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GTP cyclohydrolase 1 (Q1487359)

From Wikidata
mammalian protein found in Homo sapiens
  • GTP cyclohydrolase I
  • dystonia 14
  • GCH1
  • guanosine 5'-triphosphate cyclohydrolase I
  • GTP-CH-I
edit
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    English
    GTP cyclohydrolase 1
    mammalian protein found in Homo sapiens
    • GTP cyclohydrolase I
    • dystonia 14
    • GCH1
    • guanosine 5'-triphosphate cyclohydrolase I
    • GTP-CH-I

    Statements

    image
    Protein GCH1 PDB 1fb1.png
    930 × 939; 590 KB
    0 references
    molecular function
    protein binding
    determination method or standard
    IPI
    5 references
    retrieved
    8 April 2019
    stated in
    A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    GTP cyclohydrolase I feedback regulatory protein is a pentamer of identical subunits. Purification, cDNA cloning, and bacterial expression
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Toward an understanding of the protein interaction network of the human liver
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IPI
    GTP cyclohydrolase I activity
    determination method or standard
    IEA
    IDA
    TAS
    10 references
    retrieved
    24 April 2018
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    TAS
    retrieved
    24 April 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IEA
    retrieved
    24 April 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IEA
    retrieved
    24 April 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IEA
    retrieved
    24 April 2018
    stated in
    GTP cyclohydrolase I mRNA: novel splice variants in the slime mould Physarum polycephalum and in human monocytes (THP-1) indicate conservation of mRNA processing
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IDA
    retrieved
    24 April 2018
    stated in
    GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IDA
    retrieved
    24 April 2018
    stated in
    Human GTP cyclohydrolase I: only one out of three cDNA isoforms gives rise to the active enzyme
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IDA
    retrieved
    24 April 2018
    stated in
    The application of 8-aminoguanosine triphosphate, a new inhibitor of GTP cyclohydrolase I, to the purification of the enzyme from human liver
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IDA
    retrieved
    24 April 2018
    stated in
    Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IDA
    retrieved
    24 April 2018
    stated in
    Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IDA
    GTP cyclohydrolase I activity
    determination method or standard
    IBA
    IDA
    IEA
    TAS
    8 references
    retrieved
    10 September 2018
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    TAS
    retrieved
    10 September 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IEA
    retrieved
    10 September 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IEA
    retrieved
    10 September 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IEA
    retrieved
    10 September 2018
    stated in
    GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IDA
    retrieved
    10 September 2018
    stated in
    Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IDA
    retrieved
    10 September 2018
    stated in
    Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IDA
    retrieved
    10 September 2018
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IBA
    GTP cyclohydrolase I activity
    determination method or standard
    IBA
    IDA
    IEA
    7 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IBA
    cell component
    biological process
    positive regulation of nitric-oxide synthase activity
    determination method or standard
    IDA
    IMP
    4 references
    retrieved
    8 April 2019
    stated in
    Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IDA
    tetrahydrobiopterin biosynthetic process
    determination method or standard
    IDA
    IEA
    IMP
    5 references
    retrieved
    24 April 2018
    stated in
    Novel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystonia
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IMP
    retrieved
    24 April 2018
    stated in
    Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IMP
    retrieved
    24 April 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IEA
    retrieved
    24 April 2018
    stated in
    Cytokines Stimulate GTP Cyclohydrolase I Gene Expression in Cultured Human Umbilical Vein Endothelial Cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IDA
    retrieved
    24 April 2018
    stated in
    Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
    determination method or standard
    IDA
    tetrahydrobiopterin biosynthetic process
    determination method or standard
    IBA
    IDA
    IEA
    IMP
    6 references
    retrieved
    8 April 2019
    stated in
    Novel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystonia
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Cytokines Stimulate GTP Cyclohydrolase I Gene Expression in Cultured Human Umbilical Vein Endothelial Cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP
    GOA
    curator
    UniProt
    UniProt protein ID
    P30793
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
    determination method or standard
    IBA
    Gene Atlas image
    PBB GE GCH1 204224 s at fs.png
    732 × 530; 10 KB
    0 references

    Identifiers

     
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q1487359&oldid=2163004725"
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