DRAFT

B.E. Biomedical Engineering (BM)

Choice Based Credit System (CBCS)
Semester - V
Management and Entrepreneurship
Subject Code : 15EI/BM/ML51 IA Marks : 20
Number of Lecture
: 04 Exam Marks : 80
Hours /Week
Total Number of
: 50 Exam Hours : 03
Lecture Hours
Credits – 4 (Each module – 10 Hours)
Module -1
Management: Definition, importance – nature and characteristics of Management, Management
functions, Roles of Manager, Levels of Management, Managerial skills, Management & Administration,
Management as a Science, Art or Profession- Development of Management Thought - Early Management
Approaches, Modern Management Approaches.
Planning: Nature, importance and purpose of planning, Types of plans (Meaning only), steps in planning
& planning premises, limitations of planning, Decision making – meaning, types of decisions.

Module -2
Organizing and Staffing: Meaning, Nature and characteristics of organization – process of organization,
Principles of organization, Departmentalisation, Committees –meaning, types of committees,
Centralization Vs decentralization of authority and responsibility, Span of control (definition only) ,
MBO and MBE (Meaning only). Nature and importance of Staffing, sources of recruitment and steps in
selection procedure.
Directing and Controlling: Meaning and nature of directing-Leadership styles (Autocratic, Democratic
and Free-Rein), Motivation Theories (Maslow’s need-hierarchy theory and Herzberg’s two factor theory),
Communication – Meaning and importance, Coordination- meaning and importance, Techniques of
Coordination. Meaning and steps in controlling – Essentials of effective control system.

Module -3
Entrepreneur: Definition of Entrepreneur, Entrepreneurial process and structure, characteristics of
entrepreneurs, qualities of entrepreneurs, classification of entrepreneurs, Intrapreneur – an emerging
Class, comparison between entrepreneur and Intrapreneur, functions of entrepreneurs, Role of
entrepreneurs in Economic Development ; Concept of Entrepreneurship , phases of entrepreneurship and
its Barriers. Theories of entrepreneurship (in brief), conceptual model of entrepreneurship, Stages in
entrepreneurial process; Entrepreneurship in India.

Module -4
Small Scale Industry: Definition; Characteristics, Objectives and Scope; role of SSI in Economic
Development. Advantages of SSI, Steps to start an SSI – Government policy towards SSI; Impact of
Liberalization, Privatization and Globalization on SSI, Impact of WTO/GATT on SSIs, Ancillary
Industry and Tiny Industry (Definition only).
Institutional Support: Different Schemes: TECKSOK, KIADB, KSSIIDC, DIC, SISI; NSIC; SIDBI;
KSFC.

Module -5
Preparation of Project: Meaning of project, project objectives, characteristics of objectives, project
classification, project cycle, Project Identification- meaning & importance; Project Selection criteria,
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Project formulation- meaning and sequential stages of project formulation, Planning commission’s
Guidelines for project formulation/reports;
Project Report-Need and Significance of Report, Contents, formulation, Network Analysis- need and
importance of network techniques, steps , advantages and limitations of PERT and CPM, differences
between PERT and CPM.
Identification of Business Opportunities – Market Feasibility Study; Technical Feasibility Study;
Financial Feasibility Study & Social Feasibility Study.

Question Paper Pattern:

 The question paper will have TEN questions.
 Each full question carry 16 marks
 There will be TWO full questions (with maximum of THREE sub questions) from each module.
 Each full question will have sub questions covering all the topics under a module.
 The students will have to answer FIVE full questions, selecting ONE full question from each
module.

Text Books:
1. Principles of Management – P.C.Tripathi, P.N.Reddy, Tata McGraw Hill, 4th Edition, 2010.
(Module 1 and Module 2)
2. Dynamics of Entrepreneurial Development & Management – Vasant Desai, Himalaya Publishing
House, 2011 (Module 3 and Module 5)
3. Entrepreneurship Development-Small Business Enterprises – Poornima M. Charantimath,
Pearson Education, 2006 (2 & 4). (Module 4 and Module 5)

Reference Books:
1. Management Fundamentals – Concepts, Application, Skill Development -Robert Lusier, 5th
edition, Thomson Publications, 2011.
2. Entrepreneurship Development – S. S. Khanka, S Chand & Co., 2007.
3. Management – Stephen Robbins, Pearson Education / PHI – 17th Edition, 2003.
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B.E. Biomedical Engineering (BM)

Choice Based Credit System (CBCS)
Semester - V
Fundamentals of Signals and DSP
Subject Code : 15EI/BM52 IA Marks : 20
Number of Lecture
: 04 Exam Marks : 80
Hours /Week
Total Number of
: 50 Exam Hours : 03
Lecture Hours
Credits – 4 (Each module – 10 Hours)
Module -1
Introduction to Signals and Systems:
Basic elements of a DSP System, Classification of Signals, Sampling Theorem (statement and problems
on Nyquist rate), Discrete Time Signals (Representation, Standard Signals, Classification, and
Operations), Discrete Time Systems, Convolution Sum, Cross correlation and Auto correlation of
sequences.
Text 1: 1.1.1, 1.2, 1.4.2, 2.1, 2.2, 2.3.3, 2.3.7, 2.6.1.

Module -2
Z- Transform and its Application to analysis of LTI Systems:
Direct Z-Transform, Properties of the Z-Transform, Examples, Inverse Z- Transform by Partial- Fraction
Expansion method only, System Function of a LTI System, Causality and Stability (from H(z)).
Realization of Digital System: Direct Form I, Direct form II, cascade form and parallel form
Text 1: 3.1.1, 3.2, 3.4.3, 3.3.3, 3.5.3.
Text 2: 9.2,9.3

Module -3
DFT: Properties and Applications:
Definition and Problems on DFT & IDFT, DFT Properties – Periodicity, Linearity, Time Reversal,
Circular Time Shift, Circular Frequency Shift, Circular Convolution, Multiplication of two DFTs &
Circular Convolution, Parseval’s Theorem, DFT in linear filtering. Introduction to FFT, 8-point DFT
Computation using Radix-2 DIT-FFT & DIF-FFT methods only, relevant examples.
Text 1: 7.1.3, 7.2, 7.3.1, 8.1.3.

