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Pathophys of CAD

1) Arterial wall injury from risk factors like smoking can cause endothelial injury and desquamation of the endothelial lining, increasing permeability for lipids and platelets. 2) Oxidized LDL attracts monocytes and macrophages, starting plaque formation as lipids are engulfed by foam cells. 3) Plaques grow and smooth muscle cells multiply, decreasing coronary tissue perfusion and oxygenation to cause angina and myocardial infarction.

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54 views1 page

Pathophys of CAD

1) Arterial wall injury from risk factors like smoking can cause endothelial injury and desquamation of the endothelial lining, increasing permeability for lipids and platelets. 2) Oxidized LDL attracts monocytes and macrophages, starting plaque formation as lipids are engulfed by foam cells. 3) Plaques grow and smooth muscle cells multiply, decreasing coronary tissue perfusion and oxygenation to cause angina and myocardial infarction.

Uploaded by

shaitabligan
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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PATHOPHYSIOLOGY

RISK FACTORS A.NON-SPECIFIC


NON-MODIFIABLE INJURY TO
AND MODIFIABLE ARTERIAL WALL
(ENDOTHELIAL
INJURY)

DESQUAMATION OF
ENDOTHELIAL LINING

B. LIPIDS AND PLATELET INCREASED


ACCUMULATION IN THE PERMEABILITY
AREA

OXIDIZED LDL ATTRACTS PLAQUES BEGIN TO


MONOCYTES AND FORM
MACROPHAGES

CAHD LIPIDS ARE ENGULFED


BY FOAM CELLS AND
SMOOTH MUSCLE CELLS
MULTIPLY

DECREASED CORONARY CORONARY ISCHEMIA


TISSUE PERFUSION

DECREASED MYOCARDIAL OXYGENATION


ANGINA PECTORIS
MYOCARDIAL INFARCTION

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