KAPS Paper 2 Sample 1
KAPS Paper 2 Sample 1
the Australian Pharmacy Council Ltd (APC) for practice purposes only.
All questions in this sample paper are no longer used in live or actual
examinations and have been chosen to allow candidates to gain exposure
to the type of content and layout of questions on the examination. Live or
actual KAPS Examinations delivered contemporaneously will vary from this
sample paper.
Due to the frequent changes to the scope and content within the practice of
pharmacy in Australia, the APC does not guarantee that the information in
this paper is accurate or relevant once published publicly.
A phenytoin
B warfarin
C digoxin
D carbamazepine
E sodium valproate
D dosing interval
C until it is metabolised
D until it is in solution
A a foam
B an emulsion
C a suspension
D an aerosol
E a gel
1
5 Which of the following characteristics is CORRECT for cationic aqueous creams?
D The stability of the emulsion is increased when mixed with anionic drugs
E The activity of the drug is increased when mixed with anionic drugs
6 Which of the following drugs is NOT absorbed systemically when given by mouth?
A Cephalexin
B Oxytetracycline
C Nystatin
D Trimethoprim
E Rifampicin
8 If a drug has a very small volume of distribution (Vd), it is likely that this drug
C is not bioavailable
2
9 The route of drug administration that will give the MOST rapid onset of the
pharmacologic effect is
A intramuscular injection
B sublingual administration
C subcutaneous injection
D oral administration
E rectal administration
10 The bioequivalence of two tablets containing an identical amount of the same drug
manufactured by different companies is best determined by measuring
A Propoxyphene
B Ibuprofen
C Verapamil
D Esomeprazole
E Warfarin
3
13 Drugs that demonstrate non-linear pharmacokinetics show which of the following
properties?
D Both low and high doses follow first order elimination kinetics
14 It was determined that 95% of an oral 80-mg dose of verapamil was absorbed
in a 70 kg test subject.
However, because of extensive biotransformation during its first pass through the
portal circulation, the bioavailability of verapamil was only 25%.
Assuming a liver blood flow of 1500 mL/min, the hepatic clearance of verapamil in this
situation was:
A 60 mL/min
B 375 mL/min
C 740 mL/min
D 1110 mL/min
E 1425 mL/min
4
15 A new cardiac glycoside has been developed for oral and intravenous (IV)
administration. The drug has an elimination half-life of 24 hours and an apparent
volume of distribution (Vd) of 3 L/kg.
The effective drug concentration in plasma is 1.5 ng/mL. Toxic effects of the drug are
observed at drug concentrations above 4 ng/mL. The drug is 75% bioavailable after an
oral dose.
Calculate an oral maintenance dose to be given once a day for a 65 kg male patient
(age 68 years) with congestive heart failure and normal renal function. The aim is to
achieve an average plasma concentration of 1.5 ng/mL. The dose should be
A 0.125 mg
B 0.180 mg
C 0.203 mg
D 0.270 mg
E 0.333 mg
16 Salicylic acid has a pKa of 3.0 and undergoes significant renal tubular reabsorption. In
aspirin overdose the renal clearance of salicylic acid will be increased to the greatest
extent by
A Theophylline
B Morphine
C Verapamil
D Amlodipine
5
18 The most common bacterial genus associated with acne vulgaris is
A Propionibacterium
B Staphylococcus
C Streptococcus
D Corynebacterium
E Bacillus
A Fusobacterium nucleatum
B Peptostreptococcus species
C Clostridium difficle
D Clostridium septicum
E Bacteroides fragilis
21 Which of the following statements is FALSE in regards to the use of combination anti-
infective therapy?
6
22 Which of the following regimens is appropriate for managing herpes simplex
encephalitis?
23 All of the following are official pharmacopoeial testing procedures for tablets EXCEPT
A dissolution
B hardness
C disintegration
D friability
E content uniformity
A sennoside tablets
B docusate tablets
C psyllium
D magnesium sulphate
E bisacodyl
A Intra-articular
B Intradermal
C Intramuscular
D Intravenous
E Subcutaneous
7
26 Insulin preparations are usually administered by
A intradermal injection
B intramuscular injection
C intravenous bolus
D intravenous infusion
E subcutaneous injection
27 Methylcellulose and similar agents are MOST commonly used in ophthalmic solutions
to
A bad tasting
C greasy
D non-greasy
E tasteless
8
30 Sodium metabisulphite is used as
A a buffering agent
B an antipruritic
C an antioxidant
D an oxidising agent
E a chelating agent
31 Data obtained from two different batches of tablets of a new hypoglycaemic agent
undergoing clinical trial revealed that Batch 1 contains 200 mg of the drug and has an
absolute bioavailability of 55%.
Batch 2 contains 200 mg of the drug and relative to the first batch has a bioavailability
of 165%.
A 33.33%
B 61.6%
C 90.75%
D 181.5%
E 300%
A 12.5 g
B 13.3 g
C 20.2 g
D 26.3 g
E 33.3 g
9
33 How many grams of chlorbutol are required to make 500 mL of an aqueous solution of
such a concentration that 25 mL diluted to 100 mL with water will give a 1:2000
solution?
A 10
B 2.5
C 1.25
D 1
E 0.1
A 0.35
B 0.40
C 0.88
D 2.0
E 5.0
A 1.2 mL
B 2.5 mL
C 3.0 mL
D 4.0 mL
E 6.0 mL
10
36 A solution with a concentration of 0.0125 % may also be described as containing
A 1 part in 80 parts
37 Lugol's Solution contains 5% of iodine, and the usual dose of the solution is 0.3 mL
three times a day. The amount of iodine contained in the daily dose of the solution is
A 450 mg
B 150 mg
C 45 mg
D 30 mg
E 15 mg
A 100 mmol/L
B 130 mmol/L
C 150 mmol/L
D 270 mmol/L
E 300 mmol/L
A 190
B 200
C 1800
D 1900
E 1990
11
40 The normal daily adult oral dose of celecoxib is within the range
A 1 - 10 mg
B 15 - 25 mg
C 30 - 100 mg
D 200 - 400 mg
E 0.5 - 1 g
A Atenolol
B Metoprolol
C Oxprenolol
D Pindolol
E Propranolol
A pulmonary failure
B epilepsy
C hepatic impairment
D heart failure
E renal impairment
A 0.5 - 2 mg
B 2 - 5 mg
C 5 - 25 mg
D 50 - 200 mg
E 0.5 - 1 g
12
44 For ongoing control of seizures phenytoin may be administered
45 Which of the following drugs should NOT be added to the therapy of a poorly
controlled diabetic patient already on maximum doses of metformin and
glibenclamide?
A Rosiglitazone
B Insulin
C Acarbose
D Repaglinide
46 Which of the following medicines is NOT safe to use in children under 12 years of
age?
A Ceftriaxone
B Norfloxacin
C Imipenem
D Azithromycin
E Rifampicin
47 Naloxone
A is an analgesic
B causes euphoria
13
48 Sodium Chloride 0.9% is a good wound cleansing agent for the following reasons
EXCEPT it
D is economical
50 Mr Earl, a patient with congestive heart failure, has been taking digoxin 125 mcg/day
for one month and has a plasma digoxin concentration of 0.5 mcg/L.
(The therapeutic range for digoxin in patients with congestive heart failure is 0.5-0.8
mcg/L.)
Mr Earl is not showing adequate clinical improvement. The MOST appropriate course
of action is to
A maintain the current dose for one month and arrange a digoxin assay when Mr
Earl is at steady state concentration
C increase the dose of digoxin to 187.5 mcg/day and arrange a digoxin assay
when Mr Earl is at steady state concentration
D give a single loading dose of 250mcg digoxin, and maintain the current dose
for one month. Then arrange a digoxin assay when Mr Earl is at steady state
concentration
14
51 Mood disorders are being more widely managed with anticonvulsants. Which of the
following is FALSE with regard to anticonvulsants used in this fashion?
