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Pathophysiology: Risk Factors

1) Arterial wall injury, such as endothelial injury, allows lipids and platelets to accumulate in the area, increasing permeability. 2) Oxidized LDL attracts monocytes and macrophages, which begin to form plaques as lipids are engulfed by foam cells. 3) Smooth muscle cells multiply within the plaques, decreasing coronary tissue perfusion and oxygenation, which can lead to angina or myocardial infarction.

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43 views1 page

Pathophysiology: Risk Factors

1) Arterial wall injury, such as endothelial injury, allows lipids and platelets to accumulate in the area, increasing permeability. 2) Oxidized LDL attracts monocytes and macrophages, which begin to form plaques as lipids are engulfed by foam cells. 3) Smooth muscle cells multiply within the plaques, decreasing coronary tissue perfusion and oxygenation, which can lead to angina or myocardial infarction.

Uploaded by

shaitabligan
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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PATHOPHYSIOLOGY

RISK FACTORS A.NON-SPECIFIC


NON-MODIFIABLE INJURY TO
AND MODIFIABLE ARTERIAL WALL
(ENDOTHELIAL
INJURY)

DESQUAMATION OF
ENDOTHELIAL LINING

B. LIPIDS AND PLATELET INCREASED


ACCUMULATION IN THE PERMEABILITY
AREA

OXIDIZED LDL ATTRACTS PLAQUES BEGIN TO


MONOCYTES AND FORM
MACROPHAGES

CAHD LIPIDS ARE ENGULFED


BY FOAM CELLS AND
SMOOTH MUSCLE CELLS
MULTIPLY

DECREASED CORONARY CORONARY ISCHEMIA


TISSUE PERFUSION

DECREASED MYOCARDIAL OXYGENATION


ANGINA PECTORIS
MYOCARDIAL INFARCTION

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