Substintion relate 1 A (2) Deachivoting #4 amie vg EAS, relate th ti Deactivaing groups “pope ortho: pare Sreciors meta: Srectors H Aicolnle, Dhensls, and Ethers N)erneral Stuctwres and nara ictic FVeganic_onaloye vg wate (recenblonte_ of structure): iatludet Ggmpownds Whe alemols 2 phenols, whet one or losth sg _waltt's ydngen atoms ort replaced by a culpstituent + Water (1,0): O,eitver cam ve (a + Qlaint QO om oe gre. ermaneage¥a (mtr 1) setter: ae 5 = ~ Fest Ota Laryl qyrony 16 gegitioe,, seem is Mga tive other dervatives stat: R = Awoynonel Ay -S-¥ - Oulde) ReS- Sulghngdyl or mexeapt Qreap *eromptes: ) cn) = mnt gular Awan ether aGre pole tout wet ac wave as allel eookts Te eeleanlt ee pala; eae ewyyen (2) 7 Miygen hos Wigh © density, mart elechonegativ, compared 1 Laver & Hydngen IB) Clatsigication 2 Womencrostre: T) Mawes: + Vassigicotion. 5) Attneding 1B mW of Iggy) great’ 1) Mevetydinyy, alainot. 3-48 4 onan nto a 12) Poyhydragy alata: 2 2 - om RAM gy f-0H on = phenol : mia2) Retmeding +9 hwye os, Swoctntwtnt: 2) Miley) alcove. = DH attacked ty an SpP-hyoridized Carrom came mene sat = ONG) Wrehonel Auge of Alley alobale: 1) Prima: 1” ~ OH is attnoned fo 9 carom Dended yo mniy A Ney gray © qenewal ctuctare > t R (4 “ + ccample: Aaawnt (CCH, OW) 2) Seumaang - 2° = DA tc attndnd fe a carom Donded te 2 alta) group on Sonera _chructare: t af wi “ + owmg\e: igvpnyy) oles Ligvpreqanol (ods CHOHCHS) = Oy CHa cH “OH CH ‘Bee: baahyh eaten Baten-t-ut New Sree act Ne CUE og Ae, sport canta =o” eomamengeeo Cmte 6) 3) Terhiang: 3° TOW ic attuned 0 caren bmded 4p_ 5 alieyl avong oH “general Shuctwe: aby Raw 4 + Crample’ YeadAowtanal ((e8), 008) ety “etn ert-atyl ey H-OU. izamvialpesoe chy 2-0) 4 Wemenclotwre (Cemmin narne) 1) Based on the alten\ ormay whet We Wed ray) ovenp is attncned 40 Sy Nsepmyy) aleal: 0 WOH CUS CHOHCH, yd -t daw my aren Qo nh ene = ignore 4 peP MN alemel +Wwwenthaart CURA We): © FOE Yee Verge Cartoon Onan gontmaning) Ame WH gene a Number AM cormat og tM porta esis egining whan aoe “UN oeong AW ware 2 Pwmlour ey, Gens titwontt aweding 1 ANGE ration MARE Therr_mut_art applicable to mart of tht alcabole4. Wee HH cubphuentt in. olpldoeded wed, 2 etqlace Aine, smi ag Ae parent nai No ‘ MIR: There ratte_avt applicable fo mart of th _aleakele. a 2-metny| peatin-2- 01 22) Vivw)ic alti gattons CH=CH, ecm 1) Gg = CROW Ls Gonstion nome: Vinyl alta’ Y Tupne mame: AL-eten 4-0) 1) Chh=cH-et chy, “ Cama nawe. ROK Le TWPAC name. 4-Pea pen-2-0l 23) Allylic alosaal: an ally\ is compsed og” CHgCH=CH example: CH CH HOR + 9° shuctwrt WRN. name. L- Prpen-3-0) AgCH? CHOW iy Com AG fame: 2- buen: 2-0) ermnneageko (mis 16) 24) Bensalic Alemnol © “OH ism a corlom ned Po G benzene ving Hol divectly guostitatta; cannecttd 4 an alkyl qronp degre the benzene ring Tertary Co Or “OW is directly pended te o loenzene Prmary Secondary ¥ing, = eta Myprcal _olesnel pinky have acidic prpedits W)Ywomn\: 4 Classi gication ~ has 0 Wigdima\ gre lomded 4p an Arrmatie ving, “chart Yee sing properties yada Gleels oul ic mat aed4 