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Aspirin Exp

This document provides the procedure for making 20 aspirin capsules. It lists the ingredients as aspirin, lactose, and sodium bicarbonate. The procedure involves accurately weighing and mixing the ingredients, filling empty capsules using the punch method, sealing with mineral oil, and proper storage. The document also addresses the physical and chemical properties of the ingredients, their uses in the formula, and appropriate storage conditions.

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Lyrojen Mae Torralba
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303 views4 pages

Aspirin Exp

This document provides the procedure for making 20 aspirin capsules. It lists the ingredients as aspirin, lactose, and sodium bicarbonate. The procedure involves accurately weighing and mixing the ingredients, filling empty capsules using the punch method, sealing with mineral oil, and proper storage. The document also addresses the physical and chemical properties of the ingredients, their uses in the formula, and appropriate storage conditions.

Uploaded by

Lyrojen Mae Torralba
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
You are on page 1/ 4

Name: Lyrojen Mae T.

Torralba Date: June 28, 2019


Preparation No. 1
Aspirin Capsule

I. Objective
To make Aspirin Capsule

II. Category
Pharmalogical

III. Materials and Ingredients


Materials: Ingredients:
Mortar & Pestle Lactose
Spatula Aspirin
Empty Amber Bottle Sodium Bicarbonate
Pill Tile Mineral Oil

IV. Formula O.A (g)


C.A = 20 capsules x
1 capsules
Aspirin – 0.165 g
Lactose – 0.165 g
Sodium Bicarbonate – 0.165 g

V. Procedure
Step 1: weigh all ingredients accurately
Step 2: Mix aspirin , Lactose, Sodium Bicarbonate by triturating in a mortar & pestle to reduce to
a fine & uniform powder.
Step 3: After triturating , place the powder in the pill tile & divide it to two equal parts.
Step 4: Separate capsule from the capsule body
Step 5: Fill using punch method
Step 6: Seal and polish capsule using mineral oil
Step 7: Place the capsules in suitable container
Step 8: Label Properly

VI. Computation O.A (g)


C.A = 20 capsules x
1 capsule

C.A = 3.3 g
Aspirin 0.165 g 3.3 g
Lactose 0.165 g 3.3 g
Sodium Bicarbonate 0.165 g 3.3 g
To make 20 capsules

VII. Questions
1. What are the different sizes of capsules?
- "000" holds about 1000 mg., "00" holds about 735 mg., "0" size holds about 500
mg., #1 holds about 400 mg., #3 about 200 mg. One teaspoon will fill about 7 "0" capsules
and about 5 "00" capsules. The weight depends on the density of the powder you are using.

2. What are the sizes of capsules intended only for humans?


- For human use capsules ranging in size from 000 to 5

3. What are the physical and chemical properties of the ingredients?


Lactose
Physical Property
- LACTOSE is a white hard crystalline powder
Chemical Property
- Lactose is very stable and inert from a chemical point of view. It has, apart from
some special cases, no significant tendency to react with the drug or other components
of a formulation.Some remarks on the chemical properties of lactose are useful however.
Aspirin
Physical Property
- acetylsalicylic acid is a colorless to white crystalline solid with a vinegar odor
due its hydrolysis yielding salicylic and acetic acid.
Chemical Property
- Aetylsalicyl acid is known by its capacity as anti-inflammatory drug.

Sodium Bicarbonate
Physical Property
- a white, crystalline powder that sometimes forms lumps.
Chemical Property
- the chemical properties of not being flammable, being easily decomposed by
acids, starting to decompose in water solution at approximately 20 degrees Celsius
and an increasing alkalinity in solution as it is heated or stirred.al Property
4. What is the use of the pharmaceutic ingredients in the formula?
Lactose
- is widely used as a filler or filler-binder in the manufacture of
pharmaceutical tablets and capsules.

Aspirin
- is used to reduce fever and relieve mild to moderate pain from conditions
such as muscle aches, toothaches, common cold, and headaches.

Sodium Bicarbonate
- used to relieve heartburn, sour stomach, or acid indigestion by
neutralizing excess stomach acid.
VIII. Synonyms
Lactose
- AKA: milk sugar.disaccharide.

Aspirin
- AKA: Acetylsalicylic acid (ASA),Salicylate, 2-acetoxybenzoic acid, acetylsalicylate, O-
acetylsalicylic acid

Sodium bicarbonate
- AKA: Baking Soda
IX. Uses of the Preparation
Aspirin
 commonly used as a pain reliever for minor aches and pains and to reduce fever.
 It is also an anti-inflammatory drug and can be used as a blood thinner.

X. Methods of Preparation
 Trituration Process
 Punching Method
 Sterilization

XI. Appropriate Container


 Amber Bottle

XII. Official Description and Finished Product


Aspirin Capsule
USP 42

XIII. Recommended Storage Condition

Aspirin should be stored at room temperature, 20 C to 25 C (68 F to 77 F), in a sealed


container, avoiding moisture.
XIV. Label

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