C Clonazepam and sodium valproate are both effective for the treatment of
depressive episodes
E Patients with bipolar mood disorder can be treated with anticonvulsants either
alone or in combination with lithium
52 When considering the usefulness of metformin monotherapy for a patient with type 2
diabetes mellitus, relevant patient factors to consider include
A sulfonamide allergy
B obesity
E sulfonamide allergy, fasting blood glucose levels > 13 mmol/L and obesity
53 When monitoring anticoagulation with heparin, which of the following does NOT
apply?
15
54 The Mantoux test uses
B DPT toxin
D old tuberculin
C A narcotic antagonist
A Sibutramine
B Tramadol
C Sertraline
D Olanzapine
E Pethidine
16
58 A 75-year-old male, with carcinoma of the prostate with local metastatasis, would be
best treated with which of the following?
A Tamsulosin
B Spironolactone
C Finasteride
D Leuprorelin
E Fludrocortisone
59 Metoclopramide is often given together with oral aspirin for the treatment of acute
migraine attacks. The rationale behind the use of metoclopramide is that it will
60 Which of the following drugs has been associated with interstitial pulmonary fibrosis?
A Trimethoprim
B Aspirin
C Nitrofurantoin
D Methysergide
E Salbutamol
17
62 Cationic exchange resins are most commonly used to treat
A hyperkalaemia
B hyperglycaemia
C hypernatraemia
D hypokalaemia
E hyperchlorhydria
D Measure antifactor Xa
64 The following drugs can cause syndrome of inappropriate anti diuretic hormone
(SIADH) EXCEPT
A cyclophosphamide
B chlorpromazine
C carbamazepine
D chlorpropamide
E captopril
A malabsorption of pyridoxine
C development of glaucoma
18
66 Which of the following properties is NOT true of indomethacin?
B Reduces inflammation
67 Which one of the following antipsychotic agents provides the lowest risk of
extrapyramidal side effects?
A Olanzepine
B Thioridazine
C Haloperidol
D Thiothixene
E Trifluoperazine
B Phenytoin
C Theophylline
D Diazepam
E Sulphonamides
A Weight loss
C Thrombocytopenia
D Heavy menses
E Hypoglycaemia
19
70 The most prevalent side effect of the chronic use of aluminium hydroxide gel is
B constipation
C flatulence
D diarrhoea
E gastrointestinal bleeding
A Skin rashes
C Vomiting
E Dry mouth
A temazepam
B ciprofloxacin
C miconazole
D spironolactone
E mirtazapine
A diarrhoea
B Tinnitus
C Miosis
D fever
E tachycardia
20
74 The use of pethidine in the management of chronic pain is discouraged because it
C has a toxic metabolite that can accumulate and cause seizures if a patient has
compromised renal function
E inhibits cytochrome P450 and therefore has the potential to cause drug
interactions
75 Halothane
B is a good analgesic
A Ketoconazole
B Itraconazole
C Etretinate
D Alendronate
E Tolnaftate
A catechol-O-methyltransferase
B monoamine oxidase B
C HMG-CoA reductase
D dopa decarboxylase
E monoamine oxidase A
21
78 Which of the following has been shown to cause syndrome of inappropriate
antidiuretic hormone release (SIADH)?
A Diazepam
B Lamotrigine
C Carbamazepine
D Propranolol
E Amiloride
79 Which of the following is associated with lethargy, nightmares and cold extremities as
side effects?
A Diazepam
B Theophylline
C Hydrochlorothiazide
D Propranolol
E Phenytoin
80 The following medicines have been reported to cause asthma attacks in susceptible
people EXCEPT
A echinacea
B propranolol
C diltiazem
D royal jelly
E pilocarpine
A skin discolouration
B Nephritis
D pulmonary fibrosis
E corneal microdeposits
22
82 The following drugs can cause an increase in the plasma concentration of digoxin with
increased risk of toxicity EXCEPT
A diltiazem
B verapamil
C phenytoin
D spironolactone
E itraconazole
83 Food containing tyramine should NOT be part of the diet of patients taking which of
the following antidepressants?
A Amitryptyline
B Doxepin
C Tranylcypromine
D Trimipramine
E Nortryptyline
84 Theophylline has a very narrow therapeutic index. This drug has severe dose related
toxicity (seizures and arrhythmias) which may occur without preceding milder
symptoms of toxicity (vomiting and diarrhoea).
23
85 Which of the following compounds may increase the effects of warfarin?
A Spironolactone
B Tibolone
C Irbersartan
D Atorvastatin
E Ezetimibe
86 Which or the following oral antibiotics should not be taken at the same time as oral
iron (Fe2+) containing products?
A Amoxycillin
B Ciprofloxacin
C Erythromycin
D Fluconazole
E Metronidazole
88 The following points should be included in your counselling advice to a person using
topical sunscreen agents to prevent sunburn EXCEPT
B chemical sunscreens are less effective than avoidance of sun exposure and
physical protection
C water immersion, sweating and infrequent application can make a 15+ broad
spectrum sunscreen less effective
24
89 The preferred thyroid preparation for maintenance replacement therapy is which of the
following drugs?
A Desiccated thyroid
B Liothyronine
D Levothyroxine
A 6 am
B Noon
C 3 pm
D 6 pm
E Bedtime
91 When dispensing a prescription for sucralfate the pharmacist should tell the patient
that
A Lamotrigine
B Gabapentin
C Phenytoin
D Topiramate
E Clonazepam
25
93 A patient with a superficial wound asks what time period is recommended between
tetanus immunisations?
A Cephalexin
B Haloperidol
C Benzhexol
D Diazepam
E Bromocriptine
26
PATIENT PROFILE
Diagnosis
Presenting Complaint: 1: Rheumatoid arthritis
2: Hypertension
Medical History:
Medication Record
Date Medication Quantity Sig
28/5 Captopril 25 mg - 2 repeats 60 one three times a
day
23/5 Paracetamol 500 mg - 1 repeat four times a day
12/4 Hydrochlorthiazide 50 mg - 5 repeats 30 one daily
12/4 Slow-K 8 mEq - 3 repeats 100 one three times a
day
Pharmacist's Notes
Date Comment
21/4 100 Pseudoephedrine sulphate tablets
27
96 Which of the following adverse effects could be seen with hydrochlorothiazide?
A Dyspnoea
B Seizures
C Rash
D Hypoglycaemia
E Anaemia
97 Each Slow-K dosage unit contains 8 mmoL of potassium as potassium chloride. How
many mg of potassium chloride are in each Slow-K tablet?
A 296 mg
B 312 mg
C 592 mg
D 740 mg
E 872 mg
A Bumetanide
B Chlorthalidone
C Frusemide
D Acetazolamide
E Ethacrynic acid
A hypermagnesaemic
B hypercalcaemia
C hyperglycaemia
D hypernatremia
E hyperkalaemia
28
100 Captopril is MOST similar in action to
A nicorandil
B pindolol
C lisinopril
D irbesartin
E verapamil
29
Question Number Correct Answer
1 A
2 C
3 D
4 B
5 B
6 C
7 C
8 A
9 B
10 C
11 B
12 D
13 B
14 D
15 D
16 D
17 D
18 A
19 C
20 C
21 A
22 D
23 B
24 D
25 D
26 E
27 B
28 C
29 B
30 C
31 C
32 D
33 D
34 C
35 C
36 C
37 C
38 C
39 E
40 D
41 A
42 E
43 C
30
44 D
45 D
46 B
47 C
48 E
49 C
50 C
51 C
52 D
53 A
54 D
55 C
56 C
57 D
58 D
59 B
60 C
61 C
62 A
63 D
64 E
65 D
66 D
67 A
68 A
69 B
70 B
71 C
72 B
73 C
74 C
75 C
76 C
77 B
78 C
79 D
80 C
81 B
82 C
83 C
84 E
85 B
86 B
87 A
88 D
89 D
90 E
91 B
92 C
93 E
94 D
95 B
96 C
97 C
98 B
31
99 E
100 C
32
33