Module -4
IIR & FIR Filters:
IIR Filters: Low-pass filter specifications, IIR filter Design by Impulse Invariance & Bilinear
Techniques, Design of Digital IIR filter by Butterworth approach, Examples. Magnitude response of
lowpass Chebyshev Type I, II filter (Theoretical concept only)
FIR Filters: Design of FIR filters – Symmetric and Antisymmetric FIR filters, Design of Linear phase
FIR filters by Rectangular Hamming & Hanning windows. Summary of window function characteristics
(window shape, transition bandwidth, stop band attenuation, etc.). Implementation of FIR filters by direct
form and Single-stage lattice structure only.
Text 1: 10.3.2, 10.3.3, 10.3.4, 9.3.1, 9.3.3, 9.3.4, 10.2.1,10.2.2, 10.2.7, 9.2.1, 9.2.4

Module -5
Multirate Digital Signal Processing & Adaptive Filters:
Introduction, Decimation Process, Interpolation Process, Digital Filter Bank, Adaptive Filters, LMS
adaptive algorithm, Applications, Features & Architectural of TMS320C54XX processor.
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Text 2: 15.1,15.2,15.3,15.4,16.2,16.3,16.5,19.2,19.3.

Question Paper Pattern:

 The question paper will have TEN questions.
 Each full question carry 16 marks
 There will be TWO full questions (with maximum of THREE sub questions) from each module.
 Each full question will have sub questions covering all the topics under a module.
 The students will have to answer FIVE full questions, selecting ONE full question from each
module.

Text Books:
1. Dimitris G Manolakis, John G. Proakis, “Digital Signal Processing: Principles, Algorithms, and
Applications”, 4th Edition, Pearson India, 2007.
2. V.Udayashankara, “Modern Digital Signal Processing”, Third Edition, PHI 2016

Reference Books:
1. Simon Haykin and Barry Van Veen “Signals and Systems”, John Wiley & Sons, 2nd edition
2. S K Mitra, “Digital Signal Processing”, 4th Edition, McGraw-Hill, Year
3. Avtar Singh, “Digital Signal Processing Implementation”, Brooks Cole
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B.E. Biomedical Engineering (BM)

Choice Based Credit System (CBCS)
Semester - V
Clinical Instrumentation-I
Subject Code : 15BM53 IA Marks : 20
Number of Lecture
: 04 Exam Marks : 80
Hours /Week
Total Number of
: 50 Exam Hours : 03
Lecture Hours
Credits – 4 (Each module – 10 Hours)
Module 1:
Electrocardiogram: Action potentials in cardiac muscle, Characteristics of the normal ECG, Cardiac
arrhythmias and their electrocardiographic interpretation- Abnormal sinus rhythms, Abnormal Rhythms
by impulse conduction blocks, Premature contractions, Paroxysmal Tachycardia, Ventricular & Atrial
Fibrillation, Atrial Flutter, Cardiac arrest. Heart sounds, Phonocardiogram, Valvular lesions (Abnormal
heart sounds)
(Text1: Chapter 9, Chapter 11, Chapter 13, Chapter 23)

Module 2:
Catheterization Laboratory Instrumentation, Arrhythmia monitor, Exercise stress testing, Ambulatory
monitoring instruments (Text2: 6.10, 7.2, 7.4, 7.5)
Foetal Monitoring Instruments: Cardiotocograph, Abdominal Foetal Electrocardiogram, Foetal
Phonocardiogram (Text2: 8.1, 8.2.1, 8.2.2)
Oximeters: Oximetry, Ear Oximeter, Pulse Oximeter, Skin reflectance Oximeters, Intravascular Oximeter
(Text2: 10.1, 10.2, 10.3, 10.4, 10.5)

Module 3:
Anatomy of human eye, Physiology of vision, Errors of refraction and their optical correction, Aqueous
humor production and drainage, Strabismus.
Clinical methods: Spectacles and contact lenses, Refractive surgery, Snellen’s Chart, Cover – uncover
test, Maddox rod test, Maddox wing test.
(Text 3: Chapter 1, Chapter 2, Chapter 3, Chapter 9, Chapter 13, Chapter 21, Chapter 23)

Module 4:
Tonometry and its types, Perimetry - Peripheral Field Charting, Central Field Charting, Fundus
Fluorescein Angiography, Electroretinography, Electro-oculography, Loupe & Lens Examination, Slit-
Lamp Examination, Gonioscopy, Retinoscope- Principle, Procedure & Types, Refractometry,
Keratometry- principle and types, subjective refraction, Ophthalmoscopy-Direct & Indirect
(Text 3: Chapter 21, Chapter 23)

Module 5:
Cataract – list of classification only, Surgical techniques for cataract extraction – Intracapsular cataract
extraction &Extracapsular cataract extraction for adulthood cataract, Phacoemulsification, Intraocular
lens implantation.
General considerations of Glaucoma, surgical procedures for Glaucoma,
Vitreous Liquefaction, Vitreous Opacities, Vitreous Haemorrhage, Vitrectomy-types and techniques,
Lasers in Ophthalmology, Cryotherapy in Ophthalmology,
(Text 3: Chapter 8, Chapter 9, Chapter 10, Chapter 18)
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Question Paper Pattern:

 The question paper will have TEN questions.
 Each full question carry 16 marks
 There will be TWO full questions (with maximum of THREE sub questions) from each module.
 Each full question will have sub questions covering all the topics under a module.
 The students will have to answer FIVE full questions, selecting ONE full question from each
module.

Text books:
1. “Textbook of Medical Physiology”, Guyton & Hall, 11th Edition, Reed Elsevier Pvt. Ltd., 2007.
2. “Handbook of Biomedical Instrumentation”, R S Khandpur, 2nd edition, McGrawHill Education,
2013.
3. “Comprehensive Ophthalmology”, A. K. Khurana, 4th Edition, New Age International Ltd., 2010
 DRAFT

B.E. Biomedical Engineering (BM)

Choice Based Credit System (CBCS)
Semester - V
Biomedical Equipment’s
Subject Code : 15BM54 IA Marks : 20
Number of Lecture
: 04 Exam Marks : 80
Hours /Week
Total Number of
: 50 Exam Hours : 03
Lecture Hours
Credits – 4 (Each module – 10 Hours)
Module 1:
Electrocardiograph, Block Diagram Description of an Electrocardiograph, The ECG leads, Effects of
Artefacts on ECG Recordings.(Text 1: 5.2, 5.1.1, 5.1.2, 5.1.3)
Electroencephalograph, Block Diagram Description of an Electroencephalograph. Other Biomedical
recorders. (Text 1: 5.4, 5.4.1, 5.6)
Bedside patient monitoring Systems, Measurement of Heart rate (Instantaneous heart rate meters).
Measurement of Pulse rate. Blood Pressure measurement(Direct and Indirect-Korotkoff”s method
,Rheographic method and Oscillometric Measurement method)
Text 1: (6.3, 6.5, 6.5.2, 6.6, 6.7, 6.7.1, 6.7.2.1, 6.7.2.2, 6.7.2.4 )
Module 2:
Pulmonary Function Measurements:-Respiratory Volumes, Respiratory Capacities, Compliance and
Related pressures, Dynamic Respiratory Parameters. Spirometry: - Basic Spirometer, Wedge Spirometer,
Ultra Sonic Spirometer.
Text 1: (13.1, 13.1.1, 13.1.2, 13.1.3, 13.1.4, ,13.2, 13.2.1,13.2.2, 13.2.3)

Basic Audiometer: - General requirements of Audiometers. Masking in audiometer, Pure Tone and
Speech Audiometer. Audiometer System (Bekesy). Evoked response Audiometry System. Calibration of
audiometers. Hearing aids-Conventional and Digital hearing aid, Cochlear Implants
Text 1: (17.3, 17.3.1, 17.3.2, 17.4, 17.5, 17.6,17.6.1, 17.6.2, 17.7, 17.8, 17.9, 17.9.1, 17.9.2, 17.9.3)
Module 3:
Cardiac pace makers: Need for Cardiac pace maker. Types of pace makers:-external and Implantable
pacemakers. Classification codes for Pacemakers. Ventricular synchronous demand pacemaker,
Programmable pacemaker. Power sources for Implantable pacemakers.
Text 1: (25.1, 25.1.1, 25.2, 25.3, 25.3.2, 25.3.3, 25.3.4, 25.3.7)

Cardiac defibrillators: Need for defibrillator. DC defibrillator. Pacer-Cardioverter-defibrillator. Text

1:(26.1, 26.2, 26.4 )
Principle of surgical diathermy. Solid state electrosurgical machine. Safety aspects in electrosurgical
units. Text 1:(27.1, 27.2, 27.3)
Module 4:
Hemodialysis Machine: Function of the Kidneys. Changes in body fluids in renal disease. Artificial
Kidney. Dialyzers: Parallel flow, coil, Hallow fibre type dialyzers. Performance analysis of dialyzers.
Hemodialysis machine. (Text 1:30.1, 30.1.1, 30.2, 30.3.1, 30.3.2, 30.3.3, 30.3.4, 30.5)
Heart lung machine (Cardiac assist device), Lithotripsy, Ventilator, Infant incubator.
(Text 2: 13.3, 13.5, 13.6, 13.7)
Module 5:
Introduction to man-Instrument system. Components of Man-Instrument system. Problems encountered
in measuring a living system. Physiological effects of Electrical current. Shock Hazards from Electrical
equipment’s. Methods of accident prevention.
(Text 3: 1.4, 1.5, 1.7, 16.1, 16.2, 16.3)
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Precautions to minimize Electric shock hazards. Safety codes for Electromedical equipment. (Text 1:
18.2.2, 18.3)
Medical equipment maintenance: Types of maintenance repair organization, Levels of capability, types of
organization. (Text 4: 26.4, 26.5, 26.6)

Question Paper Pattern:

 The question paper will have TEN questions.
 Each full question carry 16 marks
 There will be TWO full questions (with maximum of THREE sub questions) from each module.
 Each full question will have sub questions covering all the topics under a module.
 The students will have to answer FIVE full questions, selecting ONE full question from each
module.

Text Books:
1. “Handbook of Biomedical Instrumentation”, R S Khandpur, 2nd edition, McGrawHill
Education, 2013
2. “Medical Instrumentation, Application and Design”, John G. Webster, 3 rd Edition, John
Wiley & Sons
3. “Biomedical Instrumentation and Measurements”, Leslie Cromwell, Fred J. Weibell, Erich
A. Pfeiffer, 2nd Edition, Prentice Hall of India Private Limited, 2001
4. “Introduction to Biomedical Equipment Technology”, Joseph J Carr, John M. Brown, 4 th
Edition, Pearson Education, 2004.
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B.E. Biomedical Engineering (BM)

Choice Based Credit System (CBCS)
Semester - V
VLSI Design
Subject Code : 15EI/BM/ML551 IA Marks : 20
Number of Lecture : 03 Exam Marks : 80
Hours/Week
Total Number of : 40 Exam Hours : 03
Lecture Hours
Credits – 3 (Each module – 8 Hours)
Module -1
Moore’s law, speed power performance, nMOS fabrication, CMOS fabrication: n-well, p-well processes,
BiCMOS, Comparison of bipolar and CMOS.
Basic Electrical Properties of MOS And BiCMOS Circuits: Drain to source current versus
voltage characteristics, threshold voltage, transconductance.

Module -2
Basic Electrical Properties of MOS And BiCMOS Circuits: nMOS inverter, Determination of pull up
to pull down ratio, nMOS inverter driven through one or more pass transistors, alternative forms of pull
up, CMOS inverter, BiCMOS inverters, latch up.
Basic Circuit Concepts: Sheet resistance, area capacitance calculation, Delay unit, inverter
delay, estimation of CMOS inverter delay, driving of large capacitance loads, super buffers,
BiCMOS drivers.

Module -3
MOS and BiCMOS Circuit Design Processes: MOS layers, stick diagrams, nMOS design style, CMOS
design style, design rules and layout, λ - based design.
Scaling of MOS Circuits: scaling factors for device parameters, limitations of scaling.

Module -4
Subsystem Design and Layout-1 : Switch logic pass transistor, Gate logic inverter, NAND gates, NOR
gates, pseudo nMOS, Dynamic CMOS, example of structured design, Parity generator, Bus arbitration,
multiplexers, logic function block, code converter.
Subsystem Design and Layout-2 : Clocked sequential circuits, dynamic shift registers, bus
lines, subsystem design processes, General considerations, 4-bit arithmetic processes, 4-bit
shifter.

Module -5
Design Process-Computational Elements: Regularity, design of ALU subsystem, ALU using adders,
carry look ahead adders, Multipliers, serial parallel multipliers, Braun array, Bough – Wooley multiplier.
Memory, Register and Aspects of Timing: Three Transistor Dynamic RAM cell, Dynamic memory
cell, Pseudo- Static RAM, JK Flip-flop, D Flip-flop circuits, RAM arrays, practical aspects and
testability: Some thoughts of performance, optimization and CAD tools for design and simulation.

Question Paper Pattern:

 The question paper will have TEN questions.
 Each full question carry16marks
 There will be TWO full questions (with maximum of THREE sub questions) from each module.
 Each full question will have sub questions covering all the topics under a module.
 DRAFT

 The students will have to answer FIVE full questions, selecting ONE full question from
each module.

Text Books:
1. Basic VLSI Design -3rd Edition Douglas A Pucknell, Kamaran Eshraghian, Prentice Hall
of India publication, 2005.

Reference Books:
1. CMOS Digital Integrated Circuits, Analysis And Design, 3rd Edition, Sung – Mo (Steve) Kang,
Yusuf Leblbici, Tata McGraw Hill, 2002.
2. VLSI Technology - S.M. Sze, 2nd edition Tata McGraw Hill, 2003.
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B.E. Biomedical Engineering (BM)

Choice Based Credit System (CBCS)
Semester - V
Rehabilitation Engineering
Subject Code : 15BM552 IA Marks : 20
Number of Lecture
: 03 Exam Marks : 80
Hours /Week
Total Number of
: 40 Exam Hours : 03
Lecture Hours
Credits – 3 (Each module – 8 Hours)
Module 1:
Introduction to Rehabilitation:
What is Rehabilitation, Medical Rehabilitation, Preventive Rehabilitation, Impairment, Disability and
Handicap, Sociovocational Rehabilitation
Rehabilitation Team: Classification of members, Medical, The Rehabilitation team – The medical team,
Physical therapist, Occupational therapist, Prosthetist-Orthotist, Rehabilitation nurse, Speech pathologist,
Psychologist and child development Specialist, Horticultural Therapist, Music therapist, Creative
Movement Therapist, Dance and play Therapist, Recreational therapist, Biomedical engineer.
(Text 1: Chapter 1, Chapter 2)
Module 2:
Therapeutic Exercise Technique: Coordination Exercises, Balance Training, Gait, Pathological Gaits,
Gait Training – Crutch Walking: Patterns of Gait, Relaxation exercises, Methods for training Relaxation,
Strengthening exercises, Mobilization exercises
Principles in Management of Communication: Communication, Speech, Language, Aphasia,
Dysarthria, Speech therapy, Dysphagia, Communication for Visually impaired, Types of visual aids,
Writing aids,
(Text 1: Chapter 3, Chapter 5)
Module 3:
Orthotic Devices in Rehabilitation Engineering: Definition, General Principles of Orthosis,
Biomechanics of Orthosis, Classification, Material and fabrication for lower limb Orthosis, Calipers –
Foot Orthoses, Ankle-Foot Orthosis, Knee-Ankle-Foot Orthosis, Hip-Knee-Ankle-Foot Orthoses,
Functional Electrical Stimulation, Spinal Orthosis- Cervical, Head cervical Orthosis, Head cervical
thoracic orthosis, Thoraco lumbar sacral orthosis, Lumbosacro-orthosis, Splints-its functions & types.
(Text 1: Chapter 7)
Module 4:
Amputation: General Principles of Amputation Surgery, Levels of Amputation in Upper limb and Lower
limb, Rehabilitation of Lower limb amputations
Prosthetics: Classification, Components of Prosthesis, Upper limb Prosthetics – Terminal Devices,
Myoelectric Prosthesis, Lower extremity Prosthesis – Transfemoral prosthesis, Prosthesis for hip
disarticulation.
(Text 1: Chapter 8)
Module 5:
Mobility Aids: Functions, Parallel bars, Walking frames - types, Walking stick, Tripods, Quadripods,
Crutches - types, Wheel chairs – parts and maintenance
(Text 1: Chapter 9)

Question Paper Pattern:

 The question paper will have TEN questions.
 Each full question carry 16 marks
 There will be TWO full questions (with maximum of THREE sub questions) from each module.
 DRAFT

 Each full question will have sub questions covering all the topics under a module.
 The students will have to answer FIVE full questions, selecting ONE full question from each
module.

