front cover of this manual. This
CHP should be tailored to meet the specific needs of your facility.

The CHP should be reviewed at least annually, and updated as necessary.

Upon completing the assignments for the written Chemical Hygiene Plan requirements,
complete Item Numbers 3-6 on the Implementation Schedule contained in Part II of this
manual.

4. 0 EXPOSURE MONITORING

4.1 Permissible Exposure Limits

The employer must assure that employees' exposures to OSHA regulated substances do
not exceed the permissible exposure limits specified in 29 CFR part 1910, subpart Z.

4.2 Employee Exposure Determination, Initial Monitoring

The employer must measure the employee's exposure to any substance regulated by a
standard which requires monitoring if there is reason to believe that exposure levels for
that substance routinely exceed the action level (or in the absence of an action level, the
PEL). The word routinely is intended to convey a situation which would be similar to
an industrial setting where the ambient concentration of a substance is at a characteristic
level as a result of the workplaces conditions and the particular process involved.

Factors which contribute to the possibility of an overexposure include:

(a) the manner in which the chemical procedures or operations involving the
particular substance are conducted;

(b) the existence of historical monitoring data which shows elevated

exposures to the particular substance for similar operations;

(c) the use of a procedure which involves significant quantities or is

performed over an extended period of time; and

(d) signs or symptoms of exposure which are experienced by the

employees.

Part I
Implementation Plan
Page 4 of 8
 Substances regulated by standards requiring monitoring include the following:

asbestos
vinyl chloride
inorganic arsenic
lead
benzene
coke oven emissions
cotton dust
1,2-dibromo-3-chloropropane
acrylonitrile
ethylene oxide
formaldehyde

4.3 Periodic Monitoring

If the initial monitoring discloses employee exposure over the action level (or in the
absence of an action level, the PEL), the employer must immediately comply with the
exposure monitoring provisions of the relevant standard.

4.4 Termination of Monitoring

The employer may terminate monitoring in accordance with the relevant standard.

4.5 Employee Notification of Monitoring Results

The employer must notify the employee of monitoring results within 15 working days
after receipt of these results. Notification must be in writing either individually or by
posting results in an appropriate location that is accessible to employees.

Upon assigning the responsibilities for the exposure nwnitoring program, complete Item
Numbers 7-10 on the Implementation Schedule contained in Part II of this manual.

5. 0 EMPLOYEE EDUCATION AND TRAINING

The employer must provide employees with information and training to ensure they are
apprised of the hazards of chemicals present in their work area. This information must be
provided at the time of an employee's initial assignment to a work area where hazardous
chemicals are present and prior to assignments involving new exposure situations. The
frequency of refresher information and training is determined by the employer.

Part I
Implementation Plan
Page 5 of 8
Providing employees with information and training can be accomplished a number of different
ways. Many commercial training programs have been prepared and are available for $200-
$400. Commercial programs are available as video tape, films, slide-tape presentations, and
training books.

All such general, commercial programs are designed for general application and may have
limited use for specific problems. For effective training, commercial programs should be
supplemented with specific in-house training materials covering specific chemical substances.

The CHO (and where applicable the chemical hygiene committee) can also prepare specific in-
house training programs utilizing video tape, films, slides, audio-tape, training booklets and
oral presentations. Usually these programs, while taking more time, will be more pertinent to
the company's needs.

5.1 Information

Employees must be informed of the following:

(a) the contents of the OSHA Laboratory Standard and its appendices;

(b) the location and availability of the employer's CHP;

(c) the permissible exposure limits for OSHA regulated substances or

recommended exposure limits for other hazardous chemicals where
there is no applicable OSHA standard;

(d) signs and symptoms associated with exposures to hazardous chemicals

used in the laboratory; and

(e) the location and availability of known reference material on the hazards,
safe handling, storage and disposal of hazardous chemicals found in the
laboratory including, but not limited to, Material Safety Data Sheets
received from the chemical supplier.

Part I
Implementation Plan
Page 6 of 8
5.2 Training

Employees must be trained on the applicable details of the employer's CHP. In

addition employee training must include the following:

(a) methods and observations that may be used to detect the presence or
release of a hazardous chemical (such as monitoring conducted by the
employer, continuous monitoring devices, visual appearance or odor of
hazardous chemicals when being released, etc.);

(b) the physical and health hazards of chemicals in the work area; and

(c) the measures employees can take to protect themselves from these
hazards, including specific procedures the employer has implemented to
protect employees from exposure to hazardous chemicals, such as
appropriate work practices, emergency procedures, and personal
protective equipment to be used.

Upon assigning the responsibilities for the employee training and information requirements,
complete Item Numbers 11-12 on the Implementation Schedule contained in Part II of this
manual.

6. 0 MEDICAL CONSULTATION

The laboratory standard requires that employers provide employees with an opportunity to
receive appropriate medical examinations under the following circumstances:

(a) whenever an employee develops signs or symptoms associated with a

hazardous chemical to which the employee may have been exposed in the
laboratory; and

(b) whenever an event takes place in the laboratory such as a spill, leak, explosion
or other occurrence resulting in the likelihood of a hazardous exposure.

Medical surveillance programs shall be established where exposure monitoring reveals an

exposure level above the action level for an OSHA regulated substance for which there are ex-
posure monitoring and medical surveillance requirements.

Upon assigning the responsibilities for the employee medical monitoring requirements,
complete Item Numbers 13-15 on the Implementation Schedule contained in Part II of this
manual.

Part I
Implementation Plan
Page 7 of 8
7.0 HAZARD IDENTIFICATION

Employers must ensure that labels on incoming containers of hazardous chemicals are not
removed, and that any material safety data sheets received with incoming shipments of
hazardous chemicals are maintained and readily accessible to laboratory employees.

For chemicals developed in the laboratory, the following provisions shall apply:

(a) if the composition of the chemical substance which is produced exclusively for
the laboratory's use is known, the employer shall determine if it is a hazardous
chemical, and if so, provide appropriate training to the employees;

(b) if the chemical produced is a by-product whose composition is not known, the
employer shall assume the substance is hazardous and implement the provisions
of the CHP; and

(c) if the chemical substance is produced for another user outside of the laboratory,
the employer shall comply with the Hazard Communication Standard [29 CFR
191 0.1200], including the preparation of material safety data sheets and
labeling.

Upon assigning the responsibilities for the hazard identification requirements, complete Item
Numbers 16-18 on the Implementation Schedule contained in Part II of this manual.

8.0 RECORDKEEPING SYSTEMS

The employer must establish and maintain for each employee an accurate record of any
measurements taken to monitor employee exposures and any medical consultation and
examinations including tests or written opinions required by the OSHA laboratory standard.
Such records must be kept, transferred, and made available in accordance with 29 CFR
1910.20.

Upon assigning the responsibilities for the recordkeeping requirements, complete Item
Numbers I9-20 on the Implementation Schedule contained in Part II of this manual.

Part I
Implementation Plan
Page 8 of 8
 Implementation Schedule
for
OCCUPATIONAL EXPOSURE TO HAZARDOUS
CHEMICALS IN LABORATORIES

Item Target
Number Description Responsibility Completion Date

1 Detennine if your laboratory is

covered by this standard. Your
laboratory must be engaged in the
laboratory use of hazardous
chemicals.

2 Appoint Chemical Hygiene Officer

(and Chemical Hygiene Committee
if appropriate).

3 Develop a written Chemical

Hygiene Plan (CHP).

4 Implement the procedures outlined

in the CHP no later than January
31, 1991.

5 Make the CHP readily available to

employees, employee representatives,
and upon request to the Assistant
Secretary of Labor.

6 Review the effectiveness of the CHP

at least annually.

7 Measure employee's exposure to any

substance regulated by a standard
which requires monitoring if there
is reason to believe that exposure
levels routinely exceed the action
level or PEL.

8 For employee exposures above the action

level or PEL, perform periodic monitoring
according to relevant standards.

Part II
Implementation Schedule
Page 1 of 3
 Implementation Schedule

for

OCCUPATIONAL EXPOSURE TO HAZARDOUS

CHEMICALS IN LABORATORIES

Item Target
Number Description Responsibility Completion Date

9 Terminate monitoring only in

accordance with relevant standards.

10 Notify employees of monitoring

results within 15 working days after
receipt of such results.

11 Assign person responsible for

employee information and
training.

12 Provide employees with information

and training.

13 Provide opportunity for

medical consultation and
medical examinations.

14 Establish medical monitoring

programs in accordance with
relevant standards.

15 Obtain physician's written opinion

as applicable.

16 Ensure that labels on incoming

shipments of hazardous chemicals
are not removed or defaced.

17 Maintain any MSDS that are

received with incoming shipments
of hazardous chemicals, and
ensure that they are readily
available to employees.

Part II
Implementation Schedule
Page 2 of3
 Implementation Schedule
for
OCCUPATIONAL EXPOSURE TO HAZARDOUS
CHEMICALS IN LABORATORIES

Item Target
Number Description Res ponsi bili ty Completion Date

18 Implement appropriate hazard

identification procedures for
chemicals developed in the
laboratory.

19 Establish and maintain for each employee

an accurate record of any measurements
taken to monitor employee exposures and
any medical consultation and exams,
including tests and written opinions
required by this standard.

20 Assure that records are kept, transferred,

and made available in accordance with
29 CFR 1910.20.

Partll
Implementation Schedule
Page 3 of3
 Federal Register I Vol. 55, No. 21 I Wednesday, January 31, 1990 I Rules and Regulations 3327

engaged in the laboratory use of and implementation of the provisions of

hazardous chemicals as defined below. the Chemical Hygiene Plan. This
(2) Where this section applies, it shall definition is not intended to place
supersede, for laboratories, the limitations on the position description or
requirements of all other OSHA health job classification that the designated
standards in 29 CFR part 1910, subpart indvidual shall hold within the
Z, except as follows: employer's organizational structure.
(i) For any OSHA health standard, "Chemical Hygiene Plan" means a
only the requirement to limit employee written program developed and
exposure to the specific permissible implemented by the employer which
exposure limit shall apply for sets forth procedures, equipment,
laboratories, unless that particular personal protective equipment and work
standard states otherwise or unless the practices that (i) are capable of
conditions of paragraph (a)(2)(iii) of this protecting employees from the health
section apply. hazards presented by hazardous
(ii) Prohibition of eye and skin contact chemicals used in that particular
where specified by any OSHA health workplace and (ii) meets the
standard shall be observed. requirements of paragraph (e) of this
(iii) Where the action level (or in the section.
absence of an action level, the "Combustible liquid" means any
permissible exposure limit) is routinely liquid having a flashpoint at or above
exceeded for an OSHA regulated 100 'F (37.8 'C), but below 200 'F (93.3
substance with exposure monitoring and 'C), except any mixture having
medical surveillance requirements, components with flashpoints of 200 'F
paragraphs (d) and (g)(1)(ii) of this (93.3 'C), or higher, the total volume of
section shall apply. which make up 99 percent or more of the
(3) This section shall not apply to: total volume of the mixture.
(i) Uses of hazardous chemicals which
"Compressed gas" means:
do not meet the definition of laboratory
use, and in such cases, the employer (i) A gas or mixture of gases having, in
a container, an absolute pressure
shall comply with the relevant standard
exceeding 40 psi at 70 ·p (21.1 'C); or
in 29 CFR part 1910, subpart 2, even if
(ii) A gas or mixture of gases having,
such use occurs in a laboratory.
(ii) Laboratory uses of hazardous in a container, an absolute pressure
chemicals which provide no potential exceeding 104 psi at 130 'F (54.4 •q
for employee exposure. Examples of regardless of the pressure at 70 'F (21.1
'C); or
such conditions might include:
(A) Procedures using chemically- (iii) A liquid having a vapor pressure
impregnated test media such as Dip- exceeding 40 psi at 100 'F (37.8 ·c) as
and-Read tests where a reagent strip is determined by ASTM D-323-72.
dipped into the specimen to be tested "Designated area" means an area
and the results are interpreted by which may be used for work with
comparing the color reaction to a color "select carcinogens," reproductive
chart supplied by the manufacturer of toxins or substances which have a high
the test strip; and degree of acute toxicity. A designated
(B) Commercially prepared kits such area may be the entire laboratory, an
as those used in performing pregnancy area of a laboratory or a device such as
PART 1910-0CCUPATIONAL SAFETY a laboratory hood.
tests in which all of the reagents needed
AND HEALTH STANDARDS "Emergency" means any occurrence
to conduct the test are contained in the
1. The authority citation for part 1910, kit. such as, but not limited to, equipment
subpart Z is amended by adding the (b) Definitions- failure, rupture of containers or failure
following citation at the end. (Citation "Action level' means a concentration of control equipment which results in an
which precedes asterisk indicates designated in 29 CFR part 1910 for a uncontrolled release of a hazardous
general rulemaking authority.) specific substance, calculated as an chemical into the workplace.
eight (8)-hour time-weighted average, "Employee" means an individual
Authority: Sees. 6 and 8, Occupational employed in a laboratory workplace
Safety and Health Act, 29 U.S.C. 655, 657; which initiates certain required
Secretary of Labor's Orders Nos. 12-71 (36 FR activities such as exposure monitoring who may be exposed to hazardous
8754], 8-76 (41 FR 25059], or 9-83 (48 FR and medical surveillance. chemicals in the course of his or her
35736], as applicable; and 29 CFR part 1911. "Assistant Secretary" means the assignments.
• • • Section 1910.1450 is also issued under Assistant Secretary of Labor for "Explosive" means a chemical that
sec. 6(b], 8(c] and 8(g](2], Pub. L. 91-596. 84 Occupational Safety and Health, U.S. causes a sudden, almost instantaneous
Stat. 1593, 1599, 1600; 29 U.S.C. 655, 657. Department of Labor, or designee. release of pressure, gas, and heat when
2. Section 1910.1450 is added to "Carcinogen" (see "select subjected to sudden shock, pressure, or
subpart Z, part 1910 to read as follows: carcinogen"). high temperature.
"Chemical Hygiene Officer" means an "Flammable" means a chemical that
§ 191.1450 Occupational exposure to employee who is designated by the falls into one of the following categories:
hazardous chemicals in laboratories. employer, and who is qualified by (i) "Aerosol, flammable" means an
(a) Scope and application. (1) This training or experience, to provide aerosol that. when tested by the method
section shall apply to all employers technical guidance in the development described in 16 CFR 1500.45, yields a
3328 Federal Register I Vol. 55, No. 21 I Wednesday, January 31, 1990 I Rules and Regulations

