Scribd
Upload
933 views3 pages

Absorbable Dusting Powder

The document provides information on several pharmaceutical preparations including absorbable dusting powder, calcium carbonate tablets, and aspirin capsules. It describes the official titles, uses, definitions, preparation procedures, and common questions for each preparation. The preparations are used as lubricants, antacids, analgesics, and involve processes like pulverization, granulation, and capsule filling. Common questions address packaging, chemical reactions, hydrolysis products, and adverse effects of long term high dose administration.

Uploaded by

Roseanne Legaspi Casayuran
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
933 views3 pages

Absorbable Dusting Powder

The document provides information on several pharmaceutical preparations including absorbable dusting powder, calcium carbonate tablets, and aspirin capsules. It describes the official titles, uses, definitions, preparation procedures, and common questions for each preparation. The preparations are used as lubricants, antacids, analgesics, and involve processes like pulverization, granulation, and capsule filling. Common questions address packaging, chemical reactions, hydrolysis products, and adverse effects of long term high dose administration.

Uploaded by

Roseanne Legaspi Casayuran
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
You are on page 1/ 3

ABSORBABLE DUSTING POWDER

Official title: ABSORBABLE DUSTING POWDER, USP

Category: Topical Drug

Synonyms: Bath powder, Toilet powder, Starch derivative, Talcum powder, Talc powder

Uses: It was used in the past to prevent surgical gloves from sticking or simply as lubricant for surgical


gloves.

Official definition:

It is an absorbable powder prepared by processing cornstarch and intended for use as a lubricant for
surgical gloves. It contains not more than 2.0percent of magnesium oxide.

Preparation/ Compounding procedure :

Pulverize starch and magnesium oxide to fine powders, and pass through a 90-mesh sieve.

Triturate the two powders (starch over magnesium oxide) in a mortar with pestle method

Questions:

How are you going to package this preparation? 

 Preserve in well-closed containers. It may be preserved in sealed paper packets.

What is pregelatinized starch?

Pregelatinized starches are physically modified starches which are predominantly produced by wet-
thermal digestion. In contrast to native starch, they form dispersions or pastes or gels with cold water,
depending on the concentration of the pregelatinized starch used and depending on the type of starch
used to produce the pregelatinized starch

CALCIUM CARBONATE TABLET

Official title: CALCIUM CARBONATE

Category: Tablet and capsule diluent and/or antacid

Synonyms: Chalk; INS No. 170 (i)

Uses: Calcium carbonate is used as an antacid to relieve heartburn, acid indigestion, and upset stomach.

Official definition: Calcium carbonate is a dietary supplement used when the amount of calcium taken in
the diet is not enough. Calcium is needed by the body for healthy bones, muscles, nervous system, and
heart.
Preparation/ Compounding procedure :

1) add the calcium carbonate of crossing 120 mesh sieves again and fully mixes, and it is subsequent use
to cross 40 mesh sieves.

2) other adjuvants of having crossed mesh sieve except that magnesium stearate are added in (1), cross
80 mesh sieve mix homogeneously.

3) add 5% starch slurry and process soft material, cross 16 orders and granulate.

4) put in 50 ℃ of baking ovens and dry. Press formula ratio in the granule and add magnesium stearate,
cross 20 order granulate. Survey in the granule behind the drug content tableting

Questions:

1.Define:

a. tablet triturate- a small tablet made by molding fine moistened powder containing a medicinal and a
diluent

b. dispensing tablet - a tablet prepared by molding or by compression; used by the dispensing


pharmacist to obtain certain potent substances in a convenient form for accurate compounding.

c. hypodermic tablet- a water-soluble tablet that contains a specified amount of medication and is
intended for hypodermic administration.

2. What precautions should be observed in the preparation of tablet triturate?

The tablet triturate form includes a cementatory network constituted by a water-soluble but ethanol-
insoluble carbohydrate. Also included are discrete particles of a solid, water-soluble but triglyceride-
insoluble active ingredient, a polymer, an emulsifier, and sodium bicarbonate wherein the discrete
particles have a triglyceride coating.

ASPIRIN CAPSULES 

Official title: Acetyl salicylic acid

Category: non-steroidal anti-inflammatory drug (NSAID)

Synonyms: Acetylsalicylate, analgesic

Uses: Aspirin is used to reduce fever and relieve mild to moderate pain from conditions such as muscle
aches, toothaches, common cold, and headaches. It may also be used to reduce pain and swelling in
conditions such as arthritis.
Official definition: Also known as Aspirin, acetylsalicylic acid (ASA) is a commonly used drug for the
treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and
antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood
clots stroke, and myocardial infarction (MI).

Preparation/ Compounding procedure:

A: Heat about 100 mg of the Capsule contents with 10 mL of water for several minutes, cool, and add 1
drop of ferric chloride TS: a violet-red color is produced.

B: Shake a quantity of the contents of Capsules, equivalent to about 500 mg of aspirin, with 10 mL of
alcohol for several minutes.

Questions:

1.Give the chemical reactions involved in the preparation of Aspirin

The reaction that is used for the synthesis is shown below. In this reaction, an excess of acetic anhydride
(C4H6O3) is added to a measured mass of salicylic acid (C7H6O3) in the presence of a catalyst, sulfuric
acid (H2SO4). The mixture is heated to form the acetylsalicylic acid (C9H8O4) and acetic acid (C2H4O2).
After the reaction takes place, water is added to destroy the excess acetic anhydride and cause the
product to crystallize. The aspirin is then collected, purified by recrystallization, and its melting
temperature measured.

2. What acids are formed upon gradual hydrolysis of Aspirin in moist air?

Aspirin is a pain reliever and fever reducer, but if it's allowed to react with water then it can undergo
hydrolysis, forming salicylic acid and acetic acid, which is no longer effective. This reaction can occur
under acidic or basic conditions.

3.What are the adverse effects of prolonged administration of Aspirin (about 3.6 g daily)?

Severe nausea, vomiting, or stomach pain; bloody or tarry stools, coughing up blood or vomit that looks
like coffee grounds; fever lasting longer than 3 days; or. swelling, or pain lasting longer than 10 days.

You might also like

pFad - Phonifier reborn

Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy