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Acyclovir

Acyclovir is an antiviral agent used to treat herpes simplex virus infections like cold sores and genital herpes, as well as varicella zoster virus infections. It works by interfering with viral DNA synthesis and replication. Common side effects include headache, nausea, and vomiting. It should be used cautiously in patients with kidney problems or neurological disorders and interacts with other drugs like interferon, probenecid, and zidovudine.

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Muhammad Arsalan
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709 views1 page

Acyclovir

Acyclovir is an antiviral agent used to treat herpes simplex virus infections like cold sores and genital herpes, as well as varicella zoster virus infections. It works by interfering with viral DNA synthesis and replication. Common side effects include headache, nausea, and vomiting. It should be used cautiously in patients with kidney problems or neurological disorders and interacts with other drugs like interferon, probenecid, and zidovudine.

Uploaded by

Muhammad Arsalan
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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ACYCLOVIR

Therapeutic Category Antiviral agent Pharmacologic class: Synthetic purine nucleoside Use\ Indications First and recurrent episodes of mucocutaneous herpes simplex virus (HSV-1 and HSV-2) infections For genital herpes Varicella zoster infections Herpes simplex encephalitis Pharmacological Effects Interferes with DNA synthesis and inhibits viral replication Adverse Reaction CNS: headache, malaise, encephalopathic changes (including lethargy, obtundation, tremor, confusion, hallucinations, agitation, seizures, coma). GI: nausea, vomiting, diarrhea. GU: acute renal failure, hematuria. Hematologic: leukopenia, thrombocytopenia, thrombocytosis. Skin: inflammation or phlebitis at injection site, rash, urticaria. Precautions/Warnings/Contraindication Contraindicated in patients hypersensitive to drug. Use cautiously in patients with neurologic problems, renal disease, or dehydration, and in those receiving other nephrotoxic drugs. Adequate studies havent been done in pregnant women; use only if potential benefits outweigh risks to fetus. Pregnancy category: B Breast-feeding: No adverse effects reported Interactions: Interferon: May have synergistic effect. Monitor patient closely. Probenecid: May increase acyclovir level. Monitor patient for possible toxicity. Zidovudine: May cause drowsiness or lethargy. Use together cautiously. Dosing HSV encephalitis: 1500 mg/m2/day divided every 8 hours or 10 mg/kg/dose for 10 days For VZV (chicken pox): I.V.: Children and Adults: 1500 mg/m2/day divided every 8 hours or 10 mg/kg/dose every 8 hours for 7 days Brand Available: Acyclovir 500mg powder for inj Acylex 5% ointment Zovirex tablet

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