ISQ SpareParts OnlineVersion
ISQ SpareParts OnlineVersion
Xcalibur™, ISQ, TRACE GC, TRACE GC Ultra, and FOCUS GC are trademarks and/or product names of
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all previous information received by the purchaser.
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Sale shall govern all conflicting information between the two documents.
Thermo Fisher Scientific is the manufacturer of the instrument described in this manual and, as such, is responsible for
the instrument safety, reliability and performance only if:
• installation
• re-calibration
• changes and repairs
Thermo Fisher Scientific is not liable for any damages derived from the non-compliance with the aforementioned
recommendations.
Regulatory Compliance
Thermo Fisher Scientific performs complete testing and evaluation of its products to ensure full compliance with
applicable domestic and international regulations. When the system is delivered to you, it meets all pertinent
electromagnetic compatibility (EMC) and safety standards as described in the next section or sections by product name.
Changes that you make to your system may void compliance with one or more of these EMC and safety standards.
Changes to your system include replacing a part or adding components, options, or peripherals not specifically
authorized and qualified by Thermo Fisher Scientific. To ensure continued compliance with EMC and safety standards,
replacement parts and additional components, options, and peripherals must be ordered from Thermo Fisher Scientific
or one of its authorized representatives.
THIS DEVICE COMPLIES WITH PART 15 OF THE FCC RULES. OPERATION IS SUBJECT TO
THE FOLLOWING TWO CONDITIONS: (1) THIS DEVICE MAY NOT CAUSE HARMFUL
INTERFERENCE, AND (2) THIS DEVICE MUST ACCEPT ANY INTERFERENCE RECEIVED,
INCLUDING INTERFERENCE THAT MAY CAUSE UNDESIRED OPERATION.
CAUTION Read and understand the various precautionary notes, signs, and symbols contained inside
this manual pertaining to the safe use and operation of this product before using the device.
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C
Contents
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix
About Your System. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .ix
Power Ratings. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . x
Contacting Us . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . x
Related Documentation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xi
Safety Alerts and Important Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xi
Hydrogen Safety Precautions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xiii
Preface
This guide contains detailed information about ordering spare parts for the ISQ mass
spectrometer.
GC/MS represents a combination of two powerful analytical techniques: GC, which acts as a
separation technique and MS, which acts as a detection technique. Complex mixtures of
individual compounds can be injected into the GC, either manually or through the use of an
optional autosampler, and then separated for presentation to the MS. The MS will then
generate a mass spectrum of the GC eluent and its components, which can be used for
qualitative identification, as well as accurate and precise quantification of the individual
compounds present in the sample.
WARNING Thermo Fisher Scientific systems operate safely and reliably under carefully
controlled environmental conditions. If the equipment is used in manner not specified by
the manufacturer, the protections provided by the equipment may be impaired. If you
maintain a system outside the specifications listed in this guide, failures of many types,
including personal injury or death, may occur. The repair of instrument failures caused by
operation in a manner not specified by the manufacturer is specifically excluded from the
Standard Warranty and service contract coverage.
Power Ratings
Mass Spectrometer (MS)
• 100-240 V ac, 50/60 Hz, 15 A max
The foreline pump must be set to the line voltage that will be used at your location. Detailed
instrument specifications are in the Product Specification or Product Brochure.
Note Always make sure that, in case of emergency, it is easy to disconnect the electrical
cable of the system.
Contacting Us
There are several ways to contact Thermo Fisher Scientific.
Phone 800-532-4752
Fax 561-688-8736
E-mail US.Techsupport.Analyze@thermofisher.com
Phone 800-532-4752
Fax 561-688-8731
E-mail us.customer-support.analyze@thermofisher.com
Related Documentation
In addition to this guide, Thermo Scientific provides the following documents for the ISQ.
These documents are also available on a “Print-By-Request” basis.
Instrument Help is available from within the ISQ Autotune and Method Editor software.
To suggest ways we can improve the documentation, use your browser to complete our
documentation survey.
WARNING This is the general warning safety symbol and safety alert word to prevent
actions that could cause personal injury. It highlights hazards to humans or environment.
Each WARNING safety alert is preceded with this safety symbol and another appropriate
safety symbol (see Safety Symbols and Signal Words.) Then it is followed with an
appropriate safety precautionary message. When you see a safety alert on your instrument
or in the publications, please carefully follow the safety instructions before proceeding.
