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21 Compound Orange Spirit

This document provides the definition, preparation method, assay procedure, acceptance criteria, and additional requirements for Compound Orange Spirit. It defines Compound Orange Spirit as containing between 25-30 mL of mixed oils (orange oil, lemon oil, coriander oil, anise oil) in 100 mL of spirit. The preparation method involves mixing the specified quantities of oils and adding sufficient alcohol to make 1000 mL. The assay procedure involves adding the sample to a graduated bottle with kerosene, then using calcium chloride solution and centrifugation to separate and measure the volume of mixed oils. The acceptance criteria is 25-30 mL of mixed oils in 100 mL of spirit.

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Fersan Angeles
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354 views1 page

21 Compound Orange Spirit

This document provides the definition, preparation method, assay procedure, acceptance criteria, and additional requirements for Compound Orange Spirit. It defines Compound Orange Spirit as containing between 25-30 mL of mixed oils (orange oil, lemon oil, coriander oil, anise oil) in 100 mL of spirit. The preparation method involves mixing the specified quantities of oils and adding sufficient alcohol to make 1000 mL. The assay procedure involves adding the sample to a graduated bottle with kerosene, then using calcium chloride solution and centrifugation to separate and measure the volume of mixed oils. The acceptance criteria is 25-30 mL of mixed oils in 100 mL of spirit.

Uploaded by

Fersan Angeles
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Printed on: Wed Aug 04 2021, 05:47:52 PM Official Status: Currently Official on 04-Aug-2021 DocId: 1_GUID-72DB6E8B-A737-49F8-A1A9-2AACE6B2A903_1_en-US

(EST)
Printed by: Le Tran Official Date: Official Prior to 2013 Document Type: NF @2021 USPC
1

Analysis: To the Sample solution add sufficient saturated


Compound Orange Spirit calcium chloride solution, acidified with hydrochloric acid,
DEFINITION to almost fill the bulb of the bottle. Rotate the bottle
Compound Orange Spirit contains NLT 25 mL and NMT vigorously to ensure mixing, then add a sufficient quantity
30 mL of the mixed oils in 100 mL of Spirit. of the calcium chloride solution to bring the separated oil
Prepare Compound Orange Spirit as follows (see into the neck of the bottle. Centrifuge for 5 min at
Pharmaceutical Compounding—Nonsterile Preparations 1500 rpm, and read the volume of oil in the stem. Subtract
á795ñ). five divisions on the volumetric flask for the kerosene added,
and multiply the remaining number of divisions by 10.5 to
obtain the volume, in mL, of mixed oils in 100 mL of the
Orange Oil 200 mL Compound Orange Spirit.
Lemon Oil 50 mL Acceptance criteria: 25–30 mL
Coriander Oil 20 mL OTHER COMPONENTS
• ALCOHOL DETERMINATION, Method I á611ñ: 65.0%–70.0%
Anise Oil 5 mL

Alcohol, a sufficient quantity to make 1000 mL


ADDITIONAL REQUIREMENTS
• PACKAGING AND STORAGE: Package in tight containers,
protected from light, and store in a cold place.
Mix the oils with sufficient Alcohol to make the product
measure 1000 mL.
ASSAY
• PROCEDURE

al
Sample solution: Transfer 2.0 mL of Compound Orange
Spirit and 1.0 mL of kerosene to a Babcock bottle,
graduated to 8%, and mix.
ci
ffi
O

https://online.uspnf.com/uspnf/document/1_GUID-72DB6E8B-A737-49F8-A1A9-2AACE6B2A903_1_en-US 1/1

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