flame protection exceeding 18 inches at "Hazardous chemical" means a (iii] The procedures involved are not
full valve opening, or a flashback (a chemical for which there is statistically part of a production process, nor in any
flame extending back to the valve) at significant evidence based on at least way simulate a production process; and
any degree of valve opening; one study conducted in accordance with (iv] "Protective laboratory practices
(ii] "Gas, flammable" means: established scientific principles that and equipment" are available and in
(A] A gas that, at ambient acute or chronic health effects may common use to minimize the potential
temperature and pressure, forms a occur in exposed employees. The term for employee exposure to hazardous
flammable mixture with air at a "health hazard" includes chemicals chemicals.
concentration of 13 percent by volume which are carcinogens, toxic or highly "Medical consultation" means a
or less; or toxic agents, reproductive toxins, consultation which takes place between
(B) A gas that, at ambient temperature irritants, corrosives, sensitizers, an employee and a licensed physician
and pressure, forms a range of hepatotoxins, nephrotoxins, for the purpose of determining what
flammable mixtures with air wider than neurotoxins, agents which act on the medical examinations or procedures, if
12 percent by volume, regardless of the hematopoietic systems. and agents any. are appropriate in cases where a
lower limit. which damage the lungs, skin, eyes, or significant exposure to a hazardous
(iii] "Liquid, flammable" means any mucous membranes. chemical may have taken place.
liquid having a flashpoint below 100 'F Appendices A and B of the Hazard "Organic peroxide" means an organic
(37.8 'C). except any mixture having Communication Standard (29 CFR compound that contains the bivalent
components with flashpoints of 100 'F 1910.1200) provide further guidance in -D-O-structure and which may be
(37.8 'C) or higher, the total of which defining the scope of health hazards and considered to be a structural derivative
make up 99 percent or more of the total determining whether or not a chemical of hydrogen peroxide where one or both
volume of the mixture. of the hydrogen atoms has been
is to be considered hazardous for
(iv] "Solid, flammable" means a solid, replaced by an organic radical.
purposes of this standard.
other than a blasting agent or explosive "Oxidizer" means a chemical other
as defined in§ 1910.109(a], that is liable "Laboratory" means a facility where
the "laboratory use of hazardous than a blasting agent or explosive as
to cause fire through friction, absorption
chemicals" occurs. It is a workplace defined in § 1910.109(a]. that initiates or
of moisture, spontaneous chemical
where relatively small quantities of promotes combustion in other materials.
change, or retained heat from
hazardous chemicals are used on a non- thereby causing fire either of itself or
manufacturing or processing, or which
production basis. through the release of oxygen or other
can be ignited readily and when ignited
"Laboratory scale" means work with gases.
burns so vigorously and persistently as
to create a serious hazard. A chemical substances in which the containers used "Physical hazard" means a chemical
shall be considered to be a flammable for reactions, transfers, and other for which there is scientifically valid
solid if. when tested by the method handling of substances are designed to evidence that it is a combustible liquid,
described in 16 CFR 1500.44, it ignites be easily and safely manipulated by one a compressed gas, explosive. flammable,
and burns with a self-sustained flame at person. "Laboratory scale" excludes an organic peroxide, an oxidizer,
a rate greater than one-tenth of an inch those workplaces whose function is to pyrophoric, unstable (reactive) or water-
per second along its major axis. produce commercial quantities of reactive.
"Flashp01'nt" means the minimum materials. "Protective laboratory practices and
temperature at which a liquid gives off a "Laboratory-type hood" means a equipment" means those laboratory
vapor in sufficient concentration to procedures, practices and equipment
device located in a laboratory. enclosure accepted by laboratory health and
ignite when tested as follows: on five sides with a moveable sash or
(i) Tagliabue Closed Tester (See safety experts as effective, or that the
fixed partial enclosed on the remaining
American National Standard Method of employer can show to be effective, in
side; constructed and maintained to
Test for Flash Point by Tag Closed minimizing the potential for employee
draw air from the laboratory and to
Tester, 211.24-1979 (ASTM D 56-79)]-for exposure to hazardous chemicals.
prevent or minimize the escape of air
liquids with a viscosity of less than 45 contaminants into the laboratory; and "Reproductive toxins" means
Saybolt Universal Seconds (SUS] at chemicals which affect the reproductive
allows chemical manipulations to be
100 'F (37.8 'C), that do not contain capabilities including chromosomal
conducted in the enclosure without
suspended solids and do not have a damage (mutations] and effects on
insertion of any portion of the
tendency to form a surface film under fetuses (teratogenesis]
employee's body other than hands and
test; or arms.
"Select carcinogen" means any
(ii] Pensky-Martens Closed Tester (see substance which meets one of the
Walk-in hoods with adjustable sashes following criteria:
American National Standard Method of
meet the above definition provided that (i) It is regulated by OSHA as a
Test for Flash Point by Pensky-Martens
the sashes are adjusted during use so carcinogen; or
Closed Tester, 211.7-1979 (ASTM D 93-
that the airflow and the exhaust of air (ii) It is listed under the category,
79)]-for liquids with a viscosity equal to
contaminants are not compromised and "known to be carcinogens," in the
or greater than 45 SUS at 100 'F
employees do not work inside the Annual Report on Carcinogens
(37.8 'C), or that contain suspended
enclosure during the release of airborne published by the National Toxicology
solids, or that have a tendency to form a
hazardous chemicals. Program (NTP] (latest edition]; or
surface film under test; or
(iii) Setaflash Closed Tester (see "Laboratory use of hazardous (iii] It is listed under Group 1
American National Standard Method of chemicals" means handling or use of ("carcinogenic to humans"] by the
Test for Flash Point by Setaflash Closed such chemicals in which all of the International Agency for Research on
Tester (ASTM D 3278-78)]. following conditions are met: Cancer Monographs (!ARC) (latest
Organic peroxides, which undergo (i) Chemical manipulations are carried editions); or
autoaccelerating thermal decomposition, out on a "laboratory scale;" (iv] It is listed in either Group 2A or
are excluded from any of the flashpoint (ii] Multiple chemical procedures or 2B by IARC or under the category.
determination methods specified above. chemicals are used; "reasonably anticipated to be
 Federal Register I Vol. 55, No. 21 I Wednesday, January 31, 1990 I Rules and Regulations 3329

carcinogens" by NTP, and causes (i) Capable of protecting employees (B) Use of containment devices such
statistically significant tumor incidence from health hazards associated with as fume hoods or glove boxes;
in experimental animals in accordance hazardous chemicals in that laboratory (C) Procedures for safe removal of
with any of the following criteria: and contaminated waste; and
(A) After inhalation exposure of 6-7 (ii) Capable of keeping exposures (D) Decontamination procedures.
hours per day, 5 days per week, for a below the limits specified in paragraph (4) The employer shall review and
significant portion of a lifetime to (c) of this section. evaluate the effectiveness of the
dosages of less than 10 mg/m 3 ; (2) The Chemical Hygiene Plan shall
(B) After repeated skin application of Chemical Hygiene Plan at least annually
be readily available to employees, and update it as necessary.
less than 300 (mg/kg of body weight) per employee representatives and, upon
week; or (f) Employee information and training.
request, to the Assistant Secretary.
(C) After oral dosages of less than 50 (1) The employer shall provide
(3) The Chemical Hygiene Plan shall
mg/kg of body weight per day. employees with information and training
include each of the following elements
"Unstable (reactive}" means a to ensure that they are apprised of the
and shall indicate specific measures that
chemical which is the pure state, or as hazards of chemicals present in their
the employer will take to ensure
produced or transported, will vigorously work area.
laboratory employee protection:
polymerize, decompose, condense, or (i) Standard operating procedures (2) Such information shall be provided
will become self-reactive under relevant to safety and health at the time of an employee's initial
conditions of shocks, pressure or considerations to be followed when assignment to a work area where
temperature. laboratory work involves the use of hazardous chemicals are present and
"Water-reactive" means a chemical hazardous chemicals; prior to assignments involving new
that reacts with water to release a gas (ii) Criteria that the employer will use exposure situations. The frequency of
that is either flammable or presents a refresher information and training shall
to determine and implement control
health hazard. be determined by the employer.
measures to reduce employee exposure
(c) Permissible exposure limits. For (3) Information. Employees shall be
to hazardous chemicals including
laboratory uses of OSHA regulated informed of:
engineering controls, the use of personal
substances, the employer shall assure (i) The contents of this standard and
that laboratory employees' exposures to protective equipment and hygiene
practices; particular a !ten lion shall be its appendices which shall be made
such substances do not exceed the
given to the selection of control available to employees;
permissible exposure limits specified in
29 CFR part 1910, subpart z. measures for chemicals that are known (ii) The location and availability of the
(d) Employee exposure to be extremely hazardous; employer's Chemical Hygiene Plan;
determination-(1) Initial monitoring. (iii) A requirement that fume hoods (iii) The permissible exposure limits
The employer shall measure the and other protective equipment are for OSHA regulated substances or
employee's exposure to any substance functioning properly and specific recommended exposure limits for other
regulated by a standard which requires measures that shall be taken to ensure hazardous chemicals where there is no
monitoring if there is reason to believe proper and adequate performance of applicable OSHA standard;
that exposure levels for that substance such equipment; (iv) Signs and symptoms associated
routinely exceed the action level (or in (iv) Provisions for employee with exposures to hazardous chemicals
the absence of an action level, the PEL). information and training as prescribed used in the laboratory; and
(2) Periodic monitoring. If the initial in paragraph (f) of this section; (v) The location and availability of
monitoring prescribed by paragraph (v) The circumstances under which a known reference rna !erial on the
(d)(1) of this section discloses employee particular laboratory operation, hazards, safe handling, storage and
exposure over the action level (or in the procedure or activity shall require prior disposal of hazardous chemicals found
absence of an action level, the PEL), the approval from the employer or the in the laboratory including, but not
employer shall immediately comply with employer's designee before limited to, Material Safety Data Sheets
the exposure monitoring provisions of implementation; received from the chemical supplier.
the relevant standard. (vi) Provisions for medical
(4) Training. (i) Employee training
(3) Termination of monitoring. consultation and medical examinations
Monitoring may be terminated in in accordance with paragraph (g) of this shall include:
accordance with the relevant standard. section; (A) Methods and observations that
(4) Employee notification of (vii) Designation of personnel may be used to detect the presence or
monitoring results. The employer shall, responsible for implementation of the release of a hazardous chemical (such
within 15 working days after the receipt Chemical Hygiene Plan including the as monitoring conducted by the
of any monitoring results, notify the assignment of a Chemical Hygiene employer, continuous monitoring
employee of these results in writing Officer and, if appropriate, devices, visual appearance or odor of
either individually or by posting results establishment of a Chemical Hygiene hazardous chemicals when being
in an appropriate location that is Committee; and released, etc.);
accessible to employees. (viii) Provisions for additional (B) The physical and health hazards of
(e) Chemical hygiene plan-General. employee protection for work with chemicals in the work area; and
(Appendix A of this section is non- particularly hazardous substances. (C) The measures employees can take
mandatory but provides guidance to These include "select carcinogens," to protect themselves from these
assist employers in the development of reproductive toxins and substances hazards, including specific procedures
the Chemical Hygiene Plan.) (1) Where which have a high degree of acute the employer has implemented to
hazardous chemicals as defined by this toxicity. Specific consideration shall be protect employees from exposure to
standard are used in the workplace, the given to the following provisions which hazardous chemicals, such as
employer shall develop and carry out shall be included where appropriate: appropriate work practices, emergency
the provisions of a written Chemical (A) Establishment of a designated procedures, and personal protective
Hygiene Plan which is: area; equipment to be used.
3330 Federal Register I Vol. 55, No. 21 I Wednesday, January 31, 1990 I Rules and Regulations

(ii) The employee shall be trained on (C) Any medical condition which may (2) The employer shall assure that
the applicable details of the employer's be revealed in the course of the such records are kept, transferred, and
written Chemical Hygiene Plan. examination which may place the made available in accordance with 29
(g) Medical consultation and medical employee at increased risk as a result of CFR 1910.20.
examinations. (1) The employer shall exposure to a hazardous chemical found (k) Dates-(1) Effective date. This
provide all employees who work with in the workplace; and section shall become effective May 1,
hazardous chemicals an opportunity to (D) A statement that the employee has 1990.
receive medical attention, including any been informed by the physician of the (2) Start-up dates. (i) Employers shall
follow-up examinations which the results of the consultation or medical have developed and implemented a
examining physician determines to be examination and any medical condition written Chemical Hygiene Plan no later
necessary, under the following that may require further examination or than January 31, 1991.
circumstances: treatment. (ii) Paragraph (a)(2) of this section
(i) Whenever an employee develops (ii] The written opinion shall not shall not take effect until the employer
signs or symptoms associated with a reveal specific findings of diagnoses has developed and implemented a
hazardous chemical to which the unrelated to occupational exposure. written Chemical Hygiene Plan.
employee may have been exposed in the (h) Hazard identification. (1) With (I) Appendices. The information
laboratory, the employee shall be respect to labels and material safety contained in the appendices is not
provided an opportunity to receive an data sheets: intended, by itself, to create any
appropriate medical examination. (i] Employers shall ensure that labels additional obligations not otherwise
(ii) Where exposure monitoring on incoming containers of hazardous imposed or to detract from any existing
reveals an exposure level routinely chemicals are not removed or defaced. obligation.
above the action level (or in the absence (ii] Employers shall maintain any
of an action level, the PEL) for an OSHA Appendix A to § 1910.145~National
material safety data sheets that are Research Council Recommendations
regulated substance for which there are received with incoming shipments of Concerning Chemical Hygiene in Laboratories
exposure monitoring and medical hazardous chemicals, and ensure that (Non-Mandatory)
surveillance requirements, medical they are readily accessible to laboratory
surveillance shall be established for the Table of Contents
employees.
affected employee as prescribed by the Foreword
(2) The following provisions shall
particular standard.
apply to chemical substances developed Corresponding Sections of the Standard and
(iii) Whenever an event takes place in This Appendix
the work area such as a spill, leak, in the laboratory:
explosion or other occurrence resulting (i) If the composition of the chemical A. General Principles
in the likelihood of a hazardous substance which is produced 1. Minimize all Chemical Exposures
exposure, the affected employee shall be exclusively for the laboratory's use is 2. Avoid Underestimation of Risk
provided an opportunity for a medical known, the employer shall determine if 3. Provide Adequate Ventilation
consultation. Such consultation shall be it is a hazardous chemical as defined in 4. Institute a Chemical Hygiene Program
for the purpose of determining the need paragraph (b) of this section. If the 5. Observe the PELs and TLVs
for a medical examination. chemical is determined to be hazardous, B. Responsibilities
(2) All medical examinations and the employer shall provide appropriate
training as required under paragraph (f) 1. Chief Executive Officer
consultations shall be performed by or 2. Supervisor of Administrative Unit
under the direct supervision of a of this section. 3. Chemical Hygiene Officer
licensed physician and shall be (ii) If the chemical produced is a 4. Laboratory Supervisor
provided without cost to the employee, byproduct whose composition is not 5. Project Director
without loss of pay and at a reasonable known, the employer shall assume that 6. Laboratory Worker
time and place. the substance is hazardous and shall
C. The Laboratory Facility
(3)Information provided to the implement paragraph (e) of this section.
(iii) If the chemical substance is 1. Design
physician. The employer shall provide 2. Maintenance
the following information to the produced for another user outside of the
3. Usage
physician: laboratory, the employer shall comply 4. Ventilation
(i) The identity of the hazardous with the Hazard Communication
chemical(s) to which the employee may Standard (29 CFR 1910.1200) including D. Components of the Chemical Hygiene Plan
have been exposed; the requirements for preparation of 1. Basic Rules and Procedures
(ii) A description of the conditiolls material safety data sheets and labeling. 2. Chemical Procurement, Distribution, and
under which the exposure occurred (i) Use of respirators. Where the use Storage
of respirators is necessary to maintain 3. Environmental Monitoring
including quantitative exposure data, if
exposure below permissible exposure 4. Housekeeping, Maintenance and
available; and Inspections
(iii] A description of the signs and limits, the employer shall provide, at no 5. Medical Program
symptoms of exposure that the cost to the employee, the proper 6. Personal Protective Apparel and
employee is experiencing, if any. respiratory equipment. Respirators shall Equipment
(4) Physician's written opinion. (i) For be selected and used in accordance with 7. Records
examination or consultation required the requirements of 29 CFR 1910.134. 8. Signs and Labels
under this standard, the employer shall (j) Recordkeeping. (1) The employer 9. Spills and Accidents
obtain a written opinion from the shall establish and maintain for each 10. Training and Information
examining physician which shall include employee an accurate record of any 11. Waste Disposal
the following: measurements taken to monitor E. General Procedures for Working With
(A) Any recommendation for further employee exposures and any medical Chemicals
medical follow-up; consultation and examinations including 1. General Rules for all Laboratory Work
(B) The results of the medical tests or written opinions required by this with Chemicals
examination and any associated tests; standard. 2. Allergens and Embryotoxins
 Federal Register I Vol. 55, No. 21 I Wednesday, January 31, 1990 / Rules and Regulations 3331

3. Chemicals of Moderate Chronic or High B. Chemical Hygiene Responsibilities

Acute Toxicity Responsibility for chemical hygiene rests at
4. Chemicals of High Chronic Toxicity Relevant all levels [6, 11, 21) including the:
Paragraph and topic in laboratory
5. Animal Work with Chemicals of High appendix 1. Chief executive officer, who has ultimate
standard
section
Chronic Toxicity responsibility for chemical hygiene within the
institution and must, with other
F. Safety Recommendations (e)(3)(i) Standard operating procedures C, D, E
lor handling toxic chemicals.
administrators, provide continuing support
G. Material Safety Data Sheets (e)(3)(ii) Criteria to be used for imple- D for institutional chemical hygiene [7, 11).
mentation of measures to reduce ex- 2. Supervisor of the department or other
Foreword posures. administrative unit. who is responsible for
(e)(3)(iii) Fume hood performance ........... C4b chemical hygiene in that unit [7).
As guidance for each employer's (e)(3)(iv) Employee information and D10, D9 3. Chemical hygiene officer(s). whose
development of an appropriate laboratory training (including emergency proce-
appointment is essential (7) and who must:
Chemical Hygiene Plan, the following non- dures).
(e)(3)(v) Requirements for prior ap- E2b, E4b
[a) Work with administrators and other
mandatory recommendations are provided. employees to develop and implement
proval of laboratory activities.
They were extracted from "Prudent Practices (e)(3)(vi) Medical consultation and D5, E4f appropriate chemical hygiene policies and
for Handling Hazardous Chemicals in medical examinations. practices [7);
Laboratories" [referred to below as "Prudent (e)(3)(vii) Chemical hygiene responsi- 8 [b) Monitor procurement, use, and disposal
Practices"), which was published in 1981 by bilities. of chemicals used in the lab [B);
(e)(3)(viii) Special precautions for work E2, E3,
the National Research Council and is (c) See that appropriate audits are
with particularly hazardous sub- E4
available from the National Academy Press, stances. maintained [8);
2101 Constitution Ave., NW., Washington DC (d) Help project directors develop
20418. precautions and adequate facilities [10);
"Prudent Practices" is cited because of its In this appendix, those recommendations [e) Know the current legal requirements
wide distribution and acceptance and directed primarily at administrators and concerning regulated substances (50); and
supervisors are given in sections A-D. Those [f) Seek ways to improve the chemical
because of its preparation by members of the
recommendations of primary concern to hygiene program [8, 11).
laboratory community through the
employees who are actually handling 4. Laboratory supervisor, who has overall
sponsorship of the National Research responsibility for chemical hygiene in the
laboratory chemicals are given in section E.
Council. However, none of the laboratory [21) including responsibility to:
[Reference to page numbers in "Prudent
recommendations given here will modify any (a] Ensure that workers know and follow
Practices" are given in parentheses.)
requirements of the laboratory standard. This the chemical hygiene rules, that protective
Appendix merely presents pertinent A. General Principles for Work with equipment is available and in working order,
recommendations from "Prudent Practices", Laboratory Chemicals and that appropriate training has been
organized into a form convenient for quick In addition to the more detailed provided [21, 22);
reference during operation of a laboratory recommendations listed below in sections B- [b) Provide regular, formal chemical
facility and during development and E, "Prudent Practices" expresses certain hygiene and housekeeping inspections
application of a Chemical Hygiene Plan. general principles, including the following: including routine inspections of emergency
Users of this appendix should consult 1. It is prudent to minimize all chemical equipment [21, 171);
"Prudent Practices" for a more extended exposures. Because few laboratory chemicals [c) Know the current legal requirements
presentation and justification for each are without hazards, general precautions for concerning regulated substances [50, 231];
recommendution. handling all laboratory chemicals should be [d) Determine the required levels of
adopted, rather than specific guidelines for protective apparel and equipment [156, 160,
"Prudent Practices" deals with both safety
particular chemicals [2, 10). Skin contact with 162]; and
and chemical hazards while the laboratory
chemicals should be avoided as a cardinal [e) Ensure that facilities and training for
standard is concerned primarily with use of any material being ordered are
chemical hazards. Therefore. only those rule [198).
adequate [215).
recommendations directed primarily toward 2. A void underestimation of risk. Even for
5. Project director or director of other
control of toxic exposures are cited in this substances of no known significant hazard,
specific operation, who has primary
appendix, with the term "chemical hygiene" exposure should be minimized; for work with
responsibility for chemical hygiene
being substituted for the word "safety". substances which present special hazards,
procedures for that opera lion [7).
special precautions should be taken [10, 37,
However, since conditions producing or 6. Laboratory worker, who is responsible
38). One should assume that any mixture will
threatening physical injury often pose toxic for:
be more toxic than its most toxic component
risks as well, page references concerning [a) Planning and conducting each operation
[30, 103) and that all substances of unknown in accordance with the institutional chemical
major categories of safety hazards in the toxicity are toxic [3, 34).
laboratory are given in section F. hygiene procedures [7, 21. 22, 230); and
3. Provide adequate ventilation. The best [b) Developing good personal chemical
The recommendations from "Prudent way to prevent exposure to airborne
Practices" have been paraphrased, combined, hygiene habits [22).
substances is to prevent their escape into the
or otherwise reorganized, and headings have working atmosphere by use of hoods and C. The Laboratory Facility
been added. However, their sense has not other ventilation devices [32, 198). 1. Design. The laboratory facility should
been changed. 4. Institute a chemical hygiene program. A have:
mandatory chemical hygiene program [a) An appropriate general ventilation
Corresponding Sections of the Standard and
this Appendix designed to minimize exposures is needed; it system [see C4 below) with air intakes and
should be a regular, continuing effort, not exhausts located so as to avoid intake of
The following table is given for the merely a standby or short-term activity (6, contaminated air [194);
convenience of those who are developing a 11). Its recommendations should be followed (b) Adequate, well-ventilated stockrooms/
Chemical Hygiene Plan which will satisfy the in academic teaching laboratories as well as storerooms [218, 219);
requirements of paragraph [e) of the by full-time laboratory workers [13). [c) Laboratory hoods and sinks [12, 162);
standard. It indicates those sections of this 5. Observe the PELs, TL Vs. The [d) Other safety equipment including
appendix which are most pertinent to each of Permissible Exposure Limits of OSHA and eyewash fountains and drench showers [162,
the sections of paragraph [e) and related the Threshold Limit Vulues of the American 169); and
paragraphs. Conference of Governmentallndustrial [e) Arrangements for waste disposal [12,
Hygienists should not be exceeded [13). 240).
3332 Federal Register I Vol. 55, No. 21 I Wednesday, January 31, 1990 I Rules and Regulations

2. Maintenance. Chemical-hygiene-related D. Components of the Chemical Hygiene Plan 5. Medical Program

equipment (hoods. incinerator, etc.) should 1. Basic Rules and Procedures (a) Compliance with regulations. Regular
undergo continuing appraisal and be (Recommendations for these are given in medical surveillance should be established to
modified if inadequate (11. 12). section E, below) the extent required by regulations (12).
3. Usage. The work conducted (10) and its (b) Routine surveillance. Anyone whose
scale (12) must be appropriate to the 2. Chemical Procurement. Distribution, and
Storage work involves regular and frequent handling
physicial facilities available and, especially, of toxicologically significant quantities of a
to the quality of ventilation (13]. (a) Procurement. Before a substance is chemical should consult a qualified physician
4. Ventilation-(a) Genera/laboratory received, information on proper handling, to determine on an individual basis whether
ventilation. This system should: Provide a storage. and disposal should be known to a regular schedule of medical surveillance is
source of air for breathing and for input to those who will be involved (215, 216). No desirable (11, 50).
local ventilation devices (199); it should not container should be accepted without an (c) First aid. Personnel trained in first aid
be relied on for protection from toxic adequate identifying label (216). Preferably, should be available during working hours and
substances released into the laboratory (198]; all substances should be received in a central an emergency room with medical personnel
ensure that laboratory air is continually location (216). should be nearby (173). See pp. 176-178 for
replaced, preventing increase of air (b) Stockrooms/storerooms. Toxic description of some emergency first aid
concentrations of toxic substances during the substances should be segregated in a well- procedures.
working day (194); direct air flow into the identified area with local exhaust ventilation
(221). Chemicals which are highly toxic (227) 6. Protective Apparel and Equipment
laboratory from non-laboratory areas and out
to the exterior of the building (194). or other chemicals whose containers have These should include for each laboratory:
(b) Hoods. A laboratory hood with 2.5 been opened should be in unbreakable (a) Protective apparel compatible with the
linear feet of hood space per person should secondary containers (219). Stored chemicals required degree of protection for substances
be provided for every 2 workers if they spend should be examined periodically (at least being handled (158-161);
most of their time working with chemicals annually] for replacement, deterioration, and (b) An easily accessible drench-type safety
(199); each hood should have a continuous container integrity (218-19). shower (162, 169);
monitoring device to allow convenient Stockrooms/storerooms should not be used (c) An eyewash fountain (162];
confirmation of adequate hood performance as preparation or repackaging areas, should (d) A fire extinguisher (162-164);
be open during normal working hours, and (e) Respiratory protection (164-9), fire
before use (200, 209). If this is not possible,
should be controlled by one person (219). alarm and telephone for emergency use (162)
work with substances of unknown toxicity
(c) Distribution. When chemicals are hand should be available nearby; and
should be avoided (13) or other types of local
carried, the container should be placed in an (f) Other items designated by the
ventilation devices should be provided (199).
outside container or bucket. Freight-only laboratory supervisor (156, 160).
See pp. 201-206 for a discussion of hood
elevators should be used if possible (223). 7. Records
design, construction, and evaluation. (d) Laboratory storage. Amounts permitted
(c) Other local ventilation devices. (a] Accident records should be written and
should be as small as practical. Storage on
Ventilated storage cabinets, canopy hoods, bench tops and in hoods is inadvisable. retained (174).
snorkels, etc. should be provided as needed Exposure to heat or direct sunlight should be (b) Chemical Hygiene Plan records should
(199). Each canopy hood and snorkel should avoided. Periodic inventories should be document that the facilities and precautions
have a separate exhaust duct (207). conducted. with unneeded items being were compatible with current knowledge and
(d) Special ventilation areas. Exhaust air discarded or returned to the storeroom/ regula lions (7).
from glove boxes and isolation rooms should stockroom (225-6, 229). (c) Inventory and usage records for high-
be passed through scrubbers or other risk substances should be kept as specified in
treatment before release into the regular 3. Environmental Monitoring sections E3e below.
exhaust system (208). Cold rooms and warm Regular instrumental monitoring of (d) Medical records should be retained by
rooms should have provisions for rapid airborne concentrations is not usually the institution in accordance with the
escape and for escape in the event of justified or practical in laboratories but may requirements of state and federal regulations
electrical failure (209). be appropriate when testing or redesigning (12).
(e) Modifications. Any alteration of the hoods or other ventilation devices (12) or 8. Signs and Labels
ventilation system should be made only if when a highly toxic substance is stored or
thorough testing indicates that worker used regularly (e.g., 3 times/week) (13). Prominent signs and labels of the following
protection from airborne toxic substances types should be posted:
4. Housekeeping, Maintenance, and (a) Emergency telephone numbers of
will continue to be adequate (12, 193, 204). Inspections
(f) Performance. Rate: 4-12 room air
emergency personnel/facilities, supervisors,
(a] Cleaning. Floors should be cleaned and laboratory workers (28);
changes/hour is normally adequate general
regularly (24). (b) Identity labels, showing contents of
ventilation if local exhaust systems such as
(b) Inspections. Formal housekeeping and containers (including waste receptacles) and
hoods are used as the primary method of chemical hygiene inspections should be held
control (194]. associated hazards (27, 48);
at least quarterly (6, 21) for units which have (c) Location signs for safety showers,
(g) Quality. General air flow should not be frequent pesonnel changes and semiannually eyewash sta lions, other safety and first aid
turbulent and should be relatively uniform for others; informal inspections should be equipment. exits (27) and areas where food
throughout the laboratory, with no high continual (21). and beverage consumption and storage are
velocity or static areas (194, 195); airflow into (c) Maintenance. Eye wash fountains permitted (24); and
and within the hood should not be should be inspected at intervals of not less (d) Warnings at areas or equipment where
excessively turbulent (200); hood face than 3 months (6). Respirators for routine use special or unusual hazards exist (27).
velocity should be adequate (typically 60-100 should be inspected periodically by the
lfm) (200, 204). laboratory supervisor (169). Safety showers 9. Spills and Accidents
(h) Evaluation. Quality and quantity of should be tested routinely (169). Other safety (a] A written emergency plan should be
ventilation should be evaluated on equipment should be inspected regularly. established and communicated to all
installation (202), regularly monitored (at (e.g., every 3-6 months] (6, 24, 171). personnel; it should include procedures for
least every 3 months) (6, 12, 14, 195), and Procedures to prevent restarting of out-of- ventilation failure (200), evacuation, medical
reevaluated whenever a change in local service equipment should be established (25). care. reporting, and drills (172).
ventilation devices is made (12, 195. 207). See (d) Passageways. Stairways and hallways (b) There should be an alarm system to
pp. 195-198 for methods of evaluation and for should not be used as storage areas (24). alert people in all parts of the facility
calculation of estimated airborne Access to exits, emergency equipment, and including isolation areas such as cold rooms
contaminant concentrations. utility controls should never be blocked (24). (172).
 Federal Register I Vol. 55, No. 21 I Wednesday, January 31, 1990 I Rules and Regulations 3333

(c) A spill control policy should be E. Basic Rules and Procedures for Working times in the laboratory but do not wear
developed and should include consideration with Chemicals sandals, perforated shoes, or sneakers (158).
of prevention, containment, cleanup, and The Chemical Hygiene Plan should require [j) Personal housekeeping: Keep the work
reporting (175 ). that laboratory workers know and follow its area clean and uncluttered, with chemicals
(d) All accidents or near accidents should rules and procedures. In addition to the and equipment being properly labeled and
be carefully analyzed with the results procedures of the sub programs mentioned stored: clean up the work area on completion
distributed to all who might benefit (8, 28). above, these should include the rules listed of an operation or at the end of each day (24).
10. Information and Training Program below. [k) Personal protection: Assure that
(a) Aim: To assure that all individuals at 1. General Rules appropriate eye protection [154-156) is worn
risk are adequately informed about the work by all persons, including visitors, where
The following should be used for chemicals are stored or handled (22, 23, 33,
in the laboratory, its risks, and what to do if essentially all laboratory work with
an accident occurs (5, 15). 154).
chemicals: Wear appropriate gloves when the
(b) Emergency and Personal Protection [a) Accidents and spills-Eye Contact:
Training: Every laboratory worker should potential for contact with toxic materials
Promptly flush eyes with water for a exists (157): inspect the gloves before each
know the location and proper use of prolonged period (15 minutes) and seek
available protective apparel and equipment use, wash them before removal, and replace
medical attention (33, 172).
(154, 169). them periodically [157). (A table of resistance
Ingestion: Encourage the victim to drink
Some of the full-time personnel of the to chemicals of common glove materials is
large amounts of water (178).
laboratory should be trained in the proper Skin Contact: Promptly flush the affected given p. 159).
use of emergency equipment and procedures area with water (33, 172, 178) ana remove any Use appropriate [164-168) respiratory
(6). contaminated clothing (172, 178). If symptoms equipment when air contaminant
Such training as well as first aid instruction persist after washing, seek medical attention concentrations are not sufficiently restricted
should be available to (154) and encouraged [33). by engineering controls (164-5), inspecting
for (176) everyone who might need it. Clean-up. Promptly clean up spills, using the respirator before use [169).
(c) Receiving and stockroom/storeroom appropriate protective apparel and Use any other protective and emergency
personnel should know about hazards, equipment and proper disposal [24 33). See apparel and equipment as appropriate (22.
handling equipment, protective apparel, and pp. 233-237 for specific clean-up 157-162).
relevant regulations [217). recommenda lions. Avoid use of contact lenses in the
(d) Frequency of Training: The training and (b) A voidance of "routine" exposure: laboratory unless necessary: if they are used,
education program should be a regular, Develop and encourage safe habits (23): inform supervisor so special precautions can
continuing activity-not simply an annual avoid unnecessary exposure to chemicals by be taken [155).
presentation (15). any route [23): Remove laboratory coats immediately on
(e) Literature/Consultation: Literature and Do not smell or taste chemicals [32). Vent significant contamination (161).
consulting advice concerning chemical apparatus which may discharge toxic [l) Planning: Seek information and advice
hygiene should be readily available to chemicals [vacuum pumps, distillation about hazards (7), plan appropriate protective
laboratory personnel, who should be columns, etc.) into local exhaust devices
encouraged to use these information procedures, and plan positioning of
(199). equipment before beginning any new
resources (14). Inspect gloves (157) and test glove boxes operation (22, 23).
11. Waste Disposal Program. (208) before use. (m) Unattended operations: Leave lights on,
(a) Aim: To assure that minimal harm to Do not allow release of toxic substances in place an appropriate sign·on the door, and
people, other organisms, and the environment cold rooms and warm rooms, since these provide for containment of toxic substances
will result from the disposal of waste have contained recirculated atmospheres in the event of failure of a utility service
laboratory chemicals (5). (209). (such as cooling water) to an unattended
(b) Content (14, 232, 233, 240): The waste (c) Choice af chemicals: Use only those operation [27, 128).
disposal program should specify how waste chemicals for which the quality of the [n) Use af hood: Use the hood for
is to be collected, segregated, stored, and available ventilation system is appropriate operations which might result in release of
transported and include consideration of (13). toxic chemical vapors or dust (198-9).
what materials can be incinerated. Transport [d) Eating, smoking, etc.: Avoid eating. As a rule of thumb, use a hood or other
from the institution must be in accordance drinking, smoking, gum chewing, or local ventilation device when working with
with DOT regulations (244). application of cosmetics in areas where any appreciably volatile substance with a
(c) Discarding Chemical Stocks: Unlabeled laboratory chemicals are present (22, 24, 32,
TL V of less than 50 ppm (13).
containers of chemicals and solutions should 40): wash hands before conducting these
Confirm adequate hood performance
undergo prompt disposal: if partially used, activities (23, 24).
Avoid storage, handling or consumption of before use: keep hood closed at all times
they should not be opened (24, 27).
food or beverages in storage areas, except when adjustments within the hood are
Before a worker's employment in the
refrigerators, glassware or utensils which are being made (200): keep materials stored in
laboratory ends, chemicals for which that
person was responsible should be discarded also used for laboratory operations (23, 24, hoods to a minimum and do not allow them
or returned to storage (226). 226). to block vents or air flow (200).
(d) Frequency of Disposal: Waste should be [e) Equipment and glassware: Handle and Leave the hood "on" when it is not in
removed from laboratories to a central waste store laboratory glassware with care to avoid active use if toxic substances are stored in it
storage area at least once per week and from damage: do not use damaged glassware [25). or if it is uncertain whether adequate general
the central waste storage area at regular Use extra care with Dewar flasks and other laboratory ventilation will be maintained
intervals (14). evacuated glass apparatus: shield or wrap when it is "off' [200).
(e) Method of Disposal: Incineration in an them to contain chemicals and fragments [o) Vigilance: Be alert to unsafe conditions
environmentally acceptable manner is the should implosion occur [25). Use equipment and see that they are corrected when
most practical disposal method for only for its designed purpose (23, 26). detected (22).
combustible laboratory waste (14, 238, 241). [f) Exiting: Wash areas of exposed skin [p) Waste disposal: Assure that the plan
Indiscriminate disposal by pouring waste well before leaving the laboratory (23). for each laboratory operation includes plans
chemicals down the drain [14, 231, 242) or (g) Horseplay: Avoid practical jokes or and training for waste disposal (230).
adding them to mixed refuse for landfill other behavior which might confuse, startle Deposit chemical waste in appropriately
burial is unacceptable (14). or distract another worker [23). labeled receptacles and follow all other
Hoods should not be used as a means of [h) Mouth suction: Do not use mouth waste disposal procedures of the Chemical
disposal for volatile chemicals [40, ZOO). suction for pipeting or starting a siphon [23, Hygiene Plan (22, 24).
Disposal by recycling (233, 243) or chemical 32). Do not discharge to the sewer concentrated
decontamination [40, 230) should be used (i) Personal apparel: Confine long hair and acids or bases [231 ): highly toxic,
when possible. loose clothing [23, 158). Wear shoes at all malodorous, or lachrymatory substances
3334 Federal Register I Vol. 55, No. 21 I Wednesday, January 31, 1990 I Rules and Regulations

(231); or any substances which might Store breakable containers of these appropriately labeled with identity and
interfere with the biological activity of waste substances in chemically resistant trays; also warning labels (48).
water treatment plants. create fire or work and mount apparatus above such trays (i] Spills: Assure that contingency plans,
explosion hazards, cause structural damage or cover work and storage surfaces with equipment, and materials to minimize
or obstruct flow (242]. removable, absorbent, plastic backed paper exposures of people and property in case of
(q) Working alone: Avoid working alone in (40). accident are available (233-4].
a building; do not work alone in a laboratory If a major spill occurs outside the hood, (j) Storage: Store containers of these
if the procedures being conducted are evacuate the area; assure that cleanup chemicals only in a ventilated, limited access
hazardous (28). personnel wear suitable protective apparel (48, 227, 229) area in appropriately labeled,
2. Working with Allergens and Embryotoxins and equipment (41). unbreakable, chemically resistant, secondary
(g) Waste: Thoroughly decontaminate or containers (48, 229).
(a] Allergens (examples: diazomethane, (k) Glove boxes: For a negative pressure
isocyana tes, bichroma tes ): Wear suitable incinerate contaminated clothing or shoes
(41). If possible, chemically decontaminate by glove box, ventilation rate must be at least 2
gloves to prevent hand contact with allergens
chemical conversion (40). volume changes/hour and pressure at least
or substances of unknown allergenic activity
Store contaminated waste in closed, 0.5 inches of water (48). For a positive
(35].
suitably labeled, impervious containers (for pressure glove box, thoroughly check for
(b) Embryotoxins (34-5) (examples:
liquids, in glass or plastic bottles half-filled leaks before each use (49). In either case, trap
organomercurials, lead compounds,
with vermiculite] (40). the exit gases or filter them through a HEPA
formamide]: If you are a woman of
filter and then release them into the hood
childbearing age, handle these substances 4. Work with Chemicals of High Chronic
(49).
only in a hood whose satisfactory Toxicity
(I] Waste: Use chemical decontamination
performance has been confirmed, using (Examples: dimethylmercury and nickel whenever possible; ensure that containers of
appropriate protective apparel (especially carbonyl (48), benzo-a-pyrene (51), N- contaminated waste (including washings
gloves] to prevent skin contact. nitrosodiethylamine (54), other human
Review each use of these materials with from contaminated flasks] are transferred
carcinogens or substances with high from the controlled area in a secondary
the research supervisor and review carcinogenic potency in animals (38).)
continuing uses annually or whenever a container under the supervision of authorized
Further supplemental rules to be followed, personnel (49, 50, 233].
procedural change is made. in addition to all these mentioned above, for
Store these substances, properly labeled, in 5. Animal Work with Chemicals of High
work with substances of known high chronic
an adequately ventilated area in an Chronic Toxicity
toxicity (in quantities above a few milligrams
unbreakable secondary container. to a few grams, depending on the substance] (a) Access: For large scale studies, special
Notify supervisors of all incidents of (47]. (Procedure A of "Prudent Practices" pp. facilities with restricted access are preferable
exposure or spills; consult a qualified 47-50). (56).
physician when appropriate. (b) Administration of the toxic substance:
(a] Access: Conduct all transfers and work
3. Work with Chemicals of Moderate Chronic with these substances in a "controlled area": When possible, administer the substance by
or High Acute Toxicity a restricted access hood, glove box, or injection or gavage instead of in the diet. If
Examples: diisopropylflurophosphate (41), portion of a lab, designated for use of highly administration is in the diet, use a caging
hydrofluoric acid (43], hydrogen cyanide (45). toxic substances, for which all people with system under negative pressure or under
Supplemental rules to be followed in access are aware of the substances being laminar air flow directed toward I-lEPA filters
addition to those mentioned above used and necessary precautions (48]. (56).
(Procedure B of "Prudent Practices", pp. 39- (b) Approvals: Prepare a plan for use and (c) Aerosol suppression: Devise procedures
41]: disposal of these materials and obtain the which minimize formation and dispersal of
(a] Aim: To minimize exposure to these approval of the laboratory supervisor (48]. contaminated aerosols, including those from
toxic substances by any route using all (c) Non-contamination/Decontamination: food, urine, and feces (e.g., use I-lEPA filtered
reasonable precautions (39). Protect vacuum pumps against contamination vacuum equipment for cleaning, moisten
[b) Applicability: These precautions are by scrubbers or I-lEPA filters and vent them contaminated bedding before removal from
appropriate for substances with moderate into the hood (49). Decontaminate vacuum the cage. mix diets in closed containers in a
chronic or high acute toxicity used in pumps or other contaminated equipment, hood] (55, 56).
significant quantities (39]. including glassware, in the hood before (d) Personal protection: When working in
(c) Location: Use and store these removing them from the controlled area (49, the animal room, wear plastic or rubber
substances only in areas of restricted access 50). gloves, fully buttoned laboratory coat or
with special warning signs (40, 229). Decontaminate the controlled area before jumpsuit and, if needed because of
Always use a hood (previously evaluated normal work is resumed there (50]. incomplete suppression of aerosols, other
to confirm adequate performance with a face (d) Exiting: On leaving a controlled area, apparel and equipment (shoe and head
velocity of at least 60 linear feet per minute] remove any protective apparel (placing it in coverings, respirator] (56).
(40] or other containment device for an appropriate, labeled container] and (e) Waste disposal: Dispose of
procedures which may result in the thoroughly wash hands, forearms, face, and contaminated animal tissues and excreta by
generation of aerosols or vapors containing neck [49). incineration if the available incinerator can
the substance (39]; trap released vapors to (e) Housekeeping: Use a wet mop or a convert the contaminant to non-toxic
prevent their discharge with the hood vacuum cleaner equipped with a I-lEPA filter products (238); otherwise, package the waste
exhaust (40). instead of dry sweeping if the toxic substance appropriately for burial in an EPA-approved
(d) Personal protection: Always avoid skin was a dry powder (50]. site (239).
contact by use of gloves and long sleeves (f) Medical surveillance: If using F Safety Recommendations
(and other protective apparel as appropriate] toxicologically significant quantities of such a
(39). Always wash hands and arms substance on a regular basis (e.g., 3 times per The above recommendations from "Prudent
immediately after working with these week), consult a qualified physician Practices" do not include those which are
materials (40). concerning desirability of regular medical directed primarily toward prevention of
(e) Records: Maintain records of the surveillance (50). physical injury rather than toxic exposure.
amounts of these materials on hand, amounts (g) Records: Keep accurate records of the However, failure of precautions against
used, and the names of the workers involved amounts of these substances stored (229) and injury will often have the secondary effect of
[40, 229). used, the dates of use, and names of users causing toxic exposures. Therefore, we list
(f) Prevention of spi!/s and accidents: Be (48). below page references for recommendations
prepared for accidents and spills (41). (h) Signs and labels: Assure that the concerning some of the major categories of
Assure that at least 2 people are present at controlled area is conspicuously marked with safety hazards which also have implications
all times if a compound in use is highly toxic warning and restricted access signs (49] and for chemical hygiene:
or of unknown toxicity (39). that all containers of these substances are 1. Corrosive agents: (35-6)
 Federal Register I Vol. 55, No. 21 I Wednesday, January 31, 1990 / Rules and Regulations 3335

2. Electrically powered laboratory apparatus: specific endorsement of a book, opinion, 7. !ARC Monographs on the Evaluation of
(179-92) technique, policy or a specific solution for a the Carcinogenic Risk of Chemicals to Man,
3. Fires, explosions: (26, 57-74, 162-4, 174-5, safety or health problem. Other references World Health Organization Publications
219-20. 226-7) not listed here may better meet the needs of a Center, 49 Sheridan Avenue, Albany, New
4. Low temperature procedures: [26, 88) specific laboratory. (a) Materials for the York 12210 (latest editions).
5. Pressurized and vacuum opera lions development of the Chemical Hygiene Plan: 8. NIOSH/OSHA Pocket Guide to Chemical
(including use of compressed gas 1. American Chemical Society. Safety in Hazards. NIOSH Pub. No. 85-114, U.S.
cylinders): (27, 75-101) Academic Chemistry Laboratories, 4th Government Printing Office, Washington, DC,
G. Material Safety Data Sheets edition, 1985. 1985 (or latest edition].
2. Fawcett, H.H. and W. S. Wood, Safety 9. Occupational Health Guidelines,
Material safety data sheets are presented and Accident Prevention in Chemical NIOSH/OSHA NIOSH Pub. No. 81-123 U.S.
in "Prudent Practices" for the chemicals Operations, 2nd edition, Wiley-Interscience, Government Printing Office, Washington, DC,
listed below. (Asterisks denote that New York. 1982. 1981.
comprehensive material safety data sheets 3. Flury, Patricia A., Environmental Health 10. Patty, F.A .. Industrial Hygiene and
are provided). and Safety in the Hospital Laboratory, Toxicology, John Wiley & Sons, Inc., New
• Acetyl peroxide (105) Charles C. Thomas Publisher, Springfield IL, York, NY (Five Volumes).
• Acrolein (106) 1978. 11. Registry of Toxic Effects of Chemical
• Acrylonilrile (107) 3. Green, Michael E. and Turk, Amos, Substances, U.S. Department of Health and
Ammonia (anhydrous) (91) Safety in Working with Chemicals, Human Services, Public Health Service,
• Aniline (109) Macmillan Publishing Co., NY, 1978. Centers for Disease Control. National
'Benzene (110) 5. Kaufman, James A .. Laboratory Safety Institute for Occupational Safety and Health,
'Benzo[a)pyrene (112) Guidelines, Dow Chemical Co., Box 1713, Revised Annually, for sale from
'Bis(chloromethyl) ether [113) Midland, MI 48640, 1977. Superintendent of Documents U.S. Govt.
Boron trichloride (91) 6. National Institutes of Health, NIH Printing Office, Washington, DC 20402.
Boron trifluoride (92) Guidelines for the Laboratory use of 12. The Merck Index: An Encyclopedia of
Bromine (114) Chemical Carcinogens, NIH Pub. No. 81-2385, Chemicals and Drugs. Merck and Company
'Tert-butyl hydroperoxide (148) GPO, Washington, DC 20402, 1981. Inc. Rahway, N.J., 1976 [or latest edition].
'Carbon disulfide (116) 7. National Research Council, Prudent 13. Sax, N.I. Dangerous Properties of
Carbon monoxide (92) Practices for Disposal of Chemicals from
• Carbon tetrachloride (118) Industrial Materials, 5th edition, Van
Laboratories, National Academy Press, Nostrand Reinhold, NY., 1979.
'Chlorine (119) Washington, DC, 1983.
Chlorine trifluoride (94) 14. Sittig, Marshall, Handbook of Toxic and
8. National Research Council, Prudent Hazardous Chemicals, Noyes Publications,
'Chloroform (121) Practices for Handling Hazardous Chemicals
Chloromethane (93) Park Ridge, NJ, 1981.
in Laboratories, National Academy Press, (c) Information on Ventilation:
'Diethyl ether (122) Washington, DC, 1981.
Diisopropyl fluorophosphate (41) 1. American Conference of Governmental
9. Renfrew, Malcolm, Ed., Safety in the Industrial Hygienists Industrial Ventilation,
'Dimethylformamide (123) Chemical Laboratory, Vol. IV, f. Chem. Ed..
'Dimethyl sulfate (125) 16th edition Lansing, MI. 1980.
American Chemical Society, Easlon, PA, 2. American National Standards Institute,
'Dioxane (126) 1981.
'Ethylene dibromide (128) Inc. American National Standards
10. Steere, Norman V., Ed., Safety in the Fundamentals Governing the Design and
'Fluorine (95) Chemical Laboratory, f. Chem. Ed. American
'Formaldehyde (130) Operation of Local Exhaust Systems ANSI Z
Chemical Society, Easlon. PA, 18042, Vol. I, 9.2-1979 American National Standards
'Hydrazine and salts (132) 1967, Vol. II. 1971, Vol. III 1974.
Hydrofluoric acid (43) Institute, N.Y. 1979.
11. Steere, Norman V., Handbook of 3. !mad, A.P. and Watson, C.L. Ventilation
Hydrogen bromide (98) Laboratory Safety, the Chemical Rubber
Hydrogen chloride (98) Index: An Easy Way to Decide about
Company Cleveland, OH, 1971. Hazardous Liquids, Professional Safety pp
'Hydrogen cyanide (133) 12. Young, Jay A .. Ed., Improving Safety in
'Hydrogen sulfide (135) 15-18, April1980.
the Chemical Laboratory, John Wiley & Sons, 4. National Fire Protection Association,
Mercury and compounds (52) Inc. New York. 1987.
'Methanol (137) Fire Protection for Laboratories Using
(b) Hazardous Substances Information: Chemicals NFPA-45, 1982.
'Morpholine (138)
1. American Conference of Governmental Safety Standard for Laboratories in Health
'Nickel carbonyl (99) Industrial Hygienists, Threshold Limit Values
'Nitrobenzene (139) Related Institutions, NFPA, 56c, 1980.
for Chemical Substances and Physical Agents Fire Protection Guide on Hazardous
Nitrogen dioxide (100) in the Workroom Environment with Intended
N-nitrosodiethylamine (54) Materials, 7th edition, 1978.
Changes, P.O. Box 1937 Cincinnati, OH 45201 National Fire Protection Association,
'Peracetic acid (141) (latest edition).
'Phenol (142) Batterymarch Park, Quincy, MA 02269.
2. Annual Report on Carcinogens, National 5. Scientific Apparatus Makers Association
'Phosgene (143) Toxicology Program U.S. Department of
'Pyridine (144) (SAMA), Standard for Laboratory Fume
Health and Human Services, Public Health Hoods, SAMA LF7-1980, 1101 16th Street,
'Sodium azide (145) Service, U.S. Government Printing Office,
'Sodium cyanide (147) NW .. Washington, DC 20036.
Washington, DC, [latest edition]. [d) Information on Availability of
Sulfur dioxide (101) 3. Best Company, Best Safety Directory,
'Trichloroethylene (149) Referenced Material:
Vols. I and II, Oldwick, N.J., 1981. 1. American National Standards Institute
'Vinyl chloride (150) 4. Breth erick, L., Handbook of Reactive (ANSI), 1430 Broadway, New York. NY 10018.
Appendix B to § 1910.1450--References Chemical Hazards, 2nd edition, Butterworths, 2. American Society for Testing and
(Non-Mandatory) London, 1979. Materials (ASTM]. 1916 Race Street.
5. Bretherick, L.. Hazards in the Chemical Philadelphia, PA 19103.
The following references are provided to Laboratory. 3rd edition, Royal Society of
assist the employer in the development of a Chemistry, London, 1986. [Approved by the Office of Management and
Chemical Hygiene Plan. The materials listed 6. Code of Federal Regulations, 29 CFR part Budget under control number 1218-0131)
below are offered as non-mandatory 1910 subpart Z. U.S. Govt. Printing Office, [FR Doc. 90-1717 Filed 1-30-90; 8:45am]
guidance. References listed here do not imply Washington, DC 20402 [latest edition). BILLING CODE 4510-26-M

•u.s. G.P.O. 1990~56-J16o20025

24102 Federal Register I Vol. 54, No. 106 / Monday, June 5, 1900 I Propo!led Rules
~~~~~~~~~~~~~~~~~~~-~·-- __ :~---~~
Authority
This document was prepared under
the direction of Alan C. McMillan,
Acting Assistant Secretary of Labor for
Occupational Safety and Health, U.S.
Department of Labor, 200 Constitution
Avenue NW., Washington, DC 20210.
Accordingly, pursuant to sections 4,
6(b) and 8(c) of the Occupational Safety
and Health Act of 1970 (84) Stat. 1593,
1597, 1599; 29 u.s.c. 653, 655, 657,
Secretary of Labor's Order No. 9-83 (48
FR 35736]), and 29 CFR Part 1911, OSHA
proposes to add a new § 1910.146 to 29
CFR as set forth below.
Signed nt Washington, DC this 25th day of
May 1989.
Alan C. McMillan,
Acting Assistant Secretary.
 Facility

Address

CHEMICAL HYGIENE PLAN

Reference 29 CFR 1910.1450

Occupational Exposure to
Hazardous Chemicals in Laboratories

Implementation Date

Laboratory Manager

Chemical Hygiene Officer

 FOREWORD

On 31 January, 1990 the Occupational Safety and Health Administration (OSHA) promulgated
a fmal rule for occupational exposure to hazardous chemicals in laboratories. Included in the
standard, which became effective on 1 May, 1990 is a requirement for all employers covered
by the standard to develop and carry out the provisions of a Chemical Hygiene Plan (CHP).

A CHP is defined as a written program which sets forth procedures, equipment, personal
protective equipment and work practices that are capable of protecting employees from the
health hazards presented by hazardous chemicals used in that particular workplace.
Components of the CHP must include standard operating procedures for safety and health,
criteria for the implementation of control measures, measures to ensure proper operation of en-
gineering controls, provisions for training and information dissemination, permitting
requirements, provisions for medical consultation, designation of responsible personnel, and
identification of particularly hazardous substances.

This plan is the Chemical Hygiene Plan developed for _ _ _ _ _ _ _ _ _ _ _ _ _ __

located at in . This CHP is
maintained readily available to laboratory employees at . All laboratory
personnel must know and follow the procedures outlined in this plan. All operations
performed in the laboratory must be planned and executed in accordance with the enclosed pro-
cedures. In addition, each employee is expected to develop safe personal chemical hygiene
habits aimed at the reduction of chemical exposures to themselves and coworkers.

This document was developed to comply with paragraph (e) of the referenced OSHA
1910.1450 standard. will maintain the facilities and procedures
employed in the laboratory compatible with current knowledge and regulations in laboratory
safety. This CHP will be reviewed, evaluated and updated at least annually and is readily
available to employees, their representatives and any representative of the Assistant Secretary
of Labor for OSHA.

Ranking Official

i
 TABLE OF CONTENTS

Section and Title Page

FOREWORD ......................................................................... i

TABLE OF CONTENTS ........................................................... ii

1. 0 Standard Operating Procedures for

Laboratory Chemicals ............................................................... 1

1.1 Chemical Procurement ..................................................... 1

1.2 Chemical Storage ........................................................... 1

1. 3 Chemical Handling ......................................................... 2

1.4 Laboratory Equipment and Glassware ................................... 3

1.5 Personal Protective Equipment ............................................ 4

1.6 Personal Work Practices ................................................... 4

1. 7 Labeling ...................................................................... 5

2.0 Criteria for Implementation of

Control Measures .................................................................... 6

2.1 Air Sampling ................................................................ 6

2.2 Housekeeping ............................................................... 6

2.3 Safety and Emergency Equipment ........................................ 7

3.0 Engineering Controls ................................................................ 7

3.1 Intent ......................................................................... 7

3.2 Modification ................................................................. 7

3. 3 Improper Function .......................................................... 7

3.4 Usage ......................................................................... 8

3.4.1 Local Exhaust Ventilation .......................................... 8

3.4.2 Laboratory Hoods .................................................. 8

3.4.3 Glove Boxes and Isolation Rooms ............................... 9

11
 TABLE OF CONTENTS (continued)

Section and Title Page

3.4.4 Cold Rooms and Warm Rooms ................................... 9

3.4.5 Storage Cabinets .................................................... 9

4.0 Employee Information and Training ............................................... 10

4.1 Hazard Information ......................................................... 10

4.2 Forms ........................................................................ 10

4.3 Training ...................................................................... 10

5.0 Prior Approval for Laboratory Activities .......................................... 11

5.1 Permit System ............................................................... 11

5.1.1 Off-Hours Work Practices ......................................... 11

5.1.2 Sole Occupancy ..................................................... 11

5.1.3 Hazardous Work .................................................... 11

5.1.4 Unattended Operations ............................................. 11

6.0 Medical Consultations and Examinations ......................................... 12

7.0 Chemical Hygiene Responsibilities ................................................ 12

7.1 Chief Executive Officer .................................................... 12

7.2 Chemical Hygiene Officer ................................................. 12

7. 3 Laboratory Workers ........................................................ 13

8. 0 Special Precautions .................................................................. 13

8.1 Working with Allergens and Embryotoxins ............................. 13

8.2 Working with Chemicals of Moderate Chronic or

High Acute Toxicity ........................................................ 14

8.3 Working with Chemicals of High Chronic Toxicity .................... 14

8.4 Working with Animals and Chemicals of High

Chronic Toxicity ............................................................ 15

111
 TABLE OF CONTENTS (concluded)

Section and Title Page

9.0 Recordkeeping ....................................................................... 15

10. 0 Chemical Spills, Releases and Accidents ............................... 0 0 0 0 0 0 0 0 0 0 16

11.0 Annual Chemical Hygiene Audit.. 0000 00000. o• 00 .o 0 0 Ooo. o• o• 00 0 0 00 0 0 00 0 0 0 0 0 0 0 0 0 0 0 0 0 16

12 0
0 References and Recommended Reading ..................... 0 0 0 0 0 0 0 • 0 0 0 0 0 0 0 • 0 0 0 0 • 16

IV
 Appendices

A Laboratory Safety Equipment Inspection Schedule

B Resistance to Chemicals of Common Glove Materials

C New Chemical Purchasing Request

D Chemical Hazard Audit Sheet

E Air Sampling Data Record

F New Employee Chemical Hygiene Orientation and Training Checklist

G Transfer Chemical Hygiene Training Checklist

H New Chemical Training Checklist

I Chemical Hygiene Permit

J OSHA Hazardous Chemicals in Laboratories Standard Compliance Checklist

v
1. 0 Standard Operating Procedures for Laboratory Chemicals
1. 1 Chemical Procurement
1. 1.1 The decision to procure a chemical shall be a commitment to
handle and use the chemical properly from initial receipt to
ultimate disposal.

1.1.2 Requests for procurement of new chemicals shall be submitted

to the Chemical Hygiene Officer for approval. The form entitled
"New Chemical Purchasing Request", Appendix C to this plan,
shall be used for this purpose. Information on proper handling,
storage and disposal shall be known to all involved personnel
prior to the procurement of the chemical. Chemicals utilized in
the laboratory shall be those which are appropriate for the
ventilation system.

1. 1 . 3 All chemicals shall be received in a central location. Personnel

who receive chemical shipments shall be knowledgeable of the
proper procedures for receipt. Chemical containers shall not be
accepted without accompanying labels, material safety data
sheets and packaging in accordance with all appropriate
regulations. All chemical shipments should be dated when
received and opened.

1. 2 Chemical Storage
1.2.1 Received chemicals shall be immediately moved to the
designated storage area. Large glass containers shall be placed
in carrying containers or shipping containers during
transportation.

1.2.2 The storage area shall be well-illuminated, with all storage

maintained below eye level. Large bottles shall be stored no
more than two feet from ground level.

1.2.3 Chemicals shall be segregated by hazard classification and

compatibility in a well-identified area, with local exhaust ventila-
tion.

1.2.4 Mineral acids should be separated from flammable and

combustible materials. Separation is defined by NFPA 49 as
storage within the same fire area but separated by as much space
as practicable or by intervening storage from incompatible
materials.

1.2.5 Acid-resistant trays shall be placed under bottles of mineral

acids.

1.2.6 Acid-sensitive materials such as cyanides and sulfides shall be

separated from acids or protected from contact with acids.

1
 1.2.7 Highly toxic chemicals or other chemicals whose containers
have been opened shall be stored in unbreakable secondary
containers.

1.2.8 The storage area shall not be used as a preparation or

repackaging area.

1.2.9 The storage area shall be accessible during normal working

hours. The storage area is under the control of
_ _ _ _ _ _ _ _ _ _ _ (Job Title).

1.2.10 When chemicals are taken from the storage area, they shall be
placed in an outside container or bucket.

1.2.11 Storage of chemicals at the lab bench or other work areas shall
be limited to those amounts necessary for one operation or shift.
The container size shall be the minimum convenient. The
amounts of chemicals at the lab bench shall be as small as
practical. Chemicals in the workplace shall not be exposed to
sunlight or heat.

1.2.12 Stored chemicals shall be examined at least annually by the

Chemical Hygiene Officer for replacement, deterioration, and
container integrity. The inspection should determine whether
any corrosion, deterioration, or damage has occurred to the
storage facility as a result of leaking chemicals.

1.2.13 Periodic inventories of chemicals outside the storage area shall

be conducted by the Chemical Hygiene Officer. Unneeded items
shall be properly discarded or returned to the storage area.

1. 3 Chemical Handling

Each laboratory employee with the training, education and resources provided by
supervision, shall develop and implement work habits consistent with this CHP to
minimize personal and coworker exposure to the chemicals in the laboratory. Based on
the realization that all chemicals inherently present hazards in certain conditions,
exposure to all chemicals shall be minimized.

General precautions which shall be followed for the handling and use of all chemicals
are:

1. 3. 1 Skin contact with all chemicals shall be avoided.

1. 3.2 All employees shall wash all areas of exposed skin prior to
~eavingthe laboratory.

1. 3. 3 Mouth suction for pipeting or starting a siphon is prohibited.

1. 3.4 Eating, drinking, smoking, gum chewing, or application of

cosmetics in areas where laboratory chemicals are present shall
be avoided. These areas have been posted. Hands shall be
thoroughly washed prior to performing these activities.

2
 1.3.5 Storage, handling and consumption of food or beverages shall
not occur in storage areas, refrigerators, glassware or utensils
also used for laboratory operations.

1.3.6 Risk determinations shall be conservative in nature.

1.3.7 Any chemical mixture shall be assumed to be as toxic as its most

toxic component.

1.3.8 Substances of unknown toxicity shall be assumed to be toxic.

1.3.9 Laboratory employees shall be familiar with the symptoms of

exposure for the chemicals with which they work and the
precautions necessary to prevent exposure.

1.3.10 The intent and procedures of this Chemical Hygiene Plan shall
be continuously adhered to.

1.3.11 In all cases of chemical exposure, neither the Permissible

Exposure Limits (PELs) of OSHA or the Threshold Limit
Values (TL V s) of the American Conference of Governmental In-
dustrial Hygienists (ACGIH) shall be exceeded.

1.3.12 The engineering controls and safety equipment in the laboratory

shall be utilized and inspected in accordance with Appendix A of
this plan.

1.3.13 Specific precautions based on the toxicological characteristics of

individual chemicals shall be implemented as deemed necessary
by the Chemical Hygiene Officer (see 7.2). These special
precautions are listed in Section 8.0.

1. 4 Laboratory Equipment and Glassware

Each employee shall keep the work area clean and uncluttered. All chemicals and
equipment shall be properly labeled in accordance with Section 1.7. At the completion
of each work day or operation, the work area shall be thoroughly cleaned and all
equipment properly cleaned and stored.

In addition, the following procedures shall apply to the use of laboratory equipment:

1.4.1 All laboratory equipment shall be used only for its intended
purpose.

1.4.2 All glassware will be handled and stored with care to minimize
breakage; all broken glassware will be immediately disposed of
in the broken glass container.

1.4.3 All evacuated glass apparatus shall be shielded to contain

chemicals and glass fragments should implosion occur.

1.4.4 Labels shall be attached to all chemical containers, identifying

the contents and related hazards.

3
 1.4.5 Waste receptacles shall be identified as such.

1.4.6 All laboratory equipment shall be inspected on a periodic basis

as specified in Appendix A, and replaced or repaired as
necessary.

1. 5 Personal Protective Equipment

1. 5.1 Safety glasses meeting ANSI Z87 .1 are required for employees
and visitors to the laboratory and will be worn at all times when
in the laboratory. Contact lenses are prohibited in the
laboratory, except as approved by the Chemical Hygiene Officer
and supervisor.

1.5.2 Chemical goggles and/or a full face shield shall be worn during
chemical transfer and handling operations as procedures dictate.

1.5.3 Sandals, perforated shoes, sneakers and bare feet are prohibited.
Safety shoes, per ANSI 47 are required where employees
routinely lift heavy objects.

1. 5. 4 Lab coats are provided and must be worn in the laboratory.

Laboratory coats will be laundered on a periodic basis, not to
exceed monthly. Laboratory coats shall be removed immediately
upon discovery of significant contamination.

1.5.5 Appropriate chemical-resistant gloves based on the table in

Appendix B shall be worn at all times when there may be skin
contact with chemicals. Used gloves shall be inspected and
washed prior to re-use. Damaged or deteriorated gloves will be
immediately replaced. Gloves shall be washed prior to removal
from the hands.

1.5.6 Thermal-resistant gloves shall be worn for operations involving

the handling of heated materials and exothermic reaction vessels.
Thermal-resistant gloves shall be non-asbestos and shall be
replaced when damaged or deteriorated.

1. 5. 7 Respirator usage shall comply with the OSHA Respiratory

Protection Standard, 29 CFR 1910.134, and
_ _ _ _ _ _ _ _ _ _ _ _ Respiratory Program.

1. 6 Personal Work Practices

1. 6.1 Laboratory supervision must ensure that each employee knows
and follows the rules and procedures established in this plan.

1.6.2 All employees shall remain vigilant to unsafe practices and

conditions in the laboratory and shall immediately report such
practices and/or conditions to the laboratory supervisor. The
supervisor must correct unsafe practices and or conditions
promptly.

4
 1.6.3 Long hair and loose-fitting clothing shall be confmed close to the
body to avoid being caught in moving machine/equipment parts.

1.6.4 Use only those chemicals appropriate for the ventilation system.

1.6.5 A void unnecessary exposure to all chemicals by any route.

1.6.6 Do not smell or taste any chemicals.

1.6.7 Encourage safe work practices in coworkers by setting the

proper example. Horseplay is strictly forbidden.

1.6.8 Seek information and advice from knowledgeable persons,

standards and codes about the hazards present in the laboratory.
Plan operations, equipment and protective measures
accordingly.

1.6.9 Use engineering controls in accordance with Section 3.0.

1.6.10 Inspect personal protective equipment prior to use, and wear

appropriate protective equipment as procedures dictate and when
necessary to avoid exposure.

1. 7 Labeling
1. 7 .1 All containers in the laboratory shall be labeled. This includes
chemical containers and waste containers. The label shall be in-
formative and durable, and at a minimum, will identify contents,
source, date of acquisition, storage location and indication of
hazard.

1. 7.2 Portable containers shall be labeled by the individual using the

container.

1. 7. 3 Exemptions for labeling requirements shall be made for chemical

transfers from a labeled container into a container which is
intended only for the immediate use of the employee who
performed the transfer.

1. 7.4 The labeling program shall be periodically inspected by the

Chemical Hygiene Officer to ensure that labels have not been
defaced or removed. The form entitled "Chemical Hazard Audit
Checklist", Appendix D to this plan, shall be used for this
purpose.

5
2. 0 Criteria for Implementation of Control Measures
2. 1 Air Sampling

2.1.1 Air sampling for evaluating employee exposure to chemical

substances shall be conducted periodically or as specified by
specific codes or regulations.

2.1.2 Upon addition of new chemicals or changes in control

procedures, additional air sampling will be considered to
determine the exposures. Conduct air sampling if there is reason
to believe that exposure levels for regulated substances that
require sampling routinely exceed the action level, or in the
absence of an action level, the PEL. Air sampling will be
implemented when usage of highly toxic substances exceeds
three times per week.

2.1.3 The results of air sampling studies performed in the laboratory

are maintained and recorded on the form shown in Appendix E
to this plan.

2. 2 Housekeeping

2.2.1 Each laboratory worker is directly responsible for the cleanliness

of his or her work space, and jointly responsible for common
areas of the laboratory. Laboratory management shall insist on
the maintenance of housekeeping standards.

2.2.2 The following procedures apply to the housekeeping standards

of the laboratory:

2.2.2.1 All spills on lab benches or floors shall be immediately

cleaned and properly disposed of. Large spills will
necessitate the implementation of the Emergency Action
Plan per OSHA 1910.38 and 1910.120.

2.2.2.2 The lab benches shall be kept clear of equipment and

chemicals except those necessary for the work currently
being performed.

2.2.2.3 The work area shall be cleaned at the end of each

operation and each shift.

2.2.2.4 All apparatus shall be thoroughly cleaned and returned to

storage upon completion of usage.

2.2.2.5 All floors, aisles, exits, fire extinguishing equipment,

eyewashes, showers, electrical disconnects and other
emergency equipment shall remain unobstructed.

2.2.2.6 All labels shall face front.

6
 2.2.2.7 Chemical containers shall be clean, properly labeled and
returned to storage upon completion of usage.

2.2.2.8 All chemical wastes will be disposed of in accordance

with the waste disposal plan.

2. 3 Safety and Emergency Equipment

2.3.1 Telephone numbers of emergency personnel, supervisors and
other workers as deemed appropriate have been posted.

2. 3. 2 All laboratory personnel will be trained in the proper use of fire

extinguishers when hired and annually thereafter. Prior to the
procurement of new chemicals, the Chemical Hygiene Officer
shall verify that existing extinguishers and other emergency
equipment are appropriate for such chemicals.

2.3.3 All employees who might be exposed to chemical splashes shall

be instructed in the location and proper usage of emergency
showers and eyewashes. The eyewash and emergency shower
shall be inspected weekly. These inspections shall be performed
by the laboratory employees. These inspections shall be in
accordance with ANSI Z358.1 and manufacturer's
specifications. Records shall be maintained.

2.3.4 Location signs for safety and emergency equipment have been
posted.

3. 0 Engineering Controls

3.1 Intent

The engineering controls installed in the laboratory are intended to minimize employee
exposure to chemical and physical hazards in the workplace. These controls must be
maintained in proper working order for this goal to be realized.

3. 2 Modification

No modification of engineering controls will occur unless testing indicates that worker
protection will continue to be adequate.

3. 3 Improper Function

Improper function of engineering controls must be reported to the Chemical Hygiene

Officer immediately. The system shall be taken out of service until proper repairs have
been executed.

7
3.4 Usage

All employees shall follow proper work practices when using the engineering controls.

3. 4.1 Local Exhaust Ventilation

The following procedures shall apply to the use of local exhaust ventilation:

3.4.1.1 Openings of hoods shall be placed as close as possible to

sources of the air contaminant.

3.4.1.2 Clear the screen on the face of the hood prior to usage.

3.4.1.3 Hood fans shall operate when hoods are being used.

3.4.1.4 After using hoods, operate the fan for an additional

period of time sufficient to clear residual contaminants
from the ductwork.

3.4.1.5 The ventilation system shall be inspected every three

months. The duct velocity shall be maintained at 3500
feet per minute, minimum. A record of each inspection
shall be maintained by the Chemical Hygiene Officer.

3.4.1.6 Prior to a change in chemicals or procedures, the

adequacy of the ventilation system shall be determined
by the Chemical Hygiene Officer.

3. 4. 2 Laboratory Hoods
The laboratory hoods shall be utilized for all chemical procedures which might
result in release of hazardous chemical vapors or dust. As a general rule, the
hood shall be used for all chemical procedures involving substances which are
appreciably volatile and have a permissible exposure limit (PEL) less than 50
ppm.

The following work practices shall apply to the use of hoods:

3.4.2.1 Confirm adequate hood ventilation performance prior to

opening chemical containers inside the hood. An inward
flow of air can be con fumed by holding a piece of paper
at the face of the hood and observing the movement of
the paper.

3.4.2.2 Keep the sash of the hood closed at all times except
when adjustments within the hood are being made. At
these times, maintain the sash height as low as possible.

3.4.2.3 Storage of chemicals and equipment inside the hood shall

be kept to a minimum.

3.4.2.4 Minimize interference with the inward flow of air into the
hood.

8
 3.4.2.5 Leave the hood operating when it is not in active use if
hazardous chemicals are contained inside the hood or if it
is uncertain whether adequate general laboratory
ventilation will be maintained when the hood is non-
operational.

3.4.2.6 The ventilation system shall be inspected every three

months. The hood face velocity shall be maintained be-
tween 75 and 125 feet per minute. A record of each
inspection shall be maintained by the Chemical Hygiene
Officer.

3.4.2.7 The hood shall not be used as a means of disposal for

volatile chemicals.

3.4.2.8 Prior to the introduction of new chemicals, the adequacy

of hood ventilation systems shall be determined by the
Chemical Hygiene Officer.

3.4.3 Glove Boxes and Isolation Rooms

The exhaust air from a glove box or isolation room will pass through scrubbers
or other treatment before release into the regular exhaust system.

3. 4. 4 Cold Rooms and Warm Rooms

In event of electrical failure, the following provisions will be followed:

3. 4. 5 Storage Cabinets
Storage cabinets for flammable and hazardous chemicals will be ventilated as
needed.

9
4. 0 Employee Information and Training
4 .1 Hazard Information
All employees will be apprised of the hazards presented by the chemicals in use in the
laboratory. Each employee shall receive training at the time of initial assignment to the
laboratory, prior to assignments involving new exposure situations, and at a regular
frequency as determined by the Chemical Hygiene Officer.

4.2 Forms

The forms in Appendices F-H entitled "New Employee Chemical Hygiene Orientation
and Training Checklist", "Transfer Chemical Hygiene Training Checklist", and "New
Chemical Training Checklist" shall be used for these purposes.

4. 3 Training
This training shall include methods of detecting the presence of a hazardous chemical,
physical and health hazards of chemicals in the lab, and measures employees can take to
protect themselves from these hazards. The training shall present the details of the
Chemical Hygiene Plan, and shall include;

4. 3 .1 the contents of the OSHA laboratory standard, and its

appendices;

4. 3.2 the location and availability of the Chemical Hygiene Plan;

4.3.3 the permissible exposure limits for OSHA regulated substances

or recommended exposure values for other hazardous chemicals
not regulated by OSHA which are present in the laboratory;

4.3.4 signs and symptoms associated with exposure to the chemicals

present in the laboratory;

4.3.5 location and availability of reference material on chemical

hygiene;

4.3.6 training shall be conducted by _ _ _ _ __

-----,-----,-------- (Job Title). The following materials are
used during training:
Audiovisual Programs _ _ _ _ _ _ _ _ _ __
Written Materials--:-"::----------
Other Training Materials _ _ _ _ _ _ _ __

10
S. 0 Prior Approval of Laboratory Activities

S .1 Permit System

A permit system shall be used for laboratory activities which present specific,
foreseeable hazards to the employees. These activities include off-hours work, sole
occupancy of building, hazardous operations and unattended operations. The permit
entitled "Chemical Hygiene Permit" is included in Appendix I to this plan and shall be
executed prior to the performance of these activities.

S .1.1 Off-Hours Work Procedures

Laboratory personnel are not permitted to work after hours in the lab, except
when permitted.

S .1. 2 Sole Occupancy

At no time shall work be performed in the laboratory when the only person in
the building is the laboratory person performing the work. Under unusual
conditions, crosschecks, periodic security guard checks, closed circuit
television, or other measures may be taken when permitted.

5.1.3 Hazardous Work

All hazardous operations are to be performed during a time when at least two
personnel are present at the laboratory. At no time shall a laboratory person,
while working alone in the laboratory, perform work which is considered
hazardous. The determination of hazardous operations shall be made by the
laboratory supervisor and permitted.

S .1. 4 Unattended Operations

When laboratory operations are performed which will be unattended by

laboratory personnel (continuous operations, overnight reactions, etc.), the
following procedures will be employed:

5.1.4.1 The permit system shall be utilized.

5.1.4.2 The laboratory supervisor will review work procedures

to ensure for the safe completion of the operation.

5.1.4.3 An appropriate sign will be posted at all entrances to the

laboratory.

5.1.4.4 The overhead lights in the laboratory will be left on.

5.1.4.5 Precautions shall be made for the interruption of utility

service during the unattended operation (loss of water
pressure, electricity, etc.).

5.1.4.6 The person responsible for the operation will return to

the laboratory at the conclusion of the operation to assist
in the dismantling of the apparatus.

11
6. 0 Medical Consultations and Examinations

6.1 An opportunity to receive medical attention is available to all employees who

work with hazardous chemicals in the laboratory. The opportunity for medical
attention will be made available to employees under the following
circumstances:

6.1.1 Whenever an employee develops signs or symptoms associated

with a hazardous chemical to which the employee may have been
exposed in the laboratory,

6.1.2 Medical surveillance programs will be established where

exposure monitoring reveals an exposure level above the action
level for an OSHA regulated substance for which there are
exposure monitoring and medical surveillance requirements,
and/or,

6.1.3 Whenever an event takes place in the laboratory such as a spill,

leak, explosion or other occurrence resulting in the likelihood of
a hazardous exposure the employee will be provided an
opportunity for medical consultation for the purpose of
determining the need for medical examination.

6.2 These medical consultations and examinations shall be provided without cost to
the employees, without loss of pay and at a reasonable time and place.

6. 3 These medical consultations and examinations shall be administered by or under

the direct supervision of a licensed physician. A current list of available
physicians is maintained by the Chemical Hygiene Officer. Employees seeking
the opportunity of medical consultation should request the listing from the
Chemical Hygiene Officer.

7. 0 Chemical Hygiene Responsibilities

7.1 Chief Executive Officer

________________________________________________________ has the
ultimate responsibility for chemical hygiene throughout the laboratory and with
assistance of other program administrators, will provide continued support for chemical
hygiene.

7. 2 Chemical Hygiene Officer

The Chemical Hygiene Officer shall:

7 .2.1 work with administrators and other employees to develop and

implement appropriate chemical hygiene policies and practices,

7 .2.2 monitor procurement and use of chemicals in the lab, including

determining that facilities and training levels are adequate for the
chemicals in use,

12
 7.2.3 perform regular, formal chemical hygiene and housekeeping
inspections including inspections of emergency equipment,

7.2.4 help project directors develop precautions and adequate facilities,

7.2.5 maintain current knowledge concerning the legal requirements of

regulated substances in the laboratory,

7.2.6 review and improve the Chemical Hygiene Plan on an annual

basis,

7.2.7 maintain overall responsibility for the laboratory operation,

7.2.8 ensure that workers know and follow the chemical hygiene
rules,

7.2.9 determine the proper level of personal protective equipment,

ensure that such protective equipment is available and in
working order,

7.2.10 ensure that appropriate training has been provided to employees,

7 .2.11 monitor the waste disposal program.

7.3 Laboratory VVorkers

The laboratory workers are individually responsible for;

7 .3.1 planning and conducting each laboratory operation in accordance

with the Chemical Hygiene Plan,

7. 3. 2 developing good personal chemical hygiene habits.

8. 0 Special Precautions

When laboratory procedures change to require the use of additional classifications of chemicals
(allergens, embryotoxins, teratogens, carcinogens, etc.), additional special precautions shall be
implemented as deemed necessary by the Chemical Hygiene Officer. The permit system shall
be utilized for all special activities. All questions regarding the use of the permit system should
be addressed to the Chemical Hygiene Officer.

8. 1 Working with Allergens and Embryotoxins (Special Precautions)

8 .1. 1 Suitable gloves to prevent hand contact shall be worn when

exposed to allergens or substances of unknown allergen activity.

8.1.2 Women of child-bearing age will handle embryotoxins only in a

hood with confirmed satisfactory performance and will use
protective equipment to prevent skin contact as prescribed by the
supervisor and Chemical Hygiene Officer.

13
 8. 1. 3 Embryo toxins will be stored in adequate! y ventilated areas in
unbreakable secondary containers.

8. 1.4 The supervisor and Chemical Hygiene Officer will be notified of

spills and other exposure incidents. A physician will be
consulted when appropriate.

8. 2 Working with Chemicals of Moderate Chronic or High Acute

Toxicity (Special Precautions)
8. 2.1 Areas where these chemicals are stored and used are of restricted
access and have special warning signs.

8.2.2 A special hood with a minimum face velocity of 60 linear feet

per minute or other containment device will be used. Released
vapors will not discharge with the hood exhaust, but will be
trapped.

8.2.3 Gloves and long sleeves will be used. Hands and arms will be
washed immediately after working with these chemicals.

8.2.4 Two people will always be present during work with these
chemicals.

8. 3 Working with Chemicals of High Chronic Toxicity (Special

Precautions)
8. 3 .1 All transfer and work with these substances shall be in a
designated area: a restricted access hood, glove box or portion
of lab.

8. 3. 2 Approval of the supervisor will be obtained before use.

8. 3. 3 Vacuum pumps must have scrubbers or high efficiency

particulate absolute (HEPA) filters.

8.3.4 Any contaminated equipment or glassware will be

decontaminated in the hood before removing them from the
designated area.

8.3.5 For powders, a wet mop or vacuum with a HEPA filter will be
used for cleanup.

8. 3. 6 The desi.gnated area will be marked with warning and restricted

access signs.

8. 3.7 Containers will be stored in a ventilated, limited access area in

labeled, unbreakable, chemically resistant, secondary containers.

14
 8. 4 Working with Animals and Chemicals of High Chronic Toxicity
(Special Precautions)

8 .4.1 For large scale studies, special facilities with restricted access
will be provided.

8.4.2 The substance will be administered by injection or gavage when

possible rather than by diet. When diet is used, a caging system
under negative pressure or under laminar air flow directed
toward HEPA filters will be used.

8.4.3 Procedures will be used to minimize contaminated aerosols from

food, urine and feces:

HEPA filtered vacuum equipment for cleaning.

Moisten contaminated bedding before removal from

cage.

Mix diets in closed containers in hood.

8.4.4 Plastic or rubber gloves and fully buttoned lab coats will be
worn in the animal room.

9.0 Recordkeeping
9.1 Accident investigations will be conducted by the immediate supervisor with
assistance from other personnel as deemed necessary.

9.2 Accidents reports will be rewritten and retained for

9. 3 Exposure records for hazardous chemicals and harmful physical agents will be
maintained for 30 years per 29 CFR 1910.20.

9. 4 Medical records for employees exposed to hazardous chemicals and harmful

physical agents will be maintained for the duration of employment plus 30 years
per 29 CFR 1910.20.

9.5 Inventory and usage records for high risk substances (amounts of substances