Text Books:
1. Rehabilitation Medicine - By Dr. S. Sunder, 3rd Edition, Jaypee Medical Publications, Reprint
2004.
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B.E. Biomedical Engineering (BM)

Choice Based Credit System (CBCS)
Semester - V
Hospital Design, Planning & Management
Subject Code : 15BM553 IA Marks : 20
Number of Lecture
: 03 Exam Marks : 80
Hours /Week
Total Number of
: 40 Exam Hours : 03
Lecture Hours
Credits – 3 (Each module – 8 Hours)
Module-1
Planning & Building a New Hospital: Role of Hospital in Health Care, Hospital Planning & Design,
Guiding principle in Hospital facilities & services, Functional Plans for Hospital construction, Design
items, Functional program & design stage, Planning the Hospital building.
Module-2
Effective Hospital Management: Planning, Organization, Directing & Leading, Controlling, Financial
Management
Administrative Service: Medical Record, Hospital Infection, Hospital Utilization Statistics, Material
Management, Evaluation of Hospital services.
Module-3
Planning & Designing Medical Services: Out Patient service, Emergency service, Clinical laboratories,
Radiology services, Radiation Therapy Department, Surgical Department, Nursing Department,
Operation Theater, CSSD Nursing services.
Module-4
Planning & Designing Engineering Services: Engineering Department, Maintenance management,
Clinical [Bio-medical] Engineering, Electrical System, Air Condition System, Water supply & sanitary
system, Centralized Medical Gas System, Telecommunication System, Environmental Control, Safety &
Security System, Disposal of Hospital Wastes.
Module-5
Planning & Design of Supportive Services: Admitting Department, Medical Record Department,
Centralized Sterilization & Supply department, Pharmacy Material Management, Food service
Department, Laundry & Linen Services, House Keeping & Val entry Department.

Question Paper Pattern:

 The question paper will have TEN questions.
 Each full question carry 16 marks
 There will be TWO full questions (with maximum of THREE sub questions) from each module.
 Each full question will have sub questions covering all the topics under a module.
 The students will have to answer FIVE full questions, selecting ONE full question from each
module.

Textbook
1. Principles of Hospital Administration & Planning - by B. M.Sakharkar, Jaypee Publications,
1998.
2. Hospital Facilities, Planning & Management - by G. D. Kunders, Tata McGraw Hill, 2004.

REFERENCE BOOKS:
1. Hospital Administration & Management - by S. L. Goel& R. Kumar Deep & Deep Publications
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2. Applied Clinical Engineering - by Barry N. Feinberg, Prentice Hall,1984.

3. Clinical Engineering Principle & Practices - By John G. Webster &Albert M. Cook, Prentice
Hall.
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B.E. Biomedical Engineering (BM)

Choice Based Credit System (CBCS)
Semester - V
Biomedical Nanotechnology
Subject Code : 15BM554 IA Marks : 20
Number of Lecture
: 03 Exam Marks : 80
Hours /Week
Total Number of
: 40 Exam Hours : 03
Lecture Hours
Credits – 3 (Each module – 8 Hours)
Module-1
Introduction: Converging Technologies: Nanotechnology and Biomedicine, Nanotechnology
and Nanobiomedicine, Toward Biomolecular Medicine, Drug Synthesis and Delivery, Implants
and Prosthesis, Diagnostics and Screening, Nanotechnology Platforms for Biomedicine.

Module-2
Nanotechnology and Trends in Drug Delivery Systems with Self-Assembled Carriers:
Introduction, Drug Delivery Systems since the 1980s, Chemical System Engineering and
Nanotechnology, Toward Development of Drug Delivery Systems with Bionanotechnology,
Self-Assembly and Self-Organization, Nanoparticles and Nano-Sized Spaces, Quantum Dot
(Semiconductor Nanoparticle), Safety of the Human Body and the Environment.

Module-3
Implants and Prostheses: Introduction, Biomaterials, Biological Processes, Wound Healing
Processes, Macrophages, Biomaterial Interface Processes, Foreign Body Reaction,
Nanotechnology in Implantology, Current Nanofabrication Methods, Lithography, Colloidal
Resists, Self-Assembly Systems, Soft Lithography, Biomimetic Approaches.

Module-4
Nano-Enabled Components and Systems for Biodefense: Introduction, Sensor Component of
Nano-Enabled Biodefense, Nano-Enabled Sensors for Monitoring Exposures, Nano-Enabled
Sensors for Monitoring Airborne Exposures, Nano-Enabled Sensors for Monitoring Contact
Exposures, Nanoscale Components of Sensing Systems, Nanolithography of Biological
Molecules and Sensing Materials,
Nanoparticle Arrays on Surfaces, Functional Three-Dimensional Nanostructures.

Module-5
Nanobiology in Cardiology and Cardiac Surgery: Diagnostic Applications of Nanobiology
and Nanotechnology: Molecular Imaging of Angiogenesis, Cellular Imaging, Artificial
Molecular Receptors, Fluid Acceleration Sensors, Therapeutic Applications, Targeted Anti-
proliferative Drug Delivery/ Prevention of Restenosis after Percutaneous Revascularization,
Smart Drugs, Nanorobotics. Applications of Nanobiology/Nanotechnology in Cardiological
and Cardiosurgical Practice: Applications in the Therapy of Myocardial Ischemia,
Nanotechnological Applications in Trauma / Bleeding / Wound Healing in Cardiac Surgery,
Nanotechnology and Aortic Surgery.
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Question Paper Pattern:

 The question paper will have TEN questions.
 Each full question carry 16 marks
 There will be TWO full questions (with maximum of THREE sub questions) from each module.
 Each full question will have sub questions covering all the topics under a module.
 The students will have to answer FIVE full questions, selecting ONE full question from each
module.

Text Books:
1. Biomedical Nanotechnology by edited Neelina H. Malsch; CRC Press, Taylor & Francis
Group
2. Nanoscale Technology in Biological Systems edited by Ralph S. Greco, Fritz B. Prinz, R.
Lane Smith; CRC Press
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B.E. Biomedical Engineering (BM)

Choice Based Credit System (CBCS)
Semester - V
Computer Organization
Subject Code : 15EI/BM/ML561 IA Marks : 20
Number of Lecture : 03 Exam Marks : 80
Hours/Week
Total Number of : 40 Exam Hours : 03
Lecture Hours
Credits – 3 (Each module – 8 Hours)
Module -1
Basic Structure of Computers: Basic Operational Concepts, Bus Structures, Performance – Processor
Clock, Basic Performance Equation, Clock Rate, Performance Measurement. Machine Instructions and
Programs: Memory Location and Addresses, Memory Operations, Instructions and Instruction
Sequencing, Addressing Modes, Assembly Language, Basic Input and Output Operations, Stacks and
Queues, Subroutines.

Module -2
Input / Output Organization: Accessing I/O Devices, Interrupts – Interrupt Hardware, Enabling and
Disabling Interrupts, Handling Multiple Devices, Controlling Device Requests, Exceptions, Direct
Memory Access, Buses, Interface Circuits, Standard I/O Interfaces – PCI Bus, SCSI Bus, USB.

Module -3
Memory System: Basic Concepts, Semiconductor RAM Memories, Read Only Memories, Speed, Size,
and Cost, Cache Memories – Mapping Functions, Replacement Algorithms, Performance Considerations,
Virtual Memories, Secondary Storage.

Module -4
Arithmetic: Numbers, Arithmetic Operations and Characters, Addition and Subtraction of Signed
Numbers, Design of Fast Adders, Multiplication of Positive Numbers, Signed Operand Multiplication,
Fast Multiplication, Integer Division, Floating-point Numbers and Operations.

Module -5
Basic Processing Unit: Some Fundamental Concepts, Execution of a Complete Instruction, Multiple Bus
Organization, Hard-wired Control, Micro programmed Control. Embedded Systems and Large Computer
Systems: Examples of Embedded Systems, Processor chips for embedded applications, Simple
Microcontroller. The structure of General-Purpose Multiprocessors.

Question Paper Pattern:

 The question paper will have TEN questions.
 Each full question carry16marks
 There will be TWO full questions (with maximum of THREE sub questions) from each module.
 Each full question will have sub questions covering all the topics under a module.
 The students will have to answer FIVE full questions, selecting ONE full question from each
module.

Text Books:
1. Carl Hamacher, Zvonko Vranesic, Safwat Zaky: Computer Organization, 5th Edition, Tata
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McGraw Hill, 2002.

Reference Books:
1. William Stallings: Computer Organization & Architecture, 9th Edition, Pearson, 2015.
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B.E. Biomedical Engineering (BM)

Choice Based Credit System (CBCS)
Semester - V
Virtual Bio-Instrumentation
Subject Code : 15BM/ML562 IA Marks : 20
Number of Lecture : 03 Exam Marks : 80
Hours/Week
Total Number of : 40 Exam Hours : 03
Lecture Hours
Credits – 3 (Each module – 8 Hours)

Module-1
Graphical System Design (GSD): Introduction, GSD model, Design flow with GSD, Virtual
Instrumentation, Virtual Instrumentation and traditional instrumentation, Hardware and software in
virtual instrumentation, Virtual Instrumentation for test, control and design, GSD using LabVIEW,
Graphical programming and textural programming.
Introduction to LabVIEW: Introduction, Advantages of LabVIEW, Advantages of LabVIEW, Software
environment, Creating and saving a VI, Front panel toolbar, Block diagram toolbar, Palettes, Shortcut
menus, Property dialog boxes, Front panel controls and indicators, Block diagram, Data types, Data flow
program, LabVIEW documentation resourses, Keyword shortcuts.
Module-2
Modular Programming: Introduction, Modular Programming in LabVIEW, Build a VI front panel and
block diagram, ICON and connector pane, Creating an icon, Building a connector pane, Displaying
subVIs and express Vis as icons or expandable nodes, Creating subVIs from sections of a VI, Opening
and editing subVIs, Placing subVIs on block diagrams, Saving subVIs, Creating a stand-alone
application.
Data Acquisition: DAQ software architecture, DAQ assistant, Channels and task configurations,
Selecting and configuring a data acquisition device, Components of computer based measurement
system.

Module-3
General Goals of Virtual Bio-Instrumentation (VBI): Definition of VBI and importance, General
Goals of VBI applications. Basic Concepts: DAQ basics, LabVIEW basics, BioBench basics.
Neuromuscular Electrophysiology (Electromyography): Physiological basis, Experiment set up,
Experiment descriptions, Trouble shooting the nerve –Muscle Preparation.
Cardiac Electrophysiology (Electrocardiology): Physiological basis, Experiment descriptions.
Cardiopulmonary Applications: Cardiopulmonary measurement system, Hiw the Cardiopulmonary
measurement system works, Clinical Significance

Module-4
Medical Device Development Applications: The Endotester – A Virtual Instrument –Based Quality
control and Technology, Assessment System for surgical video Systems: Introduction, Materials and
Methods, Endoscope Tests, Results, Discussion.
Fluid Sense Innovative IV Pump Testing: Introduction, The test System, Training Emulator.

Module-5
Healthcare Information management Systems:
Medical Informatics: Defining medical informatics, Computers in medicine, Electronic Medical record,
Computerized physician order entry, Decision support.
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Information Retrieval, Medical Imaging, Patient Monitoring, Medical Education, Medical Simulation.
Managing Disparate Information: ActiveX, ActiveX Data Objects (ADO), Dynamic Link Libraries,
Database Connectivity, Integrated Dashboards.

Question Paper Pattern:

 The question paper will have TEN questions.
 Each full question carry16marks
 There will be TWO full questions (with maximum of THREE sub questions) from each module.
 Each full question will have sub questions covering all the topics under a module.
 The students will have to answer FIVE full questions, selecting ONE full question from each
module.

Textbook:
1. Virtual Instrumentation using LabVIEW by Jovitha Jerome, PHI Learning Private Limited, 2010.
(Module 1 & 2)
2. “Virtual Bio-Instrumentation” Biomedical, Clinical, and Healthcare Applications in Lab VIEW. ,by
JON B. OLANSEN and ERIC ROSOW, Prentice Hall Publication, 2002.
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B.E. Biomedical Engineering (BM)

Choice Based Credit System (CBCS)
Semester - V
Operating Systems
Subject Code : 15EI/BM563 IA Marks : 20
Number of Lecture : 03 Exam Marks : 80
Hours/Week
Total Number of : 40 Exam Hours : 03
Lecture Hours
Credits – 3 (Each module – 8 Hours)
Module -1
Introduction to Operating Systems and Classification: What is an operating system, Mainframe
systems, Desktop systems, multiprocessor system, Distributed system, Clustered system, Real time
system, Handled system, Feature migration, computing environments. Operating system structures:
System components, OS Services, System calls, System programs, System structure, Virtual machines.

Module -2
Process, Inter Process Communication, Threads & CPU Scheduling: Process concept, Process
scheduling, Operation on processes, Co-operating processes, Inter process communication. Threads –
overview, Multithreading models, Threading issues, P threads, Java threads. CPU scheduling – Basic
concepts, Scheduling criteria, Scheduling algorithms, multiple processors scheduling, real time
scheduling.

Module -3
Process Synchronization and Handling Deadlocks: The critical section problem, Synchronization
hardware, Semaphores, Classical problems of synchronization, critical regions, monitors.
Deadlock – System model, Deadlock characterization, Methods for handling deadlocks – deadlock
prevention, deadlock avoidance, deadlock detection and recovery from deadlock.

Module -4
Storage Management: Main memory management – Background, Swapping, Contiguous, allocation,
Paging, Segmentation, Segmentation with paging Virtual memory – Background, Demand paging,
Process creation, Page replacement algorithms, Allocation of frames, Thrashing.

Module -5
File System Interface: File concept, Access methods, Directory structure, File system mounting, File
system implementation, Directory implementation, Allocation methods, free space management. Mass
storage structures – Disk structure, Disk scheduling methods, Disk management, Swap space
management.

Question Paper Pattern:

 The question paper will have TEN questions.
 Each full question carry16marks
 There will be TWO full questions (with maximum of THREE sub questions) from each module.
 Each full question will have sub questions covering all the topics under a module.
 The students will have to answer FIVE full questions, selecting ONE full question from each
module.
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Text Books:
1. Operating System Concepts-by Abraham Silberschatz, Peter Baer Galvin, Greg Gagne, 6thEdition,
John Wiley &Sons 2003.

Reference Books:
1. Operating system concepts and design- Milan Milankovic, 2nd Edition, McGraw Hill 1992.
2. Operating systems- Harvey M Deital Addison Wesley 1990.
3. Operating Systems concepts based approach, D.M Dhamdhere, Tata Mc Graw Hill 2002.
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B.E. Biomedical Engineering (BM)

Choice Based Credit System (CBCS)
Semester - V
Medical Physics
Subject Code : 15BM564 IA Marks : 20
Number of Lecture : 03 Exam Marks : 80
Hours/Week
Total Number of : 40 Exam Hours : 03
Lecture Hours
Credits – 3 (Each module – 8 Hours)
Module-1
Heat and cold in medicine: Introduction, Physical basis of heat and temperature, Thermography and
temperature scales, mapping of body’s temperature, heat therapy, Use of cold in medicine, Cryosurgery
and safety aspects
Energy, work, power and pressure: Conservation of energy in the body, energy changes in the body,
work and power, heat losses from the body, measurement of pressure in the body, pressure inside skull,
eye, digestive system, skeleton & urinary bladder, Hyper baric Oxygen Therapy
Module-2
Physics of cardiovascular system: Introduction to cardiovascular system, major components of
cardiovascular system, oxygen and carbon dioxide exchange in the capillary system, work done by the
heart, blood pressure and its measurements, transmural pressure, Bernoulli’s principle applied to
cardiovascular system, Blood flow-laminar & turbulent, heart sounds, physics of some cardiovascular
diseases
Module-3
Physics of lung and breathing: Introduction, the air ways, blood & lung interaction, Measurement of
lung volumes, pressure-air flow-volume relationship of the lungs, Physics of alveoli, breathing
mechanism, air-way resistance, Work of breathing, Physics of some common lung diseases
Module-4
Electricity within the body: The nervous system & neurons. electrical potential of nerves,
electromyogram, electrocardiogram, electroencephalogram, electroretinogram, electrooculogram,
magneto cardiogram & magneto encephalogram, Electric shock, high frequency and low frequency
electricity in medicine, magnetism in medicine
Module-5
Sound in medicine: General properties of sound, body as a drum, the stethoscope, production of speech
Physics of ear and hearing: The outer ear, the middle ear and the inner ear, Sensitivity of ears
Physics of eyes and vision: Focusing elements of the eye, the retina, diffraction effects of the eye, optical
illusion, defective vision & correction, color vision & chromatic aberration

Question Paper Pattern:

 The question paper will have TEN questions.
 Each full question carry16marks
 There will be TWO full questions (with maximum of THREE sub questions) from each module.
 Each full question will have sub questions covering all the topics under a module.
 The students will have to answer FIVE full questions, selecting ONE full question from each
module.

