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17 views16 pagesRational Drug Design
drug design
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woojung anCopyright
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Introduction to Medicinal Chemistry
Scope of the Lecture Series
Week 1: Drug Targets
Wook 2: Pharmacodyamics and pharmacokinetics
Week 3: General Principles and Strategies for drug design and discovery
Week 4: Drug design tools and methods
Week 5: Case studies of drug discovery
Materials and References
Graham L. Patrick, An Introduction to Medicinal Chemistry, Sth Ed.
Ray Losile, NTU and Astrazeneca, Advanced Medicinal Chemistry (RSC Resource) Drug Design: Substrate Optimization
Different functionalities in a drug affect its binding properties.
-Interconvertible functional groups that play a similar biological function are called isosteres.
-Isostores have somewhat different charge distribution, and so biological activity and affinity difors
for each variant.
The study between the molecular structure and activity is called SAR.