on-hand, amounts used and names of workers involved) shall be maintained for

9. 6 Records of inspections of equipment will be maintained for

9. 7 Records of employee training will be maintained for

15
10.0 Chemical Spills, Releases and Accidents
In the event of a chemical spill, release or other accident, will
adhere to the procedures outlined in the Emergency Response plan as required by OSHA
standard 29 CFR 1910.38 and 1910.120.

11.0 Annual Chemical Hygiene Plan Audit

The Chemical Hygiene Officer will conduct an audit of all phases of the Chemical Hygiene
Plan each year. Results will be provided to the ranking official and the laboratory manager.
Supervisors are responsible for taking corrective action. Appendix J will be used as a guide
for the audit.

12.0 References and Recommended Reading

National Research Council, Prudent Practices for Handling Hazardous Chemicals in
Laboratories, National Academy Press, Washington, D.C. 1981.

National Research Council, Prudent Practices for Disposal of Chemicals from Laboratories,
National Academy Press, Washington, D.C., 1983.

Freeman, N.T., Introduction to Safety in the Chemical Laboratory, Academy Press, 1982.

Manufacturing Chemists' Association, Inc., Guide For Safety In The Chemical Laboratory, D.
Van Nostrand Company, Inc., 1954.

Green, Michael E., Safety In Working With Chemicals, MacMillan Publishing Co., Inc.
1978.

Pipitone, David A., Safe Storage of Laboratory Chemicals, Wiley & Sons, Inc. 1984.

Code of Federal Regulations, 29 CFR part 1910 subpart Z section 1910.1450, Occupational
Exposure to Hazardous Chemicals in Laboratories, 1990.

16
APPENDICES
 APPENDIX A
Laboratory Safety Equipment Inspection Schedule
 Ervis
Lumsden
~on
& Auocioter.lnc.

LABORATORY SAFETY EQUIPMENT Page of

INSPECTION SCHEDULE

Laboratory:

Addresc<;:

Laboratory Manager: Telephone:

Purpose: The purpose of this schedule is to assure that all laboratory safety equipment is inspected on a
routine basis by competent personnel. Records in the form of inspection tags, stickers or logs
will be maintained for all equipment.

Equipment Location Frequency Ref. Stand. Inspector

of Inspection Code, Procd.

Chemical Hygiene Officer: Telephone:

 APPENDIX B
Resistance to Chemicals of Common Glove Materials
 Elvis
l..nsden
Ba;tston
& Associates. oc

RESISTANCE TO CHEMICALS OF COMMON GLOVE MATERIALS

CHEMICAL NATURAL NEOPRENE NITRILE VINYL

RUBBER

Acetaldehyde G G E G
Acetic Acid E E E E
Acetone G G G F
Acrylonitrile p G -- F
Ammonium hydroxide (sat) G E E E

Aniline F G E G
Benzaldehyde F F E G
Benzenea p F G F
Benzyl chloridea F p G p
Bromine G G -- G

Butane p E -- p
Butyraldehyde p G -- G
Calcium hypochlorite p G G G
Carbon disulfide p p G F
Carbon tetrachloridea p F G F

Chlorine G G -- G
Ch loroacetone F E -- p
Chloroform 3 p F G p
Chromic acid p F F E
Cyclohexane F E -- p

Dibcnzyl ether F G -- p
Dibutyl phtalate F G -- p
Diethanolamine F E -- E
Diethyl ether F G E p
Dimethyl sulfoxideb -- - -- --

Ethyl acetate F G G F
Ethylene dichloridea p F G p
Ethylene glycol G G E E
Ethylene trichloride 3 p p -- p
Fluorine G G -- G

Formaldehyde G E E E
Formic acid G E E E
Glycerol G G E E
Hexane p E -- p
Hydrobromic acid (40%) G E -- E

Hydrochloric acid (cone) G G G E

Hydrofluoric acid (30%) G G G E
Hydrogen peroxide G G G E
Iodine G G -- G
Methylamine G G E E

Methyl cellosolve F E -- p
Methyl chloridea p E -- p
Methyl ethyl ketone F G G p
Methylene chloridea F F G F
Monoethanolaminc F E -- E
CHEMICAL NATURAL NEOPRENE NITRILE VINYL
RUBBER

Morpholinc F E E
Napthalcnea G G E G
Nitric acid (cone) p p p G
Perchloric acid F G F E
Phenol G E E

Phosphoric acid G E E
Potassium hydroxide (sat) G G G E
Propylene dichloridca p F p
Sodium hydroxide G F G E
Sodium hypochlorite G p F G

Sulfuric acid (cone) G G F G

Toluenea p F G F
Trichloroethy lenea p F G F
Tricresyl phosphate p F F
Triethanolamine F E E E
Trinitrotoluene p E p
(E=Exccllcnt, G=Good, F=Fair, P=Poor)
a Aromatic and halogenated hydrocarbons will attack all types of natural and synthetic glove materials. Should
swelling occur, the user should change to fresh gloves and allow the swollen gloves to dry and return to normal.

b No data on the resistance to dimethyl sulfoxide of natural rubber, neoprene, nitrile rubber, or vinyl materials arc
available; the manufacturer of the substance recommends the use of butyl rubber gloves.
 APPENDIX C
New Chemical Purchasing Request
 Ervis
Lumsden
~on
& Auocioter.lnc.

No.
NEW CHEMICAL PURCHASING REQUEST Date

1. Requesting Area: 2. Requestor:

3. Chemical Substance:

4. Material Safety Data Sheet (MSDS) Attached: 0 YES

This request cannot be processed unless the MSDS is attached.

5. Proposed Chemical Usc (amounts, duration, etc.):

6. Engineering Controls (enclosures, ventilation systems, etc.):

7. Storage Requirements:

8. Employee Exposure:

9. Expected Workplace Exposure Levels:

10. Personal Protective Equipment Required:

0 Respiratory Protection [J

0 Eye and Face Protection 0

0 Protective Clothing 0

11. Required Medical Surveillance:

0 Pulmonary TesL-.; 0
0 Urine Analysis 0
0 Blood Analysis 0

12. Routine Monitoring Requirements:

A. Workplace Exposure Levels:
B. Medical Surveillance:

13. Request approval by Laboratory Supervisor:

Date:

14. Request Approval by Chemical Hygiene Officer:

Date:
 APPENDIX D
Chemical Hazard Audit Sheet
 Emls
Lumsden
~on
& Associate~ Inc.

No.
CHEMICAL HAZARD AUDIT SHEET Date:

1. Chemical Substance Audited:

2. Work Area Audited:

3. Audit Performed by:

4. Reason for Audit:

0 Routine
0 Special -- Reason:

5. Date Audit Performed: 6. Time of Audit: - -a.m. _ _ p.m.

7. Items Audited and Findings:

ITEM FINDING RECOMMENDATIONS

0 Current MSDS in work area

0 Engineering controls maintained
0 Employees trained
0 Labels appropriate
0 Emergency procedures known
0 Personal protective equipment used
0 Workplace monitoring performed
0 Employees told of monitoring results
0 Required medical tests performed
0 Employee concerns, if any
0 Supervisory concerns, if any
0
0

8. Other CommcnL~:

9. Auditor's Signature: Date:

10. Route a copy to: 1- Area Supervisor, 2- Chemical Hygiene Officer, 3- Personnel Department File
 APPENDIX E
Air Sampling Data Record
 Emls
Lumsden
Boylston
& AssoCiates. Inc.

AIR SAMPLING DATA

TABLE NUMBER

COMPANY LOCATION SURVEY DATE

AIR SAMPLING RESULTS FOR: Sampled By:

TYPE SAMPLE: ANALYTE:

SAMPLE MEDIA: ANALYTICAL METHOD:

ACGIH TLV-TWA: OSHA PEL: OSHA STEL:

SAMPLE LOCATION SAMPLE TIME VOLUME SAMPLE UNffl DA1E

NUMBER (minutes) (liters) CONCENI'RATION

Remarks:

1- ppm - Parts of vapor or gas per million parts of contaminated air by volume at 25 · C and 760 torr.
mg/m3- Approximate milligrams of substance per cubic meter of air.
c - Ceiling limit - limit which shoujci_J1ever be exceeded even instantaneously.
 APPENDIX F
New Employee Chemical Hygiene Orientation and
Training Checklist
 Emls
li011Sden
&Auo~~lnc.

NEW EMPLOYEE CHEMICAL HYGIENE No.

ORIENTATION AND TRAINING CHECKLIST Date:

NAME: S.S. #:

JOB ASSIGNMENT: Supervisor: _ _ _ _ _ _ _ _ _ __

EMPLOYMENT DATE:

1. BY PERSONNEL DEPARTMENT ON THE FIRST DAY OF EMPLOYMENT:

0 Management's safety and health philosophy

0 Management's, supervisor's, and employee's safety and health responsibilities
0 General plant safety and health rules
0 Chemical Hygiene Training Program
0 Location and availability of Chemical Hygiene Plan

Completed by: Date:

2. BY CHEMICAL HYGIENE OFFICER:

A. First Day In Work Area Date:

0 Introduction to operations where chemical and physicial hazards are present-
types of hazards encountered
0 Required work practices
0 Personal protective equipment
0 Emergency procedures
0 Detection of chemical hazards
0 Location and availability of Chemical Hygiene Plan
0 Labeling systems

B. One Week Follow-up Date: _ _ _ _ _ _ _ _ _ _ _ __

0 Review work practices and procedures with employee

0 Answer employee questions
0 Return completed checklist to Personnel Department for filing in employee personnel folder

Completed By: Date:

Employee's Signature: Date:

 APPENDIX G
Transfer Chemical Hygiene Training Checklist
 EMis
lwnsden
&ADo~~ Inc.

No.

TRANSFER CHEMICAL HYGIENE TRAINING CHECKLIST Date:

1. Employee Transferred: - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

2. First day in the new work a r e a : - - - - - - - - - - - - - - - - - - - - - (date)

3. New supervisor's name: _ _ _ _ _ _ _ _ _ _ _ __ 4. Title:

5. NewWorkArea: _ _ _ _ _ _ _ _ _ _ __ 6. Old Work Area: _ _ _ _ _ _ _ _ __

7. Training date for transferred employee:

8. Employee training provided:

0 Emergency procedures 0 Labels
0 Work area safety rules 0 Work area monitoring
0 Work area hazards 0 Work practices
. Physical hazards 0 Personal protective equipment
. Health hazards 0 Chemical Hygiene Plan
0 Material Safety Data Sheets (MSDS) 0 Location of Reference Material
0 Detection of release or presence of hazardous chemicals

9. Additional safety and health information provided:

10. Instructor's Signature: Date:

11. Employee's Signature: Date:

12. Route a copy to: 1- Area Supervisor, 2- Chemical Hygiene Officer, 3- Personnel Department File
 APPENDIX H
New Chemical Training Checklist
 Emls
lwnsden
&Also~~ Inc.

No.
NEW CHEMICAL TRAINING CHECKLIST Date:

1. Work Area: 2. Instructor:

3. Chemical Substance:

4. Material Safety Data Sheet (MSDS) Attached: 0 YES

The MSDS must be attached to this New Chemical Training Sheet.

5. New Chemical Use:

6. Employee Training Provided:

0 MSDS reviewed 0 Work area monitoring
0 Engineering controls 0 Work practices
0 Personal protective equipment 0 Emergency procedures
0 Detection of release or presence 0
0 Labels 0

7. Training Date:

8. Employees Trained:

Employee Signature Employee Signature

(usc back if necessary)

9. Instructor's Signature: Date:

10. Route a copy to: 1- Area Supervisor, 2- Chemical Hygiene Officer, 3- Personnel Department File
 APPENDIX I
Chemical Hygiene Permit
 Emis
L..-nsden
&Ass~~ he.

CHEMICAL HYGIENE PERMIT Page 1 of

PERMIT NUMBER: DATE:

LOCATION: TIME:

PERSON REQUESTING PERMIT:

POTENTIAL HAZARDS AND REQUIRED CONTROLS

Safety Health Fire

Hanrrds: Hazards: Hazards:

Precautions y N NA Precautions y N NA Precautions y N NA

Provide •uards Possible oxygen deficiency Fire extinguishers

Personal protective eouip. Special ventilation Oven flame vcrmit

Special safetv traininll Toxic materials Explosion . protection

Special safetv procedures Personal protective eouiP. Remove combustibles

Lockouts required Svccial rescue procedures Test Atmosphere

Unattended operation Lockouts required Emergency Egress

Work Alone Exceed PELs Pvroohorics

Sole Occupancv Unattended Qp_eration

Special considerations: Special considerations: Special considerations:

Additional Comments:

---------------------------------------------------------------------------------------------
Approval of Chemical Hygiene Officer: Name:

Date:
 APPENDIX J
OSHA Hazardous Chemicals in Laboratories Standard
Compliance Checklist
 Emis
L..-nsden
&Ass~~ he.

OSHA HAZAROOUS CHEMICALS IN LABORATORIES STANDARD COMPLIANCE CHECKLIST

PURPOSE: This laboratory chemical hygiene program checklist is intended for use by companies in conducting annual chemical
hygiene program evaluations to ensure continuing effectiveness and regulatory compliance.
REFERENCE: Refer to OSHA Standard 29 CFR 1910.1450, Occupational Exposure to Hazardous Chemicals in Laboratories, for details
concerning the requirements of the standard.

ORGANIZATION: LOCATION:

LABORATORY: DATEOFAUDIT:

LAB MANAGER: CHEMICAL HYGIENE OFFICER:

ITEM 29 CFR 1910.1450 REQUIREMENT REF NO. YES NO COMMENTS

APPLICATION

1 Laboratory engaged in the use of hazardous chemicals

as defined by standard (a)(l)

2 Work performed on laboratory scale (b)

OCCUPATIONAL EXPOSURE

3 Employee exposure to OSHA regulated substances do

not exceed the permissible exposure limits specific
in 29 CFR part 1910, subpart Z (c)

EXPOSURE MONITORING

4 Initial monitoring performed for employees exposure

to any substance regulated by a standard which requires
monitoring if there is reason to believe that exposure
levels for that substace routinely exceed the action
level (or in the absence of an action level, the PEL) (d)(1)

5 Exposure monitoring provisions of relevant standards

complied with for employee exposures over the action
level (or in the absence of an action level, the PEL) (d)(2)

6 Employee monitoring terminated in accordance with

relevant standard (d)(3)

EMPLOYEE NOTIFICATION

7 Employees notified of monitoring results within 15

days of receipt (d)(4)

CHEMICAL HYGIENE PLAN

8 A written Chemical Hygiene Plan is developed and

implemented for hazardous chemical usc as defined
in the standard (e)(l)

9 The Chemical Hygiene Plan is capable of protecting

employees from health hazards associated with the
chemicals in the laboratory (e)(l)(i)

10 The Chemical Hygiene Plan is capable of maintaining

employee exposures below the permissible exposure
limits specified in 29 CFR part 1910, subpart Z (e)(l)(ii)
ITEM 29 CFR 1910.1450 REQUIREMENT REF NO. YES NO COMMENTS

11 The Chemical Hygiene Plan is readily available to

employees, employee representatives and, upon
request, to the Assistant Secretary (c)(2)

12 The Chemical Hygiene Plan indicates specific

measures to ensure laboratory employee protection
and includes each of the following elements: (e)(3)

13 Standard operating procedures relevant to safety and

health to be utilized when using hazardous chemicals (e)(3)(i)

14 Criteria for the implementation of control measures

including engineering controls, personal protective
equipment and hygiene practices (e)(3)(ii)

15 Measures to ensure adequate performance and proper

usage of engineering controls (e)(3)(iii)

16 Provisions for employee information and training in

accordance with the standard (e)(3)(iv)

17 Circumstances which require prior approval prior to

implementation (e)(3)(v)

18 Provisions for medical consultation and examination

in accordance with the standard (e)(3)(vi)

19 Designation of responsible personnel and

responsibilities (e)(3)(vii)

20 Identification of, and provisions for work with,

...
particularly hazardous substances, including: (e)(3)(viii)
establishment of designated areas (e)(3)(viii)(A)
use of containment devices (e)(3)(viii)(B)

. removal of waste
decontamination procedures
(c)(3)(viii)(C)
(e )(3 )(viii)(D)

PLAN REVIEW

21 The Chemical Hygiene Plan is reviewed and updated

at least annually (e)( 4)

EMPLOYEE JNFORMATIOl\' AND TRAINING

22 Employees receive information and training to

ensure that they arc apprised of the hazards of
chemicals present in their work area (f)(1)

23 Information and training provided at the time of

initial assignment and prior to assignments
involving new exposure situations (f)(2)

24
..Employees arc informed of:
contents of the standard (f)(3)(i)

. location of Chemical Hygiene Plan

PELs or recommended exposure limits for
(f)(3 )(ii)

. signs
substances in the laboratory
and symptoms associated with exposures
(f)(3 )(iii)

. to hazardous chemicals in the laboratory

location and availability of known reference
(f)(3 )(iv)

material (f)(3)(v)
ITEM 29 CFR 1910.1450 REQUIREMENT REF NO. YES NO COMMENTS

25
.Employee training includes:
methods to detect the presence of a hazardous

. chemical
physical and health hazards of chemicals in the
(f)(4)(i)(A)

. work area
measures employees can take to protect
(f)(4)(i)(B)

. themselves from hazards

details of the Chemical Hygiene Plan
(f)(4)(i)(C)
(f)(4)(ii)

MEDICAL CONSULTATIONS

26 Employees arc provided an opportunity to receive

medical attention under the circumstances defined
in the standard (g)( 1)

Medical consultantions are performed by or under the

direct supervision of a licensed physician (g)(2)

Medical consultations arc performed without cost

to the employee, without loss of pay and at a
reasonable time and place (g)(2)

27 Information on chemical identity, exposure

conditions and exposure symptoms is provided to the
physician performing medical consultation (g )(3 )(i)-(iii)

28 A written opinion is obtained from the examining

physician which includes results, recommendations
and any medical condition resulting in increase
employee risk as a result of exposure to a hazardous
chemical in the work area (g)(4 )( a)(A)-(D

29 The written opinion docs not address diagnoses

umclated to occupational exposure (g)( 4 )(ii)

HAZARD IDENTIFICATION

30 Labels on incoming containers of hazardous

chemicals are not removed or defaced (h)(1)(i)

31 All received material safety data sheets arc maintained

and readily available to laboratory employees (h)( 1)(ii)

32 Training is provided for all hazardous chemicals

produced in the laboratory which are for the exclusive
usc of the laboratory (h)(2)(i)

33 Chemical byproducts of unknown composition

produced in the laboratory are assumed hazardous
and covered in the Chemical Hygiene Plan (h)(2)(ii)

34 Chemical production for a user ouL~idc of the

laboratory comply with the Hazard Communication
Standard, 29 CFR 1910.1200 (h)(2)(iii)

RESPIRATORY PROTECTION

35 Where respirators arc used to maintain employee

.
exposure below permissible exposure limits;
respirators are provided at no cost to the

. employee
respirators arc selected and used in accordance
(i)

with 29 CFR 1910.134 (i)

ITEM 29 CFR 1910.1450 REQUIREMENT REF NO. YFS NO COMMENTS

RECORDKEEPING

36 A recordkeeping system is established to maintain,

for each employee, accurate records of measurements
taken to monitor employee exposures and any medical
consultations and examinations (j)(l)

37 Records are kept, transferred, and made available in

accordance with 29 CFR 1910.20 (j)(2)

Notes: (Use additional sheets as necessary)

Conducted By: Title(s) Date:

Reveiwed By: Title(s) Date:

FOR ASSISTANCE CONTACT: ELB & Associates, Inc., Chapel Hill, NC (800) 334-5478