Text Book(s) :
1. J. R. Cameron & J. G. Skofronick, Medical Physics , John Wiley and Sons, 1978
 DRAFT

Reference(s):
1. Herman I.P., Physics of the Human Body, Springer Publications, 2007
2. Paul Davidovits “Physics in Biology and Medicine “ , Academic Press, 3rd Edition, 2007.
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B.E. Biomedical Engineering (BM)

Choice Based Credit System (CBCS)
Semester - V
Signal Conditioning Circuits and Data Acquisition Lab
Subject Code : 15 EI/BM/ML L57 IA Marks : 20
Number of Practical : 03 Exam Marks : 80
Hours/Week
Total Number of : 42 Exam Hours : 03
Practical Hours
Credits - 2
Revised Bloom’s Taxonomy Levels: L1 – Remembering, L2 – Understanding, L3 – Applying,
L4 –Analyzing, L5 – Evaluating, and L6 - Creating
Laboratory Experiments:
Revised Bloom’s
Note: Standard design procedure to be adopted
Taxonomy
Students should build the circuit using discrete components and ICs (models
(RBT)Level
are not to be used)
1. To design and implement
 Inverting Amplifier and Inverting Attenuator L3, L4, L5, L6
 Non-Inverting Amplifier and Voltage Follower
2. To realize
L3, L4
 Full wave Precision rectifier
3. To design and implement
 Butterworth I order Low-pass filter L3, L4, L5, L6
 Butterworth II order High-pass filter
4. To design and implement
 RC Phase shift oscillator L3, L4, L5, L6
 Wein Bridge oscillator
5. To realize
 ZCD L3, L4
 Positive and Negative Voltage level detectors
6. To design and implement
 Astable Multivibrator using 555 timer L3, L4, L5, L6
 Mono-stable Multivibrator using 555 timer
7. To realize
L3, L4
 Sample and Hold circuit using discrete components
8. To realize
L3, L4
 Programmable Gain Amplifier using Analog Mux
9. To design and implement
L3, L4
 4 bit R-2R DAC using discrete components
10. To design and implement
L3, L4, L5, L6
 8-bit DAC using IC (DAC 0800)
11. To design and implement
L3, L4, L5, L6
 8-bit ADC using IC (ADC 0809)
12. To design and implement
L3, L4, L5, L6
 3 bit Flash ADC using ICs

Conduct of Practical Examination:

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1. All laboratory experiments are to be included for practical examination.

2. Students are allowed to pick one experiment from the lot.
3. Strictly follow the instructions as printed on the cover page of answer script for breakup of marks.
4. Change of experiment is allowed only once and 15% Marks allotted to the procedure part to be
made zero.
 DRAFT

B.E. Biomedical Engineering (BM)

Choice Based Credit System (CBCS)
Semester - V
Clinical Instrumentation Lab
Subject Code : 15BML58 IA Marks : 20
Number of Practical : 03 Exam Marks : 80
Hours/Week
Total Number of : 42 Exam Hours : 03
Practical Hours
Credits - 2
Revised Bloom’s Taxonomy Levels: L1 – Remembering, L2 – Understanding, L3 – Applying,
L4 –Analyzing, L5 – Evaluating, and L6 - Creating
Revised Bloom’s
Title of the Experiments Taxonomy
(RBT)Level
1. Measurement of Operational Amplifier parameters: I/P Offset current, I/P
L3, L4
bias current, Slew rate, I/P offset Voltage, PSRR, CMRR & offset nulling.
2. Design and Test the Operational Amplifier as: (i) Adder, (ii) Substractor,
L3, L4, L5, L6
(iii) Integrator, and (iv) Differentiator.
3. Conduct an experiment to perform Operational Amplifier as:
L3, L4
(i) Comparator (ii) Schmitt Trigger.
4. Design and Test the bio-potential amplifiers for ECG/ or EEG/ or EMG
5. Design and Test the Notch Filter for 50 Hz and 60 Hz. L3, L4, L5, L6
6. Design and Testing of Instrumentation amplifier for different gains. L3, L4, L5, L6
7. Testing an IC based Sample and Hold Circuit and plotting its
L3, L4
characteristics.
8. Testing and analysis of the following by hardware circuit/simulation
L3, L4
(i) DC Defibrillator (ii) Pacemaker
9. Acquisition of ECG: (i) Single lead (iii) Three lead, and (iii) 12-Leads.
L3, L4
Analysis of the acquired ECG in amplitude, time and frequency domain.
10. Acquisition and analysis (time & frequency) of EEG. L3, L4
11. Acquisition and analysis of Lung Volumes and Lung Capacities using
L3, L4
Spirometer.
12. Quantification and assessment of hearing ability using audiometer
13. (i) Measurement of corneal curvature using keratometer, and (ii)
L3, L4
Measurement of Visual Acuity using Snell’s Chart.
14. Study Experiments: Baby incubator, Ventilator, Heart-lung machine,
Dialysis machine, Pacemaker, Ophthalmoscope, Recording of pulse & L1, L2
oxygen saturation using Pulse Oximeter, and Infusion Pump.

Conduct of Practical Examination:

1. All laboratory experiments are to be included for practical examination.
2. Students are allowed to pick one experiment from the lot.
3. Strictly follow the instructions as printed on the cover page of answer script for breakup of marks.
4. Change of experiment is allowed only once and 15% Marks allotted to the procedure part to be
made zero.