POU class 5 homeobox 1 (Q409423)

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mammalian protein found in Homo sapiens

POU class 5 homeobox 1 transcript variant OCT4B2
POU5F1
octamer-binding protein 3
Oct-4
POU class 5 homeobox 1 transcript variant OCT4B3
POU-type homeodomain-containing DNA-binding protein
POU class 5 homeobox 1 transcript variant OCT4B6
OTF-3
Oct-3
POU domain, class 5, transcription factor 1
POU classV homeobox 1 variant 2
POU class 5 homeobox 1 transcript variant OCT4B1
POU class 5 homeobox 1 transcript variant OCT4B5
POU class 5 homeobox 1 transcript variant OCT4B4
POU domain transcription factor OCT4
octamer-binding transcription factor 3
octamer-binding protein 4

Language	Label	Description	Also known as
English	POU class 5 homeobox 1	mammalian protein found in Homo sapiens	POU class 5 homeobox 1 transcript variant OCT4B2 POU5F1 octamer-binding protein 3 Oct-4 POU class 5 homeobox 1 transcript variant OCT4B3 POU-type homeodomain-containing DNA-binding protein POU class 5 homeobox 1 transcript variant OCT4B6 OTF-3 Oct-3 POU domain, class 5, transcription factor 1 POU classV homeobox 1 variant 2 POU class 5 homeobox 1 transcript variant OCT4B1 POU class 5 homeobox 1 transcript variant OCT4B5 POU class 5 homeobox 1 transcript variant OCT4B4 POU domain transcription factor OCT4 octamer-binding transcription factor 3 octamer-binding protein 4

Statements

1 reference

13 November 2019

UniProt protein ID

Lambda repressor-like, DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01860

POU domain-containing protein, class 5

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01860

Homeobox-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01860

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

POU domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

POU-specific domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

Core transcriptional regulatory circuitry in human embryonic stem cells

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

DNA-binding transcription factor activity

determination method or standard

4 references

8 April 2019

Localization of the OTF3 gene within the human MHC class I region by physical and meiotic mapping

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

Core transcriptional regulatory circuitry in human embryonic stem cells

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

transcription factor binding

determination method or standard

1 reference

17 October 2017

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01860&geneProductId=UniProtKB:Q01860

determination method or standard

transcription cis-regulatory region binding

determination method or standard

1 reference

8 April 2019

MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

protein binding

determination method or standard

10 references

8 April 2019

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

Phage display screening reveals an association between germline-specific transcription factor Oct-4 and multiple cellular proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

The L1TD1 protein interactome reveals the importance of post-transcriptional regulation in human pluripotency

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

Deterministic direct reprogramming of somatic cells to pluripotency

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

DNA-binding transcription repressor activity, RNA polymerase II-specific

determination method or standard

1 reference

8 April 2019

MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method or standard

1 reference

17 October 2017

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01860&geneProductId=UniProtKB:Q01860

determination method or standard

ubiquitin protein ligase binding

determination method or standard

1 reference

8 April 2019

WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

determination method or standard

1 reference

17 October 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01860&geneProductId=UniProtKB:Q01860

determination method or standard

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method or standard

3 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

determination method or standard

1 reference

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

HEB and E2A function as SMAD/FOXH1 cofactors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

Expression profile of the embryonic markers nanog, OCT-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mesenchymal stem cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

transcription regulator complex

determination method or standard

1 reference

17 October 2017

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01860&geneProductId=UniProtKB:Q01860

determination method or standard

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

Expression profile of the embryonic markers nanog, OCT-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mesenchymal stem cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

determination method or standard

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

Evidence for the presence of stem cell-like progenitor cells in human adult pancreas

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

HEB and E2A function as SMAD/FOXH1 cofactors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

Core transcriptional regulatory circuitry in human embryonic stem cells

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

determination method or standard

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

biological process

somatic stem cell population maintenance

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

8 April 2019

MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

negative regulation of gene silencing by miRNA

determination method or standard

1 reference

8 April 2019

MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

cell fate commitment involved in formation of primary germ layer

determination method or standard

1 reference

17 October 2017

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01860&geneProductId=UniProtKB:Q01860

determination method or standard

endodermal cell fate specification

determination method or standard

1 reference

8 April 2019

Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

anatomical structure morphogenesis

determination method or standard

1 reference

8 April 2019

Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

mRNA transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

regulation of asymmetric cell division

determination method or standard

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

negative regulation of transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01860&geneProductId=UniProtKB:Q01860

determination method or standard

regulation of DNA methylation-dependent heterochromatin assembly

determination method or standard

1 reference

17 October 2017

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01860&geneProductId=UniProtKB:Q01860

determination method or standard

multicellular organism development

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

cardiac cell fate determination

determination method or standard

1 reference

17 October 2017

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01860&geneProductId=UniProtKB:Q01860

determination method or standard

response to wounding

determination method or standard

1 reference

8 April 2019

Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

BMP signaling pathway involved in heart induction

determination method or standard

1 reference

17 October 2017

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01860&geneProductId=UniProtKB:Q01860

determination method or standard

regulation of gene expression

determination method or standard

1 reference

8 April 2019

Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

regulation of heart induction by regulation of canonical Wnt signaling pathway

determination method or standard

1 reference

17 October 2017

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01860&geneProductId=UniProtKB:Q01860

determination method or standard

blastocyst development

determination method or standard

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01860

determination method or standard

positive regulation of SMAD protein signal transduction

determination method or standard

1 reference

17 October 2017

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01860&geneProductId=UniProtKB:Q01860

determination method or standard

Gene Atlas image

PBB GE POU5F1 210265 x at fs.png
732 × 530; 12 KB

0 references

http://purl.uniprot.org/uniprot/Q01860

1 reference

Identifiers.org

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000259915

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000259915

ENSP00000365419

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000365419

ENSP00000373016

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373016

ENSP00000387619

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000387619

ENSP00000387646

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000387646

ENSP00000388842

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000388842

ENSP00000391507

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000391507

ENSP00000391681

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000391681

ENSP00000392877

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000392877

ENSP00000400047

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000400047

ENSP00000405041

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000405041

ENSP00000412665

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000412665

ENSP00000413622

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000413622

ENSP00000491205

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000491205

ENSP00000484778

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000484778

ENSP00000425479

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425479

ENSP00000425083

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425083

ENSP00000475512

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000475512

ENSP00000475880

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000475880

ENSP00000492870

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000492870

ENSP00000492036

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000492036

ENSP00000389359

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000389359

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

10 November 2015

http://www.uniprot.org/uniprot/P20263.txt?version=158

1 reference

10 November 2015

http://www.uniprot.org/uniprot/P20263.txt?version=158

Sitelinks

Wikipedia(9 entries)

dewiki Oktamer-bindender Transkriptionsfaktor 4
enwiki Oct-4
etwiki OCT4
frwiki OCT4
itwiki Oct-4
jawiki Oct-4
ruwiki Oct-4
ukwiki POU5F1
zhwiki Oct4

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q409423&oldid=2022901022"

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