Noten clature: = ee_word phenol” ic weed ot ag tHe NOME VE gpecigic gubecTonce Chy lvmybenzene) and as “tee sarmithy Nome gor all Wyydveny- ral stitwed Gwemehe compounds DU O Q T) Eis 4 Clossigication DSqnmutrivat’ Dot slhey\ [aryl qrewp is om iter gibt of Mayatn art tt Eand esamnges CHC, DEH Cy 3) Asymmetrical two olay) fang oyrous art digreront we Hy O-Cty Hy S eng) meen) tae ar Oo SOyehiC Mugg ie pee ag a tng, “Ales aw wl, G emveunter mud be eum vite eomameghka (wie 6) Comey _epeyide (5 membre) owe. mumboertd) be ai ; A Nomenchate Comme ame): —Baged on ee armas attravaed tn tre Nit, 1) Swoettueets Ore acranged, aceerding Ae Comployity Sotto omnes sigs ghey A Nomenclature, (AMPAC) : VVTdenthgy tre Iergest chain / Largest ving) a) Nuwloer Ye gartoons in Yee parent Unoie whet Yine shard ic en Hee Cartom contd 7 Yen elton whggun aS home Yee -OR cwestitweal grap a “al very” Tame jae cherie guste “ON” ‘tq methane —te—mnetan iy Wy yically mm we rigid side Gy You remaing alkyl [amyl qrrap ow He Vegt is ac icsoap: CAs 0CR3 Commer name: Dimatiegs etnor TWRAG name. Metavrymetnane, cy OCH, CA, Comaten nants. Etsy meting) Cher TAIN wae: WeMevy Gthane (.Prrpertier 2 eect Cnemical Reactions : + Properties © T) Maines: T-A) Dhiysical Properticn: 1) Alodal = Motul thydimen Bends fara Aan water 74 ranching + +8P 7 44 F Carbon atoms 4 WW 2) Migeabs lity: “mitAble wl par svlventt Washer Canpraedt bol Fever = imi ccatele. wl] nonpolar swentt rmanegeo Canis 6) 3.) Lolubor\ity: - Sluble in woiler 4 alley) hain + ¥ Solu ity, “R-OH Ww) E35 Caroong = inginitely, slwele in 120 we wl 24 Cortogne: limited alata Gant Mi neha aol T.B) Chemical Properties: D)Wueleepitic propery: -alooluls Honseormed +p allaride fan aha aUcltnpWnittr 2) headity and A bas . — y ‘a = one eS, <= ROW RO alate OT alvyingesien auveride “GO EC beds are ¢ donating, Gea alta qyray = note” donating ty duyoen Gert fy O44 Nona cheitorine, Stalalizee re alkaydt im * strength of _acidA¥y | basicly fogoes“ik dyygen's (+) Unowe deotases, A dayntmates = adds ae ath ae gems cvivition AE me chable Hae Cmjngatt is, amore readily te “OH ome degntnale, S)Surephinlity vy Ovidatim = 1°79 aldehyde Sf cmp se = eacon - 2° = velme T)_Yhene \s- D.A) Physical _prepertite: \) Appearance, 2 Oder! ~calerteas = white cngcalling = sweed 2 tong / medi Give 4) poling Bsieh : ~ gunerally naw higher BP dean Vnydie cartons W] similar MAN! due 1 stengay Wydireyen Jomading, 3) SMulility: ~gi\wole in wait emmamegeko (mit 1-6) MOL alwoe in Am-priar / ogame savin’ D.B) Unveanical_ Properties: v) heidily Tweak Gad cewvpaed TP Caro my\it_ avid “Addie than alipataic alealarls = Ame AP regmance _choloilizatin on You qhemesde te he ©) marge on dnt oxiggtn is elecalized grur ae Wunzert 4 Gws8 Stolle = discociqtion os ae > vtacks wl strng bases den) peak w/ Weak longs G wt addic erragh aig Wwonced oy _gwlosthwonts Ai ‘yuntene_ v9) € -witadiranag 4 adder Ze Me prevented vilken fren ane at tet ortie ® pare C-Asnating. + addi hy TS) tihers Ts) Ply ca grryertits: 1) Mitaioility: TWidIGe WW yd = Some = 4 alntiig ~ prlar_omymads dissohe | at\earh_ ty some extent “Mon-prlar dissvlves a) Baling Yani: ~ Vener Seay aeabies, Comparratolt 1 ON anes 1.8) Unewnical Yapories: 1) Dends: dota wah hove Vhydrqun toed , tot? *Yoend con germ etween effroy & wakur H-bond San perm _lbehyiitn, atau 2 add = Was 0 ne diqalt mvement ___ 1m & pony y co teas | due_hy phowty 4 CO beds Nout Nets pelar rat alahale $Ungwi cal Reneliens” | T) Mowe: W) Synthesic og pole car'o my Compound ¥) Reduction og Madelgder 2 wetmey | cea On pal i A, & TON ey cn EN Prima sect | ——————~ "scans “Seams Bh ee retcngaget uence, | Son an > cHscHachach A Oo ama cHachachatH “Fararation, A wg nn af gh we Aegis tiptepense wo anos busbar cna —_ ROH > pnane+H20 | eu Ivana aerate (acon) ‘Meee gents ae — gece SPIE mem a rraanegebo Cis 16) crscraghOH a, Becae } CH3 a I~ Le He HS “CHE E)Gawersion inte @ Williamson Error ‘aoe telat cree se soe + Tes nite econ an rp they racan an ah wth hat metal acon wth soa base suc al On, ONT, 0 | One Oe ‘+ Itis an SN2 reaction, "Nucleophile substitution of halide ion by the alkoxide ion 0 me secre rm sae ening ee Orc ce ton ats ant 0 moss oman ‘hen acon canned W)Promle: | m)Mara\-\ite Reagtionc: + Moro certs ery SA acto hy a nm eres ase. one weer sae Noz {+ The-0H ian axing. oho. enparerecng sbstvet in EAS eaten 1 Pans we reasve stances or secre Rogen, hon, and foton, OS Or Lr ©) dyidoXin 04 Phenol (Quinme): * Pen ort inn acon he ae wa th Scie ae + Gnaten os Phat wih Sen Oktvoale ys 9 eeshena2-en-Aone or Vaal cll amps ben ri Tay + Simone: aah a ans Seneca Sos La-O0=6 |ermnnegeKa (wait 66) 8.) itraton: “e an aisle are formed when aisle inleracs wit svong suri and ie a TD) thers: A) Dwe Ay Aly Grenpe * eee ey ent nay ne oo CO} = or 0 HLOCiHe 60:9 4003+ 840 2 Halgenton in 0 of be vd stun proces hf Br B) we tp Etneeal Oxygen: = Rennes 7 Etersare unreactive to mos coton reagents aloes, il is and bases, 1, Perse Faration ‘When ether cores noun th anosphcO (nthe presence ofsunigh). itera ‘wih Oto goneate pera due fo he presence of lne pi of leona on fe oe - z and nucleophiles have no elect on ethers > Ethers undergo only one general reaction ~ they are deaved by strong acids such ‘thereat onygen, 2 aqueous Hl or Hk sets anerteag TD) Preparation a4 Ethers: 1) Quay gration. a H H3C -6-CH3. > [r20-6-c10| 4) williangen Syyteesic: ; ; Pps cen wooo ©) Reactions in Avamatic. Etre: ; 4) Holey emartion: oi CH3Br + SrecteoNs ——> CH30CH2CH3 + NaBr -inthe benzene a ‘ny! alkyl ethors undergo normal halogenation, Even nthe aoeence of acta anacle conics ornaon marl ct Mahony grup scvaes the bance Ochs er cement 1D) Appleations: a) Fried -Graets ~ewomel ic a gach odditiet 7a ay ed nf spa wh re pao ae aso a indwstal svent, and a hue agg ania an at ae the pesenes of syeos A ons cts cts = Prenol is 0 qamenal disingectont O 7 S 2 S tages acid nee ~ Wbiquinenss (thenayme, h) ave \air Onemical OfidAiAg agent a mediates € hransqur pnttel lanied 18 enemy prrduction= dighag\ ctor ic medically, wed ag o reaction Srlyent , was once geplor oon “unhaled aMcYnei¢