Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.2
3.9
Journals
Biomedicines
Special Issues
Advancements in Lung Cancer Precision Oncology Research and Treatments
share announcement

Advancements in Lung Cancer Precision Oncology Research and Treatments

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 1435

Special Issue Editors

Dr. Panagiotis Paliogiannis

E-Mail Website
Guest Editor
Anatomic Pathology and Histology Unit, Department of Medicine, Surgery and Pharmacy, University of Sassari, Viale San Pietro 43, Sassari, Italy
Interests: molecular pathology of solid tumors; lung cancer; melanoma; circulating biomarkers
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Giuseppe Palmieri

E-Mail Website
Co-Guest Editor
Unit of Immuno-Oncology, Department of Medicine, Surgery and Pharmacy, University of Sassari, Viale San Pietro 43, Sassari, Italy
Interests: cancer genetics; molecular diagnosis; biomarkers; precision medicine; melanoma and non-melanoma pathogenesis
Special Issues, Collections and Topics in MDPI journals
Dr. Francesca Colonese

E-Mail Website
Co-Guest Editor
Medical Oncology Unit, Fondazione IRCCS San Gerardo dei Tintori Hospital in Monza, Via Giambattista Pergolesi 33, 20900 Monza, Italy
Interests: immunotherapy; NSCLC
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Lung cancer is one of the most common malignancies and the first cause of cancer death worldwide. It is currently estimated that less than 21% of lung cancer patients are alive five years from diagnosis; this depends on several factors, including the silent clinical course of the disease leading to late diagnosis, advanced age, respiratory impairment, cardiovascular and metabolic comorbidities, histology, and others. Significant improvements in lung cancer survival have been obtained in the last decade by introducing two novel therapeutic approaches for patients affected by non-small cell lung cancer (NSCLC), a histological subtype that includes approximately 85% of lung cancers: immunotherapy and gene-targeted therapy. These treatments are based on identifying predictive biomarkers, revolutionizing daily practice in modern pathology and medical oncology, and bridging consistent survival advantages in NSCLC patients. Currently, EGFR, KRAS, BRAF, ERBB2, ALK, ROS1, MET, RET, and NTRK genetic alterations and PD-L1 immunohistochemical expression are used to make treatment decisions, and a great number of ongoing clinical trials investigate novel molecular targets, medications, treatment combinations and protocols against lung cancer. This Special Issue aims to shed light on the most recent advancements in precision oncology research and current innovations in targeted and immunological treatments against lung cancer.

Dr. Panagiotis Paliogiannis
Prof. Dr. Giuseppe Palmieri
Dr. Francesca Colonese
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lung
  • cancer
  • NSCLC
  • targeted therapies
  • immunotherapy
  • precision oncology
  • EGFR
  • KRAS
  • ALK
  • ROS1

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

18 pages, 302 KiB  
Article
Immunotherapy in Non-Small-Cell Lung Cancer: A Modified Delphi Survey Consensus on First Line Treatment, Special Populations and Rechallenge
by Francesca Colonese, Alessandra Bulotta, Carlo Genova, Diego Signorelli, Laura Bonanno, Claudia Proto, Immunotherapy in NSCLC Delphi Panel and Diego Luigi Cortinovis
Biomedicines 2024, 12(12), 2742; https://doi.org/10.3390/biomedicines12122742 - 29 Nov 2024
Viewed by 973
Abstract
Background: The treatment landscape for non-small cell lung cancer (NSCLC) has evolved significantly with the advent of immunotherapy. Nonetheless, uncertainty regarding optimal first-line treatments, special populations, and the feasibility of rechallenge remains. This study aims to investigate Italian oncologists’ opinions on these [...] Read more.
Background: The treatment landscape for non-small cell lung cancer (NSCLC) has evolved significantly with the advent of immunotherapy. Nonetheless, uncertainty regarding optimal first-line treatments, special populations, and the feasibility of rechallenge remains. This study aims to investigate Italian oncologists’ opinions on these aspects through a Delphi Survey. Methods: A steering committee (SC) of six oncologists identified three topics of interest, namely NSCLC (first line) therapeutic choice, NSCLC special populations, and NSCLC immunotherapy rechallenge), and drafted several topic-related statements to be voted in the Delphi Survey by the 61 oncologists forming the Delphi Panel. The survey included two rounds, wherein the experts rated their agreement/disagreement with the statements on a 5-point Likert scale. Consensus was defined as agreement/disagreement by at least 75% of the panel. Results: The SC drafted 69 statements for the first round, of which 16 (23.2%) met the agreement threshold, 5 (7.2%) met the disagreement threshold, and 48 (69.6%) did not reach consensus. The SC revised the latter statements and drafted 37 for the second round. Overall, 5 (13.5%) statements met the agreement threshold, 1 (2.7%) met the disagreement threshold, and 31 (83.8%) did not reach consensus in the second round. Conclusions: The survey showed agreement on the necessity of molecular characterization, mutations, smoke, the role of steroid therapy, and immunotherapy rechallenge, and revealed several areas of uncertainty among Italian oncologists on the use of immunotherapy in NSCLC. Statements—where consensus was not met—can be used to guide future clinical research in resolving the issues. Full article
(This article belongs to the Special Issue Advancements in Lung Cancer Precision Oncology Research and Treatments)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop pFad - Phonifier reborn

Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy