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Flyer Gas Analyser (En)

The gas analyser allows for real-time analysis of oxygen and carbon dioxide levels in bioreactor exit gases. This provides direct insight into culture conditions and metabolism. The software enables calculation of parameters like oxygen uptake and carbon dioxide evolution rates, and the respiratory quotient, allowing precise bioprocess control. The compact analyser is compatible with various bioreactor systems and includes options for multiple bioreactor monitoring.

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Ignacio Rodriguez Carrascosa
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118 views2 pages

Flyer Gas Analyser (En)

The gas analyser allows for real-time analysis of oxygen and carbon dioxide levels in bioreactor exit gases. This provides direct insight into culture conditions and metabolism. The software enables calculation of parameters like oxygen uptake and carbon dioxide evolution rates, and the respiratory quotient, allowing precise bioprocess control. The compact analyser is compatible with various bioreactor systems and includes options for multiple bioreactor monitoring.

Uploaded by

Ignacio Rodriguez Carrascosa
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Bioreactors | Accessories

Gas Analyser

Web n
Versio

solutio

low re

RQ [mol mol ]

O2 and CO2 analysis for metabolic studies and bioprocess control

Batch 1

Batch 2

Fed-batch

3
2
1
0

21

20

O2 [%]

22

ERSAL+

+U

19

IV

++

CO2 [%]

2.5
2.0
1.5
1.0
0.5
0.0

lysis 20
5 ture10ana 15
25
30
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u
rc
o
f
s
process
time
[h]
g
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Precisi
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www.infors-ht.com
May be subject to technical amendments. Product images examples only.

35

40

45

50

++

18

SOLUTIO

Bioreactors | Accessories | Gas Analyser

Real-time understanding of bioprocesses


RQ [mol mol ]

Immediate readings for culture


analysis

Batch 2

Batch 1

Fed-batch

3
2
1
0

 Direct deductions as to the condition of the culture can be made during the
actual bioprocess from the O2 and CO2 readings.

O2 [%]

22
21

20
19
18

Precision control of bioprocesses


The Iris software allows the calculation of parameters such as the CO2 evolution rate (CER), the O2 uptake rate (OUR) and the resulting respiratory quotient (RQ). This in turn makes it possible to adopt a systematic approach to
bioprocess control, to maintain specific metabolic states and to prevent O2
limitations or substrate limitations.

CO2 [%]

2.5
2.0
1.5
1.0
0.5
0.0
0

10

15

20
25
30
process time [h]

35

40

45

50

Example exit gas analysis and RQ control (fed-batch) for an


S. cerevisiae bioprocess
1.0x10

Compatible with other bioreactors

Batch 1

Batch 2

Fed-batch

0.8
1

OUR [mol L h ]

The gas analyser can be operated with both bench-top bioreactors and in-situ
sterilisable bioreactors. The analogue connection also enables analysis of exit
gases from bioreactors supplied by other manufacturers.

Compact

0.6

0.4

0.2

With a footprint of just 115 x 235 mm, the gas analyser can be mounted on a
workbench or in a rack.

0.0

1.0x10

Optional multiplexer function for


parallel bioreactors
The multiplexer function allows the INFORS HT gas analyser to read the O and

CER [mol L h ]

0.8

CO2 levels on up to six INFORS HT parallel bioreactors.

0.6

0.4

0.2

Online data acquisition

0.0

Data can be logged, archived, formatted into graphs and used for calculations
and control algorithms using the Iris software from any workstation.

Technical specifications:

Infors GmbH

10

15

20

25

30

35

40

45

50

process time [h]

Example O2 uptake rate and CO2 evolution rate trace during an


S. cerevisiae bioprocess

Gas flow: from 0.5 L/min


 Warm-up time: 2 min
Weight: 2 kg
D
 imensions w x d x h: 142 x 275 x 135 mm
 Footprint w x d: 115 x 235 mm

Infors Biotechnology
(China) Co., Ltd.
Room 505C, Building 106
The Courtyard Business 2, rue du Buisson
Fabriekstraat 38
Lize Zhongyuan
Centre, Dovers Farm,
aux Fraises
NL-7005 AR Doetinchem 8350 rue Bombardier
Wangjing New Industrial Zone
Dachauer Str. 6
Rittergasse 27
Lonesome Lane, Reigate, Btiment D13
P.O. Box 613
Anjou, Quebec
Chaoyang District, Beijing
D-85254 Einsbach
CH-4103 Bottmingen
Surrey, RH2 7QT, UK
FR-91300 Massy
NL-7000 AP Doetinchem Canada H1J 1A6
100102 P. R. of China
T +49 (0)8135 8333
T +41 (0)61 425 77 00
T +44 (0)1737 22 31 00 T +33 (0)1 69 30 95 04 T +31 (0)314 364 450
T +1 514 352 50 95
T +86 (0)10 51 65 20 68
F +49 (0)8135 8320
F +41 (0)61 425 77 01
F +44 (0)1737 24 72 13 F +33 (0)1 69 30 95 05 F +31 (0)314 378 076
F +1 514 352 56 10
F +86 (0)10 64 39 05 85
headoffice@infors-ht.com infors.de@infors-ht.com infors.uk@infors-ht.com infors.fr@infors-ht.com infors.bnl@infors-ht.com infors.ca@infors-ht.com info@infors-ht.com.cn
2

Infors UK Ltd

Infors Sarl

Metabolic analysis and bioprocess control


RQ-based nutrient supply
Calculation of growth rate ()
Automatic calculation of OUR, OTR, CER, CTR and RQ
Monitoring of decomposition rate (bioremediation)

Infors Benelux BV

Infors Canada

May be subject to technical amendments YP 792005e


For more information please visit: www.infors-ht.com

1210-en

Data can be used for the following:

O2 reading: 0 25% (+/ 2% FS),


zirconium electrolysis cell
C
 O2 reading: 0 10% (+/ 0,5% FS),
infrared spectrometer

Infors AG
Headoffice, Switzerland

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