Safety Data Sheet Mixed Tocopherols 95

1. Product and Company Identification

Product name Mixed Tocopherols 95

Product code 50 0289 3

Company information Manufacturer: Local representation:

DSM Nutritional Products AG LV0000
Wurmisweg 576 LV1111
CH-4303 Kaiseraugst LV2222
Switzerland LV3333
LV4444
Phone +41-62 866 23 14 LV5555
Fax +41-62 866 25 10 LV6666
LV7777

2. Composition/Information on ingredients

Characterization oily concentrate of natural R,R,R- resp. d-tocopherols extracted

from soy oil, with a total d-tocopherol content of min.95%

Ingredient Concentration EU-Classification

(pure ingredient)
d-α-Tocopherol
CAS: 59-02-9

d-β-Tocopherol
CAS: 148-03-8

d-δ-Tocopherol
CAS: 119-13-1

d-γ-Tocopherol
CAS: 54-28-4

3. Hazards identification

Most important hazards - No particular hazards known.

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4. First-aid measures

Eye contact - rinse immediately with tap water for 10 minutes - open eyelids
forcibly
- consult a physician if irritation persists

Skin contact - remove immediately contaminated clothes, wash affected skin

with water and soap - do not use any solvents

Inhalation - remove the casualty to fresh air

Note to physician - treat symptomatically

5. Fire-fighting measures

Suitable extinguishing media - foam, dry powder, carbon dioxide, water mist

Unsuitable extinguishing media - use water spray and water jet for cooling purposes only (fat
explosion hazard) *1

Protection of fire-fighters - precipitate gases/vapours/mists with water spray

*1 referring to: d-Tocopherols

6. Accidental release measures

Environmental protection - do not allow to enter drains or waterways *2

- nontoxic and biodegradable, but very slow biodegradation due to
low water solubility *2

Methods for cleaning up - collect spills with inert adsorbent and hand over to waste removal
- clean contaminated areas with little ethanol

*2 referring to: dl-α-Tocopherol

7. Handling and storage

Handling

Technical measures - processing in closed systems, if possible superposed by inert gas

(e.g. nitrogen)
- local exhaust ventilation necessary
- take precautionary measures against electrostatic charging

Suitable materials - stainless steel, aluminium, enamel, glass, polyethylene

Storage

Storage conditions - protected from light

- cool
- store under inert gas

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Validity - 36 months, < 15 °C, in the unopened original container, see "best
use before" date stated on the label, after opening the container,
the contents should be used within a short period, under nitrogen

Packaging materials - tightly closing; material: stainless steel, aluminium, enamel, glass,
food-approved plastics

8. Exposure controls/Personal protection

Engineering Measures - see 7.

Monitoring

Analytics - sampling on filter or impinger and chemical determination

(consider possible autooxidation)

Personal protective equipment

Hand protection - protective gloves

Eye protection - safety glasses

9. Physical and chemical properties

Colour yellow to brownish

clear

Form viscous oil

Odour odourless

Density ~ 0.94 g/cm3

Solubility virtually insoluble, water *1

soluble, ethanol *1
soluble, acetone *1
soluble, chloroform *1
soluble, ether *1
well soluble, lipophilic solvents *1
well soluble, oils and fats *1

Solidification point 2.5 to 3.5 °C (crystallization) *3

-30 °C (crystallization) *4

Boiling temperature ≥ 200 °C (13.3 Pa) *1

Note - acid value max. 1.0 ml NaOH 1 N/g

*1 referring to: d-Tocopherols

*3 referring to: d-α-Tocopherol
*4 referring to: d-γ-Tocopherol

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10. Stability and reactivity

Stability - stable under the conditions mentioned in chapter 7

Conditions to avoid - air

- light
- warming

Materials to avoid - iron, silver and metal salts, oxidizing agents, peroxides,
atmospheric oxygen

Note - in the absence of oxygen tocopherols are resistant to alkali and to

heat up to 200°C and can be vacuum-distilled without decomposition *1
- on storage, some darkening may occur which, however, will not
notably affect the quality

*1 referring to: d-Tocopherols

11. Toxicological information

Acute toxicity - LD50 > 4’000 mg/kg (oral, rat) *2

- LD50 > 3’000 mg/kg (oral, mouse) *4
- LD50 > 4’000 mg/kg (oral, mouse) *5

Local effects - skin: slightly irritating (several species) *2

- eye: slightly irritating (rabbit) *2
- eye: may be slightly irritating *4

Chronic toxicity - low toxicity (human) *2

Mutagenicity - not mutagenic (various in vitro test systems) *2

- not mutagenic (Ames test) *4

Note - natural compounds with vitaminE and antioxidant function,

showing different biological or antioxidant activity depending on
their detailed chemical structure *1
- intensive skin contact may cause contact dermatitis *2
- GRAS (generally recognized as safe for human consumption) *1

*1 referring to: d-Tocopherols

*2 referring to: dl-α-Tocopherol
*4 referring to: d-γ-Tocopherol
*5 referring to: d-δ-Tocopherol

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12. Ecological information

Inherent biodegradability - well inherently biodegradable

82 %, 28 days
(MITI Test II, OECD No. 302 C) *2

Ecotoxicity - water soluble part barely toxic for fish (rainbow trout)
LC0 (96 h) ≥ 10 mg/l *2
- barely toxic for algae (nominal concentration > 100 mg/l)
(Selenastrum capricornutum)
NOErC (72 h) 26 mg/l
ErC50 (72 h) > 26 mg/l
NOEbC (72 h) 26 mg/l
EbC50 (72 h) > 26 mg/l
(OECD No. 201) *2

*2 referring to: dl-α-Tocopherol

13. Disposal considerations

Waste from residues - incinerate in qualified installation with flue gas scrubbing
- observe local/national regulations regarding waste disposal

14. Transport information

Note - not classified by transport regulations

15. Regulatory information

Note - no classification and labelling according to EU directives

Water hazard class (Germany) 1: weakly hazardous for water (own classification according to
directive VwVwS of 17.05.1999)

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16. Other information

Use - as an antioxidant of natural origin (E306) for edible oils and fats

Note - ranking of biological vitamin E activity:

d-α- > d-beta- > d-γ- > d-δ-tocopherol *1
- ranking of antioxidative activity:
d-γ- > d-δ- >= d-beta- > d-α-tocopherol *1

Edition documentation - first edition

*1 referring to: d-Tocopherols

Important Notice

DSM N.V., headquartered in Heerlen, The Netherlands, has acquired the vitamins, carotenoids,
enzymes, food and feed ingredients, cosmetics ingredients and fine chemicals business (VFC
Business)
of the Roche group of companies, headquartered in Basel, Switzerland. Within the United States,
DSM Nutritional Products, Inc. has purchased certain assets and assumed certain liabilities of the VFC
Business formally conducted by Roche Vitamins Inc. Please note that corporate names, trade names,
trade and service marks and domain names containing the word "Roche" and the "Roche" logo will
continue to appear on our business documentation during our transition. We appreciate your under-
standing and cooperation as we complete our rebranding program. Should you have any questions,
or if DSM can be of further assistance to you, please do not hesitate to contact your Account Manager
or our Account Management Center at: +41-62 866 23 14.

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