CAUTION This is the safety alert word to prevent actions that may cause personal injury
or instrument damage. We use it to highlight information necessary to prevent personal
injury or damage to software, loss of data, or invalid test results; or might contain
information that is critical for optimal system performance. A CAUTION safety alert is
always preceded with an appropriate safety symbol (see Safety Symbols and Signal Words.)
Then it is followed with an appropriate safety precautionary message. When you see a
safety alert on your instrument or in the publications, please carefully follow the safety
instructions before proceeding.
BURN HAZARD: This symbol alerts you to the presence of a hot surface that
could or may cause burn injuries.
ELECTRICAL SHOCK HAZARD: This symbol indicates that an electrical shock
could or may occur.
FIRE HAZARD: This symbol indicates a risk of fire or flammability could or
may occur.
FLAMMABLE GAS HAZARD: This symbol alerts you to gases that are
compressed, liquefied or dissolved under pressure and can ignite on contact
with an ignition source. This symbol indicates this risk could or may cause
physical injury.
GLOVES REQUIRED: This symbol indicates that you must wear gloves when
performing a task or physical injury could or may occur.
HAND AND CHEMICAL HAZARD: This symbol indicates that chemical
damage or physical injury could or may occur.
INSTRUMENT DAMAGE: This symbol indicates that damage to the
instrument or component may occur. This damage may not be covered under
the standard warranty.
LIFTING HAZARD: This symbol indicates that a physical injury could or may
occur if two or more people do not lift an object.
MATERIAL AND EYE HAZARD: This symbol indicates that eye damage could
or may occur.
RADIOACTIVE: This symbol indicates that exposure to radioactive material
could or may occur.
READ MANUAL: This symbol alerts you to carefully read your instrument’s
documentation to ensure your safety and the instrument’s operational ability.
Failing to carefully read the documentation could or may put you at risk for a
physical injury.
TOXIC SUBSTANCES HAZARD: This symbol indicates that exposure to a
toxic substance could occur and that exposure could or may cause personal
injury or death.
This is the general warning symbol that the ISO 3864-2 standard uses to
prevent personal injury. This symbol precedes the WARNING safety alert
word. In the vocabulary of ANSI Z535 signs, this symbol indicates a possible
personal injury hazard exists if the instrument is improperly used or if unsafe
actions occur. We use this symbol and another appropriate safety symbol to
alert you to an imminent or potential hazard that could cause personal injury.
Hydrogen has a flash point of - 423 °F (- 253 °C) and an auto-ignition temperature of
1,040 °F (560 °C). It has a very low ignition energy and the highest burning velocity of any
gas. If hydrogen is allowed to expand rapidly from high pressure, it can self-ignite. Hydrogen
burns with a flame that can be invisible in bright light.
WARNING - FIRE HAZARD: The use of hydrogen as a carrier gas is dangerous. Hydrogen
is potentially explosive and must be used with extreme care. Any use of hydrogen gas must
be reviewed by appropriate health and safety staff and all installations of hydrogen systems
must be performed to applicable codes and standards. Thermo Fisher Scientific assumes
no liability for the improper use of hydrogen as a carrier gas.
Before you begin using hydrogen, you should conduct a risk assessment based on the quantity
of hydrogen to be used and the conditions of your laboratory. You should ask yourself:
“What hydrogen hazards associated with this project are most likely to occur?”
“What hydrogen hazards associated with this project have the potential to result in the
worst consequences?”
• Try to reduce or eliminate the higher risks by using the proper ventilation to remove
hydrogen gas before an ignitable concentration can accumulate. You should also consider
purging the hydrogen to further reduce hazards and ensure anyone who will be working
with hydrogen has basic hydrogen safety training.
• As with laboratory safety in general, be sure to wear safety glasses, laboratory coats, gloves,
etc. Typically there are no specific requirements for gaseous hydrogen, other than eye
protection when working with a compressed gas. If working with liquid (cryogenic)
hydrogen, insulated gloves and protective shoes should be worn in addition to eye
protection.
• You should post “No Smoking” and “No Open Flames” signs to identify hydrogen
sources and cylinders. Maintain, inspect and leak-test all hydrogen sources regularly.
• All hydrogen shutoff valves should be clearly marked and permanent hydrogen piping
should be labeled as such at the supply or discharge point and at regular intervals along its
length. Where hydrogen gas piping passes through a wall, the piping should be labeled on
both sides of the wall.
• There should also be contingency plans in place should an incident occur.
• The site emergency response team, as well as the local fire department, should know the
location of all hydrogen storage tanks.
Front Panel
Screw
Make sure all the covers and panels of the ISQ are firmly attached before powering on the
ISQ. If you vented the system, make sure the vent valve is tightly closed before powering on
the system. Make sure the vacuum manifold is vacuum-tight before powering on the system.
Note When powering on the system, do NOT reach over the top of the instrument to
power it on. Instead, reach around the right side or go to the back of the instrument and
flip up the power switch.
Manual shutoff valves should be provided near each point of use, within immediate reach.
If a hydrogen cylinder or hydrogen generation system is located within immediate reach,
a separate point-of-use shutoff valve is usually not necessary.
Line regulators that have their source away from the point of use should have a manual
shutoff valve near the point of use.
An emergency gas shutoff device in an accessible location outside the use area should be
provided in addition to the manual point-of-use valve in each educational and
instructional laboratory space that has a piped gas supply system.
If necessary, the piping system should have uninterruptible pressure relief. The pressure
relief system should be designed to provide a discharge rate sufficient to avoid further
pressure increase and should vent to a safe location outside or to a ventilation system
exhaust.
Purchasing Hydrogen
Use the following guidelines when purchasing hydrogen:
• Hydrogen Generator—Because it minimizes the amount of hydrogen present and reduces
the degree of hazard, a hydrogen generator (also called an electrolyzer) is the safest way to
purchase hydrogen in the quantity used in GC/MS.
However, to minimize the degree of hazard, the hydrogen generator must only be
operated in a non-explosive environment because hydrogen buildup can be ignitable.
This means that your ventilation system for the room or lab hood must maintain an air
exchange rate that is at least two orders of magnitude greater than the maximum
hydrogen production rate of the hydrogen generator. Be sure to follow the manufacturers'
directions about proper use and maintenance of the regulator.
To prevent the possibility of releasing hydrogen, the hydrogen generator should be set to
shut down if:
− There is a loss of flow to the ventilation system
− A hydrogen detector alarms at 25% of the lower flammable limit of hydrogen in air.
The oxygen exhausted by the electrolyzer should be vented to the outside as well.
• Hydrogen Cylinder—Hydrogen can be delivered in standard laboratory gas bottles or
cylinders. These cylinders have a limited amount of hydrogen in them and are a safe way
to transport and store hydrogen. However, compressed hydrogen gas cylinders, like all
compressed gas cylinders, must be secured in an upright position, ideally with a
non-combustible chain or cable. If the cylinder falls over, the valve can be knocked off
and the pressurized cylinder can take off like a rocket, which leads to the release of
hydrogen and possibly an explosion, severe injury, or death. Never crack a hydrogen
cylinder valve to remove dust or dirt from fittings prior to attaching a regulator, as there is
a risk of self-ignition.
• NFPA 497, Recommended Practice for the Classification of Flammable Liquids, Gases,
or Vapors and of Hazardous (Classified) Locations for Electrical Installations in Chemical
Process Areas
• NFPA 13, Standard for the Installation of Sprinkler Systems
• NFPA 45, Standard on Fire Protection for Laboratories Using Chemicals
• NFPA 55, Standard for the Storage, Use, and Handling of Compressed Gases and
Cryogenic Fluids in Portable and Stationary Containers, Cylinders, and Tanks
• NFPA 68, 2007 Standard on Explosion Protection by Deflagration Venting
• NFPA 69, Standard on Explosion Prevention Systems
• NFPA 91, Standard for Exhaust Systems for Air Conveying of Vapors
• NFPA 255, Standard Method of Test of Surface Burning Characteristics of Building
Materials
• OSHA 29CFR1910.103 1910.103 Hydrogen
Contents
• Identifying A Part
• Calibration Gas Components
• Column Components
• Filter Components
• Ion Source Components
• Electron Multiplier Components
• Dual Filament Components
• Analyzer Components
• Board Components
• Power Supply Components
• Vacuum Interlock Components
• Manifold Components
• Cover Components
• ISQ Toolkit
• Upgrade Equipment
Identifying A Part
To identify a part, you need to know where it was located in the ISQ or the part’s relationship
to a particular functionality of the ISQ. Use the categories in the table below to find a location
or functionality that relates to the component you need. For example, if you know the part is
related to the calibration gas, look in the Calibration Gas Components category. Then refer to
the illustrations in that category to visually identify that particular part.
IMPORTANT Only components with a part number are available for purchase. The part
you are looking for may be shown in an illustration, but if it does not list a part number, it
is not available.
• Transfer Line
• Single-Level Calibration Gas Controller
• Dual-Level Calibration Gas Controller
• Calibrant Reservoir Kit
• Gas Mixing Chamber
• FC-43 Calibration Compound
Gas Mixing
Chamber
Calibration
Gas Controller
Transfer Line
Calibrant
Reservoir Kit
O-Ring
Single-Level Calibration Gas Controller Click here to view in 3D motion Quantity: Each
Dual-Level Calibration Gas Controller Click here to view in 3D motion Quantity: Each
Column Components
You can purchase the following column components for the ISQ mass spectrometer. Be sure
to reference the component’s part number when placing an order with your local Sales/Service
Representative. See the ISQ Hardware Manual for information about installing these
components or Table 1 for a comprehensive list of available components.
Graphite Vespel Ferrule for 0.25 mm Columns Click here to view in 3D motion Quantity: Pkg of 10
Graphite Vespel Ferrule for 0.32 mm Columns Click here to view in 3D motion Quantity: Pkg of 10
Graphite Vespel Ferrule for 0.53 mm Columns Click here to view in 3D motion Quantity: Pkg of 10
No-Hole Graphite Vespel Ferrule Click here to view in 3D motion Quantity: Pkg of 10
SilTite Ferrule for 0.25 mm Columns Click here to view in 3D motion Quantity: Pkg of 10
SilTite Ferrule for 0.32mm Columns Click here to view in 3D motion Quantity: Pkg of 10
SilTite Ferrule for 0.53mm Columns Click here to view in 3D motion Quantity: Pkg of 10
Nut for SilTite Ferrules Click here to view in 3D motion Quantity: Pkg of 5
Filter Components
You can purchase the following filter components for the ISQ mass spectrometer. Be sure to
reference the component’s part number when placing an order with your local Sales/Service
Representative. See the ISQ Hardware Manual for information about installing these
components or Table 1 for a comprehensive list of available components.
Nylon
Rivets
Ion Lens 2
Repeller Volume
Plate
Ion Volume
Locking Ring
Source-Repeller
Thumbscrews Ion
Cartridge
Sleeve
Repeller
Lens Heater Block
Lens 3/RF Lens
Grounding Strap
Lens Plate
Repeller and Springs
Spring
Ion Volume-Repeller
Thumbscrew-Repeller Insulator
Spacers
Insulating
Spacers
Lens Heater Block Grounding Strap Click here to view in 3D motion Quantity: Each
Lens Plate and Springs Click here to view in 3D motion Quantity: Each
Source to Ion Guide Spacer Click here to view in 3D motion Quantity: Each
Ion Volume Locking Ring Click here to view in 3D motion Quantity: Each
• Electron Multiplier
• Electron Multiplier Plate
• Large Feedthrough
• Anode Feedthrough
Electron
Multiplier
Plate
Large Feedthroughs
Anode Feedthrough
Large
Feedthrough
O-Ring
Standoff Anode
Feedthrough
O-Ring
• Dual Filament
• Filament Retaining Spring
Filament
Retaining Spring
Filament
Analyzer Components
You can purchase the following analyzer components for the ISQ mass spectrometer. Be sure
to reference the component’s part number when placing an order with your local Sales/Service
Representative. See the ISQ Hardware Manual for information about installing these
components or Table 1 for a comprehensive list of available components.
• Analyzer Tray
• Ion Guide
• Ion Guide-Quadrupole Stabilizer
• Ion Guide Wire Set
• Quad Wire Set
• Quadrupole
• Quadrupole Rod Endcap (Metal)
• Quadrupole Rod Endcap (Plastic)
• Quad Entrance Lens
Quad Entrance
Ion Guide-Quadrupole
Lens
Stabilizer
Source Interface
Board*
Quadrupole Rod
Ion Guide Endcap (Plastic)
Quadrupole Rod
Endcap (Metal)
Ion Guide
Wire Set
Quadrupole
Analyzer
Tray
Ion Source**
* See Board Components for information about ordering the source interface board.
** See Ion Source Components for information about ordering the ion source.
Ion Guide Wire Set Click here to view in 3D motion Quantity: Pkg of 2
Quadrupole Rod Endcap (Metal) Click here to view in 3D motion Quantity: Each
Quadrupole Rod Endcap (Plastic) Click here to view in 3D motion Quantity: Each
Board Components
You can purchase the following board components for the ISQ mass spectrometer. Be sure to
reference the component’s part number when placing an order with your local Sales/Service
Representative. See the ISQ Hardware Manual for information about installing these
components or Table 1 for a comprehensive list of available components.
• RF Board
• RF Board/Rod Driver Board Kit
• Rod Driver Board
• Lens Driver Board
• Source Interface Board
• Heat Shield for the Source Interface Board
• Electrometer Board
• Electrometer Shield
• Control Board
• Control Board Support Bracket
• PC Communication Board
• Distribution Board
• 20-Pin Feedthrough
• 4-Pin Feedthrough
Electrometer Shield
RF Board
Electrometer Board
20-Pin Connector
Control Board
Support Bracket
4-Pin Connector
Heat Shield for Source
Interface Board
Source Interface
Board
Control Board
RF Board/Rod Driver Board Kit Click here to view in 3D motion Quantity: Each
WARNING ELECTRICAL SHOCK HAZARD: For safety reasons, the fuses on the lens driver
board can only be replaced by Field Service Engineers.
Heat Shield for the Source Interface Board Click here to view in 3D motion Quantity: Each
Control Board Support Bracket Click here to view in 3D motion Quantity: Each
20-Pin
Feedthrough
O-Ring
4-Pin
Feedthrough
O-Ring
Power Supply
System
Dynode/Multiplier
Power Supply
Dynode and Multiplier Power Supply Click here to view in 3D motion Quantity: Each
Clip
Sealing Ball
Manifold Components
You can purchase the following manifold components for the ISQ mass spectrometer. Be sure
to reference the component’s part number when placing an order with your local Sales/Service
Representative. See the ISQ Hardware Manual for information about installing these
components or Table 1 for a comprehensive list of available components.
Vent Valve
Knob and
O-Ring
Source
Magnets Manifold O-ring
Front Plate Bracket
Cover Components
You can purchase the following cover components for the ISQ mass spectrometer. Be sure to
reference the component’s part number when placing an order with your local Sales/Service
Representative. See the ISQ Hardware Manual for information about installing these
components or Table 1 for a comprehensive list of available components.
Right Side
Left Side Panel
Panel
Top Manifold Cover (glass) Click here to view in 3D motion Quantity: Each
Front Door Hinge Support Click here to view in 3D motion Quantity: Each
ISQ Toolkit
The ISQ ships with a toolkit that contains all the tools you will need to perform maintenance
on the instrument. It does not contain any consumable items or cleaning supplies. You can
purchase any item in the toolkit individually or you can order a complete kit. Contact your
local Sales/Service Representative to place an order. See Table 1 for a comprehensive list of
available components.
• ISQ Toolkit
• Source Exchange Tool
• Bushing in the Source Exchange Tool
• Seal in the Source Exchange Tool
• Clip in the Source Exchange Tool
• Column Measuring Tool
• Source Holder
• T10 Torxhead Key
• T20 Torxhead Key
• T30 Torxhead Key
• Forceps, 8 in.
• Wrench, open-ended, 1/4-in., 5/16-in.
• Wrench, open-ended, 3/8 in., 7/16-in.
Bushing in the Source Exchange Tool Click here to view in 3D motion Quantity: Each
Seal in the Source Exchange Tool Click here to view in 3D motion Quantity: Each
Clip in the Source Exchange Tool Click here to view in 3D motion Quantity: Pkg of 5
Wrench, open-ended, 1/4-in., 5/16-in. Click here to view in 3D motion Quantity: Each
Wrench, open-ended, 3/8 in., 7/16-in. Click here to view in 3D motion Quantity: Each
Upgrade Equipment
The following upgrade equipment is available for the ISQ. Contact your local Sales/Service
Representative to place an order. Once you receive the equipment, refer to the ISQ Hardware
Manual for installation information or Table 1 for a comprehensive list of available
components.
CI Reagent Gas Flow Module Click here to view in 3D motion Quantity: Each
Ion Gauge Tube Shield Click here to view in 3D motion Quantity: Each
Standard Capacity Turbomolecular Pump Click here to view in 3D motion Quantity: Each
Extended Capacity Turbomolecular Pump Click here to view in 3D motion Quantity: Each
High Capacity Turbomolecular Pump Click here to view in 3D motion Quantity: Each
Components in 3D Motion
This section contains 3D models of each available ISQ component. Once you click the
graphic, the window will open as shown below and you can completely control how you view
the component. Only those components with a part number can be ordered from Thermo
Fisher Scientific.
Note You must click on the component to activate 3D motion